Adverse events occurred more frequently with higher doses, 800 mg once daily when compared to a lower dose of 200 mg once daily. In the 200 mg group, frequent adverse events (occurring in ?2% of patients) included: elevated creatine phosphokinase (6%), increased lipase (5%), muscle spasms (3%), asthenia (3%), and hypertension (3%). In the 800 mg group, frequent adverse events included: elevated creatine phosphokinase (13%), increased lipase (5%), weight loss (5%), muscle spasms (5%), decreased appetite (4%), rhabdomyolysis (3%), nausea (3%), hypertension (3%), increased alanine aminotransferase (3%), increased aspartate aminotransferase (3%), fatigue (2%), syncope (2%), anaemia (2%), dehydration (2%), hyperkalaemia (2%) and myalgia (2%). Rhabdomyolysis cases reported by investigators were not confirmed by the adjudication committee on muscle toxicity or the independent safety review. (2)
Sonidegib is a Hedgehog signaling pathway inhibitor (via smoothened antagonism) developed as an anticancer agent by Novartis. It was FDA approved in 2015 for the treatment of basal cell carcinoma.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Modafinil | The metabolism of Sonidegib can be increased when combined with Modafinil. |
| Armodafinil | The metabolism of Sonidegib can be increased when combined with Armodafinil. |
| Fluvoxamine | The metabolism of Sonidegib can be decreased when combined with Fluvoxamine. |
| Voriconazole | The metabolism of Sonidegib can be decreased when combined with Voriconazole. |
| Fluconazole | The metabolism of Sonidegib can be decreased when combined with Fluconazole. |
| Erythromycin | The metabolism of Sonidegib can be decreased when combined with Erythromycin. |
| Ziprasidone | The metabolism of Sonidegib can be decreased when combined with Ziprasidone. |
| Isradipine | The metabolism of Sonidegib can be decreased when combined with Isradipine. |
| Diltiazem | The metabolism of Sonidegib can be decreased when combined with Diltiazem. |
| Haloperidol | The metabolism of Sonidegib can be decreased when combined with Haloperidol. |
| Nicardipine | The metabolism of Sonidegib can be decreased when combined with Nicardipine. |
| Verapamil | The metabolism of Sonidegib can be decreased when combined with Verapamil. |
| Isoniazid | The metabolism of Sonidegib can be decreased when combined with Isoniazid. |
| Primaquine | The metabolism of Sonidegib can be decreased when combined with Primaquine. |
| Miconazole | The metabolism of Sonidegib can be decreased when combined with Miconazole. |
| Danazol | The metabolism of Sonidegib can be decreased when combined with Danazol. |
| Fusidic acid | The metabolism of Sonidegib can be decreased when combined with Fusidic acid. |
| Zimelidine | The metabolism of Sonidegib can be decreased when combined with Zimelidine. |
| Milnacipran | The metabolism of Sonidegib can be decreased when combined with Milnacipran. |
| Simeprevir | The metabolism of Sonidegib can be decreased when combined with Simeprevir. |
| Desvenlafaxine | The metabolism of Sonidegib can be decreased when combined with Desvenlafaxine. |
| Nilvadipine | The metabolism of Sonidegib can be decreased when combined with Nilvadipine. |
| Seproxetine | The metabolism of Sonidegib can be decreased when combined with Seproxetine. |
| Crizotinib | The metabolism of Sonidegib can be decreased when combined with Crizotinib. |
| Linagliptin | The metabolism of Sonidegib can be decreased when combined with Linagliptin. |
| Indalpine | The metabolism of Sonidegib can be decreased when combined with Indalpine. |
| Netupitant | The metabolism of Sonidegib can be decreased when combined with Netupitant. |
| Barnidipine | The metabolism of Sonidegib can be decreased when combined with Barnidipine. |
| Benidipine | The metabolism of Sonidegib can be decreased when combined with Benidipine. |
| Venetoclax | The metabolism of Sonidegib can be decreased when combined with Venetoclax. |
| Fosnetupitant | The metabolism of Sonidegib can be decreased when combined with Fosnetupitant. |
| Clozapine | The metabolism of Sonidegib can be decreased when combined with Clozapine. |
| Isavuconazonium | The metabolism of Sonidegib can be decreased when combined with Isavuconazonium. |
| Cyclosporine | The metabolism of Sonidegib can be decreased when combined with Cyclosporine. |
| Aprepitant | The metabolism of Sonidegib can be decreased when combined with Aprepitant. |
| Dronedarone | The metabolism of Sonidegib can be decreased when combined with Dronedarone. |
| Isavuconazole | The metabolism of Sonidegib can be decreased when combined with Isavuconazole. |
| Ciprofloxacin | The metabolism of Sonidegib can be decreased when combined with Ciprofloxacin. |
| Berotralstat | The metabolism of Sonidegib can be decreased when combined with Berotralstat. |
| Metreleptin | The metabolism of Sonidegib can be increased when combined with Metreleptin. |
| Pitolisant | The serum concentration of Sonidegib can be decreased when it is combined with Pitolisant. |
| Bexarotene | The metabolism of Sonidegib can be increased when combined with Bexarotene. |
| Bosentan | The metabolism of Sonidegib can be increased when combined with Bosentan. |
| Nafcillin | The metabolism of Sonidegib can be increased when combined with Nafcillin. |
| Etravirine | The metabolism of Sonidegib can be increased when combined with Etravirine. |
| Avasimibe | The metabolism of Sonidegib can be increased when combined with Avasimibe. |
| Echinacea | The metabolism of Sonidegib can be increased when combined with Echinacea. |
| Dexamethasone acetate | The metabolism of Sonidegib can be increased when combined with Dexamethasone acetate. |
| Topiramate | The metabolism of Sonidegib can be increased when combined with Topiramate. |
| Rifabutin | The metabolism of Sonidegib can be increased when combined with Rifabutin. |
| Warfarin | The metabolism of Sonidegib can be increased when combined with Warfarin. |
| Felbamate | The metabolism of Sonidegib can be increased when combined with Felbamate. |
| Genistein | The metabolism of Sonidegib can be increased when combined with Genistein. |
| Oritavancin | The metabolism of Sonidegib can be increased when combined with Oritavancin. |
| Rufinamide | The metabolism of Sonidegib can be increased when combined with Rufinamide. |
| Glycerol phenylbutyrate | The metabolism of Sonidegib can be increased when combined with Glycerol phenylbutyrate. |
| Eslicarbazepine acetate | The metabolism of Sonidegib can be increased when combined with Eslicarbazepine acetate. |
| Lesinurad | The metabolism of Sonidegib can be increased when combined with Lesinurad. |
| Asunaprevir | The metabolism of Sonidegib can be increased when combined with Asunaprevir. |
| Sarilumab | The metabolism of Sonidegib can be increased when combined with Sarilumab. |
| Esketamine | The metabolism of Sonidegib can be increased when combined with Esketamine. |
| Alpelisib | The metabolism of Sonidegib can be increased when combined with Alpelisib. |
| Calcitriol | The metabolism of Sonidegib can be increased when combined with Calcitriol. |
| Vitamin E | The metabolism of Sonidegib can be increased when combined with Vitamin E. |
| Flunisolide | The metabolism of Sonidegib can be increased when combined with Flunisolide. |
| Troglitazone | The metabolism of Sonidegib can be increased when combined with Troglitazone. |
| Butalbital | The metabolism of Sonidegib can be increased when combined with Butalbital. |
| Flucloxacillin | The metabolism of Sonidegib can be increased when combined with Flucloxacillin. |
| Acetaminophen | The metabolism of Sonidegib can be increased when combined with Acetaminophen. |
| Clobazam | The metabolism of Sonidegib can be increased when combined with Clobazam. |
| Aminoglutethimide | The metabolism of Sonidegib can be increased when combined with Aminoglutethimide. |
| Beclomethasone dipropionate | The metabolism of Sonidegib can be increased when combined with Beclomethasone dipropionate. |
| Griseofulvin | The metabolism of Sonidegib can be increased when combined with Griseofulvin. |
| Secobarbital | The metabolism of Sonidegib can be increased when combined with Secobarbital. |
| Cerivastatin | The metabolism of Sonidegib can be increased when combined with Cerivastatin. |
| Betamethasone | The metabolism of Sonidegib can be increased when combined with Betamethasone. |
| Quinine | The metabolism of Sonidegib can be increased when combined with Quinine. |
| Chlorpromazine | The metabolism of Sonidegib can be increased when combined with Chlorpromazine. |
| Dicloxacillin | The metabolism of Sonidegib can be increased when combined with Dicloxacillin. |
| Cyclophosphamide | The metabolism of Sonidegib can be increased when combined with Cyclophosphamide. |
| Rofecoxib | The metabolism of Sonidegib can be increased when combined with Rofecoxib. |
| Vinblastine | The metabolism of Sonidegib can be increased when combined with Vinblastine. |
| Fluocinolone acetonide | The metabolism of Sonidegib can be increased when combined with Fluocinolone acetonide. |
| Medroxyprogesterone acetate | The metabolism of Sonidegib can be increased when combined with Medroxyprogesterone acetate. |
| Triamcinolone | The metabolism of Sonidegib can be increased when combined with Triamcinolone. |
| Testosterone | The metabolism of Sonidegib can be increased when combined with Testosterone. |
| Clofibrate | The metabolism of Sonidegib can be increased when combined with Clofibrate. |
| Tamoxifen | The metabolism of Sonidegib can be increased when combined with Tamoxifen. |
| Hydrocortisone | The metabolism of Sonidegib can be increased when combined with Hydrocortisone. |
| Hydrocortamate | The metabolism of Sonidegib can be increased when combined with Hydrocortamate. |
| Oxcarbazepine | The metabolism of Sonidegib can be increased when combined with Oxcarbazepine. |
| Phenylbutazone | The metabolism of Sonidegib can be increased when combined with Phenylbutazone. |
| Mifepristone | The metabolism of Sonidegib can be increased when combined with Mifepristone. |
| Methylphenobarbital | The metabolism of Sonidegib can be increased when combined with Methylphenobarbital. |
| Terbinafine | The metabolism of Sonidegib can be increased when combined with Terbinafine. |
| Prednisolone | The metabolism of Sonidegib can be increased when combined with Prednisolone. |
| Ethanol | The metabolism of Sonidegib can be increased when combined with Ethanol. |
| Norgestimate | The metabolism of Sonidegib can be increased when combined with Norgestimate. |
| Methylprednisolone | The metabolism of Sonidegib can be increased when combined with Methylprednisolone. |
| Metyrapone | The metabolism of Sonidegib can be increased when combined with Metyrapone. |