Technetium Tc-99m mebrofenin

DB09137

small molecule approved

Deskripsi

Technetium Tc 99m Mebrofenin is a diagnostic radiopharmaceutical composed of diisopropyl-iminodiacetic acid (DISIDA) attached to a technetium-99m ion. Following intravenous injection, single photon emission computer tomography (SPECT) imaging of the liver or gallbladder is performed using a gamma camera to detect the gamma rays emitted by the technetium-99m as it decays. This is possible as Technetium-99m decays by isomeric transition to technetium-99 through the release of a gamma ray. Liver and gallbladder imaging is enabled through attachment to mebrofenin as this molecule has high hepatic uptake and fast biliary excretion, resulting in improved hepatic imaging. More specifically, mebrofenin is taken up into hepatocytes through the action of OATP1B1 and OATP1B3 transporters.

Currently available within a sterile kit, Tc-99m Mebrofenin is indicated for imaging of the liver and gallbladder.

Struktur Molekul 2D

Berat 484.23

Wujud solid

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) Technetium Tc 99m decays by isomeric transition with a physical half-life of 6.02 hours.

Volume Distribusi -

Klirens (Clearance) Following intravenous administration in normal subjects, Technetium Tc 99m Mebrofenin was rapidly cleared from the circulation.

Absorpsi

Visualisation in the liver could be detected by 5 minutes and maximum liver uptake occurred at 11 minutes post-injection. Hepatic duct and gallbladder visualization occurred by 10 to 15 minutes and intestinal activity was visualized by 30 to 60 minutes in subjects with normal hepatobiliary function The mean percent injected dose remaining in the blood at 10 minutes was 17%.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

The mean percent injected dose excreted in the urine during the first 3 hours was 1%.

Interaksi Makanan

1 Data

1. Take on an empty stomach. Administer Technetium Tc-99m mebrofenin at least 4 hours after food to avoid false positives caused by food stimulating emptying of the gallbladder.

Interaksi Obat

831 Data

Valsartan	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Valsartan.
Troglitazone	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Troglitazone.
Erythromycin	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Erythromycin.
Sildenafil	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Sildenafil.
Nelfinavir	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Nelfinavir.
Indinavir	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Indinavir.
Diethylstilbestrol	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Diethylstilbestrol.
Beclomethasone dipropionate	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Beclomethasone dipropionate.
Progesterone	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Progesterone.
Cerivastatin	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Cerivastatin.
Quinine	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Quinine.
Ritonavir	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Ritonavir.
Caspofungin	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Caspofungin.
Vincristine	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Vincristine.
Vinblastine	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Vinblastine.
Fluticasone propionate	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Fluticasone propionate.
Ivermectin	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Ivermectin.
Nicardipine	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Nicardipine.
Simvastatin	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Simvastatin.
Nystatin	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Nystatin.
Amprenavir	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Amprenavir.
Irinotecan	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Irinotecan.
Roxithromycin	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Roxithromycin.
Mifepristone	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Mifepristone.
Sirolimus	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Sirolimus.
Tipranavir	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Tipranavir.
Dipyridamole	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Dipyridamole.
Telithromycin	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Telithromycin.
Ketoconazole	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Ketoconazole.
Novobiocin	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Novobiocin.
Atorvastatin	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Atorvastatin.
Ouabain	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Ouabain.
Fluvastatin	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Fluvastatin.
Rosuvastatin	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Rosuvastatin.
Saquinavir	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Saquinavir.
Darunavir	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Darunavir.
Bezafibrate	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Bezafibrate.
Everolimus	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Everolimus.
Genistein	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Genistein.
Hyperforin	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Hyperforin.
Cholic Acid	The excretion of Technetium Tc-99m mebrofenin can be increased when combined with Cholic Acid.
Fusidic acid	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Fusidic acid.
Quercetin	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Quercetin.
Taurocholic acid	The excretion of Technetium Tc-99m mebrofenin can be increased when combined with Taurocholic acid.
Posizolid	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Posizolid.
Nilotinib	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Nilotinib.
Telaprevir	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Telaprevir.
Dovitinib	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Dovitinib.
Acetylcysteine	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Acetylcysteine.
Eltrombopag	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Eltrombopag.
Simeprevir	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Simeprevir.
Pazopanib	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Pazopanib.
Axitinib	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Axitinib.
Cholecystokinin	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Cholecystokinin.
Rilpivirine	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Rilpivirine.
Teriflunomide	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Teriflunomide.
Dabrafenib	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Dabrafenib.
Idelalisib	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Idelalisib.
Cobicistat	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Cobicistat.
Lenvatinib	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Lenvatinib.
Daclatasvir	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Daclatasvir.
Lobeglitazone	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Lobeglitazone.
Eluxadoline	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Eluxadoline.
Paritaprevir	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Paritaprevir.
Silibinin	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Silibinin.
Venetoclax	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Venetoclax.
Asunaprevir	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Asunaprevir.
Velpatasvir	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Velpatasvir.
Valspodar	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Valspodar.
Voxilaprevir	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Voxilaprevir.
Benzbromarone	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Benzbromarone.
Fluticasone	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Fluticasone.
Enasidenib	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Enasidenib.
Pibrentasvir	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Pibrentasvir.
Glecaprevir	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Glecaprevir.
Candesartan	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Candesartan.
Estradiol benzoate	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Estradiol benzoate.
Pexidartinib	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Pexidartinib.
Fedratinib	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Fedratinib.
Istradefylline	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Istradefylline.
Dronedarone	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Dronedarone.
Elexacaftor	The serum concentration of Technetium Tc-99m mebrofenin can be increased when it is combined with Elexacaftor.
Bempedoic acid	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Bempedoic acid.
Fostemsavir	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Fostemsavir.
Pralsetinib	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Pralsetinib.
Remdesivir	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Remdesivir.
Clarithromycin	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Clarithromycin.
Darolutamide	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Darolutamide.
Belumosudil	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Belumosudil.
Cyclosporine	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Cyclosporine.
Icosapent	Icosapent may decrease the excretion rate of Technetium Tc-99m mebrofenin which could result in a higher serum level.
Cefotiam	Cefotiam may decrease the excretion rate of Technetium Tc-99m mebrofenin which could result in a higher serum level.
Mesalazine	Mesalazine may decrease the excretion rate of Technetium Tc-99m mebrofenin which could result in a higher serum level.
Cefmenoxime	Cefmenoxime may decrease the excretion rate of Technetium Tc-99m mebrofenin which could result in a higher serum level.
Cefmetazole	Cefmetazole may decrease the excretion rate of Technetium Tc-99m mebrofenin which could result in a higher serum level.
Pamidronic acid	Pamidronic acid may decrease the excretion rate of Technetium Tc-99m mebrofenin which could result in a higher serum level.
Tenofovir disoproxil	Tenofovir disoproxil may decrease the excretion rate of Technetium Tc-99m mebrofenin which could result in a higher serum level.
Indomethacin	The excretion of Technetium Tc-99m mebrofenin can be decreased when combined with Indomethacin.
Cidofovir	Cidofovir may decrease the excretion rate of Technetium Tc-99m mebrofenin which could result in a higher serum level.
Cefpiramide	Cefpiramide may decrease the excretion rate of Technetium Tc-99m mebrofenin which could result in a higher serum level.

Referensi & Sumber

Artikel (PubMed)

PMID: 2184521
Krishnamurthy GT, Turner FE: Pharmacokinetics and clinical application of technetium 99m-labeled hepatobiliary agents. Semin Nucl Med. 1990 Apr;20(2):130-49.
PMID: 21163547
de Graaf W, Hausler S, Heger M, van Ginhoven TM, van Cappellen G, Bennink RJ, Kullak-Ublick GA, Hesselmann R, van Gulik TM, Stieger B: Transporters involved in the hepatic uptake of (99m)Tc-mebrofenin and indocyanine green. J Hepatol. 2011 Apr;54(4):738-45. doi: 10.1016/j.jhep.2010.07.047. Epub 2010 Oct 1.

Contoh Produk & Brand

Produk: 0 • International brands: 0

Belum ada data produk/brand untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field produk/brand.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.