Peringatan Keamanan

Renal toxicity has been reported in a few patients with liver dysfunction who were given an oral cholecystographic agent followed by intravascular contrast agents. Administration of any intravascular contrast agent should therefore be postponed in any patient with a known or suspected hepatic or biliary disorder who has recently received a cholecystographic contrast agent.

Other drugs should not be admixed with this product.

Pregnancy Category B

Ioxilan

DB09135

small molecule approved

Deskripsi

Ioxilan is a tri-iodinated diagnostic contrast agent. Intravascular injection results in opacification of vessels in the path of flow of the contrast medium, permitting radiographic visualization of the internal structures of the human body until significant hemodilution occurs.

Struktur Molekul 2D

Berat 791.116
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) An initial fast distribution phase with a half-life of 13.1 ± 4.2 minutes (women) or 23.5 ± 15.3 minutes (men) was followed by an elimination phase with a half-life of 102.0 ± 16.9 minutes (women) and 137 ± 35.4 minutes (men).
Volume Distribusi Ioxilan is distributed mainly in the blood as suggested by the apparent volume of distribution (central compartment), 7.2 ± 1.0 L in women and 10.0 ± 2.4 L in men
Klirens (Clearance) The total clearance values were 95.4 ± 11.1 mL·min-1 and 101.0 ± 14.7 mL·min-1 and the renal clearance values were 89.4 ± 13.3 mL·min-1 and 94.9 ± 16.6 mL·min-1 for women and men, respectively.

Absorpsi

Peak iodine plasma levels occur immediately following rapid intravenous injection. Iodine plasma levels fall rapidly within 5 to 10 minutes. This can be accounted for by the dilution in the vascular and extravascular fluid compartments.

Metabolisme

There is no evidence for metabolism.

Rute Eliminasi

The average amount of ioxilan excreted unchanged in urine at 24 hours represents 93.7% of the dose in young healthy subjects (21-27 years) after intravenous administration. This finding suggests that, compared to the renal excretion, biliary and/or gastrointestinal excretion are not important.

Interaksi Obat

727 Data
Aldesleukin The risk of a hypersensitivity reaction to Ioxilan is increased when it is combined with Aldesleukin.
Metformin The risk or severity of adverse effects can be increased when Ioxilan is combined with Metformin.
Cyclosporine Cyclosporine may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Icosapent Icosapent may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Cefotiam Cefotiam may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Mesalazine Mesalazine may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Cefmenoxime Cefmenoxime may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Cefmetazole Cefmetazole may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Pamidronic acid Pamidronic acid may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Tenofovir disoproxil Tenofovir disoproxil may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Indomethacin Indomethacin may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Cidofovir Cidofovir may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Cefpiramide Cefpiramide may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Ceftazidime Ceftazidime may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Loracarbef Loracarbef may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Cefalotin Cefalotin may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Nabumetone Nabumetone may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Ketorolac Ketorolac may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Tenoxicam Tenoxicam may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Celecoxib Celecoxib may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Cefotaxime Cefotaxime may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Tolmetin Tolmetin may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Foscarnet Foscarnet may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Rofecoxib Rofecoxib may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Piroxicam Piroxicam may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Methotrexate Methotrexate may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Cephalexin Cephalexin may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Fenoprofen Fenoprofen may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Valaciclovir Valaciclovir may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Valdecoxib Valdecoxib may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Diclofenac Diclofenac may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Sulindac Sulindac may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Bacitracin Bacitracin may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Amphotericin B Amphotericin B may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Cephaloglycin Cephaloglycin may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Flurbiprofen Flurbiprofen may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Adefovir dipivoxil Adefovir dipivoxil may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Pentamidine Pentamidine may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Etodolac Etodolac may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Mefenamic acid Mefenamic acid may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Acyclovir Acyclovir may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Naproxen Naproxen may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Sulfasalazine Sulfasalazine may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Phenylbutazone Phenylbutazone may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Meloxicam Meloxicam may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Carprofen Carprofen may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Cefaclor Cefaclor may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Diflunisal Diflunisal may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Tacrolimus Tacrolimus may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Ceforanide Ceforanide may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Salicylic acid Salicylic acid may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Meclofenamic acid Meclofenamic acid may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Acetylsalicylic acid Acetylsalicylic acid may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Carboplatin Carboplatin may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Oxaprozin Oxaprozin may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Ketoprofen Ketoprofen may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Balsalazide Balsalazide may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Ibuprofen Ibuprofen may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Cefditoren Cefditoren may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Atazanavir Atazanavir may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Colistimethate Colistimethate may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Cefuroxime Cefuroxime may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Cefapirin Cefapirin may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Cefadroxil Cefadroxil may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Cefprozil Cefprozil may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Ceftriaxone Ceftriaxone may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Olsalazine Olsalazine may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Lumiracoxib Lumiracoxib may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Cefamandole Cefamandole may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Cefazolin Cefazolin may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Cefonicid Cefonicid may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Cefoperazone Cefoperazone may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Cefotetan Cefotetan may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Cefoxitin Cefoxitin may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Ceftizoxime Ceftizoxime may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Cefradine Cefradine may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Magnesium salicylate Magnesium salicylate may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Salsalate Salsalate may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Choline magnesium trisalicylate Choline magnesium trisalicylate may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Cefepime Cefepime may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Cefacetrile Cefacetrile may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Ceftibuten Ceftibuten may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Cefpodoxime Cefpodoxime may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Antrafenine Antrafenine may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Aminophenazone Aminophenazone may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Antipyrine Antipyrine may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Tiaprofenic acid Tiaprofenic acid may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Lopinavir Lopinavir may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Etoricoxib Etoricoxib may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Hydrolyzed Cephalothin Hydrolyzed Cephalothin may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Cephalothin Group Cephalothin Group may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Oxyphenbutazone Oxyphenbutazone may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Latamoxef Latamoxef may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Nimesulide Nimesulide may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Benoxaprofen Benoxaprofen may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Metamizole Metamizole may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Zomepirac Zomepirac may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Ceftobiprole Ceftobiprole may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Cimicoxib Cimicoxib may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Ceftaroline fosamil Ceftaroline fosamil may decrease the excretion rate of Ioxilan which could result in a higher serum level.

Referensi & Sumber

Belum ada data referensi/link/attachment untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field referensi.

Contoh Produk & Brand

Produk: 2 • International brands: 0
Produk
  • Oxilan
    Injection, solution • 300 mg/1mL • Intravascular • US • Approved
  • Oxilan
    Injection, solution • 350 mg/1mL • Intravascular • US • Approved

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
© 2025 Digital Pharmacy Research - Universitas Esa Unggul