Ioversol overdosage causes life-threatening adverse effects, mainly in the pulmonary and cardiovascular system.L41780 In case of an overdose, treatment must focus on the support of vital functions and the prompt institution of symptomatic therapy.L41785 The carcinogenic potential of ioversol has not been evaluated, and non-clinical studies suggest that ioversol is not mutagenic and does not affect fertility.L41780 The LD50 values in mice and rats are 17 g/kg and 15 g/kg respectively. Developmental toxicity studies were carried out in rats (gestation day 7 to 17) and rabbits (gestation day 6 to 18) given ioversol at the following intravenous doses: 0, 0.2, 0.8, and 3.2 g iodine/kg/day. Adverse effects on embryo-fetal development were not detected in either species, while maternal toxicity was detected in rabbits at 0.8, and 3.2 g iodine/kg/day.L41780
Serious adverse reactions have been reported due to the inadvertent intrathecal administration of iodinated contrast media that are not indicated for intrathecal use such as ioversol. These serious adverse reactions include death, convulsions, cerebral hemorrhage, coma, paralysis, arachnoiditis, acute renal failure, cardiac arrest, seizures, rhabdomyolysis, hyperthermia, and brain edema.L41780 Caution must be exercised in patients with severely impaired renal function, combined renal and hepatic disease, severe thyrotoxicosis, myelomatosis, or anuria, particularly when large doses are administered.L41785
Ioversol is a non-ionic compound with a tri-iodinated benzene ring used as a contrast dye in diagnostic procedures to visualize different types of organs and tissues.L41780 Iodine has a high atomic density, which gives it the ability to attenuate X-rays.L41790 The intravascular administration of iodine compounds, such as ioversol, enhances the contrast between vessels in the path of the flow of the contrast medium and normal tissue, allowing the visualization of internal structures.L41780 Ioversol is a highly hydrophilic agent considered to be generally safeL41790; however, serious adverse reactions have been reported due to the inadvertent intrathecal administration of ioversol, which is only indicated for intra-arterial and intravenous use.L41780
Ioversol was approved by the FDA in 1989 and is currently indicated for computed tomographic (CT) imaging and contrast enhancement in peripheral arteriography, coronary arteriography, and left ventriculography.L41780,L41790
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Aldesleukin | The risk of a hypersensitivity reaction to Ioversol is increased when it is combined with Aldesleukin. |
| Metformin | The risk or severity of adverse effects can be increased when Ioversol is combined with Metformin. |
| Cyclosporine | Cyclosporine may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Icosapent | Icosapent may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Cefotiam | Cefotiam may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Mesalazine | Mesalazine may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Cefmenoxime | Cefmenoxime may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Cefmetazole | Cefmetazole may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Pamidronic acid | Pamidronic acid may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Tenofovir disoproxil | Tenofovir disoproxil may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Indomethacin | Indomethacin may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Cidofovir | Cidofovir may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Cefpiramide | Cefpiramide may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Ceftazidime | Ceftazidime may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Loracarbef | Loracarbef may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Cefalotin | Cefalotin may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Nabumetone | Nabumetone may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Ketorolac | Ketorolac may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Tenoxicam | Tenoxicam may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Celecoxib | Celecoxib may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Cefotaxime | Cefotaxime may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Tolmetin | Tolmetin may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Foscarnet | Foscarnet may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Rofecoxib | Rofecoxib may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Piroxicam | Piroxicam may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Methotrexate | Methotrexate may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Cephalexin | Cephalexin may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Fenoprofen | Fenoprofen may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Valaciclovir | Valaciclovir may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Valdecoxib | Valdecoxib may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Diclofenac | Diclofenac may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Sulindac | Sulindac may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Bacitracin | Bacitracin may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Amphotericin B | Amphotericin B may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Cephaloglycin | Cephaloglycin may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Flurbiprofen | Flurbiprofen may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Adefovir dipivoxil | Adefovir dipivoxil may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Pentamidine | Pentamidine may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Etodolac | Etodolac may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Mefenamic acid | Mefenamic acid may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Acyclovir | Acyclovir may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Naproxen | Naproxen may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Sulfasalazine | Sulfasalazine may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Phenylbutazone | Phenylbutazone may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Meloxicam | Meloxicam may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Carprofen | Carprofen may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Cefaclor | Cefaclor may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Diflunisal | Diflunisal may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Tacrolimus | Tacrolimus may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Ceforanide | Ceforanide may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Salicylic acid | Salicylic acid may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Meclofenamic acid | Meclofenamic acid may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Acetylsalicylic acid | Acetylsalicylic acid may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Carboplatin | Carboplatin may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Oxaprozin | Oxaprozin may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Ketoprofen | Ketoprofen may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Balsalazide | Balsalazide may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Ibuprofen | Ibuprofen may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Cefditoren | Cefditoren may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Atazanavir | Atazanavir may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Colistimethate | Colistimethate may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Cefuroxime | Cefuroxime may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Cefapirin | Cefapirin may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Cefadroxil | Cefadroxil may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Cefprozil | Cefprozil may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Ceftriaxone | Ceftriaxone may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Olsalazine | Olsalazine may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Lumiracoxib | Lumiracoxib may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Cefamandole | Cefamandole may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Cefazolin | Cefazolin may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Cefonicid | Cefonicid may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Cefoperazone | Cefoperazone may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Cefotetan | Cefotetan may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Cefoxitin | Cefoxitin may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Ceftizoxime | Ceftizoxime may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Cefradine | Cefradine may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Magnesium salicylate | Magnesium salicylate may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Salsalate | Salsalate may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Choline magnesium trisalicylate | Choline magnesium trisalicylate may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Cefepime | Cefepime may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Cefacetrile | Cefacetrile may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Ceftibuten | Ceftibuten may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Cefpodoxime | Cefpodoxime may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Antrafenine | Antrafenine may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Aminophenazone | Aminophenazone may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Antipyrine | Antipyrine may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Tiaprofenic acid | Tiaprofenic acid may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Lopinavir | Lopinavir may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Etoricoxib | Etoricoxib may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Hydrolyzed Cephalothin | Hydrolyzed Cephalothin may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Cephalothin Group | Cephalothin Group may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Oxyphenbutazone | Oxyphenbutazone may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Latamoxef | Latamoxef may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Nimesulide | Nimesulide may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Benoxaprofen | Benoxaprofen may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Metamizole | Metamizole may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Zomepirac | Zomepirac may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Ceftobiprole | Ceftobiprole may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Cimicoxib | Cimicoxib may decrease the excretion rate of Ioversol which could result in a higher serum level. |
| Ceftaroline fosamil | Ceftaroline fosamil may decrease the excretion rate of Ioversol which could result in a higher serum level. |