Peringatan Keamanan

Copper toxicity is belevied to be due to fenton-type redox reactions occuring with high copper concentrations which produce damaging reactive oxygen species A19514.

Copper

DB09130

small molecule approved investigational

Deskripsi

Copper is a transition metal and a trace element in the body. It is important to the function of many enzymes including cytochrome c oxidase, monoamine oxidase and superoxide dismutase FDA Label. Copper is commonly used in contraceptive intrauterine devices (IUD) L801.

Struktur Molekul 2D

Berat 63.546
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Copper absorption varies inversely with intake. Absorption range is 12-65%.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Copper appears to be eliminated primarily through bile A19514.

Interaksi Obat

22 Data
Dehydroascorbic acid The serum concentration of Dehydroascorbic acid can be decreased when it is combined with Copper.
Zinc ascorbate The serum concentration of Zinc ascorbate can be decreased when it is combined with Copper.
Chlorotrianisene Chlorotrianisene can cause an increase in the absorption of Copper resulting in an increased serum concentration and potentially a worsening of adverse effects.
Conjugated estrogens Conjugated estrogens can cause an increase in the absorption of Copper resulting in an increased serum concentration and potentially a worsening of adverse effects.
Estrone Estrone can cause an increase in the absorption of Copper resulting in an increased serum concentration and potentially a worsening of adverse effects.
Estradiol Estradiol can cause an increase in the absorption of Copper resulting in an increased serum concentration and potentially a worsening of adverse effects.
Dienestrol Dienestrol can cause an increase in the absorption of Copper resulting in an increased serum concentration and potentially a worsening of adverse effects.
Ethinylestradiol Ethinylestradiol can cause an increase in the absorption of Copper resulting in an increased serum concentration and potentially a worsening of adverse effects.
Estriol Estriol can cause an increase in the absorption of Copper resulting in an increased serum concentration and potentially a worsening of adverse effects.
Estrone sulfate Estrone sulfate can cause an increase in the absorption of Copper resulting in an increased serum concentration and potentially a worsening of adverse effects.
Quinestrol Quinestrol can cause an increase in the absorption of Copper resulting in an increased serum concentration and potentially a worsening of adverse effects.
Hexestrol Hexestrol can cause an increase in the absorption of Copper resulting in an increased serum concentration and potentially a worsening of adverse effects.
Polyestradiol phosphate Polyestradiol phosphate can cause an increase in the absorption of Copper resulting in an increased serum concentration and potentially a worsening of adverse effects.
Zeranol Zeranol can cause an increase in the absorption of Copper resulting in an increased serum concentration and potentially a worsening of adverse effects.
Equol Equol can cause an increase in the absorption of Copper resulting in an increased serum concentration and potentially a worsening of adverse effects.
Promestriene Promestriene can cause an increase in the absorption of Copper resulting in an increased serum concentration and potentially a worsening of adverse effects.
Methallenestril Methallenestril can cause an increase in the absorption of Copper resulting in an increased serum concentration and potentially a worsening of adverse effects.
Epimestrol Epimestrol can cause an increase in the absorption of Copper resulting in an increased serum concentration and potentially a worsening of adverse effects.
Moxestrol Moxestrol can cause an increase in the absorption of Copper resulting in an increased serum concentration and potentially a worsening of adverse effects.
Estradiol acetate Estradiol acetate can cause an increase in the absorption of Copper resulting in an increased serum concentration and potentially a worsening of adverse effects.
Biochanin A Biochanin A can cause an increase in the absorption of Copper resulting in an increased serum concentration and potentially a worsening of adverse effects.
Formononetin Formononetin can cause an increase in the absorption of Copper resulting in an increased serum concentration and potentially a worsening of adverse effects.

Target Protein

Amyloid-beta precursor protein APP
Adenosylhomocysteinase AHCY
Histone H2B type 1-C/E/F/G/I H2BC4
Glyceraldehyde-3-phosphate dehydrogenase GAPDH
Nucleoside diphosphate kinase A NME1
Histone H1.4 H1-4
Peroxiredoxin-1 PRDX1
Protein S100-A8 S100A8
Small ribosomal subunit protein uS2 RPSA
Actin, cytoplasmic 2 ACTG1
Alpha-enolase ENO1
Elongation factor 1-alpha 1 EEF1A1
Keratin, type II cytoskeletal 8 KRT8
Protein disulfide-isomerase P4HB
Protein disulfide-isomerase A3 PDIA3
60 kDa heat shock protein, mitochondrial HSPD1
Heat shock 70 kDa protein 13 HSPA13
Endoplasmic reticulum chaperone BiP HSPA5
Endoplasmin HSP90B1
Serotransferrin TF
Cell growth-regulating nucleolar protein Lyar
Small ribosomal subunit protein uS5 RPS2
Serine/arginine-rich splicing factor 1 SRSF1
Heterogeneous nuclear ribonucleoproteins A2/B1 HNRNPA2B1
Heterogeneous nuclear ribonucleoprotein H HNRNPH1
Heterogeneous nuclear ribonucleoprotein H3 HNRNPH3
Cobalt-precorrin-5B C(1)-methyltransferase cbiD
Heterogeneous nuclear ribonucleoprotein L HNRNPL
Splicing factor, proline- and glutamine-rich SFPQ
Splicing factor 3A subunit 2 SF3A2
Small ribosomal subunit protein RACK1 RACK1
Alpha-actinin-1 ACTN1
Aminoacylase-1 ACY1
Annexin A4 ANXA4
Annexin A5 ANXA5
Calreticulin CALR
Pyruvate kinase PKM PKM
Aldo-keto reductase family 1 member A1 AKR1A1
NADH-cytochrome b5 reductase 3 CYB5R3
Glutathione reductase, mitochondrial GSR
Transketolase TKT
Peroxiredoxin-2 PRDX2
Peroxiredoxin-6 PRDX6
Peptidyl-prolyl cis-trans isomerase A PPIA
Heat shock cognate 71 kDa protein HSPA8
Heat shock protein HSP 90-alpha HSP90AA1
Prostaglandin E synthase 3 PTGES3
Stress-induced-phosphoprotein 1 STIP1
Eukaryotic translation initiation factor 6 EIF6
Eukaryotic initiation factor 4A-I EIF4A1
Glucose-6-phosphate isomerase GPI
L-lactate dehydrogenase A chain LDHA
Phosphoglycerate kinase 1 PGK1
Tubulin beta chain TUBB
Cofilin-1 CFL1
14-3-3 protein beta/alpha YWHAB
Aspartate aminotransferase, cytoplasmic GOT1
Glutathione synthetase GSS
Hepatoma-derived growth factor HDGF
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A
Chloride intracellular channel protein 1 CLIC1
Proteasome activator complex subunit 1 PSME1
Phosphatidylethanolamine-binding protein 1 PEBP1
Phosphoglycerate mutase 1 PGAM1
Ran-specific GTPase-activating protein RANBP1
UDP-glucose 6-dehydrogenase UGDH
Beta-2-microglobulin B2M
Protein SCO1 homolog, mitochondrial SCO1
Alternative prion protein PRNP
Glycine receptor subunit alpha-1 GLRA1
Huntingtin HTT
Endonuclease 8-like 1 NEIL1
Endonuclease 8-like 2 NEIL2
Ferroxidase HEPHL1 HEPHL1
Plasminogen activator inhibitor 1 SERPINE1
Protein S100-A2 S100A2
Protein S100-A4 S100A4
Alpha-synuclein SNCA
Neurotrophic factor BDNF precursor form BDNF
Parkinson disease protein 7 PARK7
Islet amyloid polypeptide IAPP
Tachykinin-3 TAC3
Alpha-1B-glycoprotein A1BG
Afamin AFM
Angiotensinogen AGT
Alpha-2-HS-glycoprotein AHSG
Serum amyloid P-component APCS
Apolipoprotein A-I APOA1
Apolipoprotein A-II APOA2
Apolipoprotein A-IV APOA4
Apolipoprotein B receptor APOBR
Apolipoprotein C-II APOC2
Apolipoprotein C-III APOC3
Apolipoprotein D APOD
Apolipoprotein E APOE
Beta-2-glycoprotein 1 APOH
Zinc-alpha-2-glycoprotein AZGP1
Complement C1q subcomponent subunit C C1QC
Complement C1s subcomponent C1S
Complement C3 C3
Complement C4-B C4B
C4b-binding protein alpha chain C4BPA
Complement C5 C5
Complement component C8 beta chain C8B
Complement component C9 C9
Complement factor H CFH
Complement factor I CFI
Tetranectin CLEC3B
Clusterin CLU
Prothrombin F2
Complement component 1 Q subcomponent-binding protein, mitochondrial C1QBP
Gelsolin GSN
Hemoglobin subunit alpha HBA1
Hemoglobin subunit beta HBB
Chromobox protein homolog 5 CBX5
Haptoglobin-related protein HPR
Insulin-like growth factor-binding protein complex acid labile subunit IGFALS
Immunoglobulin heavy constant gamma 1 IGHG1
Immunoglobulin heavy constant gamma 4 IGHG4
Immunoglobulin kappa variable 3-20 IGKV3-20
Immunoglobulin lambda-like polypeptide 1 IGLL1
Inter-alpha-trypsin inhibitor heavy chain H2 ITIH2
Kininogen-1 KNG1
Keratin, type II cytoskeletal 1 KRT1
Keratin, type I cytoskeletal 10 KRT10
Keratin, type II cytoskeletal 2 epidermal KRT2
Keratin, type I cytoskeletal 9 KRT9
Leucine-rich alpha-2-glycoprotein LRG1
Lumican LUM
N-acetylmuramoyl-L-alanine amidase PGLYRP2
Plasminogen PLG
Serum paraoxonase/arylesterase 1 PON1
Platelet basic protein PPBP
Alpha-1-antitrypsin SERPINA1
Kallistatin SERPINA4
Corticosteroid-binding globulin SERPINA6
Thyroxine-binding globulin SERPINA7
Antithrombin-III SERPINC1
Heparin cofactor 2 SERPIND1
Pigment epithelium-derived factor SERPINF1
Alpha-2-antiplasmin SERPINF2
Plasma protease C1 inhibitor SERPING1
Transthyretin TTR
Vitronectin VTN
Amyloid beta precursor like protein 1 APLP1
Tubulin alpha 3C/D chain TUBA3C

Referensi & Sumber

Artikel (PubMed)
  • PMID: 27049134
    Bost M, Houdart S, Oberli M, Kalonji E, Huneau JF, Margaritis I: Dietary copper and human health: Current evidence and unresolved issues. J Trace Elem Med Biol. 2016 May;35:107-15. doi: 10.1016/j.jtemb.2016.02.006. Epub 2016 Mar 5.
  • PMID: 14652164
    Tapiero H, Townsend DM, Tew KD: Trace elements in human physiology and pathology. Copper. Biomed Pharmacother. 2003 Nov;57(9):386-98.
  • PMID: 17531610
    Ortiz ME, Croxatto HB: Copper-T intrauterine device and levonorgestrel intrauterine system: biological bases of their mechanism of action. Contraception. 2007 Jun;75(6 Suppl):S16-30. Epub 2007 Mar 29.
  • PMID: 19906252
    van den Berghe PV, Klomp LW: New developments in the regulation of intestinal copper absorption. Nutr Rev. 2009 Nov;67(11):658-72. doi: 10.1111/j.1753-4887.2009.00250.x.

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