Oral LD50 in mouse is 4 mg/kg MSDS. In a long-term carcinogenicity study involving rats and mice, exposure of 10 times the dose of maximum recommended clinical dose of dienogest resulted in increased incidences of pituitary adenomas, fibroepithelial mammary tumours, stromal polyps of the uterus and malignant lymphoma L932. These tumors are thought to arise from marked species differences in the optimal oestrogen:progestogen ratio for reproductive function. In rat liver foci assay, dienogest did not induce tumor promotion activity L932. Dienogest does not display genotoxic potential.
Dienogest is an orally-active semisynthetic progestogen which also possesses the properties of 17?-hydroxyprogesterone. It is a derivative of 19-nortestosterone and has antiandrogenic properties. It is primarily used as a contraceptive in combination with ethinylestradiol, or in other combination form pills approved in United States and Europe however it is not available in the US by itself. In Europe, Australia, Malaysia, Singapore and Japan, dienogest single therapy is an approved treatment for endometriosis to alleviate painful symptoms of endometriosis and reduce endometriotic lesions A20330. Dienogest is commonly marketed as Visanne, Natazia and Qlaira.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Acitretin | The therapeutic efficacy of Dienogest can be decreased when used in combination with Acitretin. |
| Aprepitant | The serum concentration of Dienogest can be decreased when it is combined with Aprepitant. |
| Atazanavir | The serum concentration of Dienogest can be increased when it is combined with Atazanavir. |
| Boceprevir | The serum concentration of Dienogest can be increased when it is combined with Boceprevir. |
| Prucalopride | The serum concentration of Dienogest can be decreased when it is combined with Prucalopride. |
| Sugammadex | The serum concentration of Dienogest can be decreased when it is combined with Sugammadex. |
| Thalidomide | Dienogest may increase the thrombogenic activities of Thalidomide. |
| Ulipristal | The therapeutic efficacy of Dienogest can be decreased when used in combination with Ulipristal. |
| Ursodeoxycholic acid | The therapeutic efficacy of Ursodeoxycholic acid can be decreased when used in combination with Dienogest. |
| Glycochenodeoxycholic Acid | The therapeutic efficacy of Glycochenodeoxycholic Acid can be decreased when used in combination with Dienogest. |
| Cholic Acid | The therapeutic efficacy of Cholic Acid can be decreased when used in combination with Dienogest. |
| Glycocholic acid | The therapeutic efficacy of Glycocholic acid can be decreased when used in combination with Dienogest. |
| Deoxycholic acid | The therapeutic efficacy of Deoxycholic acid can be decreased when used in combination with Dienogest. |
| Taurocholic acid | The therapeutic efficacy of Taurocholic acid can be decreased when used in combination with Dienogest. |
| Obeticholic acid | The therapeutic efficacy of Obeticholic acid can be decreased when used in combination with Dienogest. |
| Tauroursodeoxycholic acid | The therapeutic efficacy of Tauroursodeoxycholic acid can be decreased when used in combination with Dienogest. |
| Bamet-UD2 | The therapeutic efficacy of Bamet-UD2 can be decreased when used in combination with Dienogest. |
| cis-Diamminechlorocholylglycinateplatinum(II) | The therapeutic efficacy of cis-Diamminechlorocholylglycinateplatinum(II) can be decreased when used in combination with Dienogest. |
| Dehydrocholic acid | The therapeutic efficacy of Dehydrocholic acid can be decreased when used in combination with Dienogest. |
| Hyodeoxycholic Acid | The therapeutic efficacy of Hyodeoxycholic Acid can be decreased when used in combination with Dienogest. |
| Aramchol | The therapeutic efficacy of Aramchol can be decreased when used in combination with Dienogest. |
| Ox bile extract | The therapeutic efficacy of Ox bile extract can be decreased when used in combination with Dienogest. |
| Chenodeoxycholic acid | The therapeutic efficacy of Chenodeoxycholic acid can be decreased when used in combination with Dienogest. |
| Taurochenodeoxycholic acid | The therapeutic efficacy of Taurochenodeoxycholic acid can be decreased when used in combination with Dienogest. |
| Tranexamic acid | Dienogest may increase the thrombogenic activities of Tranexamic acid. |
| Clobazam | The serum concentration of Dienogest can be decreased when it is combined with Clobazam. |
| Colestipol | Colestipol can cause a decrease in the absorption of Dienogest resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Sevelamer | Sevelamer can cause a decrease in the absorption of Dienogest resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Colesevelam | Colesevelam can cause a decrease in the absorption of Dienogest resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Cholestyramine | Cholestyramine can cause a decrease in the absorption of Dienogest resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Griseofulvin | The metabolism of Dienogest can be increased when combined with Griseofulvin. |
| Clobetasol propionate | The serum concentration of Clobetasol propionate can be increased when it is combined with Dienogest. |
| Fluocinonide | The serum concentration of Fluocinonide can be increased when it is combined with Dienogest. |
| Hydrocortisone butyrate | The serum concentration of Hydrocortisone butyrate can be increased when it is combined with Dienogest. |
| Desoximetasone | The serum concentration of Desoximetasone can be increased when it is combined with Dienogest. |
| Mometasone | The serum concentration of Mometasone can be increased when it is combined with Dienogest. |
| Fluocortolone | The serum concentration of Fluocortolone can be increased when it is combined with Dienogest. |
| Prednisolone acetate | The serum concentration of Prednisolone acetate can be increased when it is combined with Dienogest. |
| Fluorometholone | The serum concentration of Fluorometholone can be increased when it is combined with Dienogest. |
| Difluocortolone | The serum concentration of Difluocortolone can be increased when it is combined with Dienogest. |
| Flumethasone | The serum concentration of Flumethasone can be increased when it is combined with Dienogest. |
| Methylprednisolone aceponate | The serum concentration of Methylprednisolone aceponate can be increased when it is combined with Dienogest. |
| Vitamin A | The therapeutic efficacy of Dienogest can be decreased when used in combination with Vitamin A. |
| Bexarotene | The therapeutic efficacy of Dienogest can be decreased when used in combination with Bexarotene. |
| Alitretinoin | The therapeutic efficacy of Dienogest can be decreased when used in combination with Alitretinoin. |
| Tretinoin | The therapeutic efficacy of Dienogest can be decreased when used in combination with Tretinoin. |
| Tazarotene | The therapeutic efficacy of Dienogest can be decreased when used in combination with Tazarotene. |
| Etretinate | The therapeutic efficacy of Dienogest can be decreased when used in combination with Etretinate. |
| 4-Oxoretinol | The therapeutic efficacy of Dienogest can be decreased when used in combination with 4-Oxoretinol. |
| Fenretinide | The therapeutic efficacy of Dienogest can be decreased when used in combination with Fenretinide. |
| Ro 12-7310 | The therapeutic efficacy of Dienogest can be decreased when used in combination with Ro 12-7310. |
| Zuretinol acetate | The therapeutic efficacy of Dienogest can be decreased when used in combination with Zuretinol acetate. |
| Motretinide | The therapeutic efficacy of Dienogest can be decreased when used in combination with Motretinide. |
| Isotretinoin | The therapeutic efficacy of Dienogest can be decreased when used in combination with Isotretinoin. |
| Bosentan | The serum concentration of Dienogest can be decreased when it is combined with Bosentan. |
| Phenoxymethylpenicillin | The therapeutic efficacy of Dienogest can be decreased when used in combination with Phenoxymethylpenicillin. |
| Carbenicillin | The therapeutic efficacy of Dienogest can be decreased when used in combination with Carbenicillin. |
| Hetacillin | The therapeutic efficacy of Dienogest can be decreased when used in combination with Hetacillin. |
| Benzylpenicilloyl polylysine | The therapeutic efficacy of Dienogest can be decreased when used in combination with Benzylpenicilloyl polylysine. |
| Mezlocillin | The therapeutic efficacy of Dienogest can be decreased when used in combination with Mezlocillin. |
| Cyclacillin | The therapeutic efficacy of Dienogest can be decreased when used in combination with Cyclacillin. |
| Benzylpenicillin | The therapeutic efficacy of Dienogest can be decreased when used in combination with Benzylpenicillin. |
| Azlocillin | The therapeutic efficacy of Dienogest can be decreased when used in combination with Azlocillin. |
| Cloxacillin | The therapeutic efficacy of Dienogest can be decreased when used in combination with Cloxacillin. |
| Amdinocillin | The therapeutic efficacy of Dienogest can be decreased when used in combination with Amdinocillin. |
| Bacampicillin | The therapeutic efficacy of Dienogest can be decreased when used in combination with Bacampicillin. |
| Meticillin | The therapeutic efficacy of Dienogest can be decreased when used in combination with Meticillin. |
| Pivampicillin | The therapeutic efficacy of Dienogest can be decreased when used in combination with Pivampicillin. |
| Pivmecillinam | The therapeutic efficacy of Dienogest can be decreased when used in combination with Pivmecillinam. |
| Ticarcillin | The therapeutic efficacy of Dienogest can be decreased when used in combination with Ticarcillin. |
| Azidocillin | The therapeutic efficacy of Dienogest can be decreased when used in combination with Azidocillin. |
| Carindacillin | The therapeutic efficacy of Dienogest can be decreased when used in combination with Carindacillin. |
| Sultamicillin | The therapeutic efficacy of Dienogest can be decreased when used in combination with Sultamicillin. |
| Temocillin | The therapeutic efficacy of Dienogest can be decreased when used in combination with Temocillin. |
| Epicillin | The therapeutic efficacy of Dienogest can be decreased when used in combination with Epicillin. |
| Pheneticillin | The therapeutic efficacy of Dienogest can be decreased when used in combination with Pheneticillin. |
| Carfecillin | The therapeutic efficacy of Dienogest can be decreased when used in combination with Carfecillin. |
| Propicillin | The therapeutic efficacy of Dienogest can be decreased when used in combination with Propicillin. |
| Clometocillin | The therapeutic efficacy of Dienogest can be decreased when used in combination with Clometocillin. |
| Sulbenicillin | The therapeutic efficacy of Dienogest can be decreased when used in combination with Sulbenicillin. |
| Penamecillin | The therapeutic efficacy of Dienogest can be decreased when used in combination with Penamecillin. |
| Talampicillin | The therapeutic efficacy of Dienogest can be decreased when used in combination with Talampicillin. |
| Aspoxicillin | The therapeutic efficacy of Dienogest can be decreased when used in combination with Aspoxicillin. |
| Metampicillin | The therapeutic efficacy of Dienogest can be decreased when used in combination with Metampicillin. |
| Mycophenolate mofetil | The serum concentration of Dienogest can be decreased when it is combined with Mycophenolate mofetil. |
| Mycophenolic acid | The serum concentration of Dienogest can be decreased when it is combined with Mycophenolic acid. |
| Nafcillin | The metabolism of Dienogest can be increased when combined with Nafcillin. |
| Modafinil | The metabolism of Dienogest can be increased when combined with Modafinil. |
| Etravirine | The metabolism of Dienogest can be increased when combined with Etravirine. |
| Avasimibe | The metabolism of Dienogest can be increased when combined with Avasimibe. |
| Echinacea | The metabolism of Dienogest can be increased when combined with Echinacea. |
| Dexamethasone acetate | The serum concentration of Dexamethasone acetate can be increased when it is combined with Dienogest. |
| Selegiline | The bioavailability of Selegiline can be increased when combined with Dienogest. |
| Exenatide | Exenatide can cause a decrease in the absorption of Dienogest resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Flibanserin | The risk or severity of adverse effects can be increased when Dienogest is combined with Flibanserin. |
| Telaprevir | The serum concentration of Dienogest can be decreased when it is combined with Telaprevir. |
| Cobicistat | The serum concentration of Dienogest can be decreased when it is combined with Cobicistat. |
| Elvitegravir | The serum concentration of Dienogest can be decreased when it is combined with Elvitegravir. |
| Insulin human | The therapeutic efficacy of Insulin human can be decreased when used in combination with Dienogest. |
| Insulin lispro | The therapeutic efficacy of Insulin lispro can be decreased when used in combination with Dienogest. |