Oral LD50 of 157.9mg/kg observed in rats and 175mg/kg observed in mice MSDS. Estimated oral LD50 of 35mg/kg in humans A19440. Sodium nitrite toxicity manifests as cardiovascular collapse following severe hypotension due to nitrite's vasodilatory action.
Nitrous acid (as sodium nitrite) is used as part of an intravenous mixture with sodium thiosulfate to treat cyanide poisoning. It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system. There is also research to investigate its applicability towards treatments for heart attacks, brain aneurysms, pulmonary hypertension in infants, and Pseudomonas aeruginosa infections.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Duloxetine | The risk or severity of orthostatic hypotension and syncope can be increased when Nitrous acid is combined with Duloxetine. |
| Levodopa | The risk or severity of hypotension and orthostatic hypotension can be increased when Nitrous acid is combined with Levodopa. |
| Risperidone | Nitrous acid may increase the hypotensive activities of Risperidone. |
| Aripiprazole | Aripiprazole may increase the hypotensive activities of Nitrous acid. |
| Aripiprazole lauroxil | Aripiprazole lauroxil may increase the hypotensive activities of Nitrous acid. |
| Nicorandil | Nicorandil may increase the hypotensive activities of Nitrous acid. |
| Linezolid | Linezolid may increase the orthostatic hypotensive activities of Nitrous acid. |
| Furazolidone | Furazolidone may increase the orthostatic hypotensive activities of Nitrous acid. |
| Procaine | Procaine may increase the orthostatic hypotensive activities of Nitrous acid. |
| Tranylcypromine | Tranylcypromine may increase the orthostatic hypotensive activities of Nitrous acid. |
| Phenelzine | Phenelzine may increase the orthostatic hypotensive activities of Nitrous acid. |
| Minaprine | Minaprine may increase the orthostatic hypotensive activities of Nitrous acid. |
| Selegiline | Selegiline may increase the orthostatic hypotensive activities of Nitrous acid. |
| Procarbazine | Procarbazine may increase the orthostatic hypotensive activities of Nitrous acid. |
| Moclobemide | Moclobemide may increase the orthostatic hypotensive activities of Nitrous acid. |
| Isocarboxazid | Isocarboxazid may increase the orthostatic hypotensive activities of Nitrous acid. |
| Rasagiline | Rasagiline may increase the orthostatic hypotensive activities of Nitrous acid. |
| Pargyline | Pargyline may increase the orthostatic hypotensive activities of Nitrous acid. |
| Clorgiline | Clorgiline may increase the orthostatic hypotensive activities of Nitrous acid. |
| Iproniazid | Iproniazid may increase the orthostatic hypotensive activities of Nitrous acid. |
| Nialamide | Nialamide may increase the orthostatic hypotensive activities of Nitrous acid. |
| Safinamide | Safinamide may increase the orthostatic hypotensive activities of Nitrous acid. |
| 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline | 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline may increase the orthostatic hypotensive activities of Nitrous acid. |
| Methylene blue | Methylene blue may increase the orthostatic hypotensive activities of Nitrous acid. |
| Hydracarbazine | Hydracarbazine may increase the orthostatic hypotensive activities of Nitrous acid. |
| Pirlindole | Pirlindole may increase the orthostatic hypotensive activities of Nitrous acid. |
| Toloxatone | Toloxatone may increase the orthostatic hypotensive activities of Nitrous acid. |
| Benmoxin | Benmoxin may increase the orthostatic hypotensive activities of Nitrous acid. |
| Mebanazine | Mebanazine may increase the orthostatic hypotensive activities of Nitrous acid. |
| Octamoxin | Octamoxin may increase the orthostatic hypotensive activities of Nitrous acid. |
| Pheniprazine | Pheniprazine may increase the orthostatic hypotensive activities of Nitrous acid. |
| Phenoxypropazine | Phenoxypropazine may increase the orthostatic hypotensive activities of Nitrous acid. |
| Pivhydrazine | Pivhydrazine may increase the orthostatic hypotensive activities of Nitrous acid. |
| Safrazine | Safrazine may increase the orthostatic hypotensive activities of Nitrous acid. |
| Caroxazone | Caroxazone may increase the orthostatic hypotensive activities of Nitrous acid. |
| Harmaline | Harmaline may increase the orthostatic hypotensive activities of Nitrous acid. |
| Brofaromine | Brofaromine may increase the orthostatic hypotensive activities of Nitrous acid. |
| Butalbital | Butalbital may increase the hypotensive activities of Nitrous acid. |
| Pentobarbital | Pentobarbital may increase the hypotensive activities of Nitrous acid. |
| Secobarbital | Secobarbital may increase the hypotensive activities of Nitrous acid. |
| Methohexital | Methohexital may increase the hypotensive activities of Nitrous acid. |
| Thiopental | Thiopental may increase the hypotensive activities of Nitrous acid. |
| Primidone | Primidone may increase the hypotensive activities of Nitrous acid. |
| Methylphenobarbital | Methylphenobarbital may increase the hypotensive activities of Nitrous acid. |
| Thiamylal | Thiamylal may increase the hypotensive activities of Nitrous acid. |
| Phenobarbital | Phenobarbital may increase the hypotensive activities of Nitrous acid. |
| Amobarbital | Amobarbital may increase the hypotensive activities of Nitrous acid. |
| Hexobarbital | Hexobarbital may increase the hypotensive activities of Nitrous acid. |
| Barbital | Barbital may increase the hypotensive activities of Nitrous acid. |
| Barbexaclone | Barbexaclone may increase the hypotensive activities of Nitrous acid. |
| Butabarbital | Butabarbital may increase the hypotensive activities of Nitrous acid. |
| Aldesleukin | The risk or severity of adverse effects can be increased when Aldesleukin is combined with Nitrous acid. |
| Streptokinase | The risk or severity of adverse effects can be increased when Streptokinase is combined with Nitrous acid. |
| Methyclothiazide | The risk or severity of adverse effects can be increased when Methyclothiazide is combined with Nitrous acid. |
| Ropinirole | The risk or severity of adverse effects can be increased when Ropinirole is combined with Nitrous acid. |
| Morphine | The risk or severity of adverse effects can be increased when Morphine is combined with Nitrous acid. |
| Ropivacaine | The risk or severity of adverse effects can be increased when Ropivacaine is combined with Nitrous acid. |
| Bupivacaine | The risk or severity of adverse effects can be increased when Bupivacaine is combined with Nitrous acid. |
| Tolcapone | The risk or severity of adverse effects can be increased when Tolcapone is combined with Nitrous acid. |
| Olanzapine | The risk or severity of adverse effects can be increased when Olanzapine is combined with Nitrous acid. |
| Clozapine | The risk or severity of adverse effects can be increased when Clozapine is combined with Nitrous acid. |
| Triamterene | The risk or severity of adverse effects can be increased when Triamterene is combined with Nitrous acid. |
| Pramipexole | The risk or severity of adverse effects can be increased when Pramipexole is combined with Nitrous acid. |
| Spironolactone | The risk or severity of adverse effects can be increased when Spironolactone is combined with Nitrous acid. |
| Nitric Oxide | The risk or severity of adverse effects can be increased when Nitric Oxide is combined with Nitrous acid. |
| Imipramine | The risk or severity of adverse effects can be increased when Imipramine is combined with Nitrous acid. |
| Chlorpromazine | The risk or severity of adverse effects can be increased when Chlorpromazine is combined with Nitrous acid. |
| Nabilone | The risk or severity of adverse effects can be increased when Nabilone is combined with Nitrous acid. |
| Sotalol | The risk or severity of adverse effects can be increased when Sotalol is combined with Nitrous acid. |
| Amiloride | The risk or severity of adverse effects can be increased when Amiloride is combined with Nitrous acid. |
| Clofarabine | The risk or severity of adverse effects can be increased when Clofarabine is combined with Nitrous acid. |
| Dexmedetomidine | The risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Nitrous acid. |
| Verapamil | The risk or severity of adverse effects can be increased when Verapamil is combined with Nitrous acid. |
| Thioridazine | The risk or severity of adverse effects can be increased when Thioridazine is combined with Nitrous acid. |
| Amphotericin B | The risk or severity of adverse effects can be increased when Amphotericin B is combined with Nitrous acid. |
| Furosemide | The risk or severity of adverse effects can be increased when Furosemide is combined with Nitrous acid. |
| Tizanidine | The risk or severity of adverse effects can be increased when Tizanidine is combined with Nitrous acid. |
| Methazolamide | The risk or severity of adverse effects can be increased when Methazolamide is combined with Nitrous acid. |
| Tamsulosin | The risk or severity of adverse effects can be increased when Tamsulosin is combined with Nitrous acid. |
| Sufentanil | The risk or severity of adverse effects can be increased when Sufentanil is combined with Nitrous acid. |
| Apomorphine | The risk or severity of adverse effects can be increased when Apomorphine is combined with Nitrous acid. |
| Mannitol | The risk or severity of adverse effects can be increased when Mannitol is combined with Nitrous acid. |
| Isoflurane | The risk or severity of adverse effects can be increased when Isoflurane is combined with Nitrous acid. |
| Propofol | The risk or severity of adverse effects can be increased when Propofol is combined with Nitrous acid. |
| Conivaptan | The risk or severity of adverse effects can be increased when Conivaptan is combined with Nitrous acid. |
| Isosorbide dinitrate | The risk or severity of adverse effects can be increased when Isosorbide dinitrate is combined with Nitrous acid. |
| Bumetanide | The risk or severity of adverse effects can be increased when Bumetanide is combined with Nitrous acid. |
| Remifentanil | The risk or severity of adverse effects can be increased when Remifentanil is combined with Nitrous acid. |
| Etacrynic acid | The risk or severity of adverse effects can be increased when Etacrynic acid is combined with Nitrous acid. |
| Levosimendan | The risk or severity of adverse effects can be increased when Levosimendan is combined with Nitrous acid. |
| Dipyridamole | The risk or severity of adverse effects can be increased when Dipyridamole is combined with Nitrous acid. |
| Levobupivacaine | The risk or severity of adverse effects can be increased when Levobupivacaine is combined with Nitrous acid. |
| Isosorbide mononitrate | The risk or severity of adverse effects can be increased when Isosorbide mononitrate is combined with Nitrous acid. |
| Thalidomide | The risk or severity of adverse effects can be increased when Thalidomide is combined with Nitrous acid. |
| Iloprost | The risk or severity of adverse effects can be increased when Iloprost is combined with Nitrous acid. |
| Papaverine | The risk or severity of adverse effects can be increased when Papaverine is combined with Nitrous acid. |
| Nifedipine | The risk or severity of adverse effects can be increased when Nifedipine is combined with Nitrous acid. |
| Amiodarone | The risk or severity of adverse effects can be increased when Amiodarone is combined with Nitrous acid. |
| Amifostine | The risk or severity of adverse effects can be increased when Amifostine is combined with Nitrous acid. |
| Diclofenamide | The risk or severity of adverse effects can be increased when Diclofenamide is combined with Nitrous acid. |