Pentastarch

DB09111

small molecule approved investigational

Deskripsi

Pentastarch is an artificial colloid (hydroxyethyl starch derivative). Pentastarch is characterized by presenting five hydroxyethyl groups, which signifies an approximate 50% hydroxyethylation. It is sold under the name Pentaspan by Bristol-Myers Squibb and is used for fluid resuscitation. When administered, pentastarch remains mainly in the circulatory system and hence, it is considered a plasma expander.

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) ~2.5 hours.
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Pentastarch is hydrolyzed by plasma amylase. This is more rapid and complete compared to hetastarch.

Rute Eliminasi

As a result of its lower molecular weight and lesser degree of substitution, pentastarch is eliminated from the circulation at a faster rate than hetastarch. Ordinarily, only 10% of an intravenous dose remains after 24 hours, and levels are undetectable after 4 to 7 days. Up to 70% of a dose is excreted in the urine within 24 hours.

Interaksi Obat

727 Data
Cyclosporine Cyclosporine may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Icosapent Icosapent may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Cefotiam Cefotiam may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Mesalazine Mesalazine may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Cefmenoxime Cefmenoxime may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Cefmetazole Cefmetazole may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Pamidronic acid Pamidronic acid may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Tenofovir disoproxil Tenofovir disoproxil may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Indomethacin Indomethacin may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Cidofovir Cidofovir may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Cefpiramide Cefpiramide may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Ceftazidime Ceftazidime may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Loracarbef Loracarbef may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Cefalotin Cefalotin may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Nabumetone Nabumetone may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Ketorolac Ketorolac may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Tenoxicam Tenoxicam may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Celecoxib Celecoxib may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Cefotaxime Cefotaxime may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Tolmetin Tolmetin may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Foscarnet Foscarnet may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Rofecoxib Rofecoxib may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Piroxicam Piroxicam may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Methotrexate Methotrexate may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Cephalexin Cephalexin may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Fenoprofen Fenoprofen may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Valaciclovir Valaciclovir may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Valdecoxib Valdecoxib may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Diclofenac Diclofenac may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Sulindac Sulindac may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Bacitracin Bacitracin may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Amphotericin B Amphotericin B may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Cephaloglycin Cephaloglycin may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Flurbiprofen Flurbiprofen may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Adefovir dipivoxil Adefovir dipivoxil may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Pentamidine Pentamidine may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Etodolac Etodolac may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Mefenamic acid Mefenamic acid may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Acyclovir Acyclovir may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Naproxen Naproxen may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Sulfasalazine Sulfasalazine may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Phenylbutazone Phenylbutazone may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Meloxicam Meloxicam may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Carprofen Carprofen may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Cefaclor Cefaclor may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Diflunisal Diflunisal may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Tacrolimus Tacrolimus may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Ceforanide Ceforanide may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Salicylic acid Salicylic acid may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Meclofenamic acid Meclofenamic acid may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Acetylsalicylic acid Acetylsalicylic acid may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Carboplatin Carboplatin may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Oxaprozin Oxaprozin may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Ketoprofen Ketoprofen may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Balsalazide Balsalazide may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Ibuprofen Ibuprofen may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Cefditoren Cefditoren may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Atazanavir Atazanavir may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Colistimethate Colistimethate may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Cefuroxime Cefuroxime may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Cefapirin Cefapirin may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Cefadroxil Cefadroxil may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Cefprozil Cefprozil may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Ceftriaxone Ceftriaxone may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Olsalazine Olsalazine may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Lumiracoxib Lumiracoxib may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Cefamandole Cefamandole may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Cefazolin Cefazolin may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Cefonicid Cefonicid may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Cefoperazone Cefoperazone may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Cefotetan Cefotetan may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Cefoxitin Cefoxitin may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Ceftizoxime Ceftizoxime may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Cefradine Cefradine may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Magnesium salicylate Magnesium salicylate may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Salsalate Salsalate may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Choline magnesium trisalicylate Choline magnesium trisalicylate may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Cefepime Cefepime may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Cefacetrile Cefacetrile may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Ceftibuten Ceftibuten may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Cefpodoxime Cefpodoxime may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Antrafenine Antrafenine may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Aminophenazone Aminophenazone may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Antipyrine Antipyrine may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Tiaprofenic acid Tiaprofenic acid may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Lopinavir Lopinavir may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Etoricoxib Etoricoxib may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Hydrolyzed Cephalothin Hydrolyzed Cephalothin may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Cephalothin Group Cephalothin Group may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Oxyphenbutazone Oxyphenbutazone may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Latamoxef Latamoxef may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Nimesulide Nimesulide may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Benoxaprofen Benoxaprofen may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Metamizole Metamizole may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Zomepirac Zomepirac may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Ceftobiprole Ceftobiprole may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Cimicoxib Cimicoxib may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Ceftaroline fosamil Ceftaroline fosamil may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Lornoxicam Lornoxicam may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Aceclofenac Aceclofenac may decrease the excretion rate of Pentastarch which could result in a higher serum level.

Referensi & Sumber

Artikel (PubMed)
  • PMID: 9465753
    Younes RN, Yin KC, Amino CJ, Itinoshe M, Rocha e Silva M, Birolini D: Use of pentastarch solution in the treatment of patients with hemorrhagic hypovolemia: randomized phase II study in the emergency room. World J Surg. 1998 Jan;22(1):2-5.

Contoh Produk & Brand

Produk: 1 • International brands: 1
Produk
  • Pentaspan
    Solution • 10 g / 100 mL • Intravenous • Canada • Approved
International Brands
  • StarQuin — Biomed

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
© 2025 Digital Pharmacy Research - Universitas Esa Unggul