Peringatan Keamanan

Overdosage can cause severe hypertension.

Methoxy polyethylene glycol-epoetin beta

DB09107

biotech approved

Deskripsi

Methoxy polyethylene glycol-epoetin beta is a chemically synthesised Erythropoiesis Stimulating Agent (ESA) with a longer half-life than erythropoietin. ESA is used to increase synthesis of red blood cells to treat chronic kidney disease associated anemia.

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) In CKD patients on peritoneal dialysis with IV administration: 134 ± 65 hours In CKD patients on peritoneal dialysis with SC administration: 139 ± 67 hours
Volume Distribusi ~94.74 ml/kg
Klirens (Clearance) In CKD patients on peritoneal dialysis : 0.49 ± 0.18 mL/hr/kg

Absorpsi

Administered parenterally (subcutaneous or IV) therefore not absorbed.

Metabolisme

Not metabolized.

Rute Eliminasi

Undergoes proteolysis at erythropoietin receptor

Interaksi Obat

619 Data
Cyclophosphamide The risk or severity of pulmonary toxicity can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Cyclophosphamide.
Pegfilgrastim The therapeutic efficacy of Methoxy polyethylene glycol-epoetin beta can be decreased when used in combination with Pegfilgrastim.
Peginterferon alfa-2b The therapeutic efficacy of Methoxy polyethylene glycol-epoetin beta can be decreased when used in combination with Peginterferon alfa-2b.
Pegademase The therapeutic efficacy of Methoxy polyethylene glycol-epoetin beta can be decreased when used in combination with Pegademase.
Pegvisomant The therapeutic efficacy of Methoxy polyethylene glycol-epoetin beta can be decreased when used in combination with Pegvisomant.
Propylene glycol The therapeutic efficacy of Methoxy polyethylene glycol-epoetin beta can be decreased when used in combination with Propylene glycol.
Heptaethylene glycol The therapeutic efficacy of Methoxy polyethylene glycol-epoetin beta can be decreased when used in combination with Heptaethylene glycol.
Pegaptanib The therapeutic efficacy of Methoxy polyethylene glycol-epoetin beta can be decreased when used in combination with Pegaptanib.
Egaptivon pegol The therapeutic efficacy of Methoxy polyethylene glycol-epoetin beta can be decreased when used in combination with Egaptivon pegol.
PEG-uricase The therapeutic efficacy of Methoxy polyethylene glycol-epoetin beta can be decreased when used in combination with PEG-uricase.
Peginterferon alfacon-1 The therapeutic efficacy of Methoxy polyethylene glycol-epoetin beta can be decreased when used in combination with Peginterferon alfacon-1.
GlycoPEG-GCSF The therapeutic efficacy of Methoxy polyethylene glycol-epoetin beta can be decreased when used in combination with GlycoPEG-GCSF.
Pegnivacogin The therapeutic efficacy of Methoxy polyethylene glycol-epoetin beta can be decreased when used in combination with Pegnivacogin.
Pegpleranib The therapeutic efficacy of Methoxy polyethylene glycol-epoetin beta can be decreased when used in combination with Pegpleranib.
Pegsunercept The therapeutic efficacy of Methoxy polyethylene glycol-epoetin beta can be decreased when used in combination with Pegsunercept.
Polidocanol The therapeutic efficacy of Methoxy polyethylene glycol-epoetin beta can be decreased when used in combination with Polidocanol.
Peginesatide The therapeutic efficacy of Methoxy polyethylene glycol-epoetin beta can be decreased when used in combination with Peginesatide.
Certolizumab pegol The therapeutic efficacy of Methoxy polyethylene glycol-epoetin beta can be decreased when used in combination with Certolizumab pegol.
Peginterferon beta-1a The therapeutic efficacy of Peginterferon beta-1a can be decreased when used in combination with Methoxy polyethylene glycol-epoetin beta.
Pegloticase The therapeutic efficacy of Pegloticase can be decreased when used in combination with Methoxy polyethylene glycol-epoetin beta.
Polyethylene glycol The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Methoxy polyethylene glycol-epoetin beta.
Antihemophilic factor (recombinant), PEGylated The therapeutic efficacy of Antihemophilic factor (recombinant), PEGylated can be decreased when used in combination with Methoxy polyethylene glycol-epoetin beta.
Insulin peglispro The therapeutic efficacy of Insulin peglispro can be decreased when used in combination with Methoxy polyethylene glycol-epoetin beta.
Eptacog alfa pegol (activated) The therapeutic efficacy of Eptacog alfa pegol (activated) can be decreased when used in combination with Methoxy polyethylene glycol-epoetin beta.
Olaptesed Pegol The therapeutic efficacy of Olaptesed Pegol can be decreased when used in combination with Methoxy polyethylene glycol-epoetin beta.
Abicipar Pegol The therapeutic efficacy of Abicipar Pegol can be decreased when used in combination with Methoxy polyethylene glycol-epoetin beta.
Lexaptepid pegol The therapeutic efficacy of Lexaptepid pegol can be decreased when used in combination with Methoxy polyethylene glycol-epoetin beta.
Cepeginterferon alfa-2B The therapeutic efficacy of Cepeginterferon alfa-2B can be decreased when used in combination with Methoxy polyethylene glycol-epoetin beta.
Pegvaliase The therapeutic efficacy of Pegvaliase can be decreased when used in combination with Methoxy polyethylene glycol-epoetin beta.
Pegamotecan The therapeutic efficacy of Pegamotecan can be decreased when used in combination with Methoxy polyethylene glycol-epoetin beta.
Lipegfilgrastim The therapeutic efficacy of Lipegfilgrastim can be decreased when used in combination with Methoxy polyethylene glycol-epoetin beta.
Nonacog beta pegol The therapeutic efficacy of Nonacog beta pegol can be decreased when used in combination with Methoxy polyethylene glycol-epoetin beta.
Damoctocog alfa pegol The therapeutic efficacy of Damoctocog alfa pegol can be decreased when used in combination with Methoxy polyethylene glycol-epoetin beta.
Elapegademase The therapeutic efficacy of Elapegademase can be decreased when used in combination with Methoxy polyethylene glycol-epoetin beta.
Nandrolone phenpropionate The therapeutic efficacy of Methoxy polyethylene glycol-epoetin beta can be increased when used in combination with Nandrolone phenpropionate.
Nandrolone decanoate The therapeutic efficacy of Methoxy polyethylene glycol-epoetin beta can be increased when used in combination with Nandrolone decanoate.
Nandrolone The therapeutic efficacy of Methoxy polyethylene glycol-epoetin beta can be increased when used in combination with Nandrolone.
Vindesine The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Vindesine.
Vinorelbine The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Vinorelbine.
Vincristine The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Vincristine.
Vinblastine The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Vinblastine.
Vintafolide The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Vintafolide.
Vinflunine The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Vinflunine.
Vincamine The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Vincamine.
Lenalidomide The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Lenalidomide.
Thalidomide The risk or severity of thromboembolism can be increased when Thalidomide is combined with Methoxy polyethylene glycol-epoetin beta.
Pomalidomide The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Pomalidomide.
Peginterferon alfa-2a The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Peginterferon alfa-2a.
Pegaspargase The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Pegaspargase.
Cetuximab The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Cetuximab.
Denileukin diftitox The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Denileukin diftitox.
Leuprolide The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Leuprolide.
Goserelin The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Goserelin.
Asparaginase Escherichia coli The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Asparaginase Escherichia coli.
Aldesleukin The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Aldesleukin.
Gemtuzumab ozogamicin The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Gemtuzumab ozogamicin.
Trastuzumab The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Trastuzumab.
Rituximab The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Rituximab.
Tositumomab The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Tositumomab.
Alemtuzumab The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Alemtuzumab.
Octreotide The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Octreotide.
Interferon alfa-2b The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Interferon alfa-2b.
Bevacizumab The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Bevacizumab.
Masoprocol The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Masoprocol.
Bortezomib The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Bortezomib.
Pipobroman The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Pipobroman.
Cladribine The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Cladribine.
Cabergoline The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Cabergoline.
Anagrelide The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Anagrelide.
Carmustine The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Carmustine.
Chlorotrianisene The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Chlorotrianisene.
Amsacrine The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Amsacrine.
Pamidronic acid The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Pamidronic acid.
Bleomycin The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Bleomycin.
Chlorambucil The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Chlorambucil.
Raltitrexed The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Raltitrexed.
Mitomycin The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Mitomycin.
Bexarotene The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Bexarotene.
Valproic acid The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Valproic acid.
Gefitinib The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Gefitinib.
Floxuridine The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Floxuridine.
Megestrol acetate The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Megestrol acetate.
Tioguanine The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Tioguanine.
Aminoglutethimide The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Aminoglutethimide.
Valrubicin The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Valrubicin.
Sorafenib The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Sorafenib.
Streptozocin The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Streptozocin.
Trifluridine The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Trifluridine.
Gemcitabine The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Gemcitabine.
Teniposide The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Teniposide.
Epirubicin The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Epirubicin.
Altretamine The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Altretamine.
Flutamide The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Flutamide.
Cisplatin The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Cisplatin.
Alitretinoin The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Alitretinoin.
Oxaliplatin The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Oxaliplatin.
Erlotinib The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Erlotinib.
Toremifene The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Toremifene.
Fluorouracil The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Fluorouracil.
Pentostatin The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Pentostatin.

Target Protein

Erythropoietin receptor EPOR

Referensi & Sumber

Artikel (PubMed)
  • PMID: 15358619
    Walrafen P, Verdier F, Kadri Z, Chretien S, Lacombe C, Mayeux P: Both proteasomes and lysosomes degrade the activated erythropoietin receptor. Blood. 2005 Jan 15;105(2):600-8. Epub 2004 Sep 9.

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Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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