Peringatan Keamanan

LDF50 (IV, rabbit): 8460 mg/Kg.

Hydroxyethyl Starch

DB09106

small molecule approved

Deskripsi

Hydroxyethyl starch (HES/HAES) is a nonionic starch derivative. Hydroxyethyl starches (HES) are synthetic colloids commonly used for fluid resuscitation to replace intravascular volume.
HES is a general term and can be sub-classified according to average molecular weight, molar substitution, concentration, C2/C6 ratio and Maximum Daily Dose.

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Terminal half-life is 16.1 h. Elimination half-life is 12 h.
Volume Distribusi 5.9 L.
Klirens (Clearance) 31.4 mL/min

Absorpsi

Peak concentration (C(max), 4.34 mg/mL)

Metabolisme

When given intravenously, molecules smaller than the renal threshold (60,000-70,000 daltons) are readily and rapidly excreted in the urine, while molecules with higher molecular weights are metabolized by plasma ?-amylase prior to excretion via the renal route.

Rute Eliminasi

Approximately 62 % of HES was excreted as hydroxyethyl starch molecules in urine within 72 hours.

Interaksi Obat

724 Data
Cyclosporine Cyclosporine may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Icosapent Icosapent may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Cefotiam Cefotiam may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Mesalazine Mesalazine may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Cefmenoxime Cefmenoxime may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Cefmetazole Cefmetazole may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Pamidronic acid Pamidronic acid may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Tenofovir disoproxil Tenofovir disoproxil may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Indomethacin Indomethacin may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Cidofovir Cidofovir may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Cefpiramide Cefpiramide may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Ceftazidime Ceftazidime may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Loracarbef Loracarbef may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Cefalotin Cefalotin may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Nabumetone Nabumetone may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Ketorolac Ketorolac may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Tenoxicam Tenoxicam may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Celecoxib Celecoxib may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Cefotaxime Cefotaxime may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Tolmetin Tolmetin may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Foscarnet Foscarnet may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Rofecoxib Rofecoxib may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Piroxicam Piroxicam may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Methotrexate Methotrexate may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Cephalexin Cephalexin may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Fenoprofen Fenoprofen may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Valaciclovir Valaciclovir may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Valdecoxib Valdecoxib may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Diclofenac Diclofenac may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Sulindac Sulindac may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Bacitracin Bacitracin may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Amphotericin B Amphotericin B may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Cephaloglycin Cephaloglycin may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Flurbiprofen Flurbiprofen may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Adefovir dipivoxil Adefovir dipivoxil may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Pentamidine Pentamidine may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Etodolac Etodolac may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Mefenamic acid Mefenamic acid may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Acyclovir Acyclovir may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Naproxen Naproxen may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Sulfasalazine Sulfasalazine may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Phenylbutazone Phenylbutazone may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Meloxicam Meloxicam may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Carprofen Carprofen may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Cefaclor Cefaclor may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Diflunisal Diflunisal may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Tacrolimus Tacrolimus may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Ceforanide Ceforanide may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Salicylic acid Salicylic acid may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Meclofenamic acid Meclofenamic acid may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Acetylsalicylic acid Acetylsalicylic acid may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Carboplatin Carboplatin may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Oxaprozin Oxaprozin may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Ketoprofen Ketoprofen may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Balsalazide Balsalazide may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Ibuprofen Ibuprofen may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Cefditoren Cefditoren may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Atazanavir Atazanavir may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Colistimethate Colistimethate may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Cefuroxime Cefuroxime may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Cefapirin Cefapirin may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Cefadroxil Cefadroxil may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Cefprozil Cefprozil may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Ceftriaxone Ceftriaxone may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Olsalazine Olsalazine may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Lumiracoxib Lumiracoxib may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Cefamandole Cefamandole may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Cefazolin Cefazolin may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Cefonicid Cefonicid may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Cefoperazone Cefoperazone may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Cefotetan Cefotetan may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Cefoxitin Cefoxitin may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Ceftizoxime Ceftizoxime may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Cefradine Cefradine may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Magnesium salicylate Magnesium salicylate may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Salsalate Salsalate may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Choline magnesium trisalicylate Choline magnesium trisalicylate may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Cefepime Cefepime may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Cefacetrile Cefacetrile may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Ceftibuten Ceftibuten may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Cefpodoxime Cefpodoxime may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Antrafenine Antrafenine may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Aminophenazone Aminophenazone may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Antipyrine Antipyrine may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Tiaprofenic acid Tiaprofenic acid may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Lopinavir Lopinavir may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Etoricoxib Etoricoxib may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Hydrolyzed Cephalothin Hydrolyzed Cephalothin may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Cephalothin Group Cephalothin Group may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Oxyphenbutazone Oxyphenbutazone may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Latamoxef Latamoxef may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Nimesulide Nimesulide may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Benoxaprofen Benoxaprofen may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Metamizole Metamizole may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Zomepirac Zomepirac may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Ceftobiprole Ceftobiprole may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Cimicoxib Cimicoxib may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Ceftaroline fosamil Ceftaroline fosamil may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Lornoxicam Lornoxicam may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Aceclofenac Aceclofenac may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.

Referensi & Sumber

Artikel (PubMed)
  • PMID: 23881659
    Mutter TC, Ruth CA, Dart AB: Hydroxyethyl starch (HES) versus other fluid therapies: effects on kidney function. Cochrane Database Syst Rev. 2013 Jul 23;(7):CD007594. doi: 10.1002/14651858.CD007594.pub3.
Link

Contoh Produk & Brand

Produk: 12 • International brands: 0
Produk
  • 6% Hetastarch In 0.9% Sodium Chloride
    Injection, solution • 6 g/100mL • Intravenous • US • Generic • Approved
  • Hespan
    Injection, solution • - • Intravenous • US • Approved
  • Hespan
    Injection, solution • - • Intravenous • US • Approved
  • Hetastarch
    Injection • 6 g/100mL • Intravenous • US • Generic • Approved
  • Hetastarch in Sodium Chloride
    Injection, solution • 6 g/100mL • Intravenous • US • Generic • Approved
  • Hextend
    Injection, solution • 6 g/100mL • Intravenous • US • Approved
  • Hextend
    Solution • 6 g / 100 mL • Intravenous • Canada • Approved
  • Hydroxyethyl Starch in Sodium Chloride
    Injection, solution • - • Intravenous • US • Generic • Approved
Menampilkan 8 dari 12 produk.

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