Peringatan Keamanan

Ancestim was not genotoxic for gene mutation or chromosomal damage and it did not have any effect in fertility.^L1089

Ancestim

DB09103

biotech approved investigational withdrawn

Deskripsi

Ancestim is a non-glycosylated recombinant methionyl human stem cell factor. It is a 166 amino acid protein produced by E. coli with an amino acid sequence that is identical to the natural sequence predicted from human DNA sequence analysis, except for the addition of an N-terminal methionine^L1088. Ancestim was developed by Amgen and sold to Biovitrium in December 2008. It was submitted to the FDA under the status of recommendation for approval with a 10 to 1 votes.T68 It was also approved by Health Canada in 1999 but it is currently under the status of canceled post-market.^L1087

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) In clinical trials, the reported half life for ancestim was between 2-5 hours.[L1089]

Volume Distribusi Preclinical reports demonstrate that after intravenous administration of ancestim, the distribution profile is primarily in plasma and kidneys with a subsequent and rapid loss from all tissues.[L1089]

Klirens (Clearance) The apparent clearance reported for ancestim is approximately 35-40 ml/h/kg.[L1089]

Absorpsi

The pharmacokinetics of ancestim has a dose-linear profile. After subcutaneous administration, ancestim has an absorption half-life of 35-41 hours following a mean lag of 2 hours. When a dose of 5-25 mcg/kg is administered, the peak concentration of 3.6-13.7 ng/ml is reached after 15-24 hours. In preclinical studies, the bioavailability of ancestim was reported to be greater than 60%. After multiple dosing, the steady state was reached after 4-5 days from the beginning of the treatment.^L1089

Metabolisme

Administration of ancestim in preclinical trials have proven that from the excreted dose all of it is formed by degraded ancestim into lower molecular weigth products.^L1089

Rute Eliminasi

In preclinical studies, it was shown that 90% of the administered dose is excreted in the urine.^L1089

Interaksi Obat

735 Data

Cyclophosphamide	The risk or severity of pulmonary toxicity can be increased when Ancestim is combined with Cyclophosphamide.
Methotrexate	Methotrexate may decrease the excretion rate of Ancestim which could result in a higher serum level.
Cyclosporine	Cyclosporine may decrease the excretion rate of Ancestim which could result in a higher serum level.
Icosapent	Icosapent may decrease the excretion rate of Ancestim which could result in a higher serum level.
Cefotiam	Cefotiam may decrease the excretion rate of Ancestim which could result in a higher serum level.
Mesalazine	Mesalazine may decrease the excretion rate of Ancestim which could result in a higher serum level.
Cefmenoxime	Cefmenoxime may decrease the excretion rate of Ancestim which could result in a higher serum level.
Cefmetazole	Cefmetazole may decrease the excretion rate of Ancestim which could result in a higher serum level.
Pamidronic acid	Pamidronic acid may decrease the excretion rate of Ancestim which could result in a higher serum level.
Tenofovir disoproxil	Tenofovir disoproxil may decrease the excretion rate of Ancestim which could result in a higher serum level.
Indomethacin	Indomethacin may decrease the excretion rate of Ancestim which could result in a higher serum level.
Cidofovir	Cidofovir may decrease the excretion rate of Ancestim which could result in a higher serum level.
Cefpiramide	Cefpiramide may decrease the excretion rate of Ancestim which could result in a higher serum level.
Ceftazidime	Ceftazidime may decrease the excretion rate of Ancestim which could result in a higher serum level.
Loracarbef	Loracarbef may decrease the excretion rate of Ancestim which could result in a higher serum level.
Cefalotin	Cefalotin may decrease the excretion rate of Ancestim which could result in a higher serum level.
Nabumetone	Nabumetone may decrease the excretion rate of Ancestim which could result in a higher serum level.
Ketorolac	Ketorolac may decrease the excretion rate of Ancestim which could result in a higher serum level.
Tenoxicam	Tenoxicam may decrease the excretion rate of Ancestim which could result in a higher serum level.
Celecoxib	Celecoxib may decrease the excretion rate of Ancestim which could result in a higher serum level.
Cefotaxime	Cefotaxime may decrease the excretion rate of Ancestim which could result in a higher serum level.
Tolmetin	Tolmetin may decrease the excretion rate of Ancestim which could result in a higher serum level.
Foscarnet	Foscarnet may decrease the excretion rate of Ancestim which could result in a higher serum level.
Rofecoxib	Rofecoxib may decrease the excretion rate of Ancestim which could result in a higher serum level.
Piroxicam	Piroxicam may decrease the excretion rate of Ancestim which could result in a higher serum level.
Cephalexin	Cephalexin may decrease the excretion rate of Ancestim which could result in a higher serum level.
Fenoprofen	Fenoprofen may decrease the excretion rate of Ancestim which could result in a higher serum level.
Valaciclovir	Valaciclovir may decrease the excretion rate of Ancestim which could result in a higher serum level.
Valdecoxib	Valdecoxib may decrease the excretion rate of Ancestim which could result in a higher serum level.
Diclofenac	Diclofenac may decrease the excretion rate of Ancestim which could result in a higher serum level.
Sulindac	Sulindac may decrease the excretion rate of Ancestim which could result in a higher serum level.
Bacitracin	Bacitracin may decrease the excretion rate of Ancestim which could result in a higher serum level.
Amphotericin B	Amphotericin B may decrease the excretion rate of Ancestim which could result in a higher serum level.
Cephaloglycin	Cephaloglycin may decrease the excretion rate of Ancestim which could result in a higher serum level.
Flurbiprofen	Flurbiprofen may decrease the excretion rate of Ancestim which could result in a higher serum level.
Adefovir dipivoxil	Adefovir dipivoxil may decrease the excretion rate of Ancestim which could result in a higher serum level.
Pentamidine	Pentamidine may decrease the excretion rate of Ancestim which could result in a higher serum level.
Etodolac	Etodolac may decrease the excretion rate of Ancestim which could result in a higher serum level.
Mefenamic acid	Mefenamic acid may decrease the excretion rate of Ancestim which could result in a higher serum level.
Acyclovir	Acyclovir may decrease the excretion rate of Ancestim which could result in a higher serum level.
Naproxen	Naproxen may decrease the excretion rate of Ancestim which could result in a higher serum level.
Sulfasalazine	Sulfasalazine may decrease the excretion rate of Ancestim which could result in a higher serum level.
Phenylbutazone	Phenylbutazone may decrease the excretion rate of Ancestim which could result in a higher serum level.
Meloxicam	Meloxicam may decrease the excretion rate of Ancestim which could result in a higher serum level.
Carprofen	Carprofen may decrease the excretion rate of Ancestim which could result in a higher serum level.
Cefaclor	Cefaclor may decrease the excretion rate of Ancestim which could result in a higher serum level.
Diflunisal	Diflunisal may decrease the excretion rate of Ancestim which could result in a higher serum level.
Tacrolimus	Tacrolimus may decrease the excretion rate of Ancestim which could result in a higher serum level.
Ceforanide	Ceforanide may decrease the excretion rate of Ancestim which could result in a higher serum level.
Salicylic acid	Salicylic acid may decrease the excretion rate of Ancestim which could result in a higher serum level.
Meclofenamic acid	Meclofenamic acid may decrease the excretion rate of Ancestim which could result in a higher serum level.
Acetylsalicylic acid	Acetylsalicylic acid may decrease the excretion rate of Ancestim which could result in a higher serum level.
Carboplatin	Carboplatin may decrease the excretion rate of Ancestim which could result in a higher serum level.
Oxaprozin	Oxaprozin may decrease the excretion rate of Ancestim which could result in a higher serum level.
Ketoprofen	Ketoprofen may decrease the excretion rate of Ancestim which could result in a higher serum level.
Balsalazide	Balsalazide may decrease the excretion rate of Ancestim which could result in a higher serum level.
Ibuprofen	Ibuprofen may decrease the excretion rate of Ancestim which could result in a higher serum level.
Cefditoren	Cefditoren may decrease the excretion rate of Ancestim which could result in a higher serum level.
Atazanavir	Atazanavir may decrease the excretion rate of Ancestim which could result in a higher serum level.
Colistimethate	Colistimethate may decrease the excretion rate of Ancestim which could result in a higher serum level.
Cefuroxime	Cefuroxime may decrease the excretion rate of Ancestim which could result in a higher serum level.
Cefapirin	Cefapirin may decrease the excretion rate of Ancestim which could result in a higher serum level.
Cefadroxil	Cefadroxil may decrease the excretion rate of Ancestim which could result in a higher serum level.
Cefprozil	Cefprozil may decrease the excretion rate of Ancestim which could result in a higher serum level.
Ceftriaxone	Ceftriaxone may decrease the excretion rate of Ancestim which could result in a higher serum level.
Olsalazine	Olsalazine may decrease the excretion rate of Ancestim which could result in a higher serum level.
Lumiracoxib	Lumiracoxib may decrease the excretion rate of Ancestim which could result in a higher serum level.
Cefamandole	Cefamandole may decrease the excretion rate of Ancestim which could result in a higher serum level.
Cefazolin	Cefazolin may decrease the excretion rate of Ancestim which could result in a higher serum level.
Cefonicid	Cefonicid may decrease the excretion rate of Ancestim which could result in a higher serum level.
Cefoperazone	Cefoperazone may decrease the excretion rate of Ancestim which could result in a higher serum level.
Cefotetan	Cefotetan may decrease the excretion rate of Ancestim which could result in a higher serum level.
Cefoxitin	Cefoxitin may decrease the excretion rate of Ancestim which could result in a higher serum level.
Ceftizoxime	Ceftizoxime may decrease the excretion rate of Ancestim which could result in a higher serum level.
Cefradine	Cefradine may decrease the excretion rate of Ancestim which could result in a higher serum level.
Magnesium salicylate	Magnesium salicylate may decrease the excretion rate of Ancestim which could result in a higher serum level.
Salsalate	Salsalate may decrease the excretion rate of Ancestim which could result in a higher serum level.
Choline magnesium trisalicylate	Choline magnesium trisalicylate may decrease the excretion rate of Ancestim which could result in a higher serum level.
Cefepime	Cefepime may decrease the excretion rate of Ancestim which could result in a higher serum level.
Cefacetrile	Cefacetrile may decrease the excretion rate of Ancestim which could result in a higher serum level.
Ceftibuten	Ceftibuten may decrease the excretion rate of Ancestim which could result in a higher serum level.
Cefpodoxime	Cefpodoxime may decrease the excretion rate of Ancestim which could result in a higher serum level.
Antrafenine	Antrafenine may decrease the excretion rate of Ancestim which could result in a higher serum level.
Aminophenazone	Aminophenazone may decrease the excretion rate of Ancestim which could result in a higher serum level.
Antipyrine	Antipyrine may decrease the excretion rate of Ancestim which could result in a higher serum level.
Tiaprofenic acid	Tiaprofenic acid may decrease the excretion rate of Ancestim which could result in a higher serum level.
Lopinavir	Lopinavir may decrease the excretion rate of Ancestim which could result in a higher serum level.
Etoricoxib	Etoricoxib may decrease the excretion rate of Ancestim which could result in a higher serum level.
Hydrolyzed Cephalothin	Hydrolyzed Cephalothin may decrease the excretion rate of Ancestim which could result in a higher serum level.
Cephalothin Group	Cephalothin Group may decrease the excretion rate of Ancestim which could result in a higher serum level.
Oxyphenbutazone	Oxyphenbutazone may decrease the excretion rate of Ancestim which could result in a higher serum level.
Latamoxef	Latamoxef may decrease the excretion rate of Ancestim which could result in a higher serum level.
Nimesulide	Nimesulide may decrease the excretion rate of Ancestim which could result in a higher serum level.
Benoxaprofen	Benoxaprofen may decrease the excretion rate of Ancestim which could result in a higher serum level.
Metamizole	Metamizole may decrease the excretion rate of Ancestim which could result in a higher serum level.
Zomepirac	Zomepirac may decrease the excretion rate of Ancestim which could result in a higher serum level.
Ceftobiprole	Ceftobiprole may decrease the excretion rate of Ancestim which could result in a higher serum level.
Cimicoxib	Cimicoxib may decrease the excretion rate of Ancestim which could result in a higher serum level.
Ceftaroline fosamil	Ceftaroline fosamil may decrease the excretion rate of Ancestim which could result in a higher serum level.
Lornoxicam	Lornoxicam may decrease the excretion rate of Ancestim which could result in a higher serum level.

Target Protein

Mast/stem cell growth factor receptor Kit KIT

Referensi & Sumber

Artikel (PubMed)

PMID: 15526160
Ronnstrand L: Signal transduction via the stem cell factor receptor/c-Kit. Cell Mol Life Sci. 2004 Oct;61(19-20):2535-48. doi: 10.1007/s00018-004-4189-6.

Textbook

Trahan P. (1999). Clinical Handbook for biotherapy. Jones and Bartlett Publishers Inc..
ISBN: 1741031443
Galbraith A., Bullock S., Manias E., Hunt B., and Richards A. (2013). Fundamentals of Pharmacology: An applied approach for nursing and health (2nd ed.). Pearson Education Limited.

Link

Contoh Produk & Brand

Produk: 2 • International brands: 0

Produk

Stemgen

Kit; Powder, for solution • - • Subcutaneous • Canada • Approved
Stemgen

Kit; Powder, for solution • - • Subcutaneous • Canada • Approved

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.