Eugenol

DB09086

small molecule approved

Deskripsi

Eugenol is a naturally occurring phenolic molecule found in several plants such as cinnamon, clove, and bay leaves. It has been used as a topical antiseptic as a counter-irritant and in dental preparations with zinc oxide for root canal sealing and pain control. Although not currently available in any FDA-approved products (including OTC), eugenol has been found to have anti-inflammatory, neuroprotective, antipyretic, antioxidant, antifungal and analgesic properties. Its exact mechanism of action is unknown, however, it has been shown to interfere with action potential conduction.
There are a number of unapproved OTC products available containing eugenol that advertise its use for the treatment of toothache.

Struktur Molekul 2D

Berat 164.2011
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

0 Data
Tidak ada data.

Target Protein

Amine oxidase [flavin-containing] B MAOB
Estrogen receptor ESR1
Estrogen receptor beta ESR2
Androgen receptor AR
Transient receptor potential cation channel subfamily V member 3 TRPV3

Referensi & Sumber

Artikel (PubMed)
  • PMID: 27355133
    Fonseca DV, Salgado PR, Aragao Neto Hde C, Golzio AM, Caldas Filho MR, Melo CG, Leite FC, Piuvezam MR, Pordeus LC, Barbosa Filho JM, Almeida RN: Ortho-eugenol exhibits anti-nociceptive and anti-inflammatory activities. Int Immunopharmacol. 2016 Sep;38:402-8. doi: 10.1016/j.intimp.2016.06.005. Epub 2016 Jun 27.
  • PMID: 21547684
    Park SH, Sim YB, Lee JK, Kim SM, Kang YJ, Jung JS, Suh HW: The analgesic effects and mechanisms of orally administered eugenol. Arch Pharm Res. 2011 Mar;34(3):501-7. doi: 10.1007/s12272-011-0320-z. Epub 2011 May 6.
  • PMID: 22775297
    Dal Bo W, Luiz AP, Martins DF, Mazzardo-Martins L, Santos AR: Eugenol reduces acute pain in mice by modulating the glutamatergic and tumor necrosis factor alpha (TNF-alpha) pathways. Fundam Clin Pharmacol. 2013 Oct;27(5):517-25. doi: 10.1111/j.1472-8206.2012.01052.x. Epub 2012 Jul 8.

Contoh Produk & Brand

Produk: 27 • International brands: 0
Produk
  • AnaDent Childrens Kanka Gel
    Gel • 12 mg/1g • Dental • US • OTC
  • Anti Paronychia Relief
    Oil • - • Topical • US • OTC
  • Baby Orajel Naturals Remedy for Teething Pain Relief
    Gel • 12 mg/1g • Topical • US • OTC
  • DenTek Eugenol
    Liquid • 850 mg/1mL • Dental • US • OTC
  • DenTek Eugenol
    Liquid • 850 mg/1mL • Dental • US • OTC
  • DenTek Eugenol
    Liquid • 850 mg/1mL • Dental • US • OTC
  • Dry Socket
    Paste • - • Dental • US
  • Dry Socket Paste
    Paste • - • Dental • Canada • Approved
Menampilkan 8 dari 27 produk.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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