The severity of adverse effects to a corticorelin injection appear to be dose-dependent. Dosages above 1 mcg/kg are not recommended. While few adverse effects have been observed at the 1 mcg/kg or 100 mcg dose, higher doses have been associated with transient tachycardia, decreased blood pressure, loss of consciousness, and asystole.
Corticorelin, available commercially as corticorelin ovine triflutate (tradename Acthrel), is a synthetic form of the peptide human corticotropin-releasing hormone (hCRH), a potent stimulator of adrenocorticotropic hormone (ACTH) release from the anterior pituitary. Endogenous forms hCRH are involved in the stress response and its main function is stimulation of the pituitary to release ACTH.
It is used as a diagnostic agent to evaluate the status of the pituitary-adrenal axis in the differentiation of a pituitary source from an ectopic source of excessive ACTH secretion. It provides a differential diagnosis for Cushing's disease (a pituitary source of ACTH excess) or of ectopic ACTH syndrome (an ectopic source of ACTH excess). If corticorelin injection results in an increase of plasma ACTH and cortisol, the patient is diagnosed with Cushing's disease. However, if corticorelin injection does not result in an increase of plasma ACTH and cortisol, the patient is diagnosed with ectopic ACTH syndrome.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Flunisolide | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Flunisolide. |
| Beclomethasone dipropionate | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Beclomethasone dipropionate. |
| Betamethasone | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Betamethasone. |
| Fluticasone propionate | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Fluticasone propionate. |
| Fluocinolone acetonide | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Fluocinolone acetonide. |
| Triamcinolone | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Triamcinolone. |
| Prednisone | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Prednisone. |
| Fludrocortisone | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Fludrocortisone. |
| Hydrocortisone | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Hydrocortisone. |
| Prednisolone | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Prednisolone. |
| Methylprednisolone | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Methylprednisolone. |
| Trilostane | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Trilostane. |
| Budesonide | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Budesonide. |
| Dexamethasone | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Dexamethasone. |
| Corticotropin | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Corticotropin. |
| Cortisone acetate | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Cortisone acetate. |
| Paramethasone | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Paramethasone. |
| Ciclesonide | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Ciclesonide. |
| Aldosterone | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Aldosterone. |
| Fluticasone furoate | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Fluticasone furoate. |
| Fluprednidene | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Fluprednidene. |
| Tixocortol | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Tixocortol. |
| Fluprednisolone | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Fluprednisolone. |
| Meprednisone | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Meprednisone. |
| Dexamethasone isonicotinate | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Dexamethasone isonicotinate. |
| Melengestrol | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Melengestrol. |
| Deflazacort | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Deflazacort. |
| Cortivazol | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Cortivazol. |
| Prednylidene | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Prednylidene. |
| Fluocortin | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Fluocortin. |
| Fluperolone | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Fluperolone. |
| Cloprednol | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Cloprednol. |
| Fluclorolone | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Fluclorolone. |
| Fluticasone | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Fluticasone. |
| Mometasone furoate | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Mometasone furoate. |
| Hydrocortisone acetate | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Hydrocortisone acetate. |
| Hydrocortisone cypionate | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Hydrocortisone cypionate. |
| Hydrocortisone succinate | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Hydrocortisone succinate. |
| Prednisolone phosphate | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Prednisolone phosphate. |
| Prednisolone hemisuccinate | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Prednisolone hemisuccinate. |
| Methylprednisolone hemisuccinate | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Methylprednisolone hemisuccinate. |
| Prednisone acetate | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Prednisone acetate. |
| Clocortolone acetate | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Clocortolone acetate. |
| Melengestrol acetate | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Melengestrol acetate. |
| Betamethasone phosphate | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Betamethasone phosphate. |
| Cortisone | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Cortisone. |
| Clobetasol propionate | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Clobetasol propionate. |
| Fluocinonide | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Fluocinonide. |
| Hydrocortisone butyrate | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Hydrocortisone butyrate. |
| Desoximetasone | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Desoximetasone. |
| Mometasone | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Mometasone. |
| Fluocortolone | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Fluocortolone. |
| Prednisolone acetate | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Prednisolone acetate. |
| Fluorometholone | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Fluorometholone. |
| Difluocortolone | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Difluocortolone. |
| Flumethasone | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Flumethasone. |
| Methylprednisolone aceponate | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Methylprednisolone aceponate. |
| Ardeparin | The risk or severity of hypotension and sinus node depression can be increased when Ardeparin is combined with Corticorelin ovine triflutate. |
| Heparin | The risk or severity of hypotension and sinus node depression can be increased when Heparin is combined with Corticorelin ovine triflutate. |
| Enoxaparin | The risk or severity of hypotension and sinus node depression can be increased when Enoxaparin is combined with Corticorelin ovine triflutate. |
| Sulodexide | The risk or severity of hypotension and sinus node depression can be increased when Sulodexide is combined with Corticorelin ovine triflutate. |
| Semuloparin | The risk or severity of hypotension and sinus node depression can be increased when Semuloparin is combined with Corticorelin ovine triflutate. |
| Danaparoid | The risk or severity of hypotension and sinus node depression can be increased when Danaparoid is combined with Corticorelin ovine triflutate. |
| Dalteparin | The risk or severity of hypotension and sinus node depression can be increased when Dalteparin is combined with Corticorelin ovine triflutate. |
| Tinzaparin | The risk or severity of hypotension and sinus node depression can be increased when Tinzaparin is combined with Corticorelin ovine triflutate. |
| Nadroparin | The risk or severity of hypotension and sinus node depression can be increased when Nadroparin is combined with Corticorelin ovine triflutate. |
| Bemiparin | The risk or severity of hypotension and sinus node depression can be increased when Bemiparin is combined with Corticorelin ovine triflutate. |
| Parnaparin | The risk or severity of hypotension and sinus node depression can be increased when Parnaparin is combined with Corticorelin ovine triflutate. |
| Reviparin | The risk or severity of hypotension and sinus node depression can be increased when Reviparin is combined with Corticorelin ovine triflutate. |
| Dexamethasone acetate | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Dexamethasone acetate. |
| Corticotropin zinc hydroxide | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Corticotropin zinc hydroxide. |
| Fluocortolone pivalate | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Fluocortolone pivalate. |
| Fluocortolone caproate | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Fluocortolone caproate. |
| Desoxycortone | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Desoxycortone. |
| Vamorolone | The therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Vamorolone. |