The most common side effects with Elonva (seen in between 1 and 10 patients in 100) include a headache, nausea, fatigue, pelvic pain and/or discomfort, breast tenderness and ovarian hyperstimulation syndrome (OHSS). This syndrome occurs when the ovaries have a heightened response to therapy, leading to abdominal swelling and pain, nausea and diarrhea L2270.
More than one injection of Elonva within one treatment cycle or an excessively high dose of Elonva and/or (rec)FSH can increase the risk of ovarian hyperstimulation syndrome L2270, which may cause swollen or painful ovaries, abdominal bloating, nausea, and a weight gain of up to 3kg L2275.
In severe cases, ovarian hyperstimulation syndrome may cause rapid weight gain ranging from 15 to 20 kilograms in 5-10 days. Severe abdominal pain, severe, persistent nausea, and vomiting, decreased urination, and abdominal bloating, as well as other generalized symptoms, may occur L2275. About 1 - 2 % of women undergoing ovarian stimulation develop a severe form of ovarian hyperstimulation syndrome (OHSS). Severe OHSS can be life-threatening. Complications may include: ascites, pulmonary edema, electrolyte disturbances (sodium, potassium, others), thrombosis in large vessels, usually in the lower extremities, renal failure, ovarian torsion, rupture of ovarian cysts. Some of these conditions can lead to hemorrhage, respiratory failure, spontaneous miscarriage or pregnancy termination due to complications, resulting in death L2270.
Corifollitropin alfa, also known as Elonva is used in women undergoing fertility treatment to stimulate the development of more than one mature egg (oocyte) at a time in the ovaries. This drug used together with a gonadotropin-releasing hormone (GnRH) antagonist, a type of medicine also used in fertility treatments. Elonva is available only by prescription L2270.
In July 2014, Merck announced the receipt of a Complete Response Letter (CRL) from the U.S. FDA for its New Drug Application for this drug. Corifollitropin alfa is marketed as Elonva in more than 75 countries L2272.
Corifollitropin alfa is produced by a method known as ‘recombinant DNA technology’. This means that it is made by cells into which a DNA has been introduced that makes them able to produce corifollitropin alfa L2270.
Multiple studies and a meta-analysis suggest that corifollitropin alfa is as efficacious as recombinant FSH in terms of live birth rate, ongoing pregnancy rate, as well as clinical pregnancy rate. The increased in the number of eggs retrieved under corifollitropin alfa regimen represents the elevated effectiveness of this drug, however, warns at the same time against the possibility of an increased risk of ovarian hyperstimulation in the high responder study group of women L2276, A32526.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Leuprolide | The therapeutic efficacy of Corifollitropin alfa can be increased when used in combination with Leuprolide. |
| Goserelin | The therapeutic efficacy of Corifollitropin alfa can be increased when used in combination with Goserelin. |
| Gonadorelin | The therapeutic efficacy of Corifollitropin alfa can be increased when used in combination with Gonadorelin. |
| Nafarelin | The therapeutic efficacy of Corifollitropin alfa can be increased when used in combination with Nafarelin. |
| Buserelin | The therapeutic efficacy of Corifollitropin alfa can be increased when used in combination with Buserelin. |
| Histrelin | The therapeutic efficacy of Corifollitropin alfa can be increased when used in combination with Histrelin. |
| Triptorelin | The therapeutic efficacy of Corifollitropin alfa can be increased when used in combination with Triptorelin. |
| Deslorelin | The therapeutic efficacy of Corifollitropin alfa can be increased when used in combination with Deslorelin. |
| Cyclosporine | Cyclosporine may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Icosapent | Icosapent may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Cefotiam | Cefotiam may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Mesalazine | Mesalazine may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Cefmenoxime | Cefmenoxime may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Cefmetazole | Cefmetazole may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Pamidronic acid | Pamidronic acid may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Tenofovir disoproxil | Tenofovir disoproxil may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Indomethacin | Indomethacin may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Cidofovir | Cidofovir may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Cefpiramide | Cefpiramide may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Ceftazidime | Ceftazidime may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Loracarbef | Loracarbef may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Cefalotin | Cefalotin may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Nabumetone | Nabumetone may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Ketorolac | Ketorolac may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Tenoxicam | Tenoxicam may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Celecoxib | Celecoxib may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Cefotaxime | Cefotaxime may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Tolmetin | Tolmetin may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Foscarnet | Foscarnet may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Rofecoxib | Rofecoxib may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Piroxicam | Piroxicam may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Methotrexate | Methotrexate may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Cephalexin | Cephalexin may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Fenoprofen | Fenoprofen may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Valaciclovir | Valaciclovir may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Valdecoxib | Valdecoxib may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Diclofenac | Diclofenac may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Sulindac | Sulindac may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Bacitracin | Bacitracin may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Amphotericin B | Amphotericin B may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Cephaloglycin | Cephaloglycin may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Flurbiprofen | Flurbiprofen may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Adefovir dipivoxil | Adefovir dipivoxil may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Pentamidine | Pentamidine may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Etodolac | Etodolac may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Mefenamic acid | Mefenamic acid may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Acyclovir | Acyclovir may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Naproxen | Naproxen may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Sulfasalazine | Sulfasalazine may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Phenylbutazone | Phenylbutazone may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Meloxicam | Meloxicam may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Carprofen | Carprofen may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Cefaclor | Cefaclor may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Diflunisal | Diflunisal may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Tacrolimus | Tacrolimus may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Ceforanide | Ceforanide may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Salicylic acid | Salicylic acid may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Meclofenamic acid | Meclofenamic acid may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Acetylsalicylic acid | Acetylsalicylic acid may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Carboplatin | Carboplatin may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Oxaprozin | Oxaprozin may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Ketoprofen | Ketoprofen may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Balsalazide | Balsalazide may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Ibuprofen | Ibuprofen may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Cefditoren | Cefditoren may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Atazanavir | Atazanavir may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Colistimethate | Colistimethate may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Cefuroxime | Cefuroxime may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Cefapirin | Cefapirin may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Cefadroxil | Cefadroxil may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Cefprozil | Cefprozil may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Ceftriaxone | Ceftriaxone may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Olsalazine | Olsalazine may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Lumiracoxib | Lumiracoxib may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Cefamandole | Cefamandole may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Cefazolin | Cefazolin may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Cefonicid | Cefonicid may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Cefoperazone | Cefoperazone may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Cefotetan | Cefotetan may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Cefoxitin | Cefoxitin may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Ceftizoxime | Ceftizoxime may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Cefradine | Cefradine may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Magnesium salicylate | Magnesium salicylate may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Salsalate | Salsalate may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Choline magnesium trisalicylate | Choline magnesium trisalicylate may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Cefepime | Cefepime may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Cefacetrile | Cefacetrile may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Ceftibuten | Ceftibuten may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Cefpodoxime | Cefpodoxime may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Antrafenine | Antrafenine may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Aminophenazone | Aminophenazone may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Antipyrine | Antipyrine may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Tiaprofenic acid | Tiaprofenic acid may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Lopinavir | Lopinavir may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Etoricoxib | Etoricoxib may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Hydrolyzed Cephalothin | Hydrolyzed Cephalothin may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Cephalothin Group | Cephalothin Group may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Oxyphenbutazone | Oxyphenbutazone may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Latamoxef | Latamoxef may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |
| Nimesulide | Nimesulide may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level. |