Avycaz is contraindicated in patients with known serious hypersensitivity to avibactam-containing products, ceftazidime or other members of the cephalosporin class.
Avibactam is a non-?-lactam ?-lactamase inhibitor that is available in combination with ceftazidime (Avycaz). This combination was approved by the FDA on February 25, 2015 for the treatment of complicated intra-abdominal infections in combination with metronidazole, and the treatment of complicated urinary tract infections, including pyelonephritis caused by antibiotic resistant-pathogens, including those caused by multi-drug resistant gram-negative bacterial pathogens. As there is limited clinical safety and efficacy data, Avycaz should be reserved for patients over 18 years old who have limited or not alternative treatment options.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Aspartame | The excretion of Avibactam can be decreased when combined with Aspartame. |
| Pravastatin | The excretion of Avibactam can be decreased when combined with Pravastatin. |
| Pantoprazole | The excretion of Avibactam can be decreased when combined with Pantoprazole. |
| Cefotiam | The excretion of Avibactam can be decreased when combined with Cefotiam. |
| Liothyronine | The excretion of Avibactam can be decreased when combined with Liothyronine. |
| Conjugated estrogens | The excretion of Avibactam can be decreased when combined with Conjugated estrogens. |
| Valproic acid | The excretion of Avibactam can be decreased when combined with Valproic acid. |
| Indomethacin | The excretion of Avibactam can be decreased when combined with Indomethacin. |
| Aminohippuric acid | The excretion of Avibactam can be decreased when combined with Aminohippuric acid. |
| Lansoprazole | The excretion of Avibactam can be decreased when combined with Lansoprazole. |
| Cefalotin | The excretion of Avibactam can be decreased when combined with Cefalotin. |
| Tenoxicam | The excretion of Avibactam can be decreased when combined with Tenoxicam. |
| Cefotaxime | The excretion of Avibactam can be decreased when combined with Cefotaxime. |
| Zidovudine | The excretion of Avibactam can be decreased when combined with Zidovudine. |
| Cimetidine | The excretion of Avibactam can be decreased when combined with Cimetidine. |
| Guanidine | The excretion of Avibactam can be decreased when combined with Guanidine. |
| Piroxicam | The excretion of Avibactam can be decreased when combined with Piroxicam. |
| Methotrexate | The excretion of Avibactam can be decreased when combined with Methotrexate. |
| Cephalexin | The excretion of Avibactam can be decreased when combined with Cephalexin. |
| Enalapril | The excretion of Avibactam can be decreased when combined with Enalapril. |
| Diclofenac | The excretion of Avibactam can be decreased when combined with Diclofenac. |
| Oxytetracycline | The excretion of Avibactam can be decreased when combined with Oxytetracycline. |
| Leucovorin | The excretion of Avibactam can be decreased when combined with Leucovorin. |
| Furosemide | The excretion of Avibactam can be decreased when combined with Furosemide. |
| Esomeprazole | The excretion of Avibactam can be decreased when combined with Esomeprazole. |
| Tetracycline | The excretion of Avibactam can be decreased when combined with Tetracycline. |
| Acyclovir | The excretion of Avibactam can be decreased when combined with Acyclovir. |
| Phenylbutazone | The excretion of Avibactam can be decreased when combined with Phenylbutazone. |
| Cefaclor | The excretion of Avibactam can be decreased when combined with Cefaclor. |
| Bumetanide | The excretion of Avibactam can be decreased when combined with Bumetanide. |
| Quinidine | The excretion of Avibactam can be decreased when combined with Quinidine. |
| Dinoprostone | The excretion of Avibactam can be decreased when combined with Dinoprostone. |
| Famotidine | The excretion of Avibactam can be decreased when combined with Famotidine. |
| Salicylic acid | The excretion of Avibactam can be decreased when combined with Salicylic acid. |
| Acetylsalicylic acid | The excretion of Avibactam can be decreased when combined with Acetylsalicylic acid. |
| Ganciclovir | The excretion of Avibactam can be decreased when combined with Ganciclovir. |
| Ketoprofen | The excretion of Avibactam can be decreased when combined with Ketoprofen. |
| Minocycline | The excretion of Avibactam can be decreased when combined with Minocycline. |
| Probenecid | The excretion of Avibactam can be decreased when combined with Probenecid. |
| Mercaptopurine | The excretion of Avibactam can be decreased when combined with Mercaptopurine. |
| Ibuprofen | The excretion of Avibactam can be decreased when combined with Ibuprofen. |
| Novobiocin | The excretion of Avibactam can be decreased when combined with Novobiocin. |
| Benzylpenicillin | The excretion of Avibactam can be decreased when combined with Benzylpenicillin. |
| Melatonin | The excretion of Avibactam can be decreased when combined with Melatonin. |
| Ouabain | The excretion of Avibactam can be decreased when combined with Ouabain. |
| Rosuvastatin | The excretion of Avibactam can be decreased when combined with Rosuvastatin. |
| Cefadroxil | The excretion of Avibactam can be decreased when combined with Cefadroxil. |
| Ceftriaxone | The excretion of Avibactam can be decreased when combined with Ceftriaxone. |
| Cefamandole | The excretion of Avibactam can be decreased when combined with Cefamandole. |
| Cefazolin | The excretion of Avibactam can be decreased when combined with Cefazolin. |
| Cefoperazone | The excretion of Avibactam can be decreased when combined with Cefoperazone. |
| Ceftizoxime | The excretion of Avibactam can be decreased when combined with Ceftizoxime. |
| Cefacetrile | The excretion of Avibactam can be decreased when combined with Cefacetrile. |
| Ceftibuten | The excretion of Avibactam can be decreased when combined with Ceftibuten. |
| Liotrix | The excretion of Avibactam can be decreased when combined with Liotrix. |
| Cilastatin | The excretion of Avibactam can be decreased when combined with Cilastatin. |
| Tazobactam | The excretion of Avibactam can be decreased when combined with Tazobactam. |
| trans-2-hydroxycinnamic acid | The excretion of Avibactam can be decreased when combined with trans-2-hydroxycinnamic acid. |
| Topiroxostat | The excretion of Avibactam can be decreased when combined with Topiroxostat. |
| Cholic Acid | The excretion of Avibactam can be decreased when combined with Cholic Acid. |
| Glutaric Acid | The excretion of Avibactam can be decreased when combined with Glutaric Acid. |
| Benzoic acid | The excretion of Avibactam can be decreased when combined with Benzoic acid. |
| Taurocholic acid | The excretion of Avibactam can be decreased when combined with Taurocholic acid. |
| Caprylic acid | The excretion of Avibactam can be decreased when combined with Caprylic acid. |
| Ataluren | The excretion of Avibactam can be decreased when combined with Ataluren. |
| Teriflunomide | The excretion of Avibactam can be decreased when combined with Teriflunomide. |
| Dabrafenib | The excretion of Avibactam can be decreased when combined with Dabrafenib. |
| Dolutegravir | The excretion of Avibactam can be decreased when combined with Dolutegravir. |
| Cefaloridine | The excretion of Avibactam can be decreased when combined with Cefaloridine. |
| Lenvatinib | The excretion of Avibactam can be decreased when combined with Lenvatinib. |
| Cabotegravir | The excretion of Avibactam can be decreased when combined with Cabotegravir. |
| Apalutamide | The excretion of Avibactam can be decreased when combined with Apalutamide. |
| Pradigastat | The excretion of Avibactam can be decreased when combined with Pradigastat. |
| Enasidenib | The excretion of Avibactam can be decreased when combined with Enasidenib. |
| Gemfibrozil | The excretion of Avibactam can be decreased when combined with Gemfibrozil. |
| Dronedarone | The excretion of Avibactam can be decreased when combined with Dronedarone. |
| Favipiravir | The excretion of Avibactam can be decreased when combined with Favipiravir. |
| Tafamidis | The excretion of Avibactam can be decreased when combined with Tafamidis. |
| Linezolid | The excretion of Avibactam can be decreased when combined with Linezolid. |
| Testosterone | The excretion of Avibactam can be increased when combined with Testosterone. |
| Methyltestosterone | The excretion of Avibactam can be increased when combined with Methyltestosterone. |
| Testosterone cypionate | The excretion of Avibactam can be increased when combined with Testosterone cypionate. |
| Testosterone enanthate | The excretion of Avibactam can be increased when combined with Testosterone enanthate. |
| Fexinidazole | The excretion of Avibactam can be decreased when combined with Fexinidazole. |
| Pretomanid | The serum concentration of Avibactam can be increased when it is combined with Pretomanid. |
| Vadadustat | The serum concentration of Avibactam can be increased when it is combined with Vadadustat. |
| Capivasertib | The excretion of Avibactam can be decreased when combined with Capivasertib. |
| Encorafenib | The excretion of Avibactam can be decreased when combined with Encorafenib. |