Dose-related somnolence and CNS depression are the most common adverse effects associated with the use of suvorexant. It has also been shown to impair driving skills and may increase the risk of falling asleep while driving. Next-day impairments are found to be highest if suvorexant is taken with less than a full night of sleep remaining, with higher doses, or if co-administered with other CNS depressants or CYP3A inhibitors. Complex behaviours such as sleep driving, preparing and eating food, and making phone calls have been reported in association with the use of hypnotics such as suvorexant. A dose-dependant increase in suicidal ideation has been observed, especially in patients with a previous diagnosis of depression. Sleep paralysis, hypnagogic/hypnopompic hallucinations including vivid and disturbing perceptions, and mild cataplexy have also been reported. There are no adequate studies in pregnant women to ensure its safety during pregnancy or breast feeding.
Suvorexant is a selective dual antagonist of orexin receptors OX1R and OX2R that promotes sleep by reducing wakefulness and arousal. It has been approved for the treatment of insomnia.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Afatinib | The serum concentration of Afatinib can be increased when it is combined with Suvorexant. |
| Bosutinib | The serum concentration of Bosutinib can be increased when it is combined with Suvorexant. |
| Brentuximab vedotin | The serum concentration of Brentuximab vedotin can be increased when it is combined with Suvorexant. |
| Colchicine | The serum concentration of Colchicine can be increased when it is combined with Suvorexant. |
| Edoxaban | The serum concentration of Edoxaban can be increased when it is combined with Suvorexant. |
| Ledipasvir | The serum concentration of Ledipasvir can be increased when it is combined with Suvorexant. |
| Naloxegol | The serum concentration of Naloxegol can be increased when it is combined with Suvorexant. |
| Pazopanib | The serum concentration of Pazopanib can be increased when it is combined with Suvorexant. |
| Prucalopride | The serum concentration of Prucalopride can be increased when it is combined with Suvorexant. |
| Ranolazine | The serum concentration of Ranolazine can be increased when it is combined with Suvorexant. |
| Silodosin | The excretion of Silodosin can be decreased when combined with Suvorexant. |
| Topotecan | The serum concentration of Topotecan can be increased when it is combined with Suvorexant. |
| Doxylamine | Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Metyrosine | Suvorexant may increase the sedative activities of Metyrosine. |
| Minocycline | Minocycline may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Pramipexole | Suvorexant may increase the sedative activities of Pramipexole. |
| Ropinirole | Suvorexant may increase the sedative activities of Ropinirole. |
| Botulinum toxin type B | Botulinum toxin type B may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Botulinum toxin type A | Botulinum toxin type A may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Tryptophan | Tryptophan may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Fluvoxamine | Fluvoxamine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Baclofen | Baclofen may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Lorazepam | Lorazepam may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Ethchlorvynol | Ethchlorvynol may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Tramadol | Tramadol may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Succinylcholine | Succinylcholine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Reserpine | Reserpine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Citalopram | Citalopram may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Eletriptan | Eletriptan may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Enflurane | Enflurane may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Pregabalin | Pregabalin may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Temazepam | Temazepam may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Reboxetine | Reboxetine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Butabarbital | Butabarbital may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Butalbital | Butalbital may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Ziprasidone | Ziprasidone may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Methysergide | Methysergide may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Cabergoline | Cabergoline may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Phenytoin | Phenytoin may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Topiramate | Topiramate may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Clemastine | Clemastine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Venlafaxine | Venlafaxine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Etomidate | Etomidate may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Morphine | Morphine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Talbutal | Talbutal may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Pentobarbital | Pentobarbital may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Valproic acid | Valproic acid may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Zolmitriptan | Zolmitriptan may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Codeine | Codeine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Dihydroergotamine | Dihydroergotamine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Amitriptyline | Amitriptyline may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Tolcapone | Tolcapone may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Hydromorphone | Hydromorphone may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Olanzapine | Olanzapine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Cetirizine | Cetirizine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Protriptyline | Protriptyline may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Trimethadione | Trimethadione may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Clobazam | Clobazam may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Chlorzoxazone | Chlorzoxazone may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Clozapine | Clozapine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Mirtazapine | Mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Meprobamate | Meprobamate may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Thiethylperazine | Thiethylperazine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Palonosetron | Palonosetron may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Sulpiride | Sulpiride may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Carisoprodol | Carisoprodol may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Eszopiclone | Eszopiclone may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Alprazolam | Alprazolam may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Dexbrompheniramine | Dexbrompheniramine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Loxapine | Loxapine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Remoxipride | Remoxipride may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Metocurine iodide | Metocurine iodide may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Secobarbital | Secobarbital may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Promazine | Promazine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Methocarbamol | Methocarbamol may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Zolpidem | Zolpidem may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Triprolidine | Triprolidine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Prochlorperazine | Prochlorperazine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Cyproheptadine | Cyproheptadine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Droperidol | Droperidol may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Meperidine | Meperidine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Imipramine | Imipramine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Metharbital | Metharbital may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Quinine | Quinine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Dronabinol | Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Fluoxetine | Fluoxetine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Methohexital | Methohexital may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Chlordiazepoxide | Chlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Duloxetine | Duloxetine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Chlorpromazine | Chlorpromazine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Gallamine triethiodide | Gallamine triethiodide may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Nabilone | Nabilone may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Entacapone | Entacapone may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Oxycodone | Oxycodone may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Haloperidol | Haloperidol may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Triflupromazine | Triflupromazine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Dextromethorphan | Dextromethorphan may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Mephenytoin | Mephenytoin may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Nortriptyline | Nortriptyline may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Amoxapine | Amoxapine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |