Benactyzine

DB09023

small molecule withdrawn

Deskripsi

Benactyzine is an anticholinergic drug used as an antidepressant in the treatment of depression and associated anxiety.

Benactyzine is no longer widely used in medicine, although it is still a useful drug for scientific research. It does not possess any antihistamine properties.

Struktur Molekul 2D

Berat 327.4174
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

996 Data
Buprenorphine Benactyzine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Benactyzine.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Benactyzine.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Benactyzine.
Hydrocodone Benactyzine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Benactyzine.
Magnesium sulfate The therapeutic efficacy of Benactyzine can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Benactyzine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Benactyzine may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Benactyzine.
Mirtazapine Benactyzine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Benactyzine.
Orphenadrine Benactyzine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Benactyzine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Benactyzine.
Pramipexole Benactyzine may increase the sedative activities of Pramipexole.
Ropinirole Benactyzine may increase the sedative activities of Ropinirole.
Rotigotine Benactyzine may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Benactyzine.
Sodium oxybate Benactyzine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Suvorexant Benactyzine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Benactyzine.
Thalidomide Benactyzine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Benactyzine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Aclidinium The risk or severity of adverse effects can be increased when Benactyzine is combined with Aclidinium.
Mianserin Mianserin may increase the anticholinergic activities of Benactyzine.
Mirabegron The risk or severity of urinary retention can be increased when Benactyzine is combined with Mirabegron.
Potassium chloride The risk or severity of gastrointestinal ulceration can be increased when Benactyzine is combined with Potassium chloride.
Pramlintide The risk or severity of reduced gastrointestinal motility can be increased when Pramlintide is combined with Benactyzine.
Secretin porcine The therapeutic efficacy of Secretin porcine can be decreased when used in combination with Benactyzine.
Tiotropium The risk or severity of adverse effects can be increased when Benactyzine is combined with Tiotropium.
Topiramate The risk or severity of hyperthermia and oligohydrosis can be increased when Benactyzine is combined with Topiramate.
Umeclidinium The risk or severity of adverse effects can be increased when Benactyzine is combined with Umeclidinium.
Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Benactyzine.
Glycopyrronium The risk or severity of adverse effects can be increased when Benactyzine is combined with Glycopyrronium.
Dicoumarol The risk or severity of adverse effects can be increased when Benactyzine is combined with Dicoumarol.
Phenindione The risk or severity of adverse effects can be increased when Benactyzine is combined with Phenindione.
Warfarin The risk or severity of adverse effects can be increased when Benactyzine is combined with Warfarin.
Phenprocoumon The risk or severity of adverse effects can be increased when Benactyzine is combined with Phenprocoumon.
Acenocoumarol The risk or severity of adverse effects can be increased when Benactyzine is combined with Acenocoumarol.
4-hydroxycoumarin The risk or severity of adverse effects can be increased when Benactyzine is combined with 4-hydroxycoumarin.
Coumarin The risk or severity of adverse effects can be increased when Benactyzine is combined with Coumarin.
(R)-warfarin The risk or severity of adverse effects can be increased when Benactyzine is combined with (R)-warfarin.
Ethyl biscoumacetate The risk or severity of adverse effects can be increased when Benactyzine is combined with Ethyl biscoumacetate.
Fluindione The risk or severity of adverse effects can be increased when Benactyzine is combined with Fluindione.
Clorindione The risk or severity of adverse effects can be increased when Benactyzine is combined with Clorindione.
Diphenadione The risk or severity of adverse effects can be increased when Benactyzine is combined with Diphenadione.
Tioclomarol The risk or severity of adverse effects can be increased when Benactyzine is combined with Tioclomarol.
(S)-Warfarin The risk or severity of adverse effects can be increased when Benactyzine is combined with (S)-Warfarin.
Botulinum toxin type A The risk or severity of adverse effects can be increased when Benactyzine is combined with Botulinum toxin type A.
Glucagon Benactyzine may increase the gastrointestinal motility reducing activities of Glucagon.
Sulpiride Benactyzine may increase the anticholinergic activities of Sulpiride.
Botulinum toxin type B The risk or severity of adverse effects can be increased when Benactyzine is combined with Botulinum toxin type B.
Eluxadoline The risk or severity of constipation can be increased when Benactyzine is combined with Eluxadoline.
Ramosetron The risk or severity of constipation can be increased when Benactyzine is combined with Ramosetron.
Ethanol Benactyzine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Azelastine Benactyzine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Brimonidine Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Benactyzine.
Zimelidine The risk or severity of adverse effects can be increased when Benactyzine is combined with Zimelidine.
Dapoxetine The risk or severity of adverse effects can be increased when Benactyzine is combined with Dapoxetine.
Seproxetine The risk or severity of adverse effects can be increased when Benactyzine is combined with Seproxetine.
Fluvoxamine The risk or severity of adverse effects can be increased when Benactyzine is combined with Fluvoxamine.
Citalopram The risk or severity of adverse effects can be increased when Benactyzine is combined with Citalopram.
Duloxetine The risk or severity of adverse effects can be increased when Benactyzine is combined with Duloxetine.
Trazodone The risk or severity of adverse effects can be increased when Benactyzine is combined with Trazodone.
Paroxetine The risk or severity of adverse effects can be increased when Benactyzine is combined with Paroxetine.
Sertraline The risk or severity of adverse effects can be increased when Benactyzine is combined with Sertraline.
Sibutramine The risk or severity of adverse effects can be increased when Benactyzine is combined with Sibutramine.
Nefazodone The risk or severity of adverse effects can be increased when Benactyzine is combined with Nefazodone.
Escitalopram The risk or severity of adverse effects can be increased when Benactyzine is combined with Escitalopram.
Milnacipran The risk or severity of adverse effects can be increased when Benactyzine is combined with Milnacipran.
Desvenlafaxine The risk or severity of adverse effects can be increased when Benactyzine is combined with Desvenlafaxine.
Levomilnacipran The risk or severity of adverse effects can be increased when Levomilnacipran is combined with Benactyzine.
Indalpine The risk or severity of adverse effects can be increased when Benactyzine is combined with Indalpine.
Ritanserin The risk or severity of adverse effects can be increased when Benactyzine is combined with Ritanserin.
Alaproclate The risk or severity of adverse effects can be increased when Benactyzine is combined with Alaproclate.
Naltrexone The risk or severity of adverse effects can be increased when Benactyzine is combined with Naltrexone.
Bezitramide The risk or severity of adverse effects can be increased when Benactyzine is combined with Bezitramide.
Desomorphine The risk or severity of adverse effects can be increased when Benactyzine is combined with Desomorphine.
Nicomorphine The risk or severity of adverse effects can be increased when Benactyzine is combined with Nicomorphine.
Morphine The risk or severity of adverse effects can be increased when Benactyzine is combined with Morphine.
Codeine The risk or severity of adverse effects can be increased when Benactyzine is combined with Codeine.
Hydromorphone The risk or severity of adverse effects can be increased when Benactyzine is combined with Hydromorphone.
Meperidine The risk or severity of adverse effects can be increased when Benactyzine is combined with Meperidine.
Oxycodone The risk or severity of adverse effects can be increased when Benactyzine is combined with Oxycodone.
Butorphanol The risk or severity of adverse effects can be increased when Benactyzine is combined with Butorphanol.
Dextropropoxyphene The risk or severity of adverse effects can be increased when Benactyzine is combined with Dextropropoxyphene.
Pentazocine The risk or severity of adverse effects can be increased when Benactyzine is combined with Pentazocine.
Sufentanil The risk or severity of adverse effects can be increased when Benactyzine is combined with Sufentanil.
Alfentanil The risk or severity of adverse effects can be increased when Benactyzine is combined with Alfentanil.
Fentanyl The risk or severity of adverse effects can be increased when Benactyzine is combined with Fentanyl.
Nalbuphine The risk or severity of adverse effects can be increased when Benactyzine is combined with Nalbuphine.
Levorphanol The risk or severity of adverse effects can be increased when Benactyzine is combined with Levorphanol.
Remifentanil The risk or severity of adverse effects can be increased when Benactyzine is combined with Remifentanil.
Diphenoxylate The risk or severity of adverse effects can be increased when Benactyzine is combined with Diphenoxylate.
Oxymorphone The risk or severity of adverse effects can be increased when Benactyzine is combined with Oxymorphone.
Dezocine The risk or severity of adverse effects can be increased when Benactyzine is combined with Dezocine.
Levacetylmethadol The risk or severity of adverse effects can be increased when Benactyzine is combined with Levacetylmethadol.
Methadyl acetate The risk or severity of adverse effects can be increased when Benactyzine is combined with Methadyl acetate.
Dihydroetorphine The risk or severity of adverse effects can be increased when Benactyzine is combined with Dihydroetorphine.

Target Protein

Muscarinic acetylcholine receptor M5 CHRM5

Referensi & Sumber

Synthesis reference: U.S. Patent 2,394,770.
Artikel (PubMed)
  • PMID: 4891208
    McLaughlin B, Rickels K, Abidi M, Toro R: Meprobamate-benactyzine (Deprol) and placebo in two depressed outpatient populations. Psychosomatics. 1969 Mar-Apr;10(2):73-81.

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Sekuens Gen/Protein (FASTA)

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