Benzoctamine

DB09021

small molecule experimental

Deskripsi

Benzoctamine is a drug with two main uses. It can be used as a sedative which does not depress the respiratory system, but rather stimulates it. It can also be used as an anxiolytic with the same efficacy as chlordiazepoxide for treating anxiety neurosis.

Struktur Molekul 2D

Berat 249.357
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

663 Data
Buprenorphine Benzoctamine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Benzoctamine.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Benzoctamine.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Benzoctamine.
Hydrocodone Benzoctamine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Benzoctamine.
Magnesium sulfate The therapeutic efficacy of Benzoctamine can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Benzoctamine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Benzoctamine may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Benzoctamine.
Mirtazapine Benzoctamine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Benzoctamine.
Orphenadrine Benzoctamine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Benzoctamine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Benzoctamine.
Pramipexole Benzoctamine may increase the sedative activities of Pramipexole.
Ropinirole Benzoctamine may increase the sedative activities of Ropinirole.
Rotigotine Benzoctamine may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Benzoctamine.
Sodium oxybate Benzoctamine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Suvorexant Benzoctamine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Benzoctamine.
Thalidomide Benzoctamine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Benzoctamine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Yohimbine The therapeutic efficacy of Benzoctamine can be increased when used in combination with Yohimbine.
Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Benzoctamine.
Ethanol Benzoctamine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Azelastine Benzoctamine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Brimonidine Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Benzoctamine.
Fluvoxamine The risk or severity of adverse effects can be increased when Benzoctamine is combined with Fluvoxamine.
Citalopram The risk or severity of adverse effects can be increased when Benzoctamine is combined with Citalopram.
Duloxetine The risk or severity of adverse effects can be increased when Benzoctamine is combined with Duloxetine.
Trazodone The risk or severity of adverse effects can be increased when Benzoctamine is combined with Trazodone.
Paroxetine The risk or severity of adverse effects can be increased when Benzoctamine is combined with Paroxetine.
Sertraline The risk or severity of adverse effects can be increased when Benzoctamine is combined with Sertraline.
Sibutramine The risk or severity of adverse effects can be increased when Benzoctamine is combined with Sibutramine.
Nefazodone The risk or severity of adverse effects can be increased when Benzoctamine is combined with Nefazodone.
Escitalopram The risk or severity of adverse effects can be increased when Benzoctamine is combined with Escitalopram.
Zimelidine The risk or severity of adverse effects can be increased when Benzoctamine is combined with Zimelidine.
Dapoxetine The risk or severity of adverse effects can be increased when Benzoctamine is combined with Dapoxetine.
Milnacipran The risk or severity of adverse effects can be increased when Benzoctamine is combined with Milnacipran.
Desvenlafaxine The risk or severity of adverse effects can be increased when Benzoctamine is combined with Desvenlafaxine.
Seproxetine The risk or severity of adverse effects can be increased when Benzoctamine is combined with Seproxetine.
Indalpine The risk or severity of adverse effects can be increased when Benzoctamine is combined with Indalpine.
Ritanserin The risk or severity of adverse effects can be increased when Benzoctamine is combined with Ritanserin.
Alaproclate The risk or severity of adverse effects can be increased when Benzoctamine is combined with Alaproclate.
Amitriptyline The risk or severity of CNS depression can be increased when Amitriptyline is combined with Benzoctamine.
Cyproheptadine The risk or severity of CNS depression can be increased when Cyproheptadine is combined with Benzoctamine.
Imipramine The risk or severity of CNS depression can be increased when Imipramine is combined with Benzoctamine.
Nortriptyline The risk or severity of CNS depression can be increased when Nortriptyline is combined with Benzoctamine.
Amoxapine The risk or severity of CNS depression can be increased when Amoxapine is combined with Benzoctamine.
Propiomazine The risk or severity of CNS depression can be increased when Propiomazine is combined with Benzoctamine.
Maprotiline The risk or severity of CNS depression can be increased when Maprotiline is combined with Benzoctamine.
Doxepin The risk or severity of CNS depression can be increased when Doxepin is combined with Benzoctamine.
Desipramine The risk or severity of CNS depression can be increased when Desipramine is combined with Benzoctamine.
Pizotifen The risk or severity of CNS depression can be increased when Pizotifen is combined with Benzoctamine.
Dosulepin The risk or severity of CNS depression can be increased when Benzoctamine is combined with Dosulepin.
Zopiclone The risk or severity of adverse effects can be increased when Benzoctamine is combined with Zopiclone.
Botulinum toxin type B The risk or severity of CNS depression can be increased when Botulinum toxin type B is combined with Benzoctamine.
Botulinum toxin type A The risk or severity of CNS depression can be increased when Botulinum toxin type A is combined with Benzoctamine.
Tryptophan The risk or severity of CNS depression can be increased when Tryptophan is combined with Benzoctamine.
Baclofen Baclofen may increase the central nervous system depressant (CNS depressant) activities of Benzoctamine.
Lorazepam The risk or severity of CNS depression can be increased when Lorazepam is combined with Benzoctamine.
Ethchlorvynol The risk or severity of CNS depression can be increased when Ethchlorvynol is combined with Benzoctamine.
Succinylcholine The risk or severity of CNS depression can be increased when Succinylcholine is combined with Benzoctamine.
Reserpine The risk or severity of CNS depression can be increased when Reserpine is combined with Benzoctamine.
Eletriptan The risk or severity of CNS depression can be increased when Eletriptan is combined with Benzoctamine.
Enflurane The risk or severity of CNS depression can be increased when Enflurane is combined with Benzoctamine.
Temazepam The risk or severity of CNS depression can be increased when Temazepam is combined with Benzoctamine.
Reboxetine The risk or severity of CNS depression can be increased when Reboxetine is combined with Benzoctamine.
Butabarbital The risk or severity of CNS depression can be increased when Butabarbital is combined with Benzoctamine.
Butalbital The risk or severity of CNS depression can be increased when Butalbital is combined with Benzoctamine.
Methysergide The risk or severity of CNS depression can be increased when Methysergide is combined with Benzoctamine.
Cabergoline The risk or severity of CNS depression can be increased when Cabergoline is combined with Benzoctamine.
Phenytoin The risk or severity of CNS depression can be increased when Phenytoin is combined with Benzoctamine.
Topiramate The risk or severity of CNS depression can be increased when Topiramate is combined with Benzoctamine.
Clemastine The risk or severity of CNS depression can be increased when Clemastine is combined with Benzoctamine.
Venlafaxine The risk or severity of CNS depression can be increased when Venlafaxine is combined with Benzoctamine.
Etomidate The risk or severity of CNS depression can be increased when Etomidate is combined with Benzoctamine.
Morphine The risk or severity of CNS depression can be increased when Morphine is combined with Benzoctamine.
Talbutal The risk or severity of CNS depression can be increased when Talbutal is combined with Benzoctamine.
Pentobarbital The risk or severity of CNS depression can be increased when Pentobarbital is combined with Benzoctamine.
Valproic acid The risk or severity of CNS depression can be increased when Valproic acid is combined with Benzoctamine.
Zolmitriptan The risk or severity of CNS depression can be increased when Zolmitriptan is combined with Benzoctamine.
Codeine The risk or severity of CNS depression can be increased when Codeine is combined with Benzoctamine.
Dihydroergotamine The risk or severity of CNS depression can be increased when Dihydroergotamine is combined with Benzoctamine.
Tolcapone The risk or severity of CNS depression can be increased when Tolcapone is combined with Benzoctamine.
Hydromorphone The risk or severity of CNS depression can be increased when Hydromorphone is combined with Benzoctamine.
Olanzapine The risk or severity of CNS depression can be increased when Olanzapine is combined with Benzoctamine.
Cetirizine The risk or severity of CNS depression can be increased when Cetirizine is combined with Benzoctamine.
Protriptyline The risk or severity of CNS depression can be increased when Protriptyline is combined with Benzoctamine.
Trimethadione The risk or severity of CNS depression can be increased when Trimethadione is combined with Benzoctamine.
Clobazam The risk or severity of sedation, somnolence, and CNS depression can be increased when Clobazam is combined with Benzoctamine.
Chlorzoxazone The risk or severity of CNS depression can be increased when Chlorzoxazone is combined with Benzoctamine.
Clozapine The risk or severity of CNS depression can be increased when Clozapine is combined with Benzoctamine.
Meprobamate The risk or severity of CNS depression can be increased when Meprobamate is combined with Benzoctamine.
Thiethylperazine The risk or severity of CNS depression can be increased when Thiethylperazine is combined with Benzoctamine.
Palonosetron The risk or severity of CNS depression can be increased when Palonosetron is combined with Benzoctamine.
Sulpiride The risk or severity of CNS depression can be increased when Sulpiride is combined with Benzoctamine.
Alprazolam The risk or severity of CNS depression can be increased when Alprazolam is combined with Benzoctamine.

Referensi & Sumber

Synthesis reference: U.S. Patent 3,399,201.
Artikel (PubMed)
  • PMID: 4480288
    Lippmann W, Pugsley TA: Effects of benzoctamine and chlordiazepoxide on turnover and uptake of 5-hydroxytryptamine in the brain. Br J Pharmacol. 1974 Aug;51(4):571-5.
  • PMID: 4945942
    Authors unspecified: Tacitin and nobrium: new drugs for anxiety. Drug Ther Bull. 1971 Nov 19;9(24):93-4.
  • PMID: 4479725
    Goodwin NM, Brock-Utne JG, Downing JW, Coleman AJ: Benzoctamine. A preliminary report on a new sedative drug. Anaesthesia. 1974 Nov;29(6):715-20.

Contoh Produk & Brand

Produk: 0 • International brands: 1
International Brands
  • Tacitin — Ciba-Geigy

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