Peringatan Keamanan

Side effects of tricyclic antidepressants include dry mouth, sour or metallic taste, constipation, retention of urine, blurred vision and changes in focusing, palpitations, and fast heart beat. Gastrointestinal disturbances (including nausea and vomiting), drowsiness, tremor, low blood pressure when standing, dizziness, sweating, weakness and fatigue, incoordination, epilepsy-like seizures, and speech difficulties may occur.

Butriptyline

DB09016

small molecule approved withdrawn

Deskripsi

Butriptyline is a tricyclic antidepressant which has been used in Europe since 1974. It is the isobutyl side chain homologue of amitriptyline.

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

1561 Data
Ivabradine Ivabradine may increase the QTc-prolonging activities of Butriptyline.
Valsartan Butriptyline may decrease the antihypertensive activities of Valsartan.
Ramipril Butriptyline may decrease the antihypertensive activities of Ramipril.
Remikiren Butriptyline may decrease the antihypertensive activities of Remikiren.
Torasemide Butriptyline may decrease the antihypertensive activities of Torasemide.
Guanadrel Butriptyline may decrease the antihypertensive activities of Guanadrel.
Metoprolol Butriptyline may decrease the antihypertensive activities of Metoprolol.
Olmesartan Butriptyline may decrease the antihypertensive activities of Olmesartan.
Chlorthalidone Butriptyline may decrease the antihypertensive activities of Chlorthalidone.
Nitroprusside Butriptyline may decrease the antihypertensive activities of Nitroprusside.
Atenolol Butriptyline may decrease the antihypertensive activities of Atenolol.
Minoxidil Butriptyline may decrease the antihypertensive activities of Minoxidil.
Nisoldipine Butriptyline may decrease the antihypertensive activities of Nisoldipine.
Bendroflumethiazide Butriptyline may decrease the antihypertensive activities of Bendroflumethiazide.
Prazosin Butriptyline may decrease the antihypertensive activities of Prazosin.
Fosinopril Butriptyline may decrease the antihypertensive activities of Fosinopril.
Trandolapril Butriptyline may decrease the antihypertensive activities of Trandolapril.
Metolazone Butriptyline may decrease the antihypertensive activities of Metolazone.
Lercanidipine Butriptyline may decrease the antihypertensive activities of Lercanidipine.
Benazepril Butriptyline may decrease the antihypertensive activities of Benazepril.
Bosentan Butriptyline may decrease the antihypertensive activities of Bosentan.
Enalapril Butriptyline may decrease the antihypertensive activities of Enalapril.
Doxazosin Butriptyline may decrease the antihypertensive activities of Doxazosin.
Labetalol Butriptyline may decrease the antihypertensive activities of Labetalol.
Cyclothiazide Butriptyline may decrease the antihypertensive activities of Cyclothiazide.
Bisoprolol Butriptyline may decrease the antihypertensive activities of Bisoprolol.
Candoxatril Butriptyline may decrease the antihypertensive activities of Candoxatril.
Eplerenone Butriptyline may decrease the antihypertensive activities of Eplerenone.
Lisinopril Butriptyline may decrease the antihypertensive activities of Lisinopril.
Nitroglycerin Butriptyline may decrease the antihypertensive activities of Nitroglycerin.
Hydroflumethiazide Butriptyline may decrease the antihypertensive activities of Hydroflumethiazide.
Cryptenamine Butriptyline may decrease the antihypertensive activities of Cryptenamine.
Perindopril Butriptyline may decrease the antihypertensive activities of Perindopril.
Candesartan cilexetil Butriptyline may decrease the antihypertensive activities of Candesartan cilexetil.
Fenoldopam Butriptyline may decrease the antihypertensive activities of Fenoldopam.
Tadalafil Butriptyline may decrease the antihypertensive activities of Tadalafil.
Eprosartan Butriptyline may decrease the antihypertensive activities of Eprosartan.
Chlorothiazide Butriptyline may decrease the antihypertensive activities of Chlorothiazide.
Quinapril Butriptyline may decrease the antihypertensive activities of Quinapril.
Telmisartan Butriptyline may decrease the antihypertensive activities of Telmisartan.
Trichlormethiazide Butriptyline may decrease the antihypertensive activities of Trichlormethiazide.
Irbesartan Butriptyline may decrease the antihypertensive activities of Irbesartan.
Deserpidine Butriptyline may decrease the antihypertensive activities of Deserpidine.
Diazoxide Butriptyline may decrease the antihypertensive activities of Diazoxide.
Carvedilol Butriptyline may decrease the antihypertensive activities of Carvedilol.
Terazosin Butriptyline may decrease the antihypertensive activities of Terazosin.
Guanethidine Butriptyline may decrease the antihypertensive activities of Guanethidine.
Captopril Butriptyline may decrease the antihypertensive activities of Captopril.
Nadolol Butriptyline may decrease the antihypertensive activities of Nadolol.
Epoprostenol Butriptyline may decrease the antihypertensive activities of Epoprostenol.
Hydralazine Butriptyline may decrease the antihypertensive activities of Hydralazine.
Bevantolol Butriptyline may decrease the antihypertensive activities of Bevantolol.
Practolol Butriptyline may decrease the antihypertensive activities of Practolol.
Polythiazide Butriptyline may decrease the antihypertensive activities of Polythiazide.
Cilazapril Butriptyline may decrease the antihypertensive activities of Cilazapril.
Saprisartan Butriptyline may decrease the antihypertensive activities of Saprisartan.
Spirapril Butriptyline may decrease the antihypertensive activities of Spirapril.
Dexpropranolol Butriptyline may decrease the antihypertensive activities of Dexpropranolol.
Tienilic acid Butriptyline may decrease the antihypertensive activities of Tienilic acid.
Debrisoquine Butriptyline may decrease the antihypertensive activities of Debrisoquine.
Sitaxentan Butriptyline may decrease the antihypertensive activities of Sitaxentan.
Ambrisentan Butriptyline may decrease the antihypertensive activities of Ambrisentan.
Diethylnorspermine Butriptyline may decrease the antihypertensive activities of Diethylnorspermine.
Pinacidil Butriptyline may decrease the antihypertensive activities of Pinacidil.
Temocapril Butriptyline may decrease the antihypertensive activities of Temocapril.
Riociguat Butriptyline may decrease the antihypertensive activities of Riociguat.
Macitentan Butriptyline may decrease the antihypertensive activities of Macitentan.
Aliskiren Butriptyline may decrease the antihypertensive activities of Aliskiren.
Trimazosin Butriptyline may decrease the antihypertensive activities of Trimazosin.
Manidipine Butriptyline may decrease the antihypertensive activities of Manidipine.
Rauwolfia serpentina root Butriptyline may decrease the antihypertensive activities of Rauwolfia serpentina root.
Enalaprilat Butriptyline may decrease the antihypertensive activities of Enalaprilat.
Selexipag Butriptyline may decrease the antihypertensive activities of Selexipag.
Angiotensin 1-7 Butriptyline may decrease the antihypertensive activities of Angiotensin 1-7.
Imidapril Butriptyline may decrease the antihypertensive activities of Imidapril.
BQ-123 Butriptyline may decrease the antihypertensive activities of BQ-123.
Landiolol Butriptyline may decrease the antihypertensive activities of Landiolol.
Dihydralazine Butriptyline may decrease the antihypertensive activities of Dihydralazine.
Zofenopril Butriptyline may decrease the antihypertensive activities of Zofenopril.
Guanoxan Butriptyline may decrease the antihypertensive activities of Guanoxan.
Delapril Butriptyline may decrease the antihypertensive activities of Delapril.
Vincamine Butriptyline may decrease the antihypertensive activities of Vincamine.
Linsidomine Butriptyline may decrease the antihypertensive activities of Linsidomine.
Guanoxabenz Butriptyline may decrease the antihypertensive activities of Guanoxabenz.
Tolonidine Butriptyline may decrease the antihypertensive activities of Tolonidine.
Endralazine Butriptyline may decrease the antihypertensive activities of Endralazine.
Esatenolol Butriptyline may decrease the antihypertensive activities of Esatenolol.
Cadralazine Butriptyline may decrease the antihypertensive activities of Cadralazine.
Cloranolol Butriptyline may decrease the antihypertensive activities of Cloranolol.
Cyclopenthiazide Butriptyline may decrease the antihypertensive activities of Cyclopenthiazide.
Bietaserpine Butriptyline may decrease the antihypertensive activities of Bietaserpine.
Guanazodine Butriptyline may decrease the antihypertensive activities of Guanazodine.
Methoserpidine Butriptyline may decrease the antihypertensive activities of Methoserpidine.
Epanolol Butriptyline may decrease the antihypertensive activities of Epanolol.
Guanoclor Butriptyline may decrease the antihypertensive activities of Guanoclor.
Muzolimine Butriptyline may decrease the antihypertensive activities of Muzolimine.
Xipamide Butriptyline may decrease the antihypertensive activities of Xipamide.
Candesartan Butriptyline may decrease the antihypertensive activities of Candesartan.
Dexniguldipine Butriptyline may decrease the antihypertensive activities of Dexniguldipine.
Tocopherylquinone Butriptyline may decrease the antihypertensive activities of Tocopherylquinone.

Target Protein

Sodium-dependent serotonin transporter SLC6A4
Histamine H1 receptor HRH1
5-hydroxytryptamine receptor 2A HTR2A

Referensi & Sumber

Synthesis reference: U.S. Patent 3,409,640.

Contoh Produk & Brand

Produk: 0 • International brands: 4
International Brands
  • Centrolese
  • Evadene
  • Evadyne
  • Evasidol

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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