-TDLo oral 17mg/kg (human) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX). PMID: 13535337.
-LD50 intraperitoneal 116mg/kg (mouse) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD. PMID: 13062090.
-LD50 intravenous 72mg/kg (mouse) BEHAVIORAL: ATAXIA. PMID: 14109651.
Captodiame, also known as captodiamine, is an antihistamine which is used as a sedative and anxiolytic. It is a derivative of diphenhydramine. Captodiame has been suggested for use in preventing benzodiazepine withdrawal syndrome.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Buprenorphine | Captodiame may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine. |
| Doxylamine | Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Captodiame. |
| Dronabinol | Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Captodiame. |
| Droperidol | Droperidol may increase the central nervous system depressant (CNS depressant) activities of Captodiame. |
| Hydrocodone | Captodiame may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone. |
| Hydroxyzine | Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Captodiame. |
| Magnesium sulfate | The therapeutic efficacy of Captodiame can be increased when used in combination with Magnesium sulfate. |
| Methotrimeprazine | Captodiame may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine. |
| Metyrosine | Captodiame may increase the sedative activities of Metyrosine. |
| Minocycline | Minocycline may increase the central nervous system depressant (CNS depressant) activities of Captodiame. |
| Mirtazapine | Captodiame may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine. |
| Nabilone | Nabilone may increase the central nervous system depressant (CNS depressant) activities of Captodiame. |
| Orphenadrine | Captodiame may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Paraldehyde | Captodiame may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde. |
| Perampanel | Perampanel may increase the central nervous system depressant (CNS depressant) activities of Captodiame. |
| Pramipexole | Captodiame may increase the sedative activities of Pramipexole. |
| Ropinirole | Captodiame may increase the sedative activities of Ropinirole. |
| Rotigotine | Captodiame may increase the sedative activities of Rotigotine. |
| Rufinamide | The risk or severity of adverse effects can be increased when Rufinamide is combined with Captodiame. |
| Sodium oxybate | Captodiame may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate. |
| Suvorexant | Captodiame may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Tapentadol | Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Captodiame. |
| Thalidomide | Captodiame may increase the central nervous system depressant (CNS depressant) activities of Thalidomide. |
| Zolpidem | Captodiame may increase the central nervous system depressant (CNS depressant) activities of Zolpidem. |
| Yohimbine | The therapeutic efficacy of Captodiame can be increased when used in combination with Yohimbine. |
| Methadone | The risk or severity of adverse effects can be increased when Methadone is combined with Captodiame. |
| Dicoumarol | The risk or severity of adverse effects can be increased when Captodiame is combined with Dicoumarol. |
| Phenindione | The risk or severity of adverse effects can be increased when Captodiame is combined with Phenindione. |
| Warfarin | The risk or severity of adverse effects can be increased when Captodiame is combined with Warfarin. |
| Phenprocoumon | The risk or severity of adverse effects can be increased when Captodiame is combined with Phenprocoumon. |
| Acenocoumarol | The risk or severity of adverse effects can be increased when Captodiame is combined with Acenocoumarol. |
| 4-hydroxycoumarin | The risk or severity of adverse effects can be increased when Captodiame is combined with 4-hydroxycoumarin. |
| Coumarin | The risk or severity of adverse effects can be increased when Captodiame is combined with Coumarin. |
| (R)-warfarin | The risk or severity of adverse effects can be increased when Captodiame is combined with (R)-warfarin. |
| Ethyl biscoumacetate | The risk or severity of adverse effects can be increased when Captodiame is combined with Ethyl biscoumacetate. |
| Fluindione | The risk or severity of adverse effects can be increased when Captodiame is combined with Fluindione. |
| Clorindione | The risk or severity of adverse effects can be increased when Captodiame is combined with Clorindione. |
| Diphenadione | The risk or severity of adverse effects can be increased when Captodiame is combined with Diphenadione. |
| Tioclomarol | The risk or severity of adverse effects can be increased when Captodiame is combined with Tioclomarol. |
| (S)-Warfarin | The risk or severity of adverse effects can be increased when Captodiame is combined with (S)-Warfarin. |
| Ethanol | Captodiame may increase the central nervous system depressant (CNS depressant) activities of Ethanol. |
| Azelastine | Captodiame may increase the central nervous system depressant (CNS depressant) activities of Azelastine. |
| Brimonidine | Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Captodiame. |
| Fluvoxamine | The risk or severity of adverse effects can be increased when Captodiame is combined with Fluvoxamine. |
| Citalopram | The risk or severity of adverse effects can be increased when Captodiame is combined with Citalopram. |
| Duloxetine | The risk or severity of adverse effects can be increased when Captodiame is combined with Duloxetine. |
| Trazodone | The risk or severity of adverse effects can be increased when Captodiame is combined with Trazodone. |
| Paroxetine | The risk or severity of adverse effects can be increased when Captodiame is combined with Paroxetine. |
| Sertraline | The risk or severity of adverse effects can be increased when Captodiame is combined with Sertraline. |
| Sibutramine | The risk or severity of adverse effects can be increased when Captodiame is combined with Sibutramine. |
| Nefazodone | The risk or severity of adverse effects can be increased when Captodiame is combined with Nefazodone. |
| Escitalopram | The risk or severity of adverse effects can be increased when Captodiame is combined with Escitalopram. |
| Zimelidine | The risk or severity of adverse effects can be increased when Captodiame is combined with Zimelidine. |
| Dapoxetine | The risk or severity of adverse effects can be increased when Captodiame is combined with Dapoxetine. |
| Milnacipran | The risk or severity of adverse effects can be increased when Captodiame is combined with Milnacipran. |
| Desvenlafaxine | The risk or severity of adverse effects can be increased when Captodiame is combined with Desvenlafaxine. |
| Seproxetine | The risk or severity of adverse effects can be increased when Captodiame is combined with Seproxetine. |
| Indalpine | The risk or severity of adverse effects can be increased when Captodiame is combined with Indalpine. |
| Ritanserin | The risk or severity of adverse effects can be increased when Captodiame is combined with Ritanserin. |
| Alaproclate | The risk or severity of adverse effects can be increased when Captodiame is combined with Alaproclate. |
| Zopiclone | The risk or severity of adverse effects can be increased when Captodiame is combined with Zopiclone. |
| Botulinum toxin type B | The risk or severity of CNS depression can be increased when Botulinum toxin type B is combined with Captodiame. |
| Botulinum toxin type A | The risk or severity of CNS depression can be increased when Botulinum toxin type A is combined with Captodiame. |
| Tryptophan | The risk or severity of CNS depression can be increased when Tryptophan is combined with Captodiame. |
| Baclofen | Baclofen may increase the central nervous system depressant (CNS depressant) activities of Captodiame. |
| Lorazepam | The risk or severity of CNS depression can be increased when Lorazepam is combined with Captodiame. |
| Ethchlorvynol | The risk or severity of CNS depression can be increased when Ethchlorvynol is combined with Captodiame. |
| Succinylcholine | The risk or severity of CNS depression can be increased when Succinylcholine is combined with Captodiame. |
| Reserpine | The risk or severity of CNS depression can be increased when Reserpine is combined with Captodiame. |
| Eletriptan | The risk or severity of CNS depression can be increased when Eletriptan is combined with Captodiame. |
| Enflurane | The risk or severity of CNS depression can be increased when Enflurane is combined with Captodiame. |
| Temazepam | The risk or severity of CNS depression can be increased when Temazepam is combined with Captodiame. |
| Reboxetine | The risk or severity of CNS depression can be increased when Reboxetine is combined with Captodiame. |
| Butabarbital | The risk or severity of CNS depression can be increased when Butabarbital is combined with Captodiame. |
| Butalbital | The risk or severity of CNS depression can be increased when Butalbital is combined with Captodiame. |
| Methysergide | The risk or severity of CNS depression can be increased when Methysergide is combined with Captodiame. |
| Cabergoline | The risk or severity of CNS depression can be increased when Cabergoline is combined with Captodiame. |
| Phenytoin | The risk or severity of CNS depression can be increased when Phenytoin is combined with Captodiame. |
| Topiramate | The risk or severity of CNS depression can be increased when Topiramate is combined with Captodiame. |
| Clemastine | The risk or severity of CNS depression can be increased when Clemastine is combined with Captodiame. |
| Venlafaxine | The risk or severity of CNS depression can be increased when Venlafaxine is combined with Captodiame. |
| Etomidate | The risk or severity of CNS depression can be increased when Etomidate is combined with Captodiame. |
| Morphine | The risk or severity of CNS depression can be increased when Morphine is combined with Captodiame. |
| Talbutal | The risk or severity of CNS depression can be increased when Talbutal is combined with Captodiame. |
| Pentobarbital | The risk or severity of CNS depression can be increased when Pentobarbital is combined with Captodiame. |
| Valproic acid | The risk or severity of CNS depression can be increased when Valproic acid is combined with Captodiame. |
| Zolmitriptan | The risk or severity of CNS depression can be increased when Zolmitriptan is combined with Captodiame. |
| Codeine | The risk or severity of CNS depression can be increased when Codeine is combined with Captodiame. |
| Dihydroergotamine | The risk or severity of CNS depression can be increased when Dihydroergotamine is combined with Captodiame. |
| Amitriptyline | The risk or severity of CNS depression can be increased when Amitriptyline is combined with Captodiame. |
| Tolcapone | The risk or severity of CNS depression can be increased when Tolcapone is combined with Captodiame. |
| Hydromorphone | The risk or severity of CNS depression can be increased when Hydromorphone is combined with Captodiame. |
| Olanzapine | The risk or severity of CNS depression can be increased when Olanzapine is combined with Captodiame. |
| Cetirizine | The risk or severity of CNS depression can be increased when Cetirizine is combined with Captodiame. |
| Protriptyline | The risk or severity of CNS depression can be increased when Protriptyline is combined with Captodiame. |
| Trimethadione | The risk or severity of CNS depression can be increased when Trimethadione is combined with Captodiame. |
| Clobazam | The risk or severity of sedation, somnolence, and CNS depression can be increased when Clobazam is combined with Captodiame. |
| Chlorzoxazone | The risk or severity of CNS depression can be increased when Chlorzoxazone is combined with Captodiame. |
| Clozapine | The risk or severity of CNS depression can be increased when Clozapine is combined with Captodiame. |
| Meprobamate | The risk or severity of CNS depression can be increased when Meprobamate is combined with Captodiame. |