Beclamide

DB09011

small molecule experimental

Deskripsi

Beclamide (N-benzyl-B-chloropropionamide) is a no longer used drug that possesses anticonvulsant and sedative activity. It was studied in the 1950s for generalised tonic-clonic seizures but was not effective for absence seizures.

Struktur Molekul 2D

Berat 197.661
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Rapidly metabolized. Major pathway of metabolism is oxidation of the benzene ring to yield 3-hydroxyphenyl and 4-hydroxyphenyl metabolites, and oxidation of the benyl methylene to yield benzoic acid. 3 and 4 hydroxyphenyl metabolites are excreted extensively as gluconuride and sulphate conjugates, and benzoic acid is excreted as a glycine conjugate (hippuric acid).

Rute Eliminasi

Metabolites appear in urine only. 4- hydroxybeclamide is present in the urine to a greater extent than 3 hydroxybeclamide. Approximately 20% of the radiolabel was excreted in urine.

Interaksi Obat

809 Data
Buprenorphine Beclamide may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Beclamide.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Beclamide.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Beclamide.
Hydrocodone Beclamide may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Beclamide.
Magnesium sulfate The therapeutic efficacy of Beclamide can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Beclamide may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Beclamide may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Beclamide.
Mirtazapine Beclamide may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Beclamide.
Orphenadrine Beclamide may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Beclamide may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Beclamide.
Pramipexole Beclamide may increase the sedative activities of Pramipexole.
Ropinirole Beclamide may increase the sedative activities of Ropinirole.
Rotigotine Beclamide may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Beclamide.
Sodium oxybate Beclamide may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Suvorexant Beclamide may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Beclamide.
Thalidomide Beclamide may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Beclamide may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Mefloquine The therapeutic efficacy of Beclamide can be decreased when used in combination with Mefloquine.
Mianserin The therapeutic efficacy of Beclamide can be decreased when used in combination with Mianserin.
Orlistat Orlistat can cause a decrease in the absorption of Beclamide resulting in a reduced serum concentration and potentially a decrease in efficacy.
Topotecan Beclamide may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Beclamide.
Tetracosactide The risk or severity of liver damage can be increased when Tetracosactide is combined with Beclamide.
Ethanol Beclamide may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Azelastine Beclamide may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Brimonidine Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Beclamide.
Fluvoxamine The risk or severity of adverse effects can be increased when Beclamide is combined with Fluvoxamine.
Citalopram The risk or severity of adverse effects can be increased when Beclamide is combined with Citalopram.
Duloxetine The risk or severity of adverse effects can be increased when Beclamide is combined with Duloxetine.
Trazodone The risk or severity of adverse effects can be increased when Beclamide is combined with Trazodone.
Paroxetine The risk or severity of adverse effects can be increased when Beclamide is combined with Paroxetine.
Sertraline The risk or severity of adverse effects can be increased when Beclamide is combined with Sertraline.
Sibutramine The risk or severity of adverse effects can be increased when Beclamide is combined with Sibutramine.
Nefazodone The risk or severity of adverse effects can be increased when Beclamide is combined with Nefazodone.
Escitalopram The risk or severity of adverse effects can be increased when Beclamide is combined with Escitalopram.
Zimelidine The risk or severity of adverse effects can be increased when Beclamide is combined with Zimelidine.
Dapoxetine The risk or severity of adverse effects can be increased when Beclamide is combined with Dapoxetine.
Milnacipran The risk or severity of adverse effects can be increased when Beclamide is combined with Milnacipran.
Desvenlafaxine The risk or severity of adverse effects can be increased when Beclamide is combined with Desvenlafaxine.
Seproxetine The risk or severity of adverse effects can be increased when Beclamide is combined with Seproxetine.
Indalpine The risk or severity of adverse effects can be increased when Beclamide is combined with Indalpine.
Ritanserin The risk or severity of adverse effects can be increased when Beclamide is combined with Ritanserin.
Alaproclate The risk or severity of adverse effects can be increased when Beclamide is combined with Alaproclate.
Amitriptyline The risk or severity of CNS depression can be increased when Amitriptyline is combined with Beclamide.
Cyproheptadine The risk or severity of CNS depression can be increased when Cyproheptadine is combined with Beclamide.
Imipramine The risk or severity of CNS depression can be increased when Imipramine is combined with Beclamide.
Nortriptyline The risk or severity of CNS depression can be increased when Nortriptyline is combined with Beclamide.
Amoxapine The risk or severity of CNS depression can be increased when Amoxapine is combined with Beclamide.
Propiomazine The risk or severity of CNS depression can be increased when Propiomazine is combined with Beclamide.
Cocaine The risk or severity of methemoglobinemia can be increased when Beclamide is combined with Cocaine.
Quinidine The therapeutic efficacy of Beclamide can be decreased when used in combination with Quinidine.
Maprotiline The risk or severity of CNS depression can be increased when Maprotiline is combined with Beclamide.
Doxepin The risk or severity of CNS depression can be increased when Doxepin is combined with Beclamide.
Desipramine The risk or severity of CNS depression can be increased when Desipramine is combined with Beclamide.
Pizotifen The risk or severity of CNS depression can be increased when Pizotifen is combined with Beclamide.
Dosulepin The risk or severity of CNS depression can be increased when Beclamide is combined with Dosulepin.
Zopiclone The risk or severity of adverse effects can be increased when Beclamide is combined with Zopiclone.
Botulinum toxin type B The risk or severity of CNS depression can be increased when Botulinum toxin type B is combined with Beclamide.
Botulinum toxin type A The risk or severity of CNS depression can be increased when Botulinum toxin type A is combined with Beclamide.
Tryptophan The risk or severity of CNS depression can be increased when Tryptophan is combined with Beclamide.
Baclofen Baclofen may increase the central nervous system depressant (CNS depressant) activities of Beclamide.
Lorazepam The risk or severity of CNS depression can be increased when Lorazepam is combined with Beclamide.
Ethchlorvynol The risk or severity of CNS depression can be increased when Ethchlorvynol is combined with Beclamide.
Succinylcholine The risk or severity of CNS depression can be increased when Succinylcholine is combined with Beclamide.
Reserpine The risk or severity of CNS depression can be increased when Reserpine is combined with Beclamide.
Eletriptan The risk or severity of CNS depression can be increased when Eletriptan is combined with Beclamide.
Enflurane The risk or severity of CNS depression can be increased when Enflurane is combined with Beclamide.
Temazepam The risk or severity of CNS depression can be increased when Temazepam is combined with Beclamide.
Reboxetine The risk or severity of CNS depression can be increased when Reboxetine is combined with Beclamide.
Butabarbital The risk or severity of CNS depression can be increased when Butabarbital is combined with Beclamide.
Butalbital The risk or severity of CNS depression can be increased when Butalbital is combined with Beclamide.
Methysergide The risk or severity of CNS depression can be increased when Methysergide is combined with Beclamide.
Cabergoline The risk or severity of CNS depression can be increased when Cabergoline is combined with Beclamide.
Phenytoin The risk or severity of CNS depression can be increased when Phenytoin is combined with Beclamide.
Topiramate The risk or severity of CNS depression can be increased when Topiramate is combined with Beclamide.
Clemastine The risk or severity of CNS depression can be increased when Clemastine is combined with Beclamide.
Venlafaxine The risk or severity of CNS depression can be increased when Venlafaxine is combined with Beclamide.
Etomidate The risk or severity of CNS depression can be increased when Etomidate is combined with Beclamide.
Morphine The risk or severity of CNS depression can be increased when Morphine is combined with Beclamide.
Talbutal The risk or severity of CNS depression can be increased when Talbutal is combined with Beclamide.
Pentobarbital The risk or severity of CNS depression can be increased when Pentobarbital is combined with Beclamide.
Valproic acid The risk or severity of CNS depression can be increased when Valproic acid is combined with Beclamide.
Zolmitriptan The risk or severity of CNS depression can be increased when Zolmitriptan is combined with Beclamide.
Codeine The risk or severity of CNS depression can be increased when Codeine is combined with Beclamide.
Dihydroergotamine The risk or severity of CNS depression can be increased when Dihydroergotamine is combined with Beclamide.
Tolcapone The risk or severity of CNS depression can be increased when Tolcapone is combined with Beclamide.
Hydromorphone The risk or severity of CNS depression can be increased when Hydromorphone is combined with Beclamide.
Olanzapine The risk or severity of CNS depression can be increased when Olanzapine is combined with Beclamide.
Cetirizine The risk or severity of CNS depression can be increased when Cetirizine is combined with Beclamide.
Protriptyline The risk or severity of CNS depression can be increased when Protriptyline is combined with Beclamide.
Trimethadione The risk or severity of CNS depression can be increased when Trimethadione is combined with Beclamide.
Clobazam The risk or severity of sedation, somnolence, and CNS depression can be increased when Clobazam is combined with Beclamide.
Chlorzoxazone The risk or severity of CNS depression can be increased when Chlorzoxazone is combined with Beclamide.

Referensi & Sumber

Synthesis reference: Nicholls, P. J., & Luscombe, D. K. (1979). Facile synthesis of N?(Methylene?14C) benzyl?3?chloropropionamide (beclamide). Journal of Labelled Compounds and Radiopharmaceuticals, 16(2), 369-372.
Artikel (PubMed)
  • PMID: 8583359
    Ahmadi M, Nicholls PJ, Smith HJ, Spencer PS, Preet-Ryatt MS, Spragg BP: Metabolism of beclamide after a single oral dose in man: quantitative studies. J Pharm Pharmacol. 1995 Oct;47(10):876-8.
  • PMID: 1717674
    Darmani NA, Sewell RD, Nicholls PJ: Acute effects of beclamide on brain regional monoamine concentrations, their metabolites and radioligand binding studies. J Pharm Pharmacol. 1991 Jun;43(6):425-9.
  • PMID: 2183543
    Raptis C, Garcia-Borreguero D, Weber MM, Dose M, Bremer D, Emrich HM: Anticonvulsants as adjuncts for the neuroleptic treatment of schizophrenic psychoses: a clinical study with beclamide. Acta Psychiatr Scand. 1990 Feb;81(2):162-7.

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