Eperisone

DB08992

small molecule investigational

Deskripsi

Eperisone is an antispasmodic drug which relaxes both skeletal muscles and vascular smooth muscles, and demonstrates a variety of effects such as reduction of myotonia, improvement of circulation, and suppression of the pain reflex. It is not approved for use in the United States, but is available in other countries like India, South Korea, and Bangladesh.

Struktur Molekul 2D

Berat 259.3865
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

1470 Data
Ceritinib Eperisone may increase the bradycardic activities of Ceritinib.
Ivabradine Eperisone may increase the bradycardic activities of Ivabradine.
Ruxolitinib Ruxolitinib may increase the bradycardic activities of Eperisone.
Buprenorphine Eperisone may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Eperisone.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Eperisone.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Eperisone.
Hydrocodone Eperisone may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Magnesium sulfate The therapeutic efficacy of Eperisone can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Eperisone may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Eperisone may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Eperisone.
Mirtazapine Eperisone may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Eperisone.
Orphenadrine Eperisone may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Eperisone may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Eperisone.
Pramipexole Eperisone may increase the sedative activities of Pramipexole.
Ropinirole Eperisone may increase the sedative activities of Ropinirole.
Rotigotine Eperisone may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Eperisone.
Sodium oxybate Eperisone may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Suvorexant Eperisone may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Eperisone.
Thalidomide Eperisone may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Eperisone may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Cimetidine The serum concentration of Eperisone can be increased when it is combined with Cimetidine.
Clopidogrel The therapeutic efficacy of Clopidogrel can be decreased when used in combination with Eperisone.
Efavirenz The serum concentration of Eperisone can be decreased when it is combined with Efavirenz.
Melatonin The therapeutic efficacy of Eperisone can be decreased when used in combination with Melatonin.
Nafcillin The therapeutic efficacy of Eperisone can be decreased when used in combination with Nafcillin.
Nitroprusside Eperisone may increase the hypotensive activities of Nitroprusside.
Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Eperisone.
Dantrolene The risk or severity of hyperkalemia can be increased when Dantrolene is combined with Eperisone.
Lithium citrate The risk or severity of adverse effects can be increased when Eperisone is combined with Lithium citrate.
Lithium carbonate The risk or severity of adverse effects can be increased when Eperisone is combined with Lithium carbonate.
Lithium hydroxide The risk or severity of adverse effects can be increased when Eperisone is combined with Lithium hydroxide.
Methocarbamol The risk or severity of visual accommodation disturbances can be increased when Eperisone is combined with Methocarbamol.
Boceprevir The serum concentration of Eperisone can be increased when it is combined with Boceprevir.
Ethanol Eperisone may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Azelastine Eperisone may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Brimonidine Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Eperisone.
Fluvoxamine The risk or severity of adverse effects can be increased when Eperisone is combined with Fluvoxamine.
Duloxetine The risk or severity of adverse effects can be increased when Eperisone is combined with Duloxetine.
Paroxetine The risk or severity of adverse effects can be increased when Eperisone is combined with Paroxetine.
Sertraline The risk or severity of adverse effects can be increased when Eperisone is combined with Sertraline.
Sibutramine The risk or severity of adverse effects can be increased when Eperisone is combined with Sibutramine.
Zimelidine The risk or severity of adverse effects can be increased when Eperisone is combined with Zimelidine.
Dapoxetine The risk or severity of adverse effects can be increased when Eperisone is combined with Dapoxetine.
Milnacipran The risk or severity of adverse effects can be increased when Eperisone is combined with Milnacipran.
Desvenlafaxine The risk or severity of adverse effects can be increased when Eperisone is combined with Desvenlafaxine.
Seproxetine The risk or severity of adverse effects can be increased when Eperisone is combined with Seproxetine.
Indalpine The risk or severity of adverse effects can be increased when Eperisone is combined with Indalpine.
Ritanserin The risk or severity of adverse effects can be increased when Eperisone is combined with Ritanserin.
Alaproclate The risk or severity of adverse effects can be increased when Eperisone is combined with Alaproclate.
Tocainide Tocainide may increase the arrhythmogenic activities of Eperisone.
Aprindine Aprindine may increase the arrhythmogenic activities of Eperisone.
Xylometazoline Xylometazoline may increase the arrhythmogenic activities of Eperisone.
Sparteine Sparteine may increase the arrhythmogenic activities of Eperisone.
Fasudil Fasudil may increase the arrhythmogenic activities of Eperisone.
Carteolol Eperisone may increase the arrhythmogenic activities of Carteolol.
Metipranolol Eperisone may increase the arrhythmogenic activities of Metipranolol.
Spiradoline Eperisone may increase the arrhythmogenic activities of Spiradoline.
Tiracizine Eperisone may increase the arrhythmogenic activities of Tiracizine.
Ethacizine Eperisone may increase the arrhythmogenic activities of Ethacizine.
Hydroquinine Eperisone may increase the arrhythmogenic activities of Hydroquinine.
Bioallethrin Eperisone may increase the arrhythmogenic activities of Bioallethrin.
Fosfructose Eperisone may increase the arrhythmogenic activities of Fosfructose.
Hydroquinidine Eperisone may increase the arrhythmogenic activities of Hydroquinidine.
SOR-C13 Eperisone may increase the arrhythmogenic activities of SOR-C13.
Digoxin Digoxin may increase the arrhythmogenic activities of Eperisone.
Acetyldigitoxin Acetyldigitoxin may increase the arrhythmogenic activities of Eperisone.
Deslanoside Deslanoside may increase the arrhythmogenic activities of Eperisone.
Cymarin Eperisone may increase the arrhythmogenic activities of Cymarin.
Metildigoxin Eperisone may increase the arrhythmogenic activities of Metildigoxin.
Acetyldigoxin Eperisone may increase the arrhythmogenic activities of Acetyldigoxin.
Disopyramide Disopyramide may increase the arrhythmogenic activities of Eperisone.
Ibutilide Ibutilide may increase the arrhythmogenic activities of Eperisone.
Procainamide Procainamide may increase the arrhythmogenic activities of Eperisone.
Bepridil Bepridil may increase the arrhythmogenic activities of Eperisone.
Terodiline Eperisone may increase the arrhythmogenic activities of Terodiline.
Diltiazem Diltiazem may increase the arrhythmogenic activities of Eperisone.
Nimodipine Nimodipine may increase the arrhythmogenic activities of Eperisone.
Cinnarizine Cinnarizine may increase the arrhythmogenic activities of Eperisone.
Atropine Atropine may increase the arrhythmogenic activities of Eperisone.
Adenosine Adenosine may increase the arrhythmogenic activities of Eperisone.
Levosimendan Levosimendan may increase the arrhythmogenic activities of Eperisone.
Nifedipine Nifedipine may increase the arrhythmogenic activities of Eperisone.
Flecainide Flecainide may increase the arrhythmogenic activities of Eperisone.
Prenylamine Prenylamine may increase the arrhythmogenic activities of Eperisone.
Fluspirilene Fluspirilene may increase the arrhythmogenic activities of Eperisone.
Azimilide Azimilide may increase the arrhythmogenic activities of Eperisone.
Tedisamil Tedisamil may increase the arrhythmogenic activities of Eperisone.
Nilvadipine Nilvadipine may increase the arrhythmogenic activities of Eperisone.
Fendiline Fendiline may increase the arrhythmogenic activities of Eperisone.
Benidipine Eperisone may increase the arrhythmogenic activities of Benidipine.
Simendan Eperisone may increase the arrhythmogenic activities of Simendan.
Otilonium Eperisone may increase the arrhythmogenic activities of Otilonium.
Nizofenone Eperisone may increase the arrhythmogenic activities of Nizofenone.
Bunaftine Eperisone may increase the arrhythmogenic activities of Bunaftine.

Referensi & Sumber

Artikel (PubMed)
  • PMID: 18727454
    Cabitza P, Randelli P: Efficacy and safety of eperisone in patients with low back pain: a double blind randomized study. Eur Rev Med Pharmacol Sci. 2008 Jul-Aug;12(4):229-35.
  • PMID: 17958338
    Jeoung MK, Jeong ES, Kim NH, Kim CS, Chung YB, Lee YM, Ahn SY, Cho HE, Lee YH, Hong JT, Moon DC: Determination of eperisone in human plasma by liquid chromatography-ESI-tandem mass spectrometry. Arch Pharm Res. 2007 Sep;30(9):1174-8.

Contoh Produk & Brand

Produk: 0 • International brands: 5
International Brands
  • Akitonal — Choseido Pharmaceutical
  • Elexin — South Korea
  • Myonal — Eisai
  • Myoperison — Kobayashi Kako
  • Rapisone — Abbott

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