Etifoxine

DB08986

small molecule investigational withdrawn

Deskripsi

Etifoxine is an anxiolytic and anticonvulsant drug developed by Hoechst in the 1960s. It is used in anxiety disorders and to promote peripheral nerve healing. It does not bind to the benzodiazepine receptor though the effects are similar to that of benzodiazepines. It is more effective than lorazepam as an anxiolytic, and has fewer side effects. Etifoxine has been associated with acute liver injury.

Struktur Molekul 2D

Berat 300.79
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

664 Data
Buprenorphine Etifoxine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Etifoxine.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Etifoxine.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Etifoxine.
Hydrocodone Etifoxine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Etifoxine.
Magnesium sulfate The therapeutic efficacy of Etifoxine can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Etifoxine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Etifoxine may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Etifoxine.
Mirtazapine Etifoxine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Etifoxine.
Orphenadrine Etifoxine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Etifoxine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Etifoxine.
Pramipexole Etifoxine may increase the sedative activities of Pramipexole.
Ropinirole Etifoxine may increase the sedative activities of Ropinirole.
Rotigotine Etifoxine may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Etifoxine.
Sodium oxybate Etifoxine may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Suvorexant Etifoxine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Etifoxine.
Thalidomide Etifoxine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Etifoxine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Yohimbine The therapeutic efficacy of Etifoxine can be increased when used in combination with Yohimbine.
Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Etifoxine.
Ethanol Etifoxine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Azelastine Etifoxine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Brimonidine Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Etifoxine.
Zimelidine The risk or severity of adverse effects can be increased when Etifoxine is combined with Zimelidine.
Dapoxetine The risk or severity of adverse effects can be increased when Etifoxine is combined with Dapoxetine.
Seproxetine The risk or severity of adverse effects can be increased when Etifoxine is combined with Seproxetine.
Fluvoxamine The risk or severity of adverse effects can be increased when Etifoxine is combined with Fluvoxamine.
Citalopram The risk or severity of adverse effects can be increased when Etifoxine is combined with Citalopram.
Duloxetine The risk or severity of adverse effects can be increased when Etifoxine is combined with Duloxetine.
Trazodone The risk or severity of adverse effects can be increased when Etifoxine is combined with Trazodone.
Paroxetine The risk or severity of adverse effects can be increased when Etifoxine is combined with Paroxetine.
Sertraline The risk or severity of adverse effects can be increased when Etifoxine is combined with Sertraline.
Sibutramine The risk or severity of adverse effects can be increased when Etifoxine is combined with Sibutramine.
Nefazodone The risk or severity of adverse effects can be increased when Etifoxine is combined with Nefazodone.
Escitalopram The risk or severity of adverse effects can be increased when Etifoxine is combined with Escitalopram.
Milnacipran The risk or severity of adverse effects can be increased when Etifoxine is combined with Milnacipran.
Desvenlafaxine The risk or severity of adverse effects can be increased when Etifoxine is combined with Desvenlafaxine.
Levomilnacipran The risk or severity of adverse effects can be increased when Levomilnacipran is combined with Etifoxine.
Indalpine The risk or severity of adverse effects can be increased when Etifoxine is combined with Indalpine.
Ritanserin The risk or severity of adverse effects can be increased when Etifoxine is combined with Ritanserin.
Alaproclate The risk or severity of adverse effects can be increased when Etifoxine is combined with Alaproclate.
Cyproheptadine The risk or severity of CNS depression can be increased when Cyproheptadine is combined with Etifoxine.
Propiomazine The risk or severity of CNS depression can be increased when Propiomazine is combined with Etifoxine.
Zopiclone The risk or severity of adverse effects can be increased when Etifoxine is combined with Zopiclone.
Botulinum toxin type B The risk or severity of CNS depression can be increased when Botulinum toxin type B is combined with Etifoxine.
Botulinum toxin type A The risk or severity of CNS depression can be increased when Botulinum toxin type A is combined with Etifoxine.
Baclofen Baclofen may increase the central nervous system depressant (CNS depressant) activities of Etifoxine.
Ethchlorvynol The risk or severity of CNS depression can be increased when Ethchlorvynol is combined with Etifoxine.
Succinylcholine The risk or severity of CNS depression can be increased when Succinylcholine is combined with Etifoxine.
Eletriptan The risk or severity of CNS depression can be increased when Eletriptan is combined with Etifoxine.
Enflurane The risk or severity of CNS depression can be increased when Enflurane is combined with Etifoxine.
Butabarbital The risk or severity of CNS depression can be increased when Butabarbital is combined with Etifoxine.
Butalbital The risk or severity of CNS depression can be increased when Butalbital is combined with Etifoxine.
Methysergide The risk or severity of CNS depression can be increased when Methysergide is combined with Etifoxine.
Cabergoline The risk or severity of CNS depression can be increased when Cabergoline is combined with Etifoxine.
Phenytoin The risk or severity of CNS depression can be increased when Phenytoin is combined with Etifoxine.
Topiramate The risk or severity of CNS depression can be increased when Topiramate is combined with Etifoxine.
Clemastine The risk or severity of CNS depression can be increased when Clemastine is combined with Etifoxine.
Etomidate The risk or severity of CNS depression can be increased when Etomidate is combined with Etifoxine.
Morphine The risk or severity of CNS depression can be increased when Morphine is combined with Etifoxine.
Talbutal The risk or severity of CNS depression can be increased when Talbutal is combined with Etifoxine.
Pentobarbital The risk or severity of CNS depression can be increased when Pentobarbital is combined with Etifoxine.
Zolmitriptan The risk or severity of CNS depression can be increased when Zolmitriptan is combined with Etifoxine.
Codeine The risk or severity of CNS depression can be increased when Codeine is combined with Etifoxine.
Dihydroergotamine The risk or severity of CNS depression can be increased when Dihydroergotamine is combined with Etifoxine.
Tolcapone The risk or severity of CNS depression can be increased when Tolcapone is combined with Etifoxine.
Hydromorphone The risk or severity of CNS depression can be increased when Hydromorphone is combined with Etifoxine.
Cetirizine The risk or severity of CNS depression can be increased when Cetirizine is combined with Etifoxine.
Trimethadione The risk or severity of CNS depression can be increased when Trimethadione is combined with Etifoxine.
Chlorzoxazone The risk or severity of CNS depression can be increased when Chlorzoxazone is combined with Etifoxine.
Thiethylperazine The risk or severity of CNS depression can be increased when Thiethylperazine is combined with Etifoxine.
Palonosetron The risk or severity of CNS depression can be increased when Palonosetron is combined with Etifoxine.
Dexbrompheniramine The risk or severity of CNS depression can be increased when Dexbrompheniramine is combined with Etifoxine.
Metocurine iodide The risk or severity of CNS depression can be increased when Metocurine iodide is combined with Etifoxine.
Secobarbital The risk or severity of CNS depression can be increased when Secobarbital is combined with Etifoxine.
Methocarbamol The risk or severity of CNS depression can be increased when Methocarbamol is combined with Etifoxine.
Triprolidine The risk or severity of CNS depression can be increased when Triprolidine is combined with Etifoxine.
Meperidine The risk or severity of CNS depression can be increased when Meperidine is combined with Etifoxine.
Metharbital The risk or severity of CNS depression can be increased when Metharbital is combined with Etifoxine.
Quinine The risk or severity of CNS depression can be increased when Quinine is combined with Etifoxine.
Methohexital The risk or severity of CNS depression can be increased when Methohexital is combined with Etifoxine.
Gallamine triethiodide The risk or severity of CNS depression can be increased when Gallamine triethiodide is combined with Etifoxine.
Entacapone The risk or severity of CNS depression can be increased when Entacapone is combined with Etifoxine.
Oxycodone The risk or severity of CNS depression can be increased when Oxycodone is combined with Etifoxine.
Dextromethorphan The risk or severity of CNS depression can be increased when Dextromethorphan is combined with Etifoxine.
Mephenytoin The risk or severity of CNS depression can be increased when Mephenytoin is combined with Etifoxine.
Cisatracurium The risk or severity of CNS depression can be increased when Cisatracurium is combined with Etifoxine.
Fenfluramine The risk or severity of CNS depression can be increased when Fenfluramine is combined with Etifoxine.
Mazindol The risk or severity of CNS depression can be increased when Mazindol is combined with Etifoxine.
Fluticasone propionate The risk or severity of CNS depression can be increased when Fluticasone propionate is combined with Etifoxine.
Lisuride The risk or severity of CNS depression can be increased when Lisuride is combined with Etifoxine.
Ethosuximide The risk or severity of CNS depression can be increased when Ethosuximide is combined with Etifoxine.
Thiopental The risk or severity of CNS depression can be increased when Thiopental is combined with Etifoxine.
Cisapride The risk or severity of CNS depression can be increased when Cisapride is combined with Etifoxine.

Referensi & Sumber

Synthesis reference: U.S. Patent 3,725,404.

Contoh Produk & Brand

Produk: 0 • International brands: 2
International Brands
  • Exsist — Euroetika
  • Stresam — Biocodex

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