Azosemide

DB08961

small molecule investigational

Deskripsi

Azosemide is a loop diuretic used to treat hypertension, edema, and ascites.

Struktur Molekul 2D

Berat 370.838
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Terminal half life 2-3 hours.
Volume Distribusi Poor affinity for human tissue. Small apparent post-pseudodistribution Vd of 0.262 l/kg.
Klirens (Clearance) -

Absorpsi

Peak plasma concentrations are achieved in 3-4 hours when azosemide is administered to healthy humans in a fasting state. There is an absorption lag time of approximately 1 hour. Oral bioavailability estimated to be 20.4%

Metabolisme

Considerable first pass metabolism which makes parentral administration more effective than oral administration. Eleven metabolites of azosemide were found in rats, but only azosemide and its glucuronide were detected in humans.

Rute Eliminasi

Total body clearance 112ml/min. Renal clearance 41.6ml/min. Actively secreted in the renal proximal tubule of humans. This may or may not involve a nonspecific organic acid secretory pathway. There is thus a potential for disease states and other organic acids such as NSAIDs which affect the organic acid transport pathway to affect the efficacy of azosemide.

Interaksi Obat

974 Data
Allopurinol The risk or severity of adverse effects can be increased when Azosemide is combined with Allopurinol.
Canagliflozin The risk or severity of hypotension can be increased when Canagliflozin is combined with Azosemide.
Cisplatin The risk or severity of ototoxicity and nephrotoxicity can be increased when Azosemide is combined with Cisplatin.
Dofetilide The risk or severity of QTc prolongation, torsade de pointes, hypokalemia, hypomagnesemia, and cardiac arrest can be increased when Azosemide is combined with Dofetilide.
Foscarnet Azosemide may decrease the excretion rate of Foscarnet which could result in a higher serum level.
Ivabradine The risk or severity of Cardiac Arrhythmia can be increased when Azosemide is combined with Ivabradine.
Lithium citrate Azosemide may decrease the excretion rate of Lithium citrate which could result in a higher serum level.
Lithium carbonate Azosemide may decrease the excretion rate of Lithium carbonate which could result in a higher serum level.
Lithium hydroxide Azosemide may decrease the excretion rate of Lithium hydroxide which could result in a higher serum level.
Nicotine The risk or severity of adverse effects can be increased when Azosemide is combined with Nicotine.
Mecamylamine The risk or severity of adverse effects can be increased when Azosemide is combined with Mecamylamine.
Pentolinium The risk or severity of adverse effects can be increased when Azosemide is combined with Pentolinium.
Trimethaphan The risk or severity of adverse effects can be increased when Azosemide is combined with Trimethaphan.
Hexamethonium The risk or severity of adverse effects can be increased when Azosemide is combined with Hexamethonium.
Cyclopentamine The risk or severity of adverse effects can be increased when Azosemide is combined with Cyclopentamine.
Probenecid The risk or severity of adverse effects can be increased when Probenecid is combined with Azosemide.
Risperidone The risk or severity of hypotension can be increased when Azosemide is combined with Risperidone.
Topiramate The risk or severity of hypokalemia can be increased when Azosemide is combined with Topiramate.
Methotrexate The therapeutic efficacy of Azosemide can be decreased when used in combination with Methotrexate.
Digoxin The risk or severity of adverse effects can be increased when Azosemide is combined with Digoxin.
Acetyldigitoxin The risk or severity of adverse effects can be increased when Azosemide is combined with Acetyldigitoxin.
Deslanoside The risk or severity of adverse effects can be increased when Azosemide is combined with Deslanoside.
Ouabain The risk or severity of adverse effects can be increased when Azosemide is combined with Ouabain.
Digitoxin The risk or severity of adverse effects can be increased when Azosemide is combined with Digitoxin.
Oleandrin The risk or severity of adverse effects can be increased when Azosemide is combined with Oleandrin.
Cymarin The risk or severity of adverse effects can be increased when Azosemide is combined with Cymarin.
Proscillaridin The risk or severity of adverse effects can be increased when Azosemide is combined with Proscillaridin.
Metildigoxin The risk or severity of adverse effects can be increased when Azosemide is combined with Metildigoxin.
Lanatoside C The risk or severity of adverse effects can be increased when Azosemide is combined with Lanatoside C.
Gitoformate The risk or severity of adverse effects can be increased when Azosemide is combined with Gitoformate.
Acetyldigoxin The risk or severity of adverse effects can be increased when Azosemide is combined with Acetyldigoxin.
Peruvoside The risk or severity of adverse effects can be increased when Azosemide is combined with Peruvoside.
Icosapent The therapeutic efficacy of Azosemide can be decreased when used in combination with Icosapent.
Mesalazine The risk or severity of adverse effects can be increased when Azosemide is combined with Mesalazine.
Nabumetone The therapeutic efficacy of Azosemide can be decreased when used in combination with Nabumetone.
Ketorolac The therapeutic efficacy of Azosemide can be decreased when used in combination with Ketorolac.
Tenoxicam The therapeutic efficacy of Azosemide can be decreased when used in combination with Tenoxicam.
Celecoxib The therapeutic efficacy of Azosemide can be decreased when used in combination with Celecoxib.
Tolmetin The therapeutic efficacy of Azosemide can be decreased when used in combination with Tolmetin.
Rofecoxib The therapeutic efficacy of Azosemide can be decreased when used in combination with Rofecoxib.
Piroxicam The therapeutic efficacy of Azosemide can be decreased when used in combination with Piroxicam.
Fenoprofen The therapeutic efficacy of Azosemide can be decreased when used in combination with Fenoprofen.
Valdecoxib The therapeutic efficacy of Azosemide can be decreased when used in combination with Valdecoxib.
Diclofenac The therapeutic efficacy of Azosemide can be decreased when used in combination with Diclofenac.
Sulindac The therapeutic efficacy of Azosemide can be decreased when used in combination with Sulindac.
Flurbiprofen The therapeutic efficacy of Azosemide can be decreased when used in combination with Flurbiprofen.
Etodolac The therapeutic efficacy of Azosemide can be decreased when used in combination with Etodolac.
Mefenamic acid The therapeutic efficacy of Azosemide can be decreased when used in combination with Mefenamic acid.
Naproxen The therapeutic efficacy of Azosemide can be decreased when used in combination with Naproxen.
Sulfasalazine The therapeutic efficacy of Azosemide can be decreased when used in combination with Sulfasalazine.
Phenylbutazone The therapeutic efficacy of Azosemide can be decreased when used in combination with Phenylbutazone.
Carprofen The therapeutic efficacy of Azosemide can be decreased when used in combination with Carprofen.
Diflunisal The therapeutic efficacy of Azosemide can be decreased when used in combination with Diflunisal.
Salicylic acid The therapeutic efficacy of Azosemide can be decreased when used in combination with Salicylic acid.
Meclofenamic acid The therapeutic efficacy of Azosemide can be decreased when used in combination with Meclofenamic acid.
Oxaprozin The therapeutic efficacy of Azosemide can be decreased when used in combination with Oxaprozin.
Ketoprofen The therapeutic efficacy of Azosemide can be decreased when used in combination with Ketoprofen.
Balsalazide The therapeutic efficacy of Azosemide can be decreased when used in combination with Balsalazide.
Ibuprofen The therapeutic efficacy of Azosemide can be decreased when used in combination with Ibuprofen.
Olsalazine The risk or severity of adverse effects can be increased when Azosemide is combined with Olsalazine.
Lumiracoxib The therapeutic efficacy of Azosemide can be decreased when used in combination with Lumiracoxib.
Magnesium salicylate The therapeutic efficacy of Azosemide can be decreased when used in combination with Magnesium salicylate.
Salsalate The therapeutic efficacy of Azosemide can be decreased when used in combination with Salsalate.
Choline magnesium trisalicylate The therapeutic efficacy of Azosemide can be decreased when used in combination with Choline magnesium trisalicylate.
Antrafenine The therapeutic efficacy of Azosemide can be decreased when used in combination with Antrafenine.
Aminophenazone The therapeutic efficacy of Azosemide can be decreased when used in combination with Aminophenazone.
Antipyrine The therapeutic efficacy of Azosemide can be decreased when used in combination with Antipyrine.
Tiaprofenic acid The therapeutic efficacy of Azosemide can be decreased when used in combination with Tiaprofenic acid.
Etoricoxib The therapeutic efficacy of Azosemide can be decreased when used in combination with Etoricoxib.
Taxifolin The therapeutic efficacy of Azosemide can be decreased when used in combination with Taxifolin.
Oxyphenbutazone The therapeutic efficacy of Azosemide can be decreased when used in combination with Oxyphenbutazone.
Licofelone The therapeutic efficacy of Azosemide can be decreased when used in combination with Licofelone.
Nimesulide The therapeutic efficacy of Azosemide can be decreased when used in combination with Nimesulide.
Benoxaprofen The therapeutic efficacy of Azosemide can be decreased when used in combination with Benoxaprofen.
Zomepirac The therapeutic efficacy of Azosemide can be decreased when used in combination with Zomepirac.
Cimicoxib The therapeutic efficacy of Azosemide can be decreased when used in combination with Cimicoxib.
Lornoxicam The therapeutic efficacy of Azosemide can be decreased when used in combination with Lornoxicam.
Aceclofenac The therapeutic efficacy of Azosemide can be decreased when used in combination with Aceclofenac.
Zaltoprofen The therapeutic efficacy of Azosemide can be decreased when used in combination with Zaltoprofen.
Azapropazone The therapeutic efficacy of Azosemide can be decreased when used in combination with Azapropazone.
Parecoxib The therapeutic efficacy of Azosemide can be decreased when used in combination with Parecoxib.
Salicylamide The therapeutic efficacy of Azosemide can be decreased when used in combination with Salicylamide.
Kebuzone The therapeutic efficacy of Azosemide can be decreased when used in combination with Kebuzone.
Isoxicam The therapeutic efficacy of Azosemide can be decreased when used in combination with Isoxicam.
Indoprofen The therapeutic efficacy of Azosemide can be decreased when used in combination with Indoprofen.
Ibuproxam The therapeutic efficacy of Azosemide can be decreased when used in combination with Ibuproxam.
Floctafenine The therapeutic efficacy of Azosemide can be decreased when used in combination with Floctafenine.
Fenbufen The therapeutic efficacy of Azosemide can be decreased when used in combination with Fenbufen.
Etofenamate The therapeutic efficacy of Azosemide can be decreased when used in combination with Etofenamate.
Epirizole The therapeutic efficacy of Azosemide can be decreased when used in combination with Epirizole.
Benzydamine The therapeutic efficacy of Azosemide can be decreased when used in combination with Benzydamine.
Dexibuprofen The therapeutic efficacy of Azosemide can be decreased when used in combination with Dexibuprofen.
Dexketoprofen The therapeutic efficacy of Azosemide can be decreased when used in combination with Dexketoprofen.
Droxicam The therapeutic efficacy of Azosemide can be decreased when used in combination with Droxicam.
Tolfenamic acid The therapeutic efficacy of Azosemide can be decreased when used in combination with Tolfenamic acid.
Firocoxib The therapeutic efficacy of Azosemide can be decreased when used in combination with Firocoxib.
Clonixin The therapeutic efficacy of Azosemide can be decreased when used in combination with Clonixin.
Morniflumate The therapeutic efficacy of Azosemide can be decreased when used in combination with Morniflumate.
Propacetamol The therapeutic efficacy of Azosemide can be decreased when used in combination with Propacetamol.
Talniflumate The therapeutic efficacy of Azosemide can be decreased when used in combination with Talniflumate.

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