Hexamethonium

DB08960

small molecule experimental

Deskripsi

A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been used for a variety of therapeutic purposes including hypertension but, like the other ganglionic blockers, it has been replaced by more specific drugs for most purposes, although it is widely used a research tool.

Struktur Molekul 2D

Berat 202.38
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

1422 Data
Alfuzosin Alfuzosin may increase the hypotensive activities of Hexamethonium.
Amifostine Hexamethonium may increase the hypotensive activities of Amifostine.
Diazoxide Diazoxide may increase the hypotensive activities of Hexamethonium.
Methylphenidate Methylphenidate may decrease the antihypertensive activities of Hexamethonium.
Dexmethylphenidate Dexmethylphenidate may decrease the antihypertensive activities of Hexamethonium.
Obinutuzumab Hexamethonium may increase the hypotensive activities of Obinutuzumab.
Pentoxifylline Pentoxifylline may increase the hypotensive activities of Hexamethonium.
Rituximab Hexamethonium may increase the hypotensive activities of Rituximab.
Desmopressin Desmopressin may decrease the antihypertensive activities of Hexamethonium.
Phentermine Phentermine may decrease the antihypertensive activities of Hexamethonium.
Midodrine Midodrine may decrease the antihypertensive activities of Hexamethonium.
Isoetharine Isoetharine may decrease the antihypertensive activities of Hexamethonium.
Methylergometrine Methylergometrine may decrease the antihypertensive activities of Hexamethonium.
Norepinephrine Norepinephrine may decrease the antihypertensive activities of Hexamethonium.
Phenylephrine Phenylephrine may decrease the antihypertensive activities of Hexamethonium.
Phenylpropanolamine Phenylpropanolamine may decrease the antihypertensive activities of Hexamethonium.
Doxapram Doxapram may decrease the antihypertensive activities of Hexamethonium.
Metaraminol Metaraminol may decrease the antihypertensive activities of Hexamethonium.
Epinephrine Epinephrine may decrease the antihypertensive activities of Hexamethonium.
Nicergoline Nicergoline may decrease the antihypertensive activities of Hexamethonium.
Methoxamine Methoxamine may decrease the antihypertensive activities of Hexamethonium.
Orciprenaline Orciprenaline may decrease the antihypertensive activities of Hexamethonium.
Phenmetrazine Phenmetrazine may decrease the antihypertensive activities of Hexamethonium.
Dobutamine Dobutamine may decrease the antihypertensive activities of Hexamethonium.
Pseudoephedrine Pseudoephedrine may decrease the antihypertensive activities of Hexamethonium.
Ritodrine Ritodrine may decrease the antihypertensive activities of Hexamethonium.
Bitolterol Bitolterol may decrease the antihypertensive activities of Hexamethonium.
Salmeterol Salmeterol may decrease the antihypertensive activities of Hexamethonium.
Formoterol Formoterol may decrease the antihypertensive activities of Hexamethonium.
Dopamine Dopamine may decrease the antihypertensive activities of Hexamethonium.
Albuterol Salbutamol may decrease the antihypertensive activities of Hexamethonium.
Isoprenaline Isoprenaline may decrease the antihypertensive activities of Hexamethonium.
Arbutamine Arbutamine may decrease the antihypertensive activities of Hexamethonium.
Dutasteride Dutasteride may decrease the antihypertensive activities of Hexamethonium.
Propafenone Propafenone may decrease the antihypertensive activities of Hexamethonium.
Finasteride Finasteride may decrease the antihypertensive activities of Hexamethonium.
Lisdexamfetamine Lisdexamfetamine may decrease the antihypertensive activities of Hexamethonium.
Arformoterol Arformoterol may decrease the antihypertensive activities of Hexamethonium.
Fenoterol Fenoterol may decrease the antihypertensive activities of Hexamethonium.
Pirbuterol Pirbuterol may decrease the antihypertensive activities of Hexamethonium.
Ephedra sinica root Ephedra sinica root may decrease the antihypertensive activities of Hexamethonium.
Ephedrine Ephedrine may decrease the antihypertensive activities of Hexamethonium.
Mephentermine Mephentermine may decrease the antihypertensive activities of Hexamethonium.
Procaterol Procaterol may decrease the antihypertensive activities of Hexamethonium.
Clenbuterol Clenbuterol may decrease the antihypertensive activities of Hexamethonium.
2,5-Dimethoxy-4-ethylamphetamine 2,5-Dimethoxy-4-ethylamphetamine may decrease the antihypertensive activities of Hexamethonium.
Chlorphentermine Chlorphentermine may decrease the antihypertensive activities of Hexamethonium.
Dextroamphetamine Dextroamphetamine may decrease the antihypertensive activities of Hexamethonium.
Phendimetrazine Phendimetrazine may decrease the antihypertensive activities of Hexamethonium.
Epicaptopril Epicaptopril may decrease the antihypertensive activities of Hexamethonium.
1-benzylimidazole 1-benzylimidazole may decrease the antihypertensive activities of Hexamethonium.
Dronedarone Dronedarone may decrease the antihypertensive activities of Hexamethonium.
Indacaterol Indacaterol may decrease the antihypertensive activities of Hexamethonium.
Amibegron Amibegron may decrease the antihypertensive activities of Hexamethonium.
Nylidrin Nylidrin may decrease the antihypertensive activities of Hexamethonium.
Solabegron Solabegron may decrease the antihypertensive activities of Hexamethonium.
Droxidopa Droxidopa may decrease the antihypertensive activities of Hexamethonium.
Xylometazoline Xylometazoline may decrease the antihypertensive activities of Hexamethonium.
Isometheptene Isometheptene may decrease the antihypertensive activities of Hexamethonium.
Levonordefrin Levonordefrin may decrease the antihypertensive activities of Hexamethonium.
Naphazoline Naphazoline may decrease the antihypertensive activities of Hexamethonium.
Saralasin Saralasin may decrease the antihypertensive activities of Hexamethonium.
Tetryzoline Tetryzoline may decrease the antihypertensive activities of Hexamethonium.
Tyramine Tyramine may decrease the antihypertensive activities of Hexamethonium.
Mirabegron Mirabegron may decrease the antihypertensive activities of Hexamethonium.
Adrafinil Adrafinil may decrease the antihypertensive activities of Hexamethonium.
Hexoprenaline Hexoprenaline may decrease the antihypertensive activities of Hexamethonium.
Etilefrine Etilefrine may decrease the antihypertensive activities of Hexamethonium.
Olodaterol Olodaterol may decrease the antihypertensive activities of Hexamethonium.
Vilanterol Vilanterol may decrease the antihypertensive activities of Hexamethonium.
Cirazoline Cirazoline may decrease the antihypertensive activities of Hexamethonium.
Synephrine Synephrine may decrease the antihypertensive activities of Hexamethonium.
Moxisylyte Moxisylyte may decrease the antihypertensive activities of Hexamethonium.
Iofetamine I-123 Iofetamine I-123 may decrease the antihypertensive activities of Hexamethonium.
Racepinephrine Racepinephrine may decrease the antihypertensive activities of Hexamethonium.
Dihydroergocornine Dihydroergocornine may decrease the antihypertensive activities of Hexamethonium.
DL-Methylephedrine DL-Methylephedrine may decrease the antihypertensive activities of Hexamethonium.
Amitraz Amitraz may decrease the antihypertensive activities of Hexamethonium.
Atipamezole Atipamezole may decrease the antihypertensive activities of Hexamethonium.
Ractopamine Ractopamine may decrease the antihypertensive activities of Hexamethonium.
Etafedrine Etafedrine may decrease the antihypertensive activities of Hexamethonium.
Anisodamine Anisodamine may decrease the antihypertensive activities of Hexamethonium.
PF-00610355 PF-00610355 may decrease the antihypertensive activities of Hexamethonium.
Ritobegron Ritobegron may decrease the antihypertensive activities of Hexamethonium.
Abediterol Abediterol may decrease the antihypertensive activities of Hexamethonium.
Tulobuterol Tulobuterol may decrease the antihypertensive activities of Hexamethonium.
Dopexamine Dopexamine may decrease the antihypertensive activities of Hexamethonium.
Siponimod Siponimod may decrease the antihypertensive activities of Hexamethonium.
Idazoxan Idazoxan may decrease the antihypertensive activities of Hexamethonium.
Higenamine Higenamine may decrease the antihypertensive activities of Hexamethonium.
Reproterol Reproterol may decrease the antihypertensive activities of Hexamethonium.
Theodrenaline Theodrenaline may decrease the antihypertensive activities of Hexamethonium.
Tramazoline Tramazoline may decrease the antihypertensive activities of Hexamethonium.
Mephedrone Mephedrone may decrease the antihypertensive activities of Hexamethonium.
Levosalbutamol Levosalbutamol may decrease the antihypertensive activities of Hexamethonium.
Octopamine Octopamine may decrease the antihypertensive activities of Hexamethonium.
Fenozolone Fenozolone may decrease the antihypertensive activities of Hexamethonium.
Dihydroergocristine Dihydroergocristine may decrease the antihypertensive activities of Hexamethonium.
Norfenefrine Norfenefrine may decrease the antihypertensive activities of Hexamethonium.
Dihydroergocryptine Dihydroergocryptine may decrease the antihypertensive activities of Hexamethonium.

Target Protein

Neuronal acetylcholine receptor subunit alpha-2 CHRNA2
Dihydroorotate dehydrogenase (quinone), mitochondrial

Referensi & Sumber

Synthesis reference: U.S. Patent 2,641,610.
Artikel (PubMed)
  • PMID: 1710523
    Adams DJ, Bevan S, Terrar DA: Modes of hexamethonium action on acetylcholine receptor channels in frog skeletal muscle. Br J Pharmacol. 1991 Jan;102(1):135-45.

Contoh Produk & Brand

Produk: 0 • International brands: 1
International Brands
  • Bistrium — Bristol-Myers Squibb

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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