Hexetidine

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) -

Volume Distribusi -

Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

14 Data

Dicoumarol	The therapeutic efficacy of Dicoumarol can be increased when used in combination with Hexetidine.
Phenindione	The therapeutic efficacy of Phenindione can be increased when used in combination with Hexetidine.
Warfarin	The therapeutic efficacy of Warfarin can be increased when used in combination with Hexetidine.
Phenprocoumon	The therapeutic efficacy of Phenprocoumon can be increased when used in combination with Hexetidine.
Acenocoumarol	The therapeutic efficacy of Acenocoumarol can be increased when used in combination with Hexetidine.
4-hydroxycoumarin	The therapeutic efficacy of 4-hydroxycoumarin can be increased when used in combination with Hexetidine.
Coumarin	The therapeutic efficacy of Coumarin can be increased when used in combination with Hexetidine.
(R)-warfarin	The therapeutic efficacy of (R)-warfarin can be increased when used in combination with Hexetidine.
Ethyl biscoumacetate	The therapeutic efficacy of Ethyl biscoumacetate can be increased when used in combination with Hexetidine.
Fluindione	The therapeutic efficacy of Fluindione can be increased when used in combination with Hexetidine.
Clorindione	The therapeutic efficacy of Clorindione can be increased when used in combination with Hexetidine.
Diphenadione	The therapeutic efficacy of Diphenadione can be increased when used in combination with Hexetidine.
Tioclomarol	The therapeutic efficacy of Tioclomarol can be increased when used in combination with Hexetidine.
(S)-Warfarin	The therapeutic efficacy of (S)-Warfarin can be increased when used in combination with Hexetidine.

Referensi & Sumber

Synthesis reference: U.S. Patent 3,054,797.

Artikel (PubMed)

PMID: 21356020
Afennich F, Slot DE, Hossainian N, Van der Weijden GA: The effect of hexetidine mouthwash on the prevention of plaque and gingival inflammation: a systematic review. Int J Dent Hyg. 2011 Aug;9(3):182-90. doi: 10.1111/j.1601-5037.2010.00478.x. Epub 2010 Sep 6.
PMID: 3183
Satzinger G, Herrmann W, Zimmermann F: Analytical profile of purified hexetidine (author's transl). Arzneimittelforschung. 1975;25(12):1849-53.

Contoh Produk & Brand

Produk: 1 • International brands: 13

Produk

Steri/sol Liquid

Liquid • 0.1 % • Buccal • Canada • OTC • Approved

International Brands

Actigrip Gola — Johnson & Johnson
Bactidol — Johnson & Johnson
Belosept — Belupo
Collu-Hextril — Johnson & Johnson
Hexoral — Johnson & Johnson
Hextril — Bristol-Myers Squibb
Isozid-H — Gebro
Oraldene — McNeil
Oraldine — Johnson & Johnson
Steri/Sol — Johnson & Johnson

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.

Deskripsi

Struktur Molekul 2D

Deskripsi metode visualisasi