Indoprofen

DB08951

small molecule withdrawn

Deskripsi

A drug that has analgesic and anti-inflammatory properties. Following reports of adverse reactions including reports of carcinogenicity in animal studies it was withdrawn from the market worldwide.

Struktur Molekul 2D

Berat 281.3059
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 2.3 hours.
Volume Distribusi -
Klirens (Clearance) Renal.

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Glucuronidation.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

1386 Data
Amlodipine Indoprofen may decrease the antihypertensive activities of Amlodipine.
Phentermine The risk or severity of hypertension can be increased when Phentermine is combined with Indoprofen.
Midodrine The risk or severity of hypertension can be increased when Midodrine is combined with Indoprofen.
Eletriptan The risk or severity of hypertension can be increased when Eletriptan is combined with Indoprofen.
Isoetharine The risk or severity of hypertension can be increased when Isoetharine is combined with Indoprofen.
Ziprasidone The risk or severity of hypertension can be increased when Ziprasidone is combined with Indoprofen.
Methysergide The risk or severity of hypertension can be increased when Methysergide is combined with Indoprofen.
Cabergoline The risk or severity of hypertension can be increased when Cabergoline is combined with Indoprofen.
Zolmitriptan The risk or severity of hypertension can be increased when Zolmitriptan is combined with Indoprofen.
Dihydroergotamine The risk or severity of hypertension can be increased when Dihydroergotamine is combined with Indoprofen.
Methylergometrine The risk or severity of hypertension can be increased when Methylergometrine is combined with Indoprofen.
Norepinephrine The risk or severity of hypertension can be increased when Norepinephrine is combined with Indoprofen.
Mirtazapine The risk or severity of hypertension can be increased when Mirtazapine is combined with Indoprofen.
Phenylephrine The risk or severity of hypertension can be increased when Phenylephrine is combined with Indoprofen.
Phenylpropanolamine The risk or severity of hypertension can be increased when Phenylpropanolamine is combined with Indoprofen.
Promazine The risk or severity of hypertension can be increased when Promazine is combined with Indoprofen.
Droperidol The risk or severity of hypertension can be increased when Droperidol is combined with Indoprofen.
Doxapram The risk or severity of hypertension can be increased when Doxapram is combined with Indoprofen.
Atropine The risk or severity of hypertension can be increased when Atropine is combined with Indoprofen.
Lisuride The risk or severity of hypertension can be increased when Lisuride is combined with Indoprofen.
Linezolid The risk or severity of hypertension can be increased when Linezolid is combined with Indoprofen.
Metaraminol The risk or severity of hypertension can be increased when Metaraminol is combined with Indoprofen.
Furazolidone The risk or severity of hypertension can be increased when Furazolidone is combined with Indoprofen.
Epinephrine The risk or severity of hypertension can be increased when Epinephrine is combined with Indoprofen.
Thioridazine The risk or severity of hypertension can be increased when Thioridazine is combined with Indoprofen.
Ergotamine The risk or severity of hypertension can be increased when Ergotamine is combined with Indoprofen.
Nicergoline The risk or severity of hypertension can be increased when Nicergoline is combined with Indoprofen.
Sufentanil The risk or severity of hypertension can be increased when Sufentanil is combined with Indoprofen.
Methoxamine The risk or severity of hypertension can be increased when Methoxamine is combined with Indoprofen.
Risperidone The risk or severity of hypertension can be increased when Risperidone is combined with Indoprofen.
Tranylcypromine The risk or severity of hypertension can be increased when Tranylcypromine is combined with Indoprofen.
Isoflurane The risk or severity of hypertension can be increased when Isoflurane is combined with Indoprofen.
Propiomazine The risk or severity of hypertension can be increased when Propiomazine is combined with Indoprofen.
Alfentanil The risk or severity of hypertension can be increased when Alfentanil is combined with Indoprofen.
Minaprine The risk or severity of hypertension can be increased when Minaprine is combined with Indoprofen.
Orciprenaline The risk or severity of hypertension can be increased when Orciprenaline is combined with Indoprofen.
Propofol The risk or severity of hypertension can be increased when Propofol is combined with Indoprofen.
Phenmetrazine The risk or severity of hypertension can be increased when Phenmetrazine is combined with Indoprofen.
Trifluoperazine The risk or severity of hypertension can be increased when Trifluoperazine is combined with Indoprofen.
Pseudoephedrine The risk or severity of hypertension can be increased when Pseudoephedrine is combined with Indoprofen.
Benzphetamine The risk or severity of hypertension can be increased when Benzphetamine is combined with Indoprofen.
Ritodrine The risk or severity of hypertension can be increased when Ritodrine is combined with Indoprofen.
Flupentixol The risk or severity of hypertension can be increased when Flupentixol is combined with Indoprofen.
Remifentanil The risk or severity of hypertension can be increased when Remifentanil is combined with Indoprofen.
Bitolterol The risk or severity of hypertension can be increased when Bitolterol is combined with Indoprofen.
Oxymetazoline The risk or severity of hypertension can be increased when Oxymetazoline is combined with Indoprofen.
Diethylpropion The risk or severity of hypertension can be increased when Diethylpropion is combined with Indoprofen.
Salmeterol The risk or severity of hypertension can be increased when Salmeterol is combined with Indoprofen.
Naratriptan The risk or severity of hypertension can be increased when Naratriptan is combined with Indoprofen.
Formoterol The risk or severity of hypertension can be increased when Formoterol is combined with Indoprofen.
Frovatriptan The risk or severity of hypertension can be increased when Frovatriptan is combined with Indoprofen.
Methoxyflurane The risk or severity of hypertension can be increased when Methoxyflurane is combined with Indoprofen.
Selegiline The risk or severity of hypertension can be increased when Selegiline is combined with Indoprofen.
Ergoloid mesylate The risk or severity of hypertension can be increased when Ergoloid mesylate is combined with Indoprofen.
Isoprenaline The risk or severity of hypertension can be increased when Isoprenaline is combined with Indoprofen.
Arbutamine The risk or severity of hypertension can be increased when Arbutamine is combined with Indoprofen.
Dutasteride The risk or severity of hypertension can be increased when Dutasteride is combined with Indoprofen.
Halothane The risk or severity of hypertension can be increased when Halothane is combined with Indoprofen.
Moclobemide The risk or severity of hypertension can be increased when Moclobemide is combined with Indoprofen.
Pergolide The risk or severity of hypertension can be increased when Pergolide is combined with Indoprofen.
Desflurane The risk or severity of hypertension can be increased when Desflurane is combined with Indoprofen.
Bromocriptine The risk or severity of hypertension can be increased when Bromocriptine is combined with Indoprofen.
Finasteride The risk or severity of hypertension can be increased when Finasteride is combined with Indoprofen.
Aripiprazole The risk or severity of hypertension can be increased when Aripiprazole is combined with Indoprofen.
Isocarboxazid The risk or severity of hypertension can be increased when Isocarboxazid is combined with Indoprofen.
Ergometrine The risk or severity of hypertension can be increased when Ergometrine is combined with Indoprofen.
Lisdexamfetamine The risk or severity of hypertension can be increased when Lisdexamfetamine is combined with Indoprofen.
Fenoterol The risk or severity of hypertension can be increased when Fenoterol is combined with Indoprofen.
Pirbuterol The risk or severity of hypertension can be increased when Pirbuterol is combined with Indoprofen.
Ephedra sinica root The risk or severity of hypertension can be increased when Ephedra sinica root is combined with Indoprofen.
Ephedrine The risk or severity of hypertension can be increased when Ephedrine is combined with Indoprofen.
Mephentermine The risk or severity of hypertension can be increased when Mephentermine is combined with Indoprofen.
Procaterol The risk or severity of hypertension can be increased when Procaterol is combined with Indoprofen.
Yohimbine The risk or severity of hypertension can be increased when Yohimbine is combined with Indoprofen.
Methotrimeprazine The risk or severity of hypertension can be increased when Methotrimeprazine is combined with Indoprofen.
Clenbuterol The risk or severity of hypertension can be increased when Clenbuterol is combined with Indoprofen.
Bambuterol The risk or severity of hypertension can be increased when Bambuterol is combined with Indoprofen.
MMDA The risk or severity of hypertension can be increased when MMDA is combined with Indoprofen.
Midomafetamine The risk or severity of hypertension can be increased when Midomafetamine is combined with Indoprofen.
2,5-Dimethoxy-4-ethylamphetamine The risk or severity of hypertension can be increased when 2,5-Dimethoxy-4-ethylamphetamine is combined with Indoprofen.
4-Methoxyamphetamine The risk or severity of hypertension can be increased when 4-Methoxyamphetamine is combined with Indoprofen.
4-Bromo-2,5-dimethoxyamphetamine The risk or severity of hypertension can be increased when 4-Bromo-2,5-dimethoxyamphetamine is combined with Indoprofen.
Tenamfetamine The risk or severity of hypertension can be increased when Tenamfetamine is combined with Indoprofen.
Chlorphentermine The risk or severity of hypertension can be increased when Chlorphentermine is combined with Indoprofen.
Dextroamphetamine The risk or severity of hypertension can be increased when Dextroamphetamine is combined with Indoprofen.
Phendimetrazine The risk or severity of hypertension can be increased when Phendimetrazine is combined with Indoprofen.
Solifenacin The risk or severity of hypertension can be increased when Solifenacin is combined with Indoprofen.
Periciazine The risk or severity of hypertension can be increased when Periciazine is combined with Indoprofen.
Acepromazine The risk or severity of hypertension can be increased when Acepromazine is combined with Indoprofen.
Thioproperazine The risk or severity of hypertension can be increased when Thioproperazine is combined with Indoprofen.
Zuclopenthixol The risk or severity of hypertension can be increased when Zuclopenthixol is combined with Indoprofen.
Epicaptopril The risk or severity of hypertension can be increased when Epicaptopril is combined with Indoprofen.
Clorgiline The risk or severity of hypertension can be increased when Clorgiline is combined with Indoprofen.
1-benzylimidazole The risk or severity of hypertension can be increased when 1-benzylimidazole is combined with Indoprofen.
Iproniazid The risk or severity of hypertension can be increased when Iproniazid is combined with Indoprofen.
Nialamide The risk or severity of hypertension can be increased when Nialamide is combined with Indoprofen.
Lysergic acid diethylamide The risk or severity of hypertension can be increased when Lysergic acid diethylamide is combined with Indoprofen.
Dronedarone The risk or severity of hypertension can be increased when Dronedarone is combined with Indoprofen.
Flibanserin The risk or severity of hypertension can be increased when Flibanserin is combined with Indoprofen.
Iloperidone The risk or severity of hypertension can be increased when Iloperidone is combined with Indoprofen.

Target Protein

C-X-C chemokine receptor type 1 CXCR1
Prostaglandin G/H synthase 2 PTGS2
Prostaglandin G/H synthase 1 PTGS1
Fatty acid-binding protein, liver FABP1
C-X-C chemokine receptor type 2 CXCR2
Pyruvate kinase PKM PKM

Referensi & Sumber

Synthesis reference: U.S. Patent 3,767,805.
Artikel (PubMed)
  • PMID: 3949444
    Sivelli R, Farinon AM, Ghirarduzzi A, Rinetti M: Duodenogastric reflux and gastric damage from non-steroidal antiinflammatory drugs. Int J Tissue React. 1986;8(1):61-6.

Contoh Produk & Brand

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