Indoramin

DB08950

small molecule approved withdrawn

Deskripsi

Indoramin is a discontinued piperidine antiadrenergic drug with the trade names Baratol and Doralese. It is a selective alpha-1 adrenergic antagonist with no reflex tachycardia and direct myocardial depression action.

Struktur Molekul 2D

Berat 347.4534
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

701 Data
Duloxetine The risk or severity of orthostatic hypotension and syncope can be increased when Indoramin is combined with Duloxetine.
Levodopa The risk or severity of hypotension and orthostatic hypotension can be increased when Indoramin is combined with Levodopa.
Risperidone Indoramin may increase the hypotensive activities of Risperidone.
Amifostine Indoramin may increase the hypotensive activities of Amifostine.
Diazoxide Diazoxide may increase the hypotensive activities of Indoramin.
Methylphenidate Methylphenidate may decrease the antihypertensive activities of Indoramin.
Dexmethylphenidate Dexmethylphenidate may decrease the antihypertensive activities of Indoramin.
Obinutuzumab Indoramin may increase the hypotensive activities of Obinutuzumab.
Pentoxifylline Pentoxifylline may increase the hypotensive activities of Indoramin.
Rituximab Indoramin may increase the hypotensive activities of Rituximab.
Yohimbine Yohimbine may decrease the antihypertensive activities of Indoramin.
Epicaptopril Epicaptopril may decrease the antihypertensive activities of Indoramin.
Siponimod Siponimod may decrease the antihypertensive activities of Indoramin.
Valsartan Indoramin may decrease the antihypertensive activities of Valsartan.
Ramipril Indoramin may decrease the antihypertensive activities of Ramipril.
Reserpine Indoramin may decrease the antihypertensive activities of Reserpine.
Torasemide Indoramin may decrease the antihypertensive activities of Torasemide.
Olmesartan Indoramin may decrease the antihypertensive activities of Olmesartan.
Chlorthalidone Indoramin may decrease the antihypertensive activities of Chlorthalidone.
Nitroprusside Indoramin may decrease the antihypertensive activities of Nitroprusside.
Minoxidil Indoramin may decrease the antihypertensive activities of Minoxidil.
Fosinopril Indoramin may decrease the antihypertensive activities of Fosinopril.
Trandolapril Indoramin may decrease the antihypertensive activities of Trandolapril.
Metolazone Indoramin may decrease the antihypertensive activities of Metolazone.
Benazepril Indoramin may decrease the antihypertensive activities of Benazepril.
Enalapril Indoramin may decrease the antihypertensive activities of Enalapril.
Mecamylamine Indoramin may decrease the antihypertensive activities of Mecamylamine.
Losartan Indoramin may decrease the antihypertensive activities of Losartan.
Moexipril Indoramin may decrease the antihypertensive activities of Moexipril.
Furosemide Indoramin may decrease the antihypertensive activities of Furosemide.
Eplerenone Indoramin may decrease the antihypertensive activities of Eplerenone.
Sufentanil Sufentanil may decrease the antihypertensive activities of Indoramin.
Lisinopril Indoramin may decrease the antihypertensive activities of Lisinopril.
Nitroglycerin Indoramin may decrease the antihypertensive activities of Nitroglycerin.
Isoflurane Isoflurane may decrease the antihypertensive activities of Indoramin.
Perindopril Indoramin may decrease the antihypertensive activities of Perindopril.
Candesartan cilexetil Indoramin may decrease the antihypertensive activities of Candesartan cilexetil.
Fenoldopam Indoramin may decrease the antihypertensive activities of Fenoldopam.
Propofol Propofol may decrease the antihypertensive activities of Indoramin.
Eprosartan Indoramin may decrease the antihypertensive activities of Eprosartan.
Quinapril Indoramin may decrease the antihypertensive activities of Quinapril.
Remifentanil Remifentanil may decrease the antihypertensive activities of Indoramin.
Telmisartan Indoramin may decrease the antihypertensive activities of Telmisartan.
Irbesartan Indoramin may decrease the antihypertensive activities of Irbesartan.
Bretylium Indoramin may decrease the antihypertensive activities of Bretylium.
Halothane Halothane may decrease the antihypertensive activities of Indoramin.
Desflurane Desflurane may decrease the antihypertensive activities of Indoramin.
Captopril Indoramin may decrease the antihypertensive activities of Captopril.
Sevoflurane Sevoflurane may decrease the antihypertensive activities of Indoramin.
Clomipramine Clomipramine may decrease the antihypertensive activities of Indoramin.
Hydralazine Indoramin may decrease the antihypertensive activities of Hydralazine.
Cilazapril Indoramin may decrease the antihypertensive activities of Cilazapril.
Rotigotine Rotigotine may decrease the antihypertensive activities of Indoramin.
Riociguat Indoramin may decrease the antihypertensive activities of Riociguat.
Remikiren Indoramin may decrease the antihypertensive activities of Remikiren.
Guanadrel Indoramin may decrease the antihypertensive activities of Guanadrel.
Bosentan Indoramin may decrease the antihypertensive activities of Bosentan.
Candoxatril Indoramin may decrease the antihypertensive activities of Candoxatril.
Metyrosine Indoramin may decrease the antihypertensive activities of Metyrosine.
Cryptenamine Indoramin may decrease the antihypertensive activities of Cryptenamine.
Omapatrilat Omapatrilat may decrease the antihypertensive activities of Indoramin.
Deserpidine Indoramin may decrease the antihypertensive activities of Deserpidine.
Pentolinium Indoramin may decrease the antihypertensive activities of Pentolinium.
Trimethaphan Indoramin may decrease the antihypertensive activities of Trimethaphan.
Guanethidine Indoramin may decrease the antihypertensive activities of Guanethidine.
Rescinnamine Rescinnamine may decrease the antihypertensive activities of Indoramin.
Saprisartan Indoramin may decrease the antihypertensive activities of Saprisartan.
Spirapril Indoramin may decrease the antihypertensive activities of Spirapril.
Tienilic acid Indoramin may decrease the antihypertensive activities of Tienilic acid.
Debrisoquine Indoramin may decrease the antihypertensive activities of Debrisoquine.
Sitaxentan Indoramin may decrease the antihypertensive activities of Sitaxentan.
Ambrisentan Indoramin may decrease the antihypertensive activities of Ambrisentan.
Diethylnorspermine Indoramin may decrease the antihypertensive activities of Diethylnorspermine.
Pinacidil Indoramin may decrease the antihypertensive activities of Pinacidil.
Temocapril Indoramin may decrease the antihypertensive activities of Temocapril.
Macitentan Indoramin may decrease the antihypertensive activities of Macitentan.
Hexamethonium Indoramin may decrease the antihypertensive activities of Hexamethonium.
Aliskiren Indoramin may decrease the antihypertensive activities of Aliskiren.
Rauwolfia serpentina root Indoramin may decrease the antihypertensive activities of Rauwolfia serpentina root.
Enalaprilat Indoramin may decrease the antihypertensive activities of Enalaprilat.
Selexipag Indoramin may decrease the antihypertensive activities of Selexipag.
Angiotensin 1-7 Indoramin may decrease the antihypertensive activities of Angiotensin 1-7.
Imidapril Indoramin may decrease the antihypertensive activities of Imidapril.
BQ-123 Indoramin may decrease the antihypertensive activities of BQ-123.
Cicletanine Indoramin may decrease the antihypertensive activities of Cicletanine.
Dihydralazine Indoramin may decrease the antihypertensive activities of Dihydralazine.
Zofenopril Indoramin may decrease the antihypertensive activities of Zofenopril.
Guanoxan Indoramin may decrease the antihypertensive activities of Guanoxan.
Delapril Indoramin may decrease the antihypertensive activities of Delapril.
Vincamine Indoramin may decrease the antihypertensive activities of Vincamine.
Linsidomine Indoramin may decrease the antihypertensive activities of Linsidomine.
Guanoxabenz Indoramin may decrease the antihypertensive activities of Guanoxabenz.
Tolonidine Indoramin may decrease the antihypertensive activities of Tolonidine.
Endralazine Indoramin may decrease the antihypertensive activities of Endralazine.
Cadralazine Indoramin may decrease the antihypertensive activities of Cadralazine.
Bietaserpine Indoramin may decrease the antihypertensive activities of Bietaserpine.
Guanazodine Indoramin may decrease the antihypertensive activities of Guanazodine.
Methoserpidine Indoramin may decrease the antihypertensive activities of Methoserpidine.
Guanoclor Indoramin may decrease the antihypertensive activities of Guanoclor.
Muzolimine Indoramin may decrease the antihypertensive activities of Muzolimine.

Target Protein

Alpha-1D adrenergic receptor ADRA1D
Alpha-2C adrenergic receptor ADRA2C
Alpha-2B adrenergic receptor ADRA2B
Alpha-1A adrenergic receptor ADRA1A

Referensi & Sumber

Synthesis reference: U.S. Patent 3,527,761

Contoh Produk & Brand

Produk: 0 • International brands: 4
International Brands
  • Baratol — Amdipharm
  • Doralese — GlaxoSmithKline / Chemidex
  • Vidora — Leurquin
  • Wydora — Riemser

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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