Magaldrate

DB08938

small molecule approved withdrawn

Deskripsi

Magaldrate is an antacid drug used for the treatment of esophagitis, duodenal and gastric ulcers, and gastroesophageal reflux. Magaldrate has been discontinued in the US market.

Struktur Molekul 2D

Berat 1115.3
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Aluminium oxide: absorbed Al ions are eliminated in the urine (0.1-0.5 mg of Al in aluminium-containing antacid is absorbed from standard daily doses of antacid) while insoluble or poorly absorbed Al salts in the intestines are excreted through the feces. Magnesium oxide: absorbed Mg ions (up to 30%) are eliminated in the urine, unabsorbed is excreted in the feces.

Interaksi Makanan

1 Data
  • 1. Avoid alcohol.

Interaksi Obat

410 Data
Atazanavir Magaldrate can cause a decrease in the absorption of Atazanavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Bosutinib Magaldrate can cause a decrease in the absorption of Bosutinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cefditoren The serum concentration of Cefditoren can be decreased when it is combined with Magaldrate.
Dabigatran etexilate Magaldrate can cause a decrease in the absorption of Dabigatran etexilate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Dabrafenib Magaldrate can cause a decrease in the absorption of Dabrafenib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Dasatinib Magaldrate can cause a decrease in the absorption of Dasatinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Delavirdine Magaldrate can cause a decrease in the absorption of Delavirdine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Erlotinib Magaldrate can cause a decrease in the absorption of Erlotinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Gefitinib Magaldrate can cause a decrease in the absorption of Gefitinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Itraconazole Magaldrate can cause a decrease in the absorption of Itraconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ledipasvir Magaldrate can cause a decrease in the absorption of Ledipasvir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Methylphenidate Magaldrate can cause an increase in the absorption of Methylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.
Pazopanib Magaldrate can cause a decrease in the absorption of Pazopanib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Riociguat Magaldrate can cause a decrease in the absorption of Riociguat resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcitriol The serum concentration of Magaldrate can be increased when it is combined with Calcitriol.
Calcifediol The serum concentration of Magaldrate can be increased when it is combined with Calcifediol.
Ergocalciferol The serum concentration of Magaldrate can be increased when it is combined with Ergocalciferol.
Cholecalciferol The serum concentration of Magaldrate can be increased when it is combined with Cholecalciferol.
Paricalcitol The serum concentration of Magaldrate can be increased when it is combined with Paricalcitol.
Dihydrotachysterol The serum concentration of Magaldrate can be increased when it is combined with Dihydrotachysterol.
Alfacalcidol The serum concentration of Magaldrate can be increased when it is combined with Alfacalcidol.
Seocalcitol The serum concentration of Magaldrate can be increased when it is combined with Seocalcitol.
Inecalcitol The serum concentration of Magaldrate can be increased when it is combined with Inecalcitol.
Becocalcidiol The serum concentration of Magaldrate can be increased when it is combined with Becocalcidiol.
Eldecalcitol The serum concentration of Magaldrate can be increased when it is combined with Eldecalcitol.
1alpha,24S-Dihydroxyvitamin D2 The serum concentration of Magaldrate can be increased when it is combined with 1alpha,24S-Dihydroxyvitamin D2.
Elocalcitol The serum concentration of Magaldrate can be increased when it is combined with Elocalcitol.
Maxacalcitol The serum concentration of Magaldrate can be increased when it is combined with Maxacalcitol.
Doxercalciferol The serum concentration of Magaldrate can be increased when it is combined with Doxercalciferol.
Vitamin D The serum concentration of Magaldrate can be increased when it is combined with Vitamin D.
1alpha-Hydroxyvitamin D5 The serum concentration of Magaldrate can be increased when it is combined with 1alpha-Hydroxyvitamin D5.
Previtamin D(3) The serum concentration of Magaldrate can be increased when it is combined with Previtamin D(3).
Deferiprone Magaldrate can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy.
Eltrombopag Magaldrate can cause a decrease in the absorption of Eltrombopag resulting in a reduced serum concentration and potentially a decrease in efficacy.
Levothyroxine Magaldrate can cause a decrease in the absorption of Levothyroxine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Tolevamer The risk or severity of adverse effects can be increased when Tolevamer is combined with Magaldrate.
Bisacodyl The therapeutic efficacy of Bisacodyl can be decreased when used in combination with Magaldrate.
Captopril Magaldrate can cause a decrease in the absorption of Captopril resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cefpodoxime The serum concentration of Cefpodoxime can be decreased when it is combined with Magaldrate.
Cefuroxime The serum concentration of Cefuroxime can be decreased when it is combined with Magaldrate.
Chloroquine Magaldrate can cause a decrease in the absorption of Chloroquine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Elvitegravir Magaldrate can cause a decrease in the absorption of Elvitegravir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Gabapentin enacarbil The serum concentration of Gabapentin enacarbil can be decreased when it is combined with Magaldrate.
Hyoscyamine Magaldrate can cause a decrease in the absorption of Hyoscyamine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Rifampin Magaldrate can cause a decrease in the absorption of Rifampicin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Mecamylamine Magaldrate may decrease the excretion rate of Mecamylamine which could result in a higher serum level.
Memantine Magaldrate may decrease the excretion rate of Memantine which could result in a higher serum level.
Penicillamine Magaldrate can cause a decrease in the absorption of Penicillamine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Quinidine Magaldrate may decrease the excretion rate of Quinidine which could result in a higher serum level.
Sulpiride The therapeutic efficacy of Sulpiride can be increased when used in combination with Magaldrate.
Deferasirox Magaldrate can cause a decrease in the absorption of Deferasirox resulting in a reduced serum concentration and potentially a decrease in efficacy.
Allopurinol The therapeutic efficacy of Allopurinol can be decreased when used in combination with Magaldrate.
Dolutegravir The serum concentration of Dolutegravir can be decreased when it is combined with Magaldrate.
Fexofenadine Magaldrate can cause a decrease in the absorption of Fexofenadine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Raltegravir Magaldrate can cause a decrease in the absorption of Raltegravir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Halofantrine Magaldrate can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Misoprostol The risk or severity of adverse effects can be increased when Magaldrate is combined with Misoprostol.
Mesalazine Magaldrate can cause a decrease in the absorption of Mesalazine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Mycophenolic acid The serum concentration of Mycophenolic acid can be decreased when it is combined with Magaldrate.
Ursodeoxycholic acid Magaldrate can cause a decrease in the absorption of Ursodeoxycholic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Glycochenodeoxycholic Acid Magaldrate can cause a decrease in the absorption of Glycochenodeoxycholic Acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cholic Acid Magaldrate can cause a decrease in the absorption of Cholic Acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Glycocholic acid Magaldrate can cause a decrease in the absorption of Glycocholic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Deoxycholic acid Magaldrate can cause a decrease in the absorption of Deoxycholic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Taurocholic acid Magaldrate can cause a decrease in the absorption of Taurocholic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Obeticholic acid Magaldrate can cause a decrease in the absorption of Obeticholic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Chenodeoxycholic acid Magaldrate can cause a decrease in the absorption of Chenodeoxycholic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Taurochenodeoxycholic acid Magaldrate can cause a decrease in the absorption of Taurochenodeoxycholic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Tauroursodeoxycholic acid Magaldrate can cause a decrease in the absorption of Tauroursodeoxycholic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Bamet-UD2 Magaldrate can cause a decrease in the absorption of Bamet-UD2 resulting in a reduced serum concentration and potentially a decrease in efficacy.
cis-Diamminechlorocholylglycinateplatinum(II) The serum concentration of cis-Diamminechlorocholylglycinateplatinum(II) can be decreased when it is combined with Magaldrate.
Dehydrocholic acid Magaldrate can cause a decrease in the absorption of Dehydrocholic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Hyodeoxycholic Acid Magaldrate can cause a decrease in the absorption of Hyodeoxycholic Acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Aramchol The serum concentration of Aramchol can be decreased when it is combined with Magaldrate.
Ox bile extract The serum concentration of Ox bile extract can be decreased when it is combined with Magaldrate.
Cysteamine The bioavailability of Cysteamine can be decreased when combined with Magaldrate.
Ketoconazole Magaldrate can cause a decrease in the absorption of Ketoconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Moxifloxacin Magaldrate can cause a decrease in the absorption of Moxifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Grepafloxacin Magaldrate can cause a decrease in the absorption of Grepafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Enoxacin Magaldrate can cause a decrease in the absorption of Enoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Pefloxacin Magaldrate can cause a decrease in the absorption of Pefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Trovafloxacin Magaldrate can cause a decrease in the absorption of Trovafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Nalidixic acid Magaldrate can cause a decrease in the absorption of Nalidixic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Rosoxacin Magaldrate can cause a decrease in the absorption of Rosoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cinoxacin Magaldrate can cause a decrease in the absorption of Cinoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Lomefloxacin Magaldrate can cause a decrease in the absorption of Lomefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Gatifloxacin Magaldrate can cause a decrease in the absorption of Gatifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Norfloxacin Magaldrate can cause a decrease in the absorption of Norfloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Levofloxacin Magaldrate can cause a decrease in the absorption of Levofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ofloxacin Magaldrate can cause a decrease in the absorption of Ofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sparfloxacin Magaldrate can cause a decrease in the absorption of Sparfloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Temafloxacin Magaldrate can cause a decrease in the absorption of Temafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Fleroxacin Magaldrate can cause a decrease in the absorption of Fleroxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Technetium Tc-99m ciprofloxacin Magaldrate can cause a decrease in the absorption of Technetium Tc-99m ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Garenoxacin Magaldrate can cause a decrease in the absorption of Garenoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Nemonoxacin Magaldrate can cause a decrease in the absorption of Nemonoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Flumequine Magaldrate can cause a decrease in the absorption of Flumequine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Enrofloxacin Magaldrate can cause a decrease in the absorption of Enrofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Orbifloxacin Magaldrate can cause a decrease in the absorption of Orbifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sarafloxacin Magaldrate can cause a decrease in the absorption of Sarafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.

Referensi & Sumber

Synthesis reference: U.S. Patent 2,923,660.

Contoh Produk & Brand

Produk: 9 • International brands: 11
Produk
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    Tablet • - • Oral • US • OTC
Menampilkan 8 dari 9 produk.
International Brands
  • Almadrat T — Actavis
  • Almagel T — Balkanpharma
  • Antashin — Standard
  • Bemolan — Nycomed
  • Cremag — Zuoz
  • Glysan — Riemser
  • Lowsium — Rugby
  • Magacid — Purzer
  • Malugastrin — Polfa Lódz
  • Riopan — Nycomed

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