Peringatan Keamanan

In clinical trials, no serious toxicity was reported, only local irritation (mild contact dermatitis and cellulitis) at the site of application was found.

Luliconazole

DB08933

small molecule approved

Deskripsi

Luliconazole is a topical antifungal agent that acts by unknown mechanisms but is postulated to involve altering the synthesis of fungi cell membranes. It was approved by the FDA (USA) in November 2013 and is marketed under the brand name Luzu. Luliconazole is also approved in Japan.

Struktur Molekul 2D

Berat 354.27
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) The half life of luliconazole has yet to be determined.
Volume Distribusi The volume of distribution was not quantified.
Klirens (Clearance) The clearance of luliconazole has yet to be determined.

Absorpsi

Although luliconazole is administered topically, clinical studies have shown that after the first dose in patients with tina pedis, a maximum plasma concentration of 0.40 ± 0.76 ng/mL (mean ± SD) occurred in 16.9 ± 9.39 hours (mean ± SD).

Metabolisme

The metabolism of luliconazole has yet to be determined.

Rute Eliminasi

The route of elimination of luliconazole has yet to be determined.

Interaksi Obat

135 Data
Pantoprazole The serum concentration of Pantoprazole can be increased when it is combined with Luliconazole.
Citalopram The serum concentration of Citalopram can be increased when it is combined with Luliconazole.
Phenytoin The serum concentration of Phenytoin can be increased when it is combined with Luliconazole.
Pentobarbital The serum concentration of Pentobarbital can be increased when it is combined with Luliconazole.
Amitriptyline The serum concentration of Amitriptyline can be increased when it is combined with Luliconazole.
Methadone The serum concentration of Methadone can be increased when it is combined with Luliconazole.
Omeprazole The serum concentration of Omeprazole can be increased when it is combined with Luliconazole.
Trimethadione The serum concentration of Trimethadione can be increased when it is combined with Luliconazole.
Clobazam The serum concentration of Clobazam can be increased when it is combined with Luliconazole.
Timolol The serum concentration of Timolol can be increased when it is combined with Luliconazole.
Carisoprodol The serum concentration of Carisoprodol can be increased when it is combined with Luliconazole.
Progesterone The serum concentration of Progesterone can be increased when it is combined with Luliconazole.
Zolpidem The serum concentration of Zolpidem can be increased when it is combined with Luliconazole.
Lansoprazole The serum concentration of Lansoprazole can be increased when it is combined with Luliconazole.
Imipramine The serum concentration of Imipramine can be increased when it is combined with Luliconazole.
Quinine The serum concentration of Quinine can be increased when it is combined with Luliconazole.
Fluoxetine The serum concentration of Fluoxetine can be increased when it is combined with Luliconazole.
Albendazole The serum concentration of Albendazole can be increased when it is combined with Luliconazole.
Cyclophosphamide The serum concentration of Cyclophosphamide can be increased when it is combined with Luliconazole.
Voriconazole The serum concentration of Voriconazole can be increased when it is combined with Luliconazole.
Doxazosin The serum concentration of Doxazosin can be increased when it is combined with Luliconazole.
Thiopental The serum concentration of Thiopental can be increased when it is combined with Luliconazole.
Tamoxifen The serum concentration of Tamoxifen can be increased when it is combined with Luliconazole.
Thioridazine The serum concentration of Thioridazine can be increased when it is combined with Luliconazole.
Esomeprazole The serum concentration of Esomeprazole can be increased when it is combined with Luliconazole.
Clopidogrel The serum concentration of Clopidogrel can be increased when it is combined with Luliconazole.
Primidone The serum concentration of Primidone can be increased when it is combined with Luliconazole.
Diazepam The serum concentration of Diazepam can be increased when it is combined with Luliconazole.
Methylphenobarbital The serum concentration of Methylphenobarbital can be increased when it is combined with Luliconazole.
Zonisamide The serum concentration of Zonisamide can be increased when it is combined with Luliconazole.
Ramelteon The serum concentration of Ramelteon can be increased when it is combined with Luliconazole.
Praziquantel The serum concentration of Praziquantel can be increased when it is combined with Luliconazole.
Rabeprazole The serum concentration of Rabeprazole can be increased when it is combined with Luliconazole.
Proguanil The serum concentration of Proguanil can be increased when it is combined with Luliconazole.
Doxepin The serum concentration of Doxepin can be increased when it is combined with Luliconazole.
Phenobarbital The serum concentration of Phenobarbital can be increased when it is combined with Luliconazole.
Escitalopram The serum concentration of Escitalopram can be increased when it is combined with Luliconazole.
Clomipramine The serum concentration of Clomipramine can be increased when it is combined with Luliconazole.
Lapatinib The serum concentration of Lapatinib can be increased when it is combined with Luliconazole.
Fosphenytoin The serum concentration of Fosphenytoin can be increased when it is combined with Luliconazole.
St. John's Wort The serum concentration of St. John's Wort can be increased when it is combined with Luliconazole.
Hexobarbital The serum concentration of Hexobarbital can be increased when it is combined with Luliconazole.
Acenocoumarol The serum concentration of Acenocoumarol can be increased when it is combined with Luliconazole.
Barbital The serum concentration of Barbital can be increased when it is combined with Luliconazole.
Methsuximide The serum concentration of Methsuximide can be increased when it is combined with Luliconazole.
Dexlansoprazole The serum concentration of Dexlansoprazole can be increased when it is combined with Luliconazole.
Lacosamide The serum concentration of Lacosamide can be increased when it is combined with Luliconazole.
Etravirine The serum concentration of Etravirine can be increased when it is combined with Luliconazole.
Apixaban The serum concentration of Apixaban can be increased when it is combined with Luliconazole.
Axitinib The serum concentration of Axitinib can be increased when it is combined with Luliconazole.
Artemether The serum concentration of Artemether can be increased when it is combined with Luliconazole.
Seratrodast The serum concentration of Seratrodast can be increased when it is combined with Luliconazole.
(R)-warfarin The serum concentration of (R)-warfarin can be increased when it is combined with Luliconazole.
Vortioxetine The serum concentration of Vortioxetine can be increased when it is combined with Luliconazole.
Etizolam The serum concentration of Etizolam can be increased when it is combined with Luliconazole.
Esketamine The serum concentration of Esketamine can be increased when it is combined with Luliconazole.
Triclabendazole The serum concentration of Triclabendazole can be increased when it is combined with Luliconazole.
Lynestrenol The serum concentration of Lynestrenol can be increased when it is combined with Luliconazole.
Dexrabeprazole The serum concentration of Dexrabeprazole can be increased when it is combined with Luliconazole.
(S)-Warfarin The serum concentration of (S)-Warfarin can be increased when it is combined with Luliconazole.
Paroxetine The serum concentration of Paroxetine can be increased when it is combined with Luliconazole.
Fedratinib The serum concentration of Fedratinib can be increased when it is combined with Luliconazole.
Estradiol The serum concentration of Estradiol can be increased when it is combined with Luliconazole.
Cenobamate The serum concentration of Cenobamate can be increased when it is combined with Luliconazole.
Propranolol The serum concentration of Propranolol can be increased when it is combined with Luliconazole.
Labetalol The serum concentration of Labetalol can be increased when it is combined with Luliconazole.
Testosterone The serum concentration of Testosterone can be increased when it is combined with Luliconazole.
Glyburide The serum concentration of Glyburide can be increased when it is combined with Luliconazole.
Nebivolol The serum concentration of Nebivolol can be increased when it is combined with Luliconazole.
Vilazodone The serum concentration of Vilazodone can be increased when it is combined with Luliconazole.
Sertraline The serum concentration of Sertraline can be increased when it is combined with Luliconazole.
Formoterol The serum concentration of Formoterol can be increased when it is combined with Luliconazole.
Valproic acid The serum concentration of Valproic acid can be increased when it is combined with Luliconazole.
Enasidenib The serum concentration of Enasidenib can be increased when it is combined with Luliconazole.
Teniposide The serum concentration of Teniposide can be increased when it is combined with Luliconazole.
Nilutamide The serum concentration of Nilutamide can be increased when it is combined with Luliconazole.
Pentamidine The serum concentration of Pentamidine can be increased when it is combined with Luliconazole.
Gliclazide The serum concentration of Gliclazide can be increased when it is combined with Luliconazole.
Moclobemide The serum concentration of Moclobemide can be increased when it is combined with Luliconazole.
Stiripentol The serum concentration of Stiripentol can be increased when it is combined with Luliconazole.
Ticlopidine The serum concentration of Ticlopidine can be increased when it is combined with Luliconazole.
Methylene blue The serum concentration of Methylene blue can be increased when it is combined with Luliconazole.
Benzocaine The serum concentration of Benzocaine can be increased when it is combined with Luliconazole.
Rilpivirine The serum concentration of Rilpivirine can be increased when it is combined with Luliconazole.
Pretomanid The serum concentration of Pretomanid can be increased when it is combined with Luliconazole.
Lefamulin The serum concentration of Lefamulin can be increased when it is combined with Luliconazole.
Colchicine The serum concentration of Colchicine can be increased when it is combined with Luliconazole.
Elexacaftor The serum concentration of Elexacaftor can be increased when it is combined with Luliconazole.
Voxelotor The serum concentration of Voxelotor can be increased when it is combined with Luliconazole.
Levamlodipine The serum concentration of Levamlodipine can be increased when it is combined with Luliconazole.
Lumateperone The serum concentration of Lumateperone can be increased when it is combined with Luliconazole.
Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Luliconazole.
Rimegepant The metabolism of Rimegepant can be decreased when combined with Luliconazole.
Haloperidol The serum concentration of Haloperidol can be increased when it is combined with Luliconazole.
Selumetinib The serum concentration of Selumetinib can be increased when it is combined with Luliconazole.
Pemigatinib The metabolism of Pemigatinib can be decreased when combined with Luliconazole.
Lurbinectedin The serum concentration of Lurbinectedin can be increased when it is combined with Luliconazole.
Oliceridine The serum concentration of Oliceridine can be increased when it is combined with Luliconazole.
Voclosporin The metabolism of Voclosporin can be decreased when combined with Luliconazole.
Silodosin The metabolism of Silodosin can be decreased when combined with Luliconazole.

Target Protein

Lanosterol 14-alpha demethylase ERG11

Referensi & Sumber

Synthesis reference: Niwano Y, Kuzuhara N, Kodama H, Yoshida M, Miyazaki T, Yamaguchi H: In vitro and in vivo antidermatophyte activities of NND-502, a novel optically active imidazole antimycotic agent. Antimicrob Agents Chemother. 1998 Apr;42(4):967-70.
Artikel (PubMed)
  • PMID: 9559824
    Niwano Y, Kuzuhara N, Kodama H, Yoshida M, Miyazaki T, Yamaguchi H: In vitro and in vivo antidermatophyte activities of NND-502, a novel optically active imidazole antimycotic agent. Antimicrob Agents Chemother. 1998 Apr;42(4):967-70.
  • PMID: 15365862
    Uchida K, Nishiyama Y, Yamaguchi H: In vitro antifungal activity of luliconazole (NND-502), a novel imidazole antifungal agent. J Infect Chemother. 2004 Aug;10(4):216-9.

Contoh Produk & Brand

Produk: 2 • International brands: 1
Produk
  • Luliconazole
    Cream • 10 mg/1g • Topical • US • Approved
  • Luzu
    Cream • 10 mg/1g • Topical • US • Approved
International Brands
  • Lulicon — Pola Pharma

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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