Peringatan Keamanan

The most common adverse reactions (? 10%) across all studies with GATTEX are abdominal pain, injection site reactions, nausea, headaches, abdominal distension, upper respiratory tract infection. In addition, vomiting and fluid overload were reported in the SBS studies (1 and 3) at rates ? 10%.

Teduglutide

DB08900

biotech approved

Deskripsi

Teduglutide is a glucagon-like peptide-2 (GLP-2) analogue. It is made up of 33 amino acids and is manufactured using a strain of Escherichia coli modified by recombinant DNA technology. Teduglutide differs from GLP-2 by one amino acid (alanine is substituted by glycine). The significance of this substitution is that teduglutide is longer acting than endogenous GLP-2 as it is more resistant to proteolysis from dipeptidyl peptidase-4. FDA approved on December 21, 2012.

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Terminal half-life, healthy subjects = 2 hours; Terminal half-life, SBS patients = 1.3 hours
Volume Distribusi Vd, healthy subjects = 103 mL/kg
Klirens (Clearance) Plasma clearance, healthy subjects = 123 mL/hr/kg; This value indicates that teduglutide is primarily cleared by the kidney.

Absorpsi

The pharmacokinetic profile of teduglutide (when administered subcutaneously) is described by a one-compartment model with first order absorption in the abdomen, arm, and thigh. With escalating doses, teduglutide demonstrates linear pharmacokinetics. Absolute bioavailability, SubQ = 88%; Tmax, SubQ = 3-5 hours; Cmax, 0.05 mg/kg SubQ, SBS patients = 36 ng/mL; AUC, 0.05 mg/kg SubQ, SBS patients = 0.15 µg•hr/mL; Teduglutide does not accumulate following multiple subcutaneous administrations.

Metabolisme

Although a formal investigation has not been conducted, it is expected because teduglutide is a peptide-based drug, it will be degraded into smaller peptides and amino acids via catabolic pathways. The cytochrome P450 enzyme system is not involved in the metabolism of this drug.

Rute Eliminasi

Urine

Interaksi Obat

754 Data
Lorazepam The serum concentration of Lorazepam can be increased when it is combined with Teduglutide.
Temazepam The serum concentration of Temazepam can be increased when it is combined with Teduglutide.
Clobazam The serum concentration of Clobazam can be increased when it is combined with Teduglutide.
Alprazolam The serum concentration of Alprazolam can be increased when it is combined with Teduglutide.
Chlordiazepoxide The serum concentration of Chlordiazepoxide can be increased when it is combined with Teduglutide.
Adinazolam The serum concentration of Adinazolam can be increased when it is combined with Teduglutide.
Clorazepic acid The serum concentration of Clorazepic acid can be increased when it is combined with Teduglutide.
Midazolam The serum concentration of Midazolam can be increased when it is combined with Teduglutide.
Flurazepam The serum concentration of Flurazepam can be increased when it is combined with Teduglutide.
Halazepam The serum concentration of Halazepam can be increased when it is combined with Teduglutide.
Diazepam The serum concentration of Diazepam can be increased when it is combined with Teduglutide.
Oxazepam The serum concentration of Oxazepam can be increased when it is combined with Teduglutide.
Triazolam The serum concentration of Triazolam can be increased when it is combined with Teduglutide.
Clonazepam The serum concentration of Clonazepam can be increased when it is combined with Teduglutide.
Estazolam The serum concentration of Estazolam can be increased when it is combined with Teduglutide.
Camazepam The serum concentration of Camazepam can be increased when it is combined with Teduglutide.
Delorazepam The serum concentration of Delorazepam can be increased when it is combined with Teduglutide.
Flunitrazepam The serum concentration of Flunitrazepam can be increased when it is combined with Teduglutide.
Ethyl loflazepate The serum concentration of Ethyl loflazepate can be increased when it is combined with Teduglutide.
Cloxazolam The serum concentration of Cloxazolam can be increased when it is combined with Teduglutide.
Bromazepam The serum concentration of Bromazepam can be increased when it is combined with Teduglutide.
Clotiazepam The serum concentration of Clotiazepam can be increased when it is combined with Teduglutide.
Fludiazepam The serum concentration of Fludiazepam can be increased when it is combined with Teduglutide.
Ketazolam The serum concentration of Ketazolam can be increased when it is combined with Teduglutide.
Prazepam The serum concentration of Prazepam can be increased when it is combined with Teduglutide.
Quazepam The serum concentration of Quazepam can be increased when it is combined with Teduglutide.
Cinolazepam The serum concentration of Cinolazepam can be increased when it is combined with Teduglutide.
Nitrazepam The serum concentration of Nitrazepam can be increased when it is combined with Teduglutide.
Brotizolam The serum concentration of Brotizolam can be increased when it is combined with Teduglutide.
Etizolam The serum concentration of Etizolam can be increased when it is combined with Teduglutide.
1,2-Benzodiazepine The serum concentration of 1,2-Benzodiazepine can be increased when it is combined with Teduglutide.
Pinazepam The serum concentration of Pinazepam can be increased when it is combined with Teduglutide.
Medazepam The serum concentration of Medazepam can be increased when it is combined with Teduglutide.
Loprazolam The serum concentration of Loprazolam can be increased when it is combined with Teduglutide.
Doxefazepam The serum concentration of Doxefazepam can be increased when it is combined with Teduglutide.
Lormetazepam The serum concentration of Lormetazepam can be increased when it is combined with Teduglutide.
Nordazepam The serum concentration of Nordazepam can be increased when it is combined with Teduglutide.
Oxazepam acetate The serum concentration of Oxazepam acetate can be increased when it is combined with Teduglutide.
Cinazepam The serum concentration of Cinazepam can be increased when it is combined with Teduglutide.
Bentazepam The serum concentration of Bentazepam can be increased when it is combined with Teduglutide.
Remimazolam The serum concentration of Remimazolam can be increased when it is combined with Teduglutide.
Cyclosporine Cyclosporine may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Icosapent Icosapent may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Cefotiam Cefotiam may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Mesalazine Mesalazine may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Cefmenoxime Cefmenoxime may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Cefmetazole Cefmetazole may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Pamidronic acid Pamidronic acid may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Tenofovir disoproxil Tenofovir disoproxil may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Indomethacin Indomethacin may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Cidofovir Cidofovir may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Cefpiramide Cefpiramide may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Ceftazidime Ceftazidime may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Loracarbef Loracarbef may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Cefalotin Cefalotin may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Nabumetone Nabumetone may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Ketorolac Ketorolac may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Tenoxicam Tenoxicam may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Celecoxib Celecoxib may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Cefotaxime Cefotaxime may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Tolmetin Tolmetin may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Foscarnet Foscarnet may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Rofecoxib Rofecoxib may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Piroxicam Piroxicam may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Methotrexate Methotrexate may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Cephalexin Cephalexin may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Fenoprofen Fenoprofen may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Valaciclovir Valaciclovir may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Valdecoxib Valdecoxib may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Diclofenac Diclofenac may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Sulindac Sulindac may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Bacitracin Bacitracin may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Amphotericin B Amphotericin B may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Cephaloglycin Cephaloglycin may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Flurbiprofen Flurbiprofen may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Adefovir dipivoxil Adefovir dipivoxil may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Pentamidine Pentamidine may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Etodolac Etodolac may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Mefenamic acid Mefenamic acid may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Acyclovir Acyclovir may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Naproxen Naproxen may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Sulfasalazine Sulfasalazine may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Phenylbutazone Phenylbutazone may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Meloxicam Meloxicam may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Carprofen Carprofen may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Cefaclor Cefaclor may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Diflunisal Diflunisal may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Tacrolimus Tacrolimus may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Ceforanide Ceforanide may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Salicylic acid Salicylic acid may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Meclofenamic acid Meclofenamic acid may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Acetylsalicylic acid Acetylsalicylic acid may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Carboplatin Carboplatin may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Oxaprozin Oxaprozin may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Ketoprofen Ketoprofen may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Balsalazide Balsalazide may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Ibuprofen Ibuprofen may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Cefditoren Cefditoren may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Atazanavir Atazanavir may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Colistimethate Colistimethate may decrease the excretion rate of Teduglutide which could result in a higher serum level.

Target Protein

Glucagon-like peptide 2 receptor GLP2R

Referensi & Sumber

Artikel (PubMed)
  • PMID: 23729002
    Burness CB, McCormack PL: Teduglutide: a review of its use in the treatment of patients with short bowel syndrome. Drugs. 2013 Jun;73(9):935-47. doi: 10.1007/s40265-013-0070-y.
  • PMID: 23591284
    Semrad CE: The long road to a new short-bowel therapy: teduglutide for clinical use. Clin Gastroenterol Hepatol. 2013 Jul;11(7):824-5. doi: 10.1016/j.cgh.2013.03.030. Epub 2013 Apr 13.
  • PMID: 22570676
    Jeppesen PB: Teduglutide, a novel glucagon-like peptide 2 analog, in the treatment of patients with short bowel syndrome. Therap Adv Gastroenterol. 2012 May;5(3):159-71. doi: 10.1177/1756283X11436318.

Contoh Produk & Brand

Produk: 7 • International brands: 0
Produk
  • Gattex
    Injection, powder, lyophilized, for solution • 5 mg/0.5mL • Subcutaneous • US • Approved
  • Gattex
    Injection, powder, lyophilized, for solution; Kit • - • Subcutaneous; Topical • US • Approved
  • Gattex
    Injection, powder, lyophilized, for solution; Kit • - • Subcutaneous; Topical • US • Approved
  • Revestive
    Kit; Powder, for solution • 5 mg / vial • Subcutaneous • Canada • Approved
  • Revestive
    Injection, powder, for solution • 5 mg • Subcutaneous • EU • Approved
  • Revestive
    Injection, powder, for solution • 5 mg • Subcutaneous • EU • Approved
  • Revestive
    Injection, powder, for solution • 1.25 mg • Subcutaneous • EU • Approved

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
© 2025 Digital Pharmacy Research - Universitas Esa Unggul