Peringatan Keamanan

The FDA label includes an important warning of serious or life-threatening behavioral and psychiatric adverse reactions including aggression, hostility, irritability, anger, and homicidal thoughts in patients taking perampanel.

Perampanel

DB08883

small molecule approved

Deskripsi

Perampanel is a noncompetitive AMPA glutamate receptor antagonist. It is marketed under the name Fycompa™ and is indicated as an adjunct in patients over 12 years old for the treatment of partial-onset seizures that may or may not occur with generalized seizures. The FDA label includes an important black-boxed warning of serious or life-threatening behavioral and psychiatric reactions in patients taking Fycompa™.

Struktur Molekul 2D

Berat 349.393
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Perampanel has a long elmination half-life of about 105 hours.
Volume Distribusi The volume of distribution of perampanel was not quantified.
Klirens (Clearance) In healthy patients, perampanel has a clearance of about 12 mL/min.

Absorpsi

After oral adminitration, perampanel is absorbed rapidly and completely.

Metabolisme

Perampanel is highly metabolized by CYP3A4 and/or CYP3A5 primary oxidation and by sequential glucuronidation.

Rute Eliminasi

Perampanel is eliminated mostely in the feces (48%) and to a lesser exten in the urine (22%).

Interaksi Makanan

1 Data
  • 1. Take with or without food. Food slows the rate of absorption but not the extent.

Interaksi Obat

1330 Data
Peginterferon alfa-2b The serum concentration of Perampanel can be increased when it is combined with Peginterferon alfa-2b.
Leflunomide The serum concentration of Perampanel can be decreased when it is combined with Leflunomide.
Teriflunomide The serum concentration of Perampanel can be decreased when it is combined with Teriflunomide.
Buprenorphine Perampanel may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Perampanel.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Perampanel.
Hydrocodone Perampanel may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Perampanel.
Magnesium sulfate The therapeutic efficacy of Perampanel can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Perampanel may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Perampanel may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Perampanel.
Mirtazapine Perampanel may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Perampanel.
Orphenadrine Perampanel may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Perampanel may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Botulinum toxin type B Perampanel may increase the central nervous system depressant (CNS depressant) activities of Botulinum toxin type B.
Botulinum toxin type A Perampanel may increase the central nervous system depressant (CNS depressant) activities of Botulinum toxin type A.
Tryptophan Perampanel may increase the central nervous system depressant (CNS depressant) activities of Tryptophan.
Fluvoxamine Perampanel may increase the central nervous system depressant (CNS depressant) activities of Fluvoxamine.
Baclofen Baclofen may increase the central nervous system depressant (CNS depressant) activities of Perampanel.
Lorazepam Perampanel may increase the central nervous system depressant (CNS depressant) activities of Lorazepam.
Ethchlorvynol Perampanel may increase the central nervous system depressant (CNS depressant) activities of Ethchlorvynol.
Succinylcholine Perampanel may increase the central nervous system depressant (CNS depressant) activities of Succinylcholine.
Reserpine Perampanel may increase the central nervous system depressant (CNS depressant) activities of Reserpine.
Citalopram Perampanel may increase the central nervous system depressant (CNS depressant) activities of Citalopram.
Enflurane Perampanel may increase the central nervous system depressant (CNS depressant) activities of Enflurane.
Temazepam Perampanel may increase the central nervous system depressant (CNS depressant) activities of Temazepam.
Reboxetine Perampanel may increase the central nervous system depressant (CNS depressant) activities of Reboxetine.
Butabarbital Perampanel may increase the central nervous system depressant (CNS depressant) activities of Butabarbital.
Methysergide Perampanel may increase the central nervous system depressant (CNS depressant) activities of Methysergide.
Cabergoline Perampanel may increase the central nervous system depressant (CNS depressant) activities of Cabergoline.
Clemastine Perampanel may increase the central nervous system depressant (CNS depressant) activities of Clemastine.
Venlafaxine Perampanel may increase the central nervous system depressant (CNS depressant) activities of Venlafaxine.
Etomidate Perampanel may increase the central nervous system depressant (CNS depressant) activities of Etomidate.
Morphine Perampanel may increase the central nervous system depressant (CNS depressant) activities of Morphine.
Talbutal Perampanel may increase the central nervous system depressant (CNS depressant) activities of Talbutal.
Valproic acid Perampanel may increase the central nervous system depressant (CNS depressant) activities of Valproic acid.
Zolmitriptan Perampanel may increase the central nervous system depressant (CNS depressant) activities of Zolmitriptan.
Codeine Perampanel may increase the central nervous system depressant (CNS depressant) activities of Codeine.
Dihydroergotamine Perampanel may increase the central nervous system depressant (CNS depressant) activities of Dihydroergotamine.
Amitriptyline Perampanel may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Tolcapone Perampanel may increase the central nervous system depressant (CNS depressant) activities of Tolcapone.
Hydromorphone Perampanel may increase the central nervous system depressant (CNS depressant) activities of Hydromorphone.
Olanzapine Perampanel may increase the central nervous system depressant (CNS depressant) activities of Olanzapine.
Cetirizine Perampanel may increase the central nervous system depressant (CNS depressant) activities of Cetirizine.
Protriptyline Perampanel may increase the central nervous system depressant (CNS depressant) activities of Protriptyline.
Trimethadione Perampanel may increase the central nervous system depressant (CNS depressant) activities of Trimethadione.
Chlorzoxazone Perampanel may increase the central nervous system depressant (CNS depressant) activities of Chlorzoxazone.
Meprobamate Perampanel may increase the central nervous system depressant (CNS depressant) activities of Meprobamate.
Thiethylperazine Perampanel may increase the central nervous system depressant (CNS depressant) activities of Thiethylperazine.
Palonosetron Perampanel may increase the central nervous system depressant (CNS depressant) activities of Palonosetron.
Sulpiride Perampanel may increase the central nervous system depressant (CNS depressant) activities of Sulpiride.
Alprazolam Perampanel may increase the central nervous system depressant (CNS depressant) activities of Alprazolam.
Dexbrompheniramine Perampanel may increase the central nervous system depressant (CNS depressant) activities of Dexbrompheniramine.
Loxapine Perampanel may increase the central nervous system depressant (CNS depressant) activities of Loxapine.
Remoxipride Perampanel may increase the central nervous system depressant (CNS depressant) activities of Remoxipride.
Metocurine iodide Perampanel may increase the central nervous system depressant (CNS depressant) activities of Metocurine iodide.
Promazine Perampanel may increase the central nervous system depressant (CNS depressant) activities of Promazine.
Methocarbamol Perampanel may increase the central nervous system depressant (CNS depressant) activities of Methocarbamol.
Triprolidine Perampanel may increase the central nervous system depressant (CNS depressant) activities of Triprolidine.
Prochlorperazine Perampanel may increase the central nervous system depressant (CNS depressant) activities of Prochlorperazine.
Cyproheptadine Perampanel may increase the central nervous system depressant (CNS depressant) activities of Cyproheptadine.
Imipramine Perampanel may increase the central nervous system depressant (CNS depressant) activities of Imipramine.
Metharbital Perampanel may increase the central nervous system depressant (CNS depressant) activities of Metharbital.
Chlordiazepoxide Perampanel may increase the central nervous system depressant (CNS depressant) activities of Chlordiazepoxide.
Duloxetine Perampanel may increase the central nervous system depressant (CNS depressant) activities of Duloxetine.
Gallamine triethiodide Perampanel may increase the central nervous system depressant (CNS depressant) activities of Gallamine triethiodide.
Entacapone Perampanel may increase the central nervous system depressant (CNS depressant) activities of Entacapone.
Oxycodone Perampanel may increase the central nervous system depressant (CNS depressant) activities of Oxycodone.
Triflupromazine Perampanel may increase the central nervous system depressant (CNS depressant) activities of Triflupromazine.
Dextromethorphan Perampanel may increase the central nervous system depressant (CNS depressant) activities of Dextromethorphan.
Mephenytoin Perampanel may increase the central nervous system depressant (CNS depressant) activities of Mephenytoin.
Nortriptyline Perampanel may increase the central nervous system depressant (CNS depressant) activities of Nortriptyline.
Amoxapine Perampanel may increase the central nervous system depressant (CNS depressant) activities of Amoxapine.
Adinazolam Perampanel may increase the central nervous system depressant (CNS depressant) activities of Adinazolam.
Lamotrigine Perampanel may increase the central nervous system depressant (CNS depressant) activities of Lamotrigine.
Cisatracurium Perampanel may increase the central nervous system depressant (CNS depressant) activities of Cisatracurium.
Fenfluramine Perampanel may increase the central nervous system depressant (CNS depressant) activities of Fenfluramine.
Mazindol Perampanel may increase the central nervous system depressant (CNS depressant) activities of Mazindol.
Fluticasone propionate Perampanel may increase the central nervous system depressant (CNS depressant) activities of Fluticasone propionate.
Lisuride Perampanel may increase the central nervous system depressant (CNS depressant) activities of Lisuride.
Ethosuximide Perampanel may increase the central nervous system depressant (CNS depressant) activities of Ethosuximide.
Cisapride Perampanel may increase the central nervous system depressant (CNS depressant) activities of Cisapride.
Butorphanol Perampanel may increase the central nervous system depressant (CNS depressant) activities of Butorphanol.
Furazolidone Perampanel may increase the central nervous system depressant (CNS depressant) activities of Furazolidone.
Paramethadione Perampanel may increase the central nervous system depressant (CNS depressant) activities of Paramethadione.
Fluphenazine Perampanel may increase the central nervous system depressant (CNS depressant) activities of Fluphenazine.
Clorazepic acid Perampanel may increase the central nervous system depressant (CNS depressant) activities of Clorazepic acid.
Dexmedetomidine Perampanel may increase the central nervous system depressant (CNS depressant) activities of Dexmedetomidine.
Dyclonine Perampanel may increase the central nervous system depressant (CNS depressant) activities of Dyclonine.
Dextropropoxyphene Perampanel may increase the central nervous system depressant (CNS depressant) activities of Dextropropoxyphene.
Pentazocine Perampanel may increase the central nervous system depressant (CNS depressant) activities of Pentazocine.
Trazodone Perampanel may increase the central nervous system depressant (CNS depressant) activities of Trazodone.
Metaxalone Perampanel may increase the central nervous system depressant (CNS depressant) activities of Metaxalone.
Trimethobenzamide Perampanel may increase the central nervous system depressant (CNS depressant) activities of Trimethobenzamide.
Sumatriptan Perampanel may increase the central nervous system depressant (CNS depressant) activities of Sumatriptan.
Thioridazine Perampanel may increase the central nervous system depressant (CNS depressant) activities of Thioridazine.
Moricizine Perampanel may increase the central nervous system depressant (CNS depressant) activities of Moricizine.

Target Protein

Glutamate receptor 2 GRIA2
Glutamate receptor 3 GRIA3
Glutamate receptor 4 GRIA4
Glutamate receptor 1 GRIA1

Referensi & Sumber

Synthesis reference: Francesco Fontana, "METHODS FOR PREPARING INTERMEDIATES OF PERAMPANEL." U.S. Patent US20130109862, issued May 02, 2013.
Artikel (PubMed)
  • PMID: 21635236
    Hanada T, Hashizume Y, Tokuhara N, Takenaka O, Kohmura N, Ogasawara A, Hatakeyama S, Ohgoh M, Ueno M, Nishizawa Y: Perampanel: a novel, orally active, noncompetitive AMPA-receptor antagonist that reduces seizure activity in rodent models of epilepsy. Epilepsia. 2011 Jul;52(7):1331-40. doi: 10.1111/j.1528-1167.2011.03109.x. Epub 2011 Jun 2.

Contoh Produk & Brand

Produk: 54 • International brands: 0
Produk
  • Fycompa
    Suspension • 0.5 mg/1mL • Oral • US • Approved
  • Fycompa
    Kit • - • Oral • US • Approved
  • Fycompa
    Kit • - • Oral • US • Approved
  • Fycompa
    Tablet • 2 mg/1 • Oral • US • Approved
  • Fycompa
    Tablet • 4 mg/1 • Oral • US • Approved
  • Fycompa
    Tablet • 6 mg/1 • Oral • US • Approved
  • Fycompa
    Tablet • 8 mg/1 • Oral • US • Approved
  • Fycompa
    Tablet • 10 mg/1 • Oral • US • Approved
Menampilkan 8 dari 54 produk.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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