Ellagic acid

DB08846

small molecule investigational

Deskripsi

Ellagic acid is present in several fruits such as cranberries, strawberries, raspberries, and pomegranates. In pomegranates, there are several therapeutic compounds but ellagic acid is the most active and abundant. Ellagic acid is also present in vegetables. Ellagic acid is an investigational drug studied for treatment of Follicular Lymphoma (phase 2 trial), protection from brain injury of intrauterine growth restricted babies (phase 1 and 2 trial), improvement of cardiovascular function in adolescents who are obese (phase 2 trial), and topical treatment of solar lentigines. Ellagic acid's therapeutic action mostly involves antioxidant and anti-proliferative effects.

Struktur Molekul 2D

Berat 302.1926
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) Ellagic acid is eliminated from the body in about 4 hours.

Absorpsi

After oral consumption, ellagic acid reaches maximum concentrations in about 1 hour.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

178 Data
Aspartame The excretion of Ellagic acid can be decreased when combined with Aspartame.
Pravastatin The excretion of Ellagic acid can be decreased when combined with Pravastatin.
Pantoprazole The excretion of Ellagic acid can be decreased when combined with Pantoprazole.
Cefotiam The excretion of Ellagic acid can be decreased when combined with Cefotiam.
Liothyronine The excretion of Ellagic acid can be decreased when combined with Liothyronine.
Conjugated estrogens The excretion of Ellagic acid can be decreased when combined with Conjugated estrogens.
Valproic acid The excretion of Ellagic acid can be decreased when combined with Valproic acid.
Indomethacin The excretion of Ellagic acid can be decreased when combined with Indomethacin.
Aminohippuric acid The excretion of Ellagic acid can be decreased when combined with Aminohippuric acid.
Lansoprazole The excretion of Ellagic acid can be decreased when combined with Lansoprazole.
Cefalotin The excretion of Ellagic acid can be decreased when combined with Cefalotin.
Tenoxicam The excretion of Ellagic acid can be decreased when combined with Tenoxicam.
Cefotaxime The excretion of Ellagic acid can be decreased when combined with Cefotaxime.
Zidovudine The excretion of Ellagic acid can be decreased when combined with Zidovudine.
Cimetidine The excretion of Ellagic acid can be decreased when combined with Cimetidine.
Guanidine The excretion of Ellagic acid can be decreased when combined with Guanidine.
Piroxicam The excretion of Ellagic acid can be decreased when combined with Piroxicam.
Methotrexate The excretion of Ellagic acid can be decreased when combined with Methotrexate.
Cephalexin The excretion of Ellagic acid can be decreased when combined with Cephalexin.
Enalapril The excretion of Ellagic acid can be decreased when combined with Enalapril.
Diclofenac The excretion of Ellagic acid can be decreased when combined with Diclofenac.
Oxytetracycline The excretion of Ellagic acid can be decreased when combined with Oxytetracycline.
Leucovorin The excretion of Ellagic acid can be decreased when combined with Leucovorin.
Furosemide The excretion of Ellagic acid can be decreased when combined with Furosemide.
Esomeprazole The excretion of Ellagic acid can be decreased when combined with Esomeprazole.
Tetracycline The excretion of Ellagic acid can be decreased when combined with Tetracycline.
Acyclovir The excretion of Ellagic acid can be decreased when combined with Acyclovir.
Phenylbutazone The excretion of Ellagic acid can be decreased when combined with Phenylbutazone.
Cefaclor The excretion of Ellagic acid can be decreased when combined with Cefaclor.
Bumetanide The excretion of Ellagic acid can be decreased when combined with Bumetanide.
Dinoprostone The excretion of Ellagic acid can be decreased when combined with Dinoprostone.
Famotidine The excretion of Ellagic acid can be decreased when combined with Famotidine.
Salicylic acid The excretion of Ellagic acid can be decreased when combined with Salicylic acid.
Acetylsalicylic acid The excretion of Ellagic acid can be decreased when combined with Acetylsalicylic acid.
Ganciclovir The excretion of Ellagic acid can be decreased when combined with Ganciclovir.
Ketoprofen The excretion of Ellagic acid can be decreased when combined with Ketoprofen.
Minocycline The excretion of Ellagic acid can be decreased when combined with Minocycline.
Probenecid The excretion of Ellagic acid can be decreased when combined with Probenecid.
Mercaptopurine The excretion of Ellagic acid can be decreased when combined with Mercaptopurine.
Ibuprofen The excretion of Ellagic acid can be decreased when combined with Ibuprofen.
Novobiocin The excretion of Ellagic acid can be decreased when combined with Novobiocin.
Benzylpenicillin The excretion of Ellagic acid can be decreased when combined with Benzylpenicillin.
Melatonin The excretion of Ellagic acid can be decreased when combined with Melatonin.
Ouabain The excretion of Ellagic acid can be decreased when combined with Ouabain.
Rosuvastatin The excretion of Ellagic acid can be decreased when combined with Rosuvastatin.
Cefadroxil The excretion of Ellagic acid can be decreased when combined with Cefadroxil.
Ceftriaxone The excretion of Ellagic acid can be decreased when combined with Ceftriaxone.
Cefamandole The excretion of Ellagic acid can be decreased when combined with Cefamandole.
Cefazolin The excretion of Ellagic acid can be decreased when combined with Cefazolin.
Cefoperazone The excretion of Ellagic acid can be decreased when combined with Cefoperazone.
Ceftizoxime The excretion of Ellagic acid can be decreased when combined with Ceftizoxime.
Cefacetrile The excretion of Ellagic acid can be decreased when combined with Cefacetrile.
Ceftibuten The excretion of Ellagic acid can be decreased when combined with Ceftibuten.
Liotrix The excretion of Ellagic acid can be decreased when combined with Liotrix.
Cilastatin The excretion of Ellagic acid can be decreased when combined with Cilastatin.
Tazobactam The excretion of Ellagic acid can be decreased when combined with Tazobactam.
trans-2-hydroxycinnamic acid The excretion of Ellagic acid can be decreased when combined with trans-2-hydroxycinnamic acid.
Topiroxostat The excretion of Ellagic acid can be decreased when combined with Topiroxostat.
Cholic Acid The excretion of Ellagic acid can be decreased when combined with Cholic Acid.
Glutaric Acid The excretion of Ellagic acid can be decreased when combined with Glutaric Acid.
Benzoic acid The excretion of Ellagic acid can be decreased when combined with Benzoic acid.
Taurocholic acid The excretion of Ellagic acid can be decreased when combined with Taurocholic acid.
Caprylic acid The excretion of Ellagic acid can be decreased when combined with Caprylic acid.
Ataluren The excretion of Ellagic acid can be decreased when combined with Ataluren.
Teriflunomide The excretion of Ellagic acid can be decreased when combined with Teriflunomide.
Dabrafenib The excretion of Ellagic acid can be decreased when combined with Dabrafenib.
Dolutegravir The excretion of Ellagic acid can be decreased when combined with Dolutegravir.
Cefaloridine The excretion of Ellagic acid can be decreased when combined with Cefaloridine.
Lenvatinib The excretion of Ellagic acid can be decreased when combined with Lenvatinib.
Cabotegravir The excretion of Ellagic acid can be decreased when combined with Cabotegravir.
Apalutamide The excretion of Ellagic acid can be decreased when combined with Apalutamide.
Pradigastat The excretion of Ellagic acid can be decreased when combined with Pradigastat.
Enasidenib The excretion of Ellagic acid can be decreased when combined with Enasidenib.
Gemfibrozil The excretion of Ellagic acid can be decreased when combined with Gemfibrozil.
Dronedarone The excretion of Ellagic acid can be decreased when combined with Dronedarone.
Favipiravir The excretion of Ellagic acid can be decreased when combined with Favipiravir.
Quinidine The excretion of Ellagic acid can be decreased when combined with Quinidine.
Tafamidis The excretion of Ellagic acid can be decreased when combined with Tafamidis.
Linezolid The excretion of Ellagic acid can be decreased when combined with Linezolid.
Testosterone The excretion of Ellagic acid can be increased when combined with Testosterone.
Methyltestosterone The excretion of Ellagic acid can be increased when combined with Methyltestosterone.
Testosterone cypionate The excretion of Ellagic acid can be increased when combined with Testosterone cypionate.
Testosterone enanthate The excretion of Ellagic acid can be increased when combined with Testosterone enanthate.
Cyclosporine The excretion of Ellagic acid can be decreased when combined with Cyclosporine.
Riboflavin The excretion of Ellagic acid can be decreased when combined with Riboflavin.
Folic acid The excretion of Ellagic acid can be decreased when combined with Folic acid.
Ethoxzolamide The excretion of Ellagic acid can be decreased when combined with Ethoxzolamide.
Codeine The excretion of Ellagic acid can be decreased when combined with Codeine.
Piperacillin The excretion of Ellagic acid can be decreased when combined with Piperacillin.
Cidofovir The excretion of Ellagic acid can be decreased when combined with Cidofovir.
Trifluridine The excretion of Ellagic acid can be decreased when combined with Trifluridine.
Chloramphenicol The excretion of Ellagic acid can be decreased when combined with Chloramphenicol.
Tolmetin The excretion of Ellagic acid can be decreased when combined with Tolmetin.
Caspofungin The excretion of Ellagic acid can be decreased when combined with Caspofungin.
Foscarnet The excretion of Ellagic acid can be decreased when combined with Foscarnet.
Carbenicillin The excretion of Ellagic acid can be decreased when combined with Carbenicillin.
Sulindac The excretion of Ellagic acid can be decreased when combined with Sulindac.
Cyclothiazide The excretion of Ellagic acid can be decreased when combined with Cyclothiazide.
Nafcillin The excretion of Ellagic acid can be decreased when combined with Nafcillin.
Chlorpropamide The excretion of Ellagic acid can be decreased when combined with Chlorpropamide.

Target Protein

Heat shock 70 kDa protein 1A HSPA1A
Heat shock 70 kDa protein 1B HSPA1B
Glycogen synthase kinase-3 beta GSK3B
Carbonic anhydrase 12 CA12
Carbonic anhydrase 2 CA2
Carbonic anhydrase 14 CA14
Carbonic anhydrase 6 CA6
Tyrosine-protein kinase SYK SYK
Carbonic anhydrase 9 CA9
Carbonic anhydrase 1 CA1
Squalene monooxygenase SQLE
Carbonic anhydrase 4 CA4
Casein kinase II subunit alpha CSNK2A1
Carbonic anhydrase 3 CA3
Carbonic anhydrase 5A, mitochondrial CA5A
Carbonic anhydrase 5B, mitochondrial CA5B
Carbonic anhydrase 7 CA7
cAMP-dependent protein kinase catalytic subunit alpha PRKACA
Protein kinase C alpha type PRKCA
Protein kinase C beta type PRKCB

Referensi & Sumber

Synthesis reference: A)Nierenstein M: The Formation of Ellagic Acid from Galloyl-Glycine by Penicillium. Biochem J. 1915 Jun;9(2):240-4. B)Löwe, Zeitschrift für Chemie, 1868, 4, 603.
Artikel (PubMed)
  • PMID: 15369737
    Seeram NP, Lee R, Heber D: Bioavailability of ellagic acid in human plasma after consumption of ellagitannins from pomegranate (Punica granatum L.) juice. Clin Chim Acta. 2004 Oct;348(1-2):63-8.
Textbook
  • ISBN: 978-1849736701
    O'Neil, Maryadele J. (2013). The Merck Index : An Encyclopedia of Chemicals, Drugs, and Biologicals (15th ed.). Royal Society of Chemistry, The.

Contoh Produk & Brand

Produk: 0 • International brands: 0
Belum ada data produk/brand untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field produk/brand.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
© 2025 Digital Pharmacy Research - Universitas Esa Unggul