Peringatan Keamanan

In rats, whether or male or female, the LD50 values of temocapril were higher than 5000 mg/kg.

Temocapril

DB08836

small molecule experimental investigational

Deskripsi

Temocapril is a prodrug-type angiotensin-I converting enzyme (ACE) inhibitor not approved for use in the United States, but is approved in Japan and South Korea. Temocapril can also be used in hemodialysis patients without risk of serious accumulation.

Struktur Molekul 2D

Berat 476.609
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 13.1 hours in patients with normal liver function.
Volume Distribusi -
Klirens (Clearance) 19.4% urinary recovery.

Absorpsi

Temocapril is rapidly absorbed in the gastrointestinal tract and converted into the diacid (active) metabolite, which inhibits ACE in plasma.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Temocapril is eliminated primarily through the liver and kidneys.

Interaksi Obat

935 Data
Alfuzosin Alfuzosin may increase the hypotensive activities of Temocapril.
Amifostine Temocapril may increase the hypotensive activities of Amifostine.
Diazoxide Diazoxide may increase the hypotensive activities of Temocapril.
Methylphenidate Methylphenidate may decrease the antihypertensive activities of Temocapril.
Dexmethylphenidate Dexmethylphenidate may decrease the antihypertensive activities of Temocapril.
Obinutuzumab Temocapril may increase the hypotensive activities of Obinutuzumab.
Pentoxifylline Pentoxifylline may increase the hypotensive activities of Temocapril.
Rituximab Temocapril may increase the hypotensive activities of Rituximab.
Desmopressin Desmopressin may decrease the antihypertensive activities of Temocapril.
Phentermine Phentermine may decrease the antihypertensive activities of Temocapril.
Midodrine Midodrine may decrease the antihypertensive activities of Temocapril.
Eletriptan Eletriptan may decrease the antihypertensive activities of Temocapril.
Isoetharine Isoetharine may decrease the antihypertensive activities of Temocapril.
Methysergide Methysergide may decrease the antihypertensive activities of Temocapril.
Cabergoline Cabergoline may decrease the antihypertensive activities of Temocapril.
Atomoxetine Atomoxetine may decrease the antihypertensive activities of Temocapril.
Etomidate Etomidate may decrease the antihypertensive activities of Temocapril.
Zolmitriptan Zolmitriptan may decrease the antihypertensive activities of Temocapril.
Dihydroergotamine Dihydroergotamine may decrease the antihypertensive activities of Temocapril.
Amitriptyline Amitriptyline may decrease the antihypertensive activities of Temocapril.
Protriptyline Protriptyline may decrease the antihypertensive activities of Temocapril.
Methylergometrine Methylergometrine may decrease the antihypertensive activities of Temocapril.
Norepinephrine Norepinephrine may decrease the antihypertensive activities of Temocapril.
Mirtazapine Mirtazapine may decrease the antihypertensive activities of Temocapril.
Phenylephrine Phenylephrine may decrease the antihypertensive activities of Temocapril.
Phenylpropanolamine Phenylpropanolamine may decrease the antihypertensive activities of Temocapril.
Promazine Promazine may decrease the antihypertensive activities of Temocapril.
Droperidol Droperidol may decrease the antihypertensive activities of Temocapril.
Buspirone Buspirone may decrease the antihypertensive activities of Temocapril.
Nortriptyline Nortriptyline may decrease the antihypertensive activities of Temocapril.
Amoxapine Amoxapine may decrease the antihypertensive activities of Temocapril.
Doxapram Doxapram may decrease the antihypertensive activities of Temocapril.
Atropine Atropine may decrease the antihypertensive activities of Temocapril.
Lisuride Lisuride may decrease the antihypertensive activities of Temocapril.
Metaraminol Metaraminol may decrease the antihypertensive activities of Temocapril.
Trazodone Trazodone may decrease the antihypertensive activities of Temocapril.
Epinephrine Epinephrine may decrease the antihypertensive activities of Temocapril.
Sumatriptan Sumatriptan may decrease the antihypertensive activities of Temocapril.
Ergotamine Ergotamine may decrease the antihypertensive activities of Temocapril.
Nicergoline Nicergoline may decrease the antihypertensive activities of Temocapril.
Methoxamine Methoxamine may decrease the antihypertensive activities of Temocapril.
Trimipramine Trimipramine may decrease the antihypertensive activities of Temocapril.
Risperidone Risperidone may decrease the antihypertensive activities of Temocapril.
Propiomazine Propiomazine may decrease the antihypertensive activities of Temocapril.
Alfentanil Alfentanil may decrease the antihypertensive activities of Temocapril.
Fentanyl Fentanyl may decrease the antihypertensive activities of Temocapril.
Orciprenaline Orciprenaline may decrease the antihypertensive activities of Temocapril.
Phenmetrazine Phenmetrazine may decrease the antihypertensive activities of Temocapril.
Trifluoperazine Trifluoperazine may decrease the antihypertensive activities of Temocapril.
Dobutamine Dobutamine may decrease the antihypertensive activities of Temocapril.
Pseudoephedrine Pseudoephedrine may decrease the antihypertensive activities of Temocapril.
Benzphetamine Benzphetamine may decrease the antihypertensive activities of Temocapril.
Ritodrine Ritodrine may decrease the antihypertensive activities of Temocapril.
Terbutaline Terbutaline may decrease the antihypertensive activities of Temocapril.
Flupentixol Flupentixol may decrease the antihypertensive activities of Temocapril.
Bitolterol Bitolterol may decrease the antihypertensive activities of Temocapril.
Almotriptan Almotriptan may decrease the antihypertensive activities of Temocapril.
Diethylpropion Diethylpropion may decrease the antihypertensive activities of Temocapril.
Salmeterol Salmeterol may decrease the antihypertensive activities of Temocapril.
Naratriptan Naratriptan may decrease the antihypertensive activities of Temocapril.
Rizatriptan Rizatriptan may decrease the antihypertensive activities of Temocapril.
Formoterol Formoterol may decrease the antihypertensive activities of Temocapril.
Dopamine Dopamine may decrease the antihypertensive activities of Temocapril.
Frovatriptan Frovatriptan may decrease the antihypertensive activities of Temocapril.
Albuterol Salbutamol may decrease the antihypertensive activities of Temocapril.
Methoxyflurane Methoxyflurane may decrease the antihypertensive activities of Temocapril.
Ergoloid mesylate Ergoloid mesylate may decrease the antihypertensive activities of Temocapril.
Isoprenaline Isoprenaline may decrease the antihypertensive activities of Temocapril.
Arbutamine Arbutamine may decrease the antihypertensive activities of Temocapril.
Dutasteride Dutasteride may decrease the antihypertensive activities of Temocapril.
Doxepin Doxepin may decrease the antihypertensive activities of Temocapril.
Nefazodone Nefazodone may decrease the antihypertensive activities of Temocapril.
Desipramine Desipramine may decrease the antihypertensive activities of Temocapril.
Pergolide Pergolide may decrease the antihypertensive activities of Temocapril.
Finasteride Finasteride may decrease the antihypertensive activities of Temocapril.
Ergometrine Ergometrine may decrease the antihypertensive activities of Temocapril.
Lisdexamfetamine Lisdexamfetamine may decrease the antihypertensive activities of Temocapril.
Paliperidone Paliperidone may decrease the antihypertensive activities of Temocapril.
Arformoterol Arformoterol may decrease the antihypertensive activities of Temocapril.
Fenoterol Fenoterol may decrease the antihypertensive activities of Temocapril.
Pirbuterol Pirbuterol may decrease the antihypertensive activities of Temocapril.
Ephedra sinica root Ephedra sinica root may decrease the antihypertensive activities of Temocapril.
Ephedrine Ephedrine may decrease the antihypertensive activities of Temocapril.
Mephentermine Mephentermine may decrease the antihypertensive activities of Temocapril.
Procaterol Procaterol may decrease the antihypertensive activities of Temocapril.
Yohimbine Yohimbine may decrease the antihypertensive activities of Temocapril.
Methotrimeprazine Methotrimeprazine may decrease the antihypertensive activities of Temocapril.
Clenbuterol Clenbuterol may decrease the antihypertensive activities of Temocapril.
Bambuterol Bambuterol may decrease the antihypertensive activities of Temocapril.
MMDA MMDA may decrease the antihypertensive activities of Temocapril.
Midomafetamine Midomafetamine may decrease the antihypertensive activities of Temocapril.
2,5-Dimethoxy-4-ethylamphetamine 2,5-Dimethoxy-4-ethylamphetamine may decrease the antihypertensive activities of Temocapril.
4-Methoxyamphetamine 4-Methoxyamphetamine may decrease the antihypertensive activities of Temocapril.
4-Bromo-2,5-dimethoxyamphetamine 4-Bromo-2,5-dimethoxyamphetamine may decrease the antihypertensive activities of Temocapril.
Tenamfetamine Tenamfetamine may decrease the antihypertensive activities of Temocapril.
Chlorphentermine Chlorphentermine may decrease the antihypertensive activities of Temocapril.
Dextroamphetamine Dextroamphetamine may decrease the antihypertensive activities of Temocapril.
Metamfetamine Metamfetamine may decrease the antihypertensive activities of Temocapril.
Phendimetrazine Phendimetrazine may decrease the antihypertensive activities of Temocapril.
Solifenacin Solifenacin may decrease the antihypertensive activities of Temocapril.

Target Protein

Angiotensin-converting enzyme ACE

Referensi & Sumber

Artikel (PubMed)
  • PMID: 15618677
    Tsuji A: Transporter-mediated Drug Interactions. Drug Metab Pharmacokinet. 2002;17(4):253-74.
  • PMID: 8513851
    Furuta S, Kiyosawa K, Higuchi M, Kasahara H, Saito H, Shioya H, Oguchi H: Pharmacokinetics of temocapril, an ACE inhibitor with preferential biliary excretion, in patients with impaired liver function. Eur J Clin Pharmacol. 1993;44(4):383-5.
  • PMID: 1493850
    Nakashima M, Yamamoto J, Shibata M, Uematsu T, Shinjo H, Akahori T, Shioya H, Sugiyama K, Kawahara Y: Pharmacokinetics of temocapril hydrochloride, a novel angiotensin converting enzyme inhibitor, in renal insufficiency. Eur J Clin Pharmacol. 1992;43(6):657-9.
  • PMID: 15492767
    Yasunari K, Maeda K, Nakamura M, Watanabe T, Yoshikawa J, Asada A: Pharmacological and clinical studies with temocapril, an angiotensin converting enzyme inhibitor that is excreted in the bile. Cardiovasc Drug Rev. 2004 Fall;22(3):189-98.

Contoh Produk & Brand

Produk: 0 • International brands: 1
International Brands
  • Acecol — Sankyo

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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