Dehydroascorbic acid

DB08830

small molecule experimental

Deskripsi

Dehydroascorbic acid is made from the oxidation of ascorbic acid. This reaction is reversible, but dehydroascorbic acid can instead undergo irreversible hydrolysis to 2,3-diketogulonic acid. Dehydroascorbic acid as well as ascorbic acid are both termed Vitamin C, but the latter is the main form found in humans. In the body, both dehydroascorbic acid and ascorbic acid have similar biological activity as antivirals but dehydroascorbic acid also has neuroprotective effects. Currently dehydroascorbic acid is an experimental drug with no known approved indications.

Struktur Molekul 2D

Berat 174.1082
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

64 Data
Bortezomib The therapeutic efficacy of Bortezomib can be decreased when used in combination with Dehydroascorbic acid.
Copper The serum concentration of Dehydroascorbic acid can be decreased when it is combined with Copper.
Deferoxamine The risk or severity of Cardiovascular Impairment can be increased when Dehydroascorbic acid is combined with Deferoxamine.
Chlorpropamide Dehydroascorbic acid may decrease the excretion rate of Chlorpropamide which could result in a higher serum level.
Mecamylamine Dehydroascorbic acid may increase the excretion rate of Mecamylamine which could result in a lower serum level and potentially a reduction in efficacy.
Diethylstilbestrol The serum concentration of Dehydroascorbic acid can be decreased when it is combined with Diethylstilbestrol.
Chlorotrianisene The serum concentration of Dehydroascorbic acid can be decreased when it is combined with Chlorotrianisene.
Conjugated estrogens The serum concentration of Dehydroascorbic acid can be decreased when it is combined with Conjugated estrogens.
Estrone The serum concentration of Dehydroascorbic acid can be decreased when it is combined with Estrone.
Estradiol The serum concentration of Dehydroascorbic acid can be decreased when it is combined with Estradiol.
Dienestrol The serum concentration of Dehydroascorbic acid can be decreased when it is combined with Dienestrol.
Ethinylestradiol The serum concentration of Dehydroascorbic acid can be decreased when it is combined with Ethinylestradiol.
Polyestradiol phosphate The serum concentration of Dehydroascorbic acid can be decreased when it is combined with Polyestradiol phosphate.
Mestranol The serum concentration of Dehydroascorbic acid can be decreased when it is combined with Mestranol.
Quinestrol The serum concentration of Dehydroascorbic acid can be decreased when it is combined with Quinestrol.
Hexestrol The serum concentration of Dehydroascorbic acid can be decreased when it is combined with Hexestrol.
Synthetic Conjugated Estrogens, A The serum concentration of Dehydroascorbic acid can be decreased when it is combined with Synthetic Conjugated Estrogens, A.
Synthetic Conjugated Estrogens, B The serum concentration of Dehydroascorbic acid can be decreased when it is combined with Synthetic Conjugated Estrogens, B.
Zeranol The serum concentration of Dehydroascorbic acid can be decreased when it is combined with Zeranol.
Equol The serum concentration of Dehydroascorbic acid can be decreased when it is combined with Equol.
Epimestrol The serum concentration of Dehydroascorbic acid can be decreased when it is combined with Epimestrol.
Estriol The serum concentration of Dehydroascorbic acid can be decreased when it is combined with Estriol.
Tibolone The serum concentration of Dehydroascorbic acid can be decreased when it is combined with Tibolone.
Promestriene The serum concentration of Dehydroascorbic acid can be decreased when it is combined with Promestriene.
Methallenestril The serum concentration of Dehydroascorbic acid can be decreased when it is combined with Methallenestril.
Moxestrol The serum concentration of Dehydroascorbic acid can be decreased when it is combined with Moxestrol.
Estradiol acetate The serum concentration of Dehydroascorbic acid can be decreased when it is combined with Estradiol acetate.
Estradiol cypionate The serum concentration of Dehydroascorbic acid can be decreased when it is combined with Estradiol cypionate.
Estradiol valerate The serum concentration of Dehydroascorbic acid can be decreased when it is combined with Estradiol valerate.
Esterified estrogens The serum concentration of Dehydroascorbic acid can be decreased when it is combined with Esterified estrogens.
Estrone sulfate The serum concentration of Dehydroascorbic acid can be decreased when it is combined with Estrone sulfate.
Estradiol benzoate The serum concentration of Dehydroascorbic acid can be decreased when it is combined with Estradiol benzoate.
Biochanin A The serum concentration of Dehydroascorbic acid can be decreased when it is combined with Biochanin A.
Formononetin The serum concentration of Dehydroascorbic acid can be decreased when it is combined with Formononetin.
Estetrol The serum concentration of Dehydroascorbic acid can be decreased when it is combined with Estetrol.
Amphetamine The serum concentration of Amphetamine can be decreased when it is combined with Dehydroascorbic acid.
Phentermine The serum concentration of Phentermine can be decreased when it is combined with Dehydroascorbic acid.
Pseudoephedrine The serum concentration of Pseudoephedrine can be decreased when it is combined with Dehydroascorbic acid.
Benzphetamine The serum concentration of Benzphetamine can be decreased when it is combined with Dehydroascorbic acid.
Diethylpropion The serum concentration of Diethylpropion can be decreased when it is combined with Dehydroascorbic acid.
Lisdexamfetamine The serum concentration of Lisdexamfetamine can be decreased when it is combined with Dehydroascorbic acid.
Mephentermine The serum concentration of Mephentermine can be decreased when it is combined with Dehydroascorbic acid.
MMDA The serum concentration of MMDA can be decreased when it is combined with Dehydroascorbic acid.
Midomafetamine The serum concentration of Midomafetamine can be decreased when it is combined with Dehydroascorbic acid.
2,5-Dimethoxy-4-ethylamphetamine The serum concentration of 2,5-Dimethoxy-4-ethylamphetamine can be decreased when it is combined with Dehydroascorbic acid.
4-Bromo-2,5-dimethoxyamphetamine The serum concentration of 4-Bromo-2,5-dimethoxyamphetamine can be decreased when it is combined with Dehydroascorbic acid.
Tenamfetamine The serum concentration of Tenamfetamine can be decreased when it is combined with Dehydroascorbic acid.
Chlorphentermine The serum concentration of Chlorphentermine can be decreased when it is combined with Dehydroascorbic acid.
Methylenedioxyethamphetamine The serum concentration of Methylenedioxyethamphetamine can be decreased when it is combined with Dehydroascorbic acid.
Dextroamphetamine The serum concentration of Dextroamphetamine can be decreased when it is combined with Dehydroascorbic acid.
Metamfetamine The serum concentration of Metamfetamine can be decreased when it is combined with Dehydroascorbic acid.
Iofetamine I-123 The serum concentration of Iofetamine I-123 can be decreased when it is combined with Dehydroascorbic acid.
Ritobegron The serum concentration of Ritobegron can be decreased when it is combined with Dehydroascorbic acid.
Mephedrone The serum concentration of Mephedrone can be decreased when it is combined with Dehydroascorbic acid.
Methoxyphenamine The serum concentration of Methoxyphenamine can be decreased when it is combined with Dehydroascorbic acid.
Gepefrine The serum concentration of Gepefrine can be decreased when it is combined with Dehydroascorbic acid.
2,5-Dimethoxy-4-ethylthioamphetamine The serum concentration of 2,5-Dimethoxy-4-ethylthioamphetamine can be decreased when it is combined with Dehydroascorbic acid.
Phendimetrazine The serum concentration of Phendimetrazine can be decreased when it is combined with Dehydroascorbic acid.
Erythromycin The therapeutic efficacy of Erythromycin can be decreased when used in combination with Dehydroascorbic acid.
Kanamycin The therapeutic efficacy of Kanamycin can be decreased when used in combination with Dehydroascorbic acid.
Streptomycin The therapeutic efficacy of Streptomycin can be decreased when used in combination with Dehydroascorbic acid.
Doxycycline The therapeutic efficacy of Doxycycline can be decreased when used in combination with Dehydroascorbic acid.
Lincomycin The therapeutic efficacy of Lincomycin can be decreased when used in combination with Dehydroascorbic acid.
Bleomycin The therapeutic efficacy of Bleomycin can be decreased when used in combination with Dehydroascorbic acid.

Referensi & Sumber

Artikel (PubMed)
  • PMID: 9389750
    Agus DB, Gambhir SS, Pardridge WM, Spielholz C, Baselga J, Vera JC, Golde DW: Vitamin C crosses the blood-brain barrier in the oxidized form through the glucose transporters. J Clin Invest. 1997 Dec 1;100(11):2842-8.
  • PMID: 11573006
    Huang J, Agus DB, Winfree CJ, Kiss S, Mack WJ, McTaggart RA, Choudhri TF, Kim LJ, Mocco J, Pinsky DJ, Fox WD, Israel RJ, Boyd TA, Golde DW, Connolly ES Jr: Dehydroascorbic acid, a blood-brain barrier transportable form of vitamin C, mediates potent cerebroprotection in experimental stroke. Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11720-4.
  • PMID: 18813862
    Furuya A, Uozaki M, Yamasaki H, Arakawa T, Arita M, Koyama AH: Antiviral effects of ascorbic and dehydroascorbic acids in vitro. Int J Mol Med. 2008 Oct;22(4):541-5.

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