Agranulocytosis and neutropenia may occur, which can lead to fatal infections. Hepatoxicity is also possible. Most common side effects that lead to discontinuation of therapy were the gastrointestinal adverse effects (diarrhea, ulcer, nausea, gastrointestinal disturbances)
Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA approved on October 14, 2011.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Calcium acetate | The serum concentration of Deferiprone can be decreased when it is combined with Calcium acetate. |
| Calcium glucoheptonate | The serum concentration of Deferiprone can be decreased when it is combined with Calcium glucoheptonate. |
| Calcium chloride | The serum concentration of Deferiprone can be decreased when it is combined with Calcium chloride. |
| Calcium | The serum concentration of Deferiprone can be decreased when it is combined with Calcium. |
| Calcium carbonate | The serum concentration of Deferiprone can be decreased when it is combined with Calcium carbonate. |
| Calcium citrate | The serum concentration of Deferiprone can be decreased when it is combined with Calcium citrate. |
| Calcium gluconate | The serum concentration of Deferiprone can be decreased when it is combined with Calcium gluconate. |
| Calcium Phosphate | The serum concentration of Deferiprone can be decreased when it is combined with Calcium Phosphate. |
| Calcium lactate | The serum concentration of Deferiprone can be decreased when it is combined with Calcium lactate. |
| Calcium lactate gluconate | The serum concentration of Deferiprone can be decreased when it is combined with Calcium lactate gluconate. |
| Calcium pangamate | The serum concentration of Deferiprone can be decreased when it is combined with Calcium pangamate. |
| Calcium polycarbophil | The serum concentration of Deferiprone can be decreased when it is combined with Calcium polycarbophil. |
| Troglitazone | The serum concentration of Deferiprone can be increased when it is combined with Troglitazone. |
| Phenytoin | The serum concentration of Deferiprone can be increased when it is combined with Phenytoin. |
| Fosphenytoin | The serum concentration of Deferiprone can be increased when it is combined with Fosphenytoin. |
| Eltrombopag | The serum concentration of Deferiprone can be increased when it is combined with Eltrombopag. |
| Magnesium sulfate | Magnesium sulfate can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Magnesium oxide | Magnesium oxide can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Magnesium salicylate | Magnesium salicylate can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Magaldrate | Magaldrate can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Magnesium hydroxide | Magnesium hydroxide can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Magnesium trisilicate | Magnesium trisilicate can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Magnesium chloride | Magnesium chloride can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Magnesium carbonate | Magnesium carbonate can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Talc | Talc can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Magnesium citrate | Magnesium citrate can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Magnesium silicate | Magnesium silicate can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Hydrotalcite | Hydrotalcite can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Magnesium aspartate | Magnesium aspartate can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Magnesium peroxide | Magnesium peroxide can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Magnesium gluconate | Magnesium gluconate can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Magnesium orotate | Magnesium orotate can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Magnesium | Magnesium can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Magnesium levulinate | Magnesium levulinate can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Magnesium lactate | Magnesium lactate can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Zinc | Zinc can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Zinc trihydroxide | Zinc trihydroxide can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Zinc Substituted Heme C | Zinc Substituted Heme C can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Polaprezinc | Polaprezinc can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Zinc oxide | Zinc oxide can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Zinc sulfate | Zinc sulfate can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Zinc citrate | Zinc citrate can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Zinc picolinate | Zinc picolinate can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Zinc gluconate | Zinc gluconate can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Acetylcysteine zinc | Acetylcysteine zinc can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Zinc ascorbate | Zinc ascorbate can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Zinc acetate | Zinc acetate can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Zinc glycinate | Zinc glycinate can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Zinc chloride | Zinc chloride can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Zinc sulfate, unspecified form | Zinc sulfate, unspecified form can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Zinc cation | Zinc cation can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Selenium | Selenium can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Magnesium cation | Magnesium cation can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Ferrous ascorbate | Ferrous ascorbate can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Aluminum cation | Aluminum cation can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Nitroprusside | The serum concentration of Deferiprone can be decreased when it is combined with Nitroprusside. |
| Iron Dextran | The serum concentration of Deferiprone can be decreased when it is combined with Iron Dextran. |
| Iron | The serum concentration of Deferiprone can be decreased when it is combined with Iron. |
| Ferumoxytol | The serum concentration of Deferiprone can be decreased when it is combined with Ferumoxytol. |
| Prussian blue | The serum concentration of Deferiprone can be decreased when it is combined with Prussian blue. |
| Ferric carboxymaltose | The serum concentration of Deferiprone can be decreased when it is combined with Ferric carboxymaltose. |
| Iron sucrose | The serum concentration of Deferiprone can be decreased when it is combined with Iron sucrose. |
| Ferric pyrophosphate | The serum concentration of Deferiprone can be decreased when it is combined with Ferric pyrophosphate. |
| Ferric ammonium citrate | The serum concentration of Deferiprone can be decreased when it is combined with Ferric ammonium citrate. |
| Ferumoxsil | The serum concentration of Deferiprone can be decreased when it is combined with Ferumoxsil. |
| Ferumoxides | The serum concentration of Deferiprone can be decreased when it is combined with Ferumoxides. |
| Ferric sulfate | The serum concentration of Deferiprone can be decreased when it is combined with Ferric sulfate. |
| Ferrous bisglycinate | The serum concentration of Deferiprone can be decreased when it is combined with Ferrous bisglycinate. |
| Gleptoferron | The serum concentration of Deferiprone can be decreased when it is combined with Gleptoferron. |
| Ferric oxide | The serum concentration of Deferiprone can be decreased when it is combined with Ferric oxide. |
| Perflubutane | The serum concentration of Deferiprone can be decreased when it is combined with Perflubutane. |
| Ferrous sulfate anhydrous | Ferrous sulfate anhydrous can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Sodium feredetate | The serum concentration of Deferiprone can be decreased when it is combined with Sodium feredetate. |
| Ferric hydroxide | The serum concentration of Deferiprone can be decreased when it is combined with Ferric hydroxide. |
| Ferrous chloride | The serum concentration of Deferiprone can be decreased when it is combined with Ferrous chloride. |
| Ferric cation | Ferric cation can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Ferrous gluconate | Ferrous gluconate can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Ferrous succinate | The serum concentration of Deferiprone can be decreased when it is combined with Ferrous succinate. |
| Ferrous fumarate | The serum concentration of Deferiprone can be decreased when it is combined with Ferrous fumarate. |
| Tetraferric tricitrate decahydrate | The serum concentration of Deferiprone can be decreased when it is combined with Tetraferric tricitrate decahydrate. |
| Ferric oxyhydroxide | The serum concentration of Deferiprone can be decreased when it is combined with Ferric oxyhydroxide. |
| Ferric maltol | The serum concentration of Deferiprone can be decreased when it is combined with Ferric maltol. |
| Iron isomaltoside 1000 | The serum concentration of Deferiprone can be decreased when it is combined with Iron isomaltoside 1000. |
| Iron polymaltose | The serum concentration of Deferiprone can be decreased when it is combined with Iron polymaltose. |
| Technetium Tc-99m oxidronate | Deferiprone may decrease effectiveness of Technetium Tc-99m oxidronate as a diagnostic agent. |
| Cyclosporine | Cyclosporine may decrease the excretion rate of Deferiprone which could result in a higher serum level. |
| Icosapent | Icosapent may decrease the excretion rate of Deferiprone which could result in a higher serum level. |
| Cefotiam | Cefotiam may decrease the excretion rate of Deferiprone which could result in a higher serum level. |
| Mesalazine | Mesalazine may decrease the excretion rate of Deferiprone which could result in a higher serum level. |
| Cefmenoxime | Cefmenoxime may decrease the excretion rate of Deferiprone which could result in a higher serum level. |
| Cefmetazole | Cefmetazole may decrease the excretion rate of Deferiprone which could result in a higher serum level. |
| Pamidronic acid | Pamidronic acid may decrease the excretion rate of Deferiprone which could result in a higher serum level. |
| Tenofovir disoproxil | Tenofovir disoproxil may decrease the excretion rate of Deferiprone which could result in a higher serum level. |
| Indomethacin | Indomethacin may decrease the excretion rate of Deferiprone which could result in a higher serum level. |
| Cidofovir | Cidofovir may decrease the excretion rate of Deferiprone which could result in a higher serum level. |
| Cefpiramide | Cefpiramide may decrease the excretion rate of Deferiprone which could result in a higher serum level. |
| Ceftazidime | Ceftazidime may decrease the excretion rate of Deferiprone which could result in a higher serum level. |
| Loracarbef | Loracarbef may decrease the excretion rate of Deferiprone which could result in a higher serum level. |
| Cefalotin | Cefalotin may decrease the excretion rate of Deferiprone which could result in a higher serum level. |
| Nabumetone | Nabumetone may decrease the excretion rate of Deferiprone which could result in a higher serum level. |