Ioflupane I-123

DB08824

small molecule approved

Deskripsi

Ioflupane (I-123) is a radiopharmaceutical used to image dopamine neurons and diagnose Parkinsonian syndromes.

Struktur Molekul 2D

Berat 427.291
Wujud liquid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Half life is 13.2 hours.
Volume Distribusi Compared to the entire brain, about 30% of radioactivity is taken up by the striatum.
Klirens (Clearance) -

Absorpsi

Absorption is 100% because administered I.V.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

About 60% is excreted in the urine and 14% in the feces after 48 hours.

Interaksi Makanan

1 Data
  • 1. Take with or without food.

Interaksi Obat

767 Data
Fluvoxamine Fluvoxamine may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
Citalopram Citalopram may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
Fluoxetine Fluoxetine may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
Duloxetine Duloxetine may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
Trazodone Trazodone may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
Paroxetine Paroxetine may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
Sertraline Sertraline may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
Sibutramine Sibutramine may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
Nefazodone Nefazodone may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
Escitalopram Escitalopram may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
Zimelidine Zimelidine may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
Dapoxetine Dapoxetine may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
Milnacipran Milnacipran may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
Desvenlafaxine Desvenlafaxine may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
Seproxetine Seproxetine may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
Levomilnacipran Levomilnacipran may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
Indalpine Indalpine may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
Ritanserin Ritanserin may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
Alaproclate Alaproclate may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
Amphetamine Amphetamine may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
Phentermine Phentermine may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
Pseudoephedrine Pseudoephedrine may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
Benzphetamine Benzphetamine may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
Diethylpropion Diethylpropion may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
Lisdexamfetamine Lisdexamfetamine may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
Mephentermine Mephentermine may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
MMDA MMDA may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
Midomafetamine Midomafetamine may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
2,5-Dimethoxy-4-ethylamphetamine 2,5-Dimethoxy-4-ethylamphetamine may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
4-Bromo-2,5-dimethoxyamphetamine 4-Bromo-2,5-dimethoxyamphetamine may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
Tenamfetamine Tenamfetamine may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
Chlorphentermine Chlorphentermine may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
Methylenedioxyethamphetamine Methylenedioxyethamphetamine may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
Dextroamphetamine Dextroamphetamine may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
Metamfetamine Metamfetamine may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
Iofetamine I-123 Iofetamine I-123 may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
Ritobegron Ritobegron may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
Mephedrone Mephedrone may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
Methoxyphenamine Methoxyphenamine may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
Gepefrine Gepefrine may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
2,5-Dimethoxy-4-ethylthioamphetamine 2,5-Dimethoxy-4-ethylthioamphetamine may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
Phendimetrazine Phendimetrazine may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
Benzatropine Benzatropine may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
Venlafaxine Venlafaxine may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
Norepinephrine Norepinephrine may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
Phenylephrine Phenylephrine may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
Methylphenidate Methylphenidate may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
Dexmethylphenidate Dexmethylphenidate may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
Buspirone Buspirone may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
Amoxapine Amoxapine may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
Fentanyl Fentanyl may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
Cocaine Cocaine may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
Selegiline Selegiline may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
Bupropion Bupropion may decrease effectiveness of Ioflupane I-123 as a diagnostic agent.
Cyclosporine Cyclosporine may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level.
Icosapent Icosapent may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level.
Cefotiam Cefotiam may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level.
Mesalazine Mesalazine may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level.
Cefmenoxime Cefmenoxime may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level.
Cefmetazole Cefmetazole may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level.
Pamidronic acid Pamidronic acid may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level.
Tenofovir disoproxil Tenofovir disoproxil may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level.
Indomethacin Indomethacin may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level.
Cidofovir Cidofovir may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level.
Cefpiramide Cefpiramide may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level.
Ceftazidime Ceftazidime may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level.
Loracarbef Loracarbef may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level.
Cefalotin Cefalotin may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level.
Nabumetone Nabumetone may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level.
Ketorolac Ketorolac may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level.
Tenoxicam Tenoxicam may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level.
Celecoxib Celecoxib may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level.
Cefotaxime Cefotaxime may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level.
Tolmetin Tolmetin may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level.
Foscarnet Foscarnet may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level.
Rofecoxib Rofecoxib may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level.
Piroxicam Piroxicam may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level.
Methotrexate Methotrexate may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level.
Cephalexin Cephalexin may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level.
Fenoprofen Fenoprofen may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level.
Valaciclovir Valaciclovir may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level.
Valdecoxib Valdecoxib may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level.
Diclofenac Diclofenac may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level.
Sulindac Sulindac may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level.
Bacitracin Bacitracin may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level.
Amphotericin B Amphotericin B may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level.
Cephaloglycin Cephaloglycin may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level.
Flurbiprofen Flurbiprofen may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level.
Adefovir dipivoxil Adefovir dipivoxil may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level.
Pentamidine Pentamidine may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level.
Etodolac Etodolac may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level.
Mefenamic acid Mefenamic acid may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level.
Acyclovir Acyclovir may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level.
Naproxen Naproxen may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level.
Sulfasalazine Sulfasalazine may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level.
Phenylbutazone Phenylbutazone may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level.
Meloxicam Meloxicam may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level.
Carprofen Carprofen may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level.
Cefaclor Cefaclor may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level.
Diflunisal Diflunisal may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level.

Target Protein

Sodium-dependent dopamine transporter SLC6A3

Referensi & Sumber

Artikel (PubMed)
  • PMID: 17914722
    Tolosa E, Borght TV, Moreno E: Accuracy of DaTSCAN (123I-Ioflupane) SPECT in diagnosis of patients with clinically uncertain parkinsonism: 2-year follow-up of an open-label study. Mov Disord. 2007 Dec;22(16):2346-51.
  • PMID: 10830416
    Benamer TS, Patterson J, Grosset DG, Booij J, de Bruin K, van Royen E, Speelman JD, Horstink MH, Sips HJ, Dierckx RA, Versijpt J, Decoo D, Van Der Linden C, Hadley DM, Doder M, Lees AJ, Costa DC, Gacinovic S, Oertel WH, Pogarell O, Hoeffken H, Joseph K, Tatsch K, Schwarz J, Ries V: Accurate differentiation of parkinsonism and essential tremor using visual assessment of 123I-FP-CIT SPECT imaging: the 123I-FP-CIT study group. Mov Disord. 2000 May;15(3):503-10.
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Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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