Peringatan Keamanan

Most common ocular adverse reaction is conjunctival hyperemia (range 4% – 20%).

Tafluprost

DB08819

small molecule approved

Deskripsi

A prostaglandin analogue ester prodrug used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. Chemically, tafluprost is a fluorinated analog of prostaglandin F2-alpha. Tafluprost was approved for use in the U.S. on February 10, 2012.

Struktur Molekul 2D

Berat 452.5313
Wujud liquid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi The highest concentration of tafluprost acid was found in the cornea and conjunctiva.
Klirens (Clearance) -

Absorpsi

Following instillation, tafluprost is absorbed through the cornea and is hydrolyzed to the biologically active acid metabolite, tafluprost acid. Tafluprost is an ester which makes the drug lipophillic enough to be quickly absorbed through. When administered to the eye, the peak plasma concentration (Cmax) and time to peak plasma concentration (Tmax) of tafluprost acid in healthy subjects was 26 pg/mL and 10 minutes respectively. a AUC, tafluprost acid = 394 pg*min/mL - 432 pg*min/mL.

Metabolisme

Tafluprost is an ester prodrug which is rapidly hydrolyzed by corneal esterases to form its biologically active acid metabolite. Tafluprost acid is further metabolized via fatty acid ?-oxidation and phase II conjugation into 1,2,3,4-tetranor acid.

Rute Eliminasi

Mean plasma tafluprost acid concentrations were below the limit of quantification of the bioanalytical assay (10 pg/mL) at 30 minutes following topical ocular administration of tafluprost 0.0015% ophthalmic solution. In male rats, it was observed that tafluprost was excreted into the feces.

Interaksi Obat

105 Data
Icosapent The therapeutic efficacy of Tafluprost can be decreased when used in combination with Icosapent.
Indomethacin The therapeutic efficacy of Tafluprost can be decreased when used in combination with Indomethacin.
Nabumetone The therapeutic efficacy of Tafluprost can be decreased when used in combination with Nabumetone.
Ketorolac The therapeutic efficacy of Tafluprost can be decreased when used in combination with Ketorolac.
Tenoxicam The therapeutic efficacy of Tafluprost can be decreased when used in combination with Tenoxicam.
Celecoxib The therapeutic efficacy of Tafluprost can be decreased when used in combination with Celecoxib.
Tolmetin The therapeutic efficacy of Tafluprost can be decreased when used in combination with Tolmetin.
Rofecoxib The therapeutic efficacy of Tafluprost can be decreased when used in combination with Rofecoxib.
Piroxicam The therapeutic efficacy of Tafluprost can be decreased when used in combination with Piroxicam.
Fenoprofen The therapeutic efficacy of Tafluprost can be decreased when used in combination with Fenoprofen.
Valdecoxib The therapeutic efficacy of Tafluprost can be decreased when used in combination with Valdecoxib.
Diclofenac The therapeutic efficacy of Tafluprost can be decreased when used in combination with Diclofenac.
Sulindac The therapeutic efficacy of Tafluprost can be decreased when used in combination with Sulindac.
Flurbiprofen The therapeutic efficacy of Tafluprost can be decreased when used in combination with Flurbiprofen.
Etodolac The therapeutic efficacy of Tafluprost can be decreased when used in combination with Etodolac.
Mefenamic acid The therapeutic efficacy of Tafluprost can be decreased when used in combination with Mefenamic acid.
Naproxen The therapeutic efficacy of Tafluprost can be decreased when used in combination with Naproxen.
Sulfasalazine The therapeutic efficacy of Tafluprost can be decreased when used in combination with Sulfasalazine.
Phenylbutazone The therapeutic efficacy of Tafluprost can be decreased when used in combination with Phenylbutazone.
Meloxicam The therapeutic efficacy of Tafluprost can be decreased when used in combination with Meloxicam.
Carprofen The therapeutic efficacy of Tafluprost can be decreased when used in combination with Carprofen.
Diflunisal The therapeutic efficacy of Tafluprost can be decreased when used in combination with Diflunisal.
Salicylic acid The therapeutic efficacy of Tafluprost can be decreased when used in combination with Salicylic acid.
Meclofenamic acid The therapeutic efficacy of Tafluprost can be decreased when used in combination with Meclofenamic acid.
Acetylsalicylic acid The therapeutic efficacy of Tafluprost can be decreased when used in combination with Acetylsalicylic acid.
Oxaprozin The therapeutic efficacy of Tafluprost can be decreased when used in combination with Oxaprozin.
Ketoprofen The therapeutic efficacy of Tafluprost can be decreased when used in combination with Ketoprofen.
Balsalazide The therapeutic efficacy of Tafluprost can be decreased when used in combination with Balsalazide.
Ibuprofen The therapeutic efficacy of Tafluprost can be decreased when used in combination with Ibuprofen.
Lumiracoxib The therapeutic efficacy of Tafluprost can be decreased when used in combination with Lumiracoxib.
Magnesium salicylate The therapeutic efficacy of Tafluprost can be decreased when used in combination with Magnesium salicylate.
Salsalate The therapeutic efficacy of Tafluprost can be decreased when used in combination with Salsalate.
Choline magnesium trisalicylate The therapeutic efficacy of Tafluprost can be decreased when used in combination with Choline magnesium trisalicylate.
Antrafenine The therapeutic efficacy of Tafluprost can be decreased when used in combination with Antrafenine.
Aminophenazone The therapeutic efficacy of Tafluprost can be decreased when used in combination with Aminophenazone.
Antipyrine The therapeutic efficacy of Tafluprost can be decreased when used in combination with Antipyrine.
Tiaprofenic acid The therapeutic efficacy of Tafluprost can be decreased when used in combination with Tiaprofenic acid.
Etoricoxib The therapeutic efficacy of Tafluprost can be decreased when used in combination with Etoricoxib.
Taxifolin The therapeutic efficacy of Tafluprost can be decreased when used in combination with Taxifolin.
Oxyphenbutazone The therapeutic efficacy of Tafluprost can be decreased when used in combination with Oxyphenbutazone.
Licofelone The therapeutic efficacy of Tafluprost can be decreased when used in combination with Licofelone.
Nimesulide The therapeutic efficacy of Tafluprost can be decreased when used in combination with Nimesulide.
Benoxaprofen The therapeutic efficacy of Tafluprost can be decreased when used in combination with Benoxaprofen.
Zomepirac The therapeutic efficacy of Tafluprost can be decreased when used in combination with Zomepirac.
Cimicoxib The therapeutic efficacy of Tafluprost can be decreased when used in combination with Cimicoxib.
Lornoxicam The therapeutic efficacy of Tafluprost can be decreased when used in combination with Lornoxicam.
Aceclofenac The therapeutic efficacy of Tafluprost can be decreased when used in combination with Aceclofenac.
Zaltoprofen The therapeutic efficacy of Tafluprost can be decreased when used in combination with Zaltoprofen.
Azapropazone The therapeutic efficacy of Tafluprost can be decreased when used in combination with Azapropazone.
Parecoxib The therapeutic efficacy of Tafluprost can be decreased when used in combination with Parecoxib.
Salicylamide The therapeutic efficacy of Tafluprost can be decreased when used in combination with Salicylamide.
Kebuzone The therapeutic efficacy of Tafluprost can be decreased when used in combination with Kebuzone.
Isoxicam The therapeutic efficacy of Tafluprost can be decreased when used in combination with Isoxicam.
Indoprofen The therapeutic efficacy of Tafluprost can be decreased when used in combination with Indoprofen.
Ibuproxam The therapeutic efficacy of Tafluprost can be decreased when used in combination with Ibuproxam.
Floctafenine The therapeutic efficacy of Tafluprost can be decreased when used in combination with Floctafenine.
Fenbufen The therapeutic efficacy of Tafluprost can be decreased when used in combination with Fenbufen.
Etofenamate The therapeutic efficacy of Tafluprost can be decreased when used in combination with Etofenamate.
Epirizole The therapeutic efficacy of Tafluprost can be decreased when used in combination with Epirizole.
Benzydamine The therapeutic efficacy of Tafluprost can be decreased when used in combination with Benzydamine.
Dexibuprofen The therapeutic efficacy of Tafluprost can be decreased when used in combination with Dexibuprofen.
Dexketoprofen The therapeutic efficacy of Tafluprost can be decreased when used in combination with Dexketoprofen.
Droxicam The therapeutic efficacy of Tafluprost can be decreased when used in combination with Droxicam.
Tolfenamic acid The therapeutic efficacy of Tafluprost can be decreased when used in combination with Tolfenamic acid.
Firocoxib The therapeutic efficacy of Tafluprost can be decreased when used in combination with Firocoxib.
Clonixin The therapeutic efficacy of Tafluprost can be decreased when used in combination with Clonixin.
Morniflumate The therapeutic efficacy of Tafluprost can be decreased when used in combination with Morniflumate.
Propacetamol The therapeutic efficacy of Tafluprost can be decreased when used in combination with Propacetamol.
Talniflumate The therapeutic efficacy of Tafluprost can be decreased when used in combination with Talniflumate.
Robenacoxib The therapeutic efficacy of Tafluprost can be decreased when used in combination with Robenacoxib.
Tepoxalin The therapeutic efficacy of Tafluprost can be decreased when used in combination with Tepoxalin.
Flunixin The therapeutic efficacy of Tafluprost can be decreased when used in combination with Flunixin.
Polmacoxib The therapeutic efficacy of Tafluprost can be decreased when used in combination with Polmacoxib.
Nitroaspirin The therapeutic efficacy of Tafluprost can be decreased when used in combination with Nitroaspirin.
Indobufen The therapeutic efficacy of Tafluprost can be decreased when used in combination with Indobufen.
Ebselen The therapeutic efficacy of Tafluprost can be decreased when used in combination with Ebselen.
Tinoridine The therapeutic efficacy of Tafluprost can be decreased when used in combination with Tinoridine.
Alclofenac The therapeutic efficacy of Tafluprost can be decreased when used in combination with Alclofenac.
Fentiazac The therapeutic efficacy of Tafluprost can be decreased when used in combination with Fentiazac.
Suxibuzone The therapeutic efficacy of Tafluprost can be decreased when used in combination with Suxibuzone.
Bumadizone The therapeutic efficacy of Tafluprost can be decreased when used in combination with Bumadizone.
Alminoprofen The therapeutic efficacy of Tafluprost can be decreased when used in combination with Alminoprofen.
Difenpiramide The therapeutic efficacy of Tafluprost can be decreased when used in combination with Difenpiramide.
Nifenazone The therapeutic efficacy of Tafluprost can be decreased when used in combination with Nifenazone.
Lonazolac The therapeutic efficacy of Tafluprost can be decreased when used in combination with Lonazolac.
Tenidap The therapeutic efficacy of Tafluprost can be decreased when used in combination with Tenidap.
Propyphenazone The therapeutic efficacy of Tafluprost can be decreased when used in combination with Propyphenazone.
Proglumetacin The therapeutic efficacy of Tafluprost can be decreased when used in combination with Proglumetacin.
Guacetisal The therapeutic efficacy of Tafluprost can be decreased when used in combination with Guacetisal.
Ethenzamide The therapeutic efficacy of Tafluprost can be decreased when used in combination with Ethenzamide.
Carbaspirin calcium The therapeutic efficacy of Tafluprost can be decreased when used in combination with Carbaspirin calcium.
Mofebutazone The therapeutic efficacy of Tafluprost can be decreased when used in combination with Mofebutazone.
Proquazone The therapeutic efficacy of Tafluprost can be decreased when used in combination with Proquazone.
Benorilate The therapeutic efficacy of Tafluprost can be decreased when used in combination with Benorilate.
Pirprofen The therapeutic efficacy of Tafluprost can be decreased when used in combination with Pirprofen.
Acemetacin The therapeutic efficacy of Tafluprost can be decreased when used in combination with Acemetacin.
Imidazole salicylate The therapeutic efficacy of Tafluprost can be decreased when used in combination with Imidazole salicylate.
SC-236 The therapeutic efficacy of Tafluprost can be decreased when used in combination with SC-236.
NS-398 The therapeutic efficacy of Tafluprost can be decreased when used in combination with NS-398.
Flurbiprofen axetil The therapeutic efficacy of Tafluprost can be decreased when used in combination with Flurbiprofen axetil.

Target Protein

Prostaglandin F2-alpha receptor PTGFR

Referensi & Sumber

Artikel (PubMed)
  • PMID: 21916788
    Papadia M, Bagnis A, Scotto R, Traverso CE: Tafluprost for glaucoma. Expert Opin Pharmacother. 2011 Oct;12(15):2393-401. doi: 10.1517/14656566.2011.606810.
  • PMID: 21858491
    Pantcheva MB, Seibold LK, Awadallah NS, Kahook MY: Tafluprost: a novel prostaglandin analog for treatment of glaucoma. Adv Ther. 2011 Sep;28(9):707-15. doi: 10.1007/s12325-011-0055-8. Epub 2011 Aug 18.
  • PMID: 15037111
    Takagi Y, Nakajima T, Shimazaki A, Kageyama M, Matsugi T, Matsumura Y, Gabelt BT, Kaufman PL, Hara H: Pharmacological characteristics of AFP-168 (tafluprost), a new prostanoid FP receptor agonist, as an ocular hypotensive drug. Exp Eye Res. 2004 Apr;78(4):767-76.
  • PMID: 19477946
    Fukano Y, Kawazu K: Disposition and metabolism of a novel prostanoid antiglaucoma medication, tafluprost, following ocular administration to rats. Drug Metab Dispos. 2009 Aug;37(8):1622-34. doi: 10.1124/dmd.108.024885. Epub 2009 May 28.

Contoh Produk & Brand

Produk: 9 • International brands: 1
Produk
  • Saflutan
    Solution • 4.5 mcg / 0.3 mL • Ophthalmic • Canada • Approved
  • Tafluprost
    Solution / drops • 0.0045 mg/0.3mL • Ophthalmic • US • Generic • Approved
  • Tafluprost
    Solution / drops • 0.0045 mg/0.3mL • Ophthalmic • US • Generic • Approved
  • Tafluprost
    Solution • 0.0045 mg/0.3mL • Ophthalmic • US • Generic • Approved
  • Tafluprost
    Solution / drops • 0.015 mg/1mL • Ophthalmic • US • Generic • Approved
  • Tafluprost Ophthalmic
    Solution / drops • 0.0045 mg/0.3mL • Ophthalmic • US • Generic • Approved
  • Zioptan
    Solution • 0.0045 mg/0.3mL • Ophthalmic • US • Approved
  • Zioptan
    Solution / drops • 0.0045 mg/0.3mL • Ophthalmic • US • Approved
Menampilkan 8 dari 9 produk.
International Brands
  • Taflotan — Regeneron Pharmaceuticals

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
© 2025 Digital Pharmacy Research - Universitas Esa Unggul