Lurasidone

DB08815

small molecule approved investigational

Deskripsi

Lurasidone is an atypical antipsychotic developed by Dainippon Sumitomo Pharma. It was approved by the U.S. Food and Drug Administration (FDA) for treatment of schizophrenia on October 29, 2010 and is currently pending approval for the treatment of bipolar disorder in the United States.

Struktur Molekul 2D

Berat 492.676
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 40 mg dose= 18 hours 120 mg - 160 mg dose = 29-37 hours
Volume Distribusi 6173 L
Klirens (Clearance) 3902 mL/min

Absorpsi

Lurasidone is readily absorbed and quickly reaches maximal concentrations (Cmax) within 1-4 hours. When taken with food, there is a two-fold increase in exposure and time to maximal concentration is increased by 0.5-1.5 hours. This occurs regardless of fat or caloric content. Bioavailability = 9-19%.

Metabolisme

Lurasidone is metabolized by CYP3A4 in which its major active metabolite is referred to as ID-14283 (25% of parent exposure). Its two minor metabolites are referred to as ID14326 and ID11614 which make up 3% and 1% of parent exposure respectively. Its two non-active metabolites are referred to as ID-20219 and ID-20220.

Rute Eliminasi

Urine (~9%) and feces (~80%)

Interaksi Makanan

3 Data
  • 1. Avoid alcohol. The effects of alcohol could be made worse while taking Lurasidone.
  • 2. Avoid grapefruit products. Grapefruit and grapefruit juice may affect the amount of Lurasidone in your blood.
  • 3. Take with food. The manufacturer recommends co-administration with at least 350 calories.

Interaksi Obat

1504 Data
Valsartan Lurasidone may decrease the antihypertensive activities of Valsartan.
Ramipril Lurasidone may decrease the antihypertensive activities of Ramipril.
Remikiren Lurasidone may decrease the antihypertensive activities of Remikiren.
Torasemide Lurasidone may decrease the antihypertensive activities of Torasemide.
Guanadrel Lurasidone may decrease the antihypertensive activities of Guanadrel.
Olmesartan Lurasidone may decrease the antihypertensive activities of Olmesartan.
Chlorthalidone Lurasidone may decrease the antihypertensive activities of Chlorthalidone.
Nitroprusside Lurasidone may decrease the antihypertensive activities of Nitroprusside.
Atenolol Lurasidone may decrease the antihypertensive activities of Atenolol.
Minoxidil Lurasidone may decrease the antihypertensive activities of Minoxidil.
Bendroflumethiazide Lurasidone may decrease the antihypertensive activities of Bendroflumethiazide.
Fosinopril Lurasidone may decrease the antihypertensive activities of Fosinopril.
Trandolapril Lurasidone may decrease the antihypertensive activities of Trandolapril.
Metolazone Lurasidone may decrease the antihypertensive activities of Metolazone.
Benazepril Lurasidone may decrease the antihypertensive activities of Benazepril.
Cyclothiazide Lurasidone may decrease the antihypertensive activities of Cyclothiazide.
Candoxatril Lurasidone may decrease the antihypertensive activities of Candoxatril.
Mecamylamine Lurasidone may decrease the antihypertensive activities of Mecamylamine.
Lisinopril Lurasidone may decrease the antihypertensive activities of Lisinopril.
Nitroglycerin Lurasidone may decrease the antihypertensive activities of Nitroglycerin.
Hydroflumethiazide Lurasidone may decrease the antihypertensive activities of Hydroflumethiazide.
Cryptenamine Lurasidone may decrease the antihypertensive activities of Cryptenamine.
Perindopril Lurasidone may decrease the antihypertensive activities of Perindopril.
Candesartan cilexetil Lurasidone may decrease the antihypertensive activities of Candesartan cilexetil.
Eprosartan Lurasidone may decrease the antihypertensive activities of Eprosartan.
Chlorothiazide Lurasidone may decrease the antihypertensive activities of Chlorothiazide.
Quinapril Lurasidone may decrease the antihypertensive activities of Quinapril.
Telmisartan Lurasidone may decrease the antihypertensive activities of Telmisartan.
Methyldopa Lurasidone may decrease the antihypertensive activities of Methyldopa.
Trichlormethiazide Lurasidone may decrease the antihypertensive activities of Trichlormethiazide.
Deserpidine Lurasidone may decrease the antihypertensive activities of Deserpidine.
Pentolinium Lurasidone may decrease the antihypertensive activities of Pentolinium.
Trimethaphan Lurasidone may decrease the antihypertensive activities of Trimethaphan.
Diazoxide Lurasidone may decrease the antihypertensive activities of Diazoxide.
Captopril Lurasidone may decrease the antihypertensive activities of Captopril.
Nadolol Lurasidone may decrease the antihypertensive activities of Nadolol.
Epoprostenol Lurasidone may decrease the antihypertensive activities of Epoprostenol.
Practolol Lurasidone may decrease the antihypertensive activities of Practolol.
Polythiazide Lurasidone may decrease the antihypertensive activities of Polythiazide.
Cilazapril Lurasidone may decrease the antihypertensive activities of Cilazapril.
Saprisartan Lurasidone may decrease the antihypertensive activities of Saprisartan.
Spirapril Lurasidone may decrease the antihypertensive activities of Spirapril.
Dexpropranolol Lurasidone may decrease the antihypertensive activities of Dexpropranolol.
Tienilic acid Lurasidone may decrease the antihypertensive activities of Tienilic acid.
Debrisoquine Lurasidone may decrease the antihypertensive activities of Debrisoquine.
Diethylnorspermine Lurasidone may decrease the antihypertensive activities of Diethylnorspermine.
Temocapril Lurasidone may decrease the antihypertensive activities of Temocapril.
Nicorandil Lurasidone may decrease the antihypertensive activities of Nicorandil.
Rauwolfia serpentina root Lurasidone may decrease the antihypertensive activities of Rauwolfia serpentina root.
Enalaprilat Lurasidone may decrease the antihypertensive activities of Enalaprilat.
Angiotensin 1-7 Lurasidone may decrease the antihypertensive activities of Angiotensin 1-7.
Imidapril Lurasidone may decrease the antihypertensive activities of Imidapril.
BQ-123 Lurasidone may decrease the antihypertensive activities of BQ-123.
Landiolol Lurasidone may decrease the antihypertensive activities of Landiolol.
Dihydralazine Lurasidone may decrease the antihypertensive activities of Dihydralazine.
Zofenopril Lurasidone may decrease the antihypertensive activities of Zofenopril.
Guanoxan Lurasidone may decrease the antihypertensive activities of Guanoxan.
Delapril Lurasidone may decrease the antihypertensive activities of Delapril.
Vincamine Lurasidone may decrease the antihypertensive activities of Vincamine.
Linsidomine Lurasidone may decrease the antihypertensive activities of Linsidomine.
Guanoxabenz Lurasidone may decrease the antihypertensive activities of Guanoxabenz.
Tolonidine Lurasidone may decrease the antihypertensive activities of Tolonidine.
Endralazine Lurasidone may decrease the antihypertensive activities of Endralazine.
Esatenolol Lurasidone may decrease the antihypertensive activities of Esatenolol.
Cadralazine Lurasidone may decrease the antihypertensive activities of Cadralazine.
Cloranolol Lurasidone may decrease the antihypertensive activities of Cloranolol.
Cyclopenthiazide Lurasidone may decrease the antihypertensive activities of Cyclopenthiazide.
Bietaserpine Lurasidone may decrease the antihypertensive activities of Bietaserpine.
Guanazodine Lurasidone may decrease the antihypertensive activities of Guanazodine.
Methoserpidine Lurasidone may decrease the antihypertensive activities of Methoserpidine.
Epanolol Lurasidone may decrease the antihypertensive activities of Epanolol.
Guanoclor Lurasidone may decrease the antihypertensive activities of Guanoclor.
Muzolimine Lurasidone may decrease the antihypertensive activities of Muzolimine.
Xipamide Lurasidone may decrease the antihypertensive activities of Xipamide.
Candesartan Lurasidone may decrease the antihypertensive activities of Candesartan.
Tocopherylquinone Lurasidone may decrease the antihypertensive activities of Tocopherylquinone.
Benazeprilat Lurasidone may decrease the antihypertensive activities of Benazeprilat.
Fosinoprilat Lurasidone may decrease the antihypertensive activities of Fosinoprilat.
Ramiprilat Lurasidone may decrease the antihypertensive activities of Ramiprilat.
Perindoprilat Lurasidone may decrease the antihypertensive activities of Perindoprilat.
Quinaprilat Lurasidone may decrease the antihypertensive activities of Quinaprilat.
Furosemide Lurasidone may decrease the antihypertensive activities of Furosemide.
Enalapril Lurasidone may decrease the antihypertensive activities of Enalapril.
Nisoldipine Lurasidone may decrease the antihypertensive activities of Nisoldipine.
Lercanidipine Lurasidone may decrease the antihypertensive activities of Lercanidipine.
Bisoprolol Lurasidone may decrease the antihypertensive activities of Bisoprolol.
Eplerenone Lurasidone may decrease the antihypertensive activities of Eplerenone.
Tadalafil Lurasidone may decrease the antihypertensive activities of Tadalafil.
Guanethidine Lurasidone may decrease the antihypertensive activities of Guanethidine.
Nebivolol Lurasidone may decrease the antihypertensive activities of Nebivolol.
Ambrisentan Lurasidone may decrease the antihypertensive activities of Ambrisentan.
Pinacidil Lurasidone may decrease the antihypertensive activities of Pinacidil.
Riociguat Lurasidone may decrease the antihypertensive activities of Riociguat.
Macitentan Lurasidone may decrease the antihypertensive activities of Macitentan.
Aliskiren Lurasidone may decrease the antihypertensive activities of Aliskiren.
Selexipag Lurasidone may decrease the antihypertensive activities of Selexipag.
Naftopidil Lurasidone may decrease the antihypertensive activities of Naftopidil.
Dexniguldipine Lurasidone may decrease the antihypertensive activities of Dexniguldipine.
Amlodipine Lurasidone may decrease the antihypertensive activities of Amlodipine.
Metoprolol Lurasidone may decrease the antihypertensive activities of Metoprolol.

Target Protein

D(2) dopamine receptor DRD2
5-hydroxytryptamine receptor 2A HTR2A
5-hydroxytryptamine receptor 7 HTR7
5-hydroxytryptamine receptor 1A HTR1A
Alpha-2C adrenergic receptor ADRA2C
Alpha-2A adrenergic receptor ADRA2A

Referensi & Sumber

Artikel (PubMed)
  • PMID: 23545936
    George M, Amrutheshwar R, Rajkumar RP, Kattimani S, Dkhar SA: Newer antipsychotics and upcoming molecules for schizophrenia. Eur J Clin Pharmacol. 2013 Aug;69(8):1497-509. doi: 10.1007/s00228-013-1498-4. Epub 2013 Apr 2.
  • PMID: 22849428
    Tarazi FI, Stahl SM: Iloperidone, asenapine and lurasidone: a primer on their current status. Expert Opin Pharmacother. 2012 Sep;13(13):1911-22. doi: 10.1517/14656566.2012.712114. Epub 2012 Jul 31.

Contoh Produk & Brand

Produk: 208 • International brands: 0
Produk
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    Tablet • 20 mg • Oral • Canada • Generic • Approved
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    Tablet • 40 mg • Oral • Canada • Generic • Approved
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    Tablet • 60 mg • Oral • Canada • Generic • Approved
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    Tablet • 120 mg • Oral • Canada • Generic • Approved
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    Tablet • 40 mg • Oral • Canada • Generic • Approved
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Menampilkan 8 dari 208 produk.

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