Peringatan Keamanan

The symptoms of overdose include drowsiness, confusion and extrapyramidal effects.

Cinitapride

DB08810

small molecule investigational

Deskripsi

Cinitapride is a gastroprokinetic agent and antiulcer benzamide with agonist activity at 5-HT1 and 5-HT4 receptors and antagonist activity at 5-HT2 receptors. It is marketed in Spain and Mexico.

Struktur Molekul 2D

Berat 402.4873
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 3-5 h during the first 8 h and a residual half-life greater than 15 h thereafter.
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

The absorption of cinitapride (12mg) following oral administration was rapid, with peak levels being achieved 2 h after dosing; absorption following intramuscular administration (4mg) was even more rapid, with peak levels (50% more that oral levels) being achieved 1 h after dosing.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

1071 Data
Valsartan Cinitapride may decrease the antihypertensive activities of Valsartan.
Ramipril Cinitapride may decrease the antihypertensive activities of Ramipril.
Esmolol Cinitapride may decrease the antihypertensive activities of Esmolol.
Betaxolol Cinitapride may decrease the antihypertensive activities of Betaxolol.
Remikiren Cinitapride may decrease the antihypertensive activities of Remikiren.
Torasemide Cinitapride may decrease the antihypertensive activities of Torasemide.
Guanadrel Cinitapride may decrease the antihypertensive activities of Guanadrel.
Metoprolol Cinitapride may decrease the antihypertensive activities of Metoprolol.
Isradipine Cinitapride may decrease the antihypertensive activities of Isradipine.
Olmesartan Cinitapride may decrease the antihypertensive activities of Olmesartan.
Chlorthalidone Cinitapride may decrease the antihypertensive activities of Chlorthalidone.
Nitroprusside Cinitapride may decrease the antihypertensive activities of Nitroprusside.
Atenolol Cinitapride may decrease the antihypertensive activities of Atenolol.
Diltiazem Cinitapride may decrease the antihypertensive activities of Diltiazem.
Minoxidil Cinitapride may decrease the antihypertensive activities of Minoxidil.
Timolol Cinitapride may decrease the antihypertensive activities of Timolol.
Treprostinil Cinitapride may decrease the antihypertensive activities of Treprostinil.
Amlodipine Cinitapride may decrease the antihypertensive activities of Amlodipine.
Nimodipine Cinitapride may decrease the antihypertensive activities of Nimodipine.
Nisoldipine Cinitapride may decrease the antihypertensive activities of Nisoldipine.
Bendroflumethiazide Cinitapride may decrease the antihypertensive activities of Bendroflumethiazide.
Prazosin Cinitapride may decrease the antihypertensive activities of Prazosin.
Fosinopril Cinitapride may decrease the antihypertensive activities of Fosinopril.
Trandolapril Cinitapride may decrease the antihypertensive activities of Trandolapril.
Metolazone Cinitapride may decrease the antihypertensive activities of Metolazone.
Lercanidipine Cinitapride may decrease the antihypertensive activities of Lercanidipine.
Benazepril Cinitapride may decrease the antihypertensive activities of Benazepril.
Bosentan Cinitapride may decrease the antihypertensive activities of Bosentan.
Propranolol Cinitapride may decrease the antihypertensive activities of Propranolol.
Enalapril Cinitapride may decrease the antihypertensive activities of Enalapril.
Doxazosin Cinitapride may decrease the antihypertensive activities of Doxazosin.
Labetalol Cinitapride may decrease the antihypertensive activities of Labetalol.
Cyclothiazide Cinitapride may decrease the antihypertensive activities of Cyclothiazide.
Bisoprolol Cinitapride may decrease the antihypertensive activities of Bisoprolol.
Candoxatril Cinitapride may decrease the antihypertensive activities of Candoxatril.
Mecamylamine Cinitapride may decrease the antihypertensive activities of Mecamylamine.
Losartan Cinitapride may decrease the antihypertensive activities of Losartan.
Moexipril Cinitapride may decrease the antihypertensive activities of Moexipril.
Eplerenone Cinitapride may decrease the antihypertensive activities of Eplerenone.
Lisinopril Cinitapride may decrease the antihypertensive activities of Lisinopril.
Nitroglycerin Cinitapride may decrease the antihypertensive activities of Nitroglycerin.
Hydroflumethiazide Cinitapride may decrease the antihypertensive activities of Hydroflumethiazide.
Cryptenamine Cinitapride may decrease the antihypertensive activities of Cryptenamine.
Perindopril Cinitapride may decrease the antihypertensive activities of Perindopril.
Candesartan cilexetil Cinitapride may decrease the antihypertensive activities of Candesartan cilexetil.
Fenoldopam Cinitapride may decrease the antihypertensive activities of Fenoldopam.
Indapamide Cinitapride may decrease the antihypertensive activities of Indapamide.
Tadalafil Cinitapride may decrease the antihypertensive activities of Tadalafil.
Eprosartan Cinitapride may decrease the antihypertensive activities of Eprosartan.
Chlorothiazide Cinitapride may decrease the antihypertensive activities of Chlorothiazide.
Quinapril Cinitapride may decrease the antihypertensive activities of Quinapril.
Telmisartan Cinitapride may decrease the antihypertensive activities of Telmisartan.
Methyldopa Cinitapride may decrease the antihypertensive activities of Methyldopa.
Hydrochlorothiazide Cinitapride may decrease the antihypertensive activities of Hydrochlorothiazide.
Trichlormethiazide Cinitapride may decrease the antihypertensive activities of Trichlormethiazide.
Felodipine Cinitapride may decrease the antihypertensive activities of Felodipine.
Irbesartan Cinitapride may decrease the antihypertensive activities of Irbesartan.
Nitrendipine Cinitapride may decrease the antihypertensive activities of Nitrendipine.
Deserpidine Cinitapride may decrease the antihypertensive activities of Deserpidine.
Pentolinium Cinitapride may decrease the antihypertensive activities of Pentolinium.
Trimethaphan Cinitapride may decrease the antihypertensive activities of Trimethaphan.
Diazoxide Cinitapride may decrease the antihypertensive activities of Diazoxide.
Carvedilol Cinitapride may decrease the antihypertensive activities of Carvedilol.
Bretylium Cinitapride may decrease the antihypertensive activities of Bretylium.
Terazosin Cinitapride may decrease the antihypertensive activities of Terazosin.
Guanethidine Cinitapride may decrease the antihypertensive activities of Guanethidine.
Acebutolol Cinitapride may decrease the antihypertensive activities of Acebutolol.
Captopril Cinitapride may decrease the antihypertensive activities of Captopril.
Nadolol Cinitapride may decrease the antihypertensive activities of Nadolol.
Epoprostenol Cinitapride may decrease the antihypertensive activities of Epoprostenol.
Bepridil Cinitapride may decrease the antihypertensive activities of Bepridil.
Hydralazine Cinitapride may decrease the antihypertensive activities of Hydralazine.
Bevantolol Cinitapride may decrease the antihypertensive activities of Bevantolol.
Practolol Cinitapride may decrease the antihypertensive activities of Practolol.
Polythiazide Cinitapride may decrease the antihypertensive activities of Polythiazide.
Cilazapril Cinitapride may decrease the antihypertensive activities of Cilazapril.
Saprisartan Cinitapride may decrease the antihypertensive activities of Saprisartan.
Spirapril Cinitapride may decrease the antihypertensive activities of Spirapril.
Mibefradil Cinitapride may decrease the antihypertensive activities of Mibefradil.
Dexpropranolol Cinitapride may decrease the antihypertensive activities of Dexpropranolol.
Tienilic acid Cinitapride may decrease the antihypertensive activities of Tienilic acid.
Debrisoquine Cinitapride may decrease the antihypertensive activities of Debrisoquine.
Celiprolol Cinitapride may decrease the antihypertensive activities of Celiprolol.
Nebivolol Cinitapride may decrease the antihypertensive activities of Nebivolol.
Sitaxentan Cinitapride may decrease the antihypertensive activities of Sitaxentan.
Ambrisentan Cinitapride may decrease the antihypertensive activities of Ambrisentan.
Diethylnorspermine Cinitapride may decrease the antihypertensive activities of Diethylnorspermine.
Nilvadipine Cinitapride may decrease the antihypertensive activities of Nilvadipine.
Pinacidil Cinitapride may decrease the antihypertensive activities of Pinacidil.
Bupranolol Cinitapride may decrease the antihypertensive activities of Bupranolol.
Temocapril Cinitapride may decrease the antihypertensive activities of Temocapril.
Riociguat Cinitapride may decrease the antihypertensive activities of Riociguat.
Macitentan Cinitapride may decrease the antihypertensive activities of Macitentan.
Indenolol Cinitapride may decrease the antihypertensive activities of Indenolol.
Aliskiren Cinitapride may decrease the antihypertensive activities of Aliskiren.
Trimazosin Cinitapride may decrease the antihypertensive activities of Trimazosin.
Nicorandil Cinitapride may decrease the antihypertensive activities of Nicorandil.
Efonidipine Cinitapride may decrease the antihypertensive activities of Efonidipine.
Lacidipine Cinitapride may decrease the antihypertensive activities of Lacidipine.
Manidipine Cinitapride may decrease the antihypertensive activities of Manidipine.

Target Protein

5-hydroxytryptamine receptor 1A HTR1A
5-hydroxytryptamine receptor 2A HTR2A
5-hydroxytryptamine receptor 4 HTR4

Referensi & Sumber

Artikel (PubMed)
  • PMID: 9211565
    Alarcon-de-la-Lastra Romero C, Lopez A, Martin MJ, la Casa C, Motilva V: Cinitapride protects against ethanol-induced gastric mucosal injury in rats: role of 5-hydroxytryptamine, prostaglandins and sulfhydryl compounds. Pharmacology. 1997 Apr;54(4):193-202.

Contoh Produk & Brand

Produk: 0 • International brands: 5
International Brands
  • Blaston
  • Cinmove
  • Cintapro
  • Paxapride
  • Pemix

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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