Peringatan Keamanan

Symptoms of overdose include bradycardia, cardiac failure, hypotension, and brochospasm.

Bupranolol

DB08808

small molecule experimental

Deskripsi

Bupranolol is a non-selective beta blocker with potency similar to propanolol. It does not have intrinsic sympathomimetic activity (ISA), but does have strong membrane stabilizing activity.

Struktur Molekul 2D

Berat 271.783
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 2-4 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Quickly and completely absorbed from the gut with less than 10% oral bioavailability.

Metabolisme

Over 90% undergoes first-pass metabolism. The main metabolite is carboxybupranolol, 4-chloro-3-3-(1,1-dimethylethylamino)-2-hydroxy-propyloxybenzoic acid, of which 88% are eliminated renally within 24 hours.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

1450 Data
Ceritinib Bupranolol may increase the bradycardic activities of Ceritinib.
Ivabradine Bupranolol may increase the bradycardic activities of Ivabradine.
Ruxolitinib Ruxolitinib may increase the bradycardic activities of Bupranolol.
Alfuzosin Alfuzosin may increase the hypotensive activities of Bupranolol.
Amifostine Bupranolol may increase the hypotensive activities of Amifostine.
Diazoxide Diazoxide may increase the hypotensive activities of Bupranolol.
Methylphenidate Methylphenidate may decrease the antihypertensive activities of Bupranolol.
Dexmethylphenidate Dexmethylphenidate may decrease the antihypertensive activities of Bupranolol.
Obinutuzumab Bupranolol may increase the hypotensive activities of Obinutuzumab.
Pentoxifylline Pentoxifylline may increase the hypotensive activities of Bupranolol.
Rituximab Bupranolol may increase the hypotensive activities of Rituximab.
Desmopressin Desmopressin may decrease the antihypertensive activities of Bupranolol.
Zolmitriptan Zolmitriptan may decrease the antihypertensive activities of Bupranolol.
Doxapram Doxapram may decrease the antihypertensive activities of Bupranolol.
Sumatriptan Sumatriptan may decrease the antihypertensive activities of Bupranolol.
Phenmetrazine Phenmetrazine may decrease the antihypertensive activities of Bupranolol.
Naratriptan Naratriptan may decrease the antihypertensive activities of Bupranolol.
Rizatriptan Rizatriptan may decrease the antihypertensive activities of Bupranolol.
Dopamine Dopamine may decrease the antihypertensive activities of Bupranolol.
Frovatriptan Frovatriptan may decrease the antihypertensive activities of Bupranolol.
Dutasteride Dutasteride may decrease the antihypertensive activities of Bupranolol.
Finasteride Finasteride may decrease the antihypertensive activities of Bupranolol.
Yohimbine Yohimbine may decrease the antihypertensive activities of Bupranolol.
Epicaptopril Epicaptopril may decrease the antihypertensive activities of Bupranolol.
1-benzylimidazole 1-benzylimidazole may decrease the antihypertensive activities of Bupranolol.
Amineptine Amineptine may decrease the antihypertensive activities of Bupranolol.
Flibanserin Flibanserin may decrease the antihypertensive activities of Bupranolol.
Naluzotan Naluzotan may decrease the antihypertensive activities of Bupranolol.
Nitrous oxide Nitrous oxide may decrease the antihypertensive activities of Bupranolol.
Cinitapride Cinitapride may decrease the antihypertensive activities of Bupranolol.
Tyramine Tyramine may decrease the antihypertensive activities of Bupranolol.
Ifenprodil Ifenprodil may decrease the antihypertensive activities of Bupranolol.
Dimetacrine Dimetacrine may decrease the antihypertensive activities of Bupranolol.
Moxisylyte Moxisylyte may decrease the antihypertensive activities of Bupranolol.
Tianeptine Tianeptine may decrease the antihypertensive activities of Bupranolol.
Oxaprotiline Oxaprotiline may decrease the antihypertensive activities of Bupranolol.
Atipamezole Atipamezole may decrease the antihypertensive activities of Bupranolol.
Tetrahydrocannabivarin Tetrahydrocannabivarin may decrease the antihypertensive activities of Bupranolol.
Piclozotan Piclozotan may decrease the antihypertensive activities of Bupranolol.
Siponimod Siponimod may decrease the antihypertensive activities of Bupranolol.
Idazoxan Idazoxan may decrease the antihypertensive activities of Bupranolol.
Tramazoline Tramazoline may decrease the antihypertensive activities of Bupranolol.
Amitriptylinoxide Amitriptylinoxide may decrease the antihypertensive activities of Bupranolol.
Dibenzepin Dibenzepin may decrease the antihypertensive activities of Bupranolol.
Quinupramine Quinupramine may decrease the antihypertensive activities of Bupranolol.
Trichloroethylene Trichloroethylene may decrease the antihypertensive activities of Bupranolol.
Fenozolone Fenozolone may decrease the antihypertensive activities of Bupranolol.
Melitracen Melitracen may decrease the antihypertensive activities of Bupranolol.
Lofepramine Lofepramine may decrease the antihypertensive activities of Bupranolol.
Xenon Xenon may decrease the antihypertensive activities of Bupranolol.
Iprindole Iprindole may decrease the antihypertensive activities of Bupranolol.
Buflomedil Buflomedil may decrease the antihypertensive activities of Bupranolol.
Diethyl ether Diethyl ether may decrease the antihypertensive activities of Bupranolol.
Imipramine oxide Imipramine oxide may decrease the antihypertensive activities of Bupranolol.
Mefenorex Mefenorex may decrease the antihypertensive activities of Bupranolol.
5-methoxy-N,N-dimethyltryptamine 5-methoxy-N,N-dimethyltryptamine may decrease the antihypertensive activities of Bupranolol.
Quinoline Yellow WS Quinoline Yellow WS may decrease the antihypertensive activities of Bupranolol.
Solriamfetol Solriamfetol may decrease the antihypertensive activities of Bupranolol.
Sufentanil Sufentanil may decrease the antihypertensive activities of Bupranolol.
Remifentanil Remifentanil may decrease the antihypertensive activities of Bupranolol.
Halothane Halothane may decrease the antihypertensive activities of Bupranolol.
Opipramol Opipramol may decrease the antihypertensive activities of Bupranolol.
Selpercatinib Selpercatinib may decrease the antihypertensive activities of Bupranolol.
Naxitamab Naxitamab may decrease the antihypertensive activities of Bupranolol.
Cannabidiol The metabolism of Bupranolol can be decreased when combined with Cannabidiol.
Amiodarone The therapeutic efficacy of Bupranolol can be increased when used in combination with Amiodarone.
Bupivacaine The serum concentration of Bupivacaine can be increased when it is combined with Bupranolol.
Dipyridamole Dipyridamole may increase the bradycardic activities of Bupranolol.
Disopyramide Disopyramide may increase the bradycardic activities of Bupranolol.
Dronedarone Dronedarone may increase the bradycardic activities of Bupranolol.
Fingolimod Bupranolol may increase the bradycardic activities of Fingolimod.
Floctafenine The risk or severity of adverse effects can be increased when Bupranolol is combined with Floctafenine.
Mepivacaine The serum concentration of Mepivacaine can be increased when it is combined with Bupranolol.
Methacholine Bupranolol may increase the bronchoconstrictory activities of Methacholine.
Midodrine The therapeutic efficacy of Midodrine can be decreased when used in combination with Bupranolol.
Nifedipine The risk or severity of congestive heart failure and hypotension can be increased when Nifedipine is combined with Bupranolol.
Propafenone The risk or severity of adverse effects can be increased when Propafenone is combined with Bupranolol.
Regorafenib Regorafenib may increase the bradycardic activities of Bupranolol.
Reserpine Reserpine may increase the hypotensive activities of Bupranolol.
Deserpidine Deserpidine may increase the hypotensive activities of Bupranolol.
Guanethidine Guanethidine may increase the hypotensive activities of Bupranolol.
Rivastigmine Bupranolol may increase the bradycardic activities of Rivastigmine.
Mirabegron The serum concentration of Bupranolol can be increased when it is combined with Mirabegron.
Molsidomine Molsidomine may increase the hypotensive activities of Bupranolol.
Insulin argine Bupranolol may increase the hypoglycemic activities of Insulin argine.
Remikiren Remikiren may increase the hypotensive activities of Bupranolol.
Guanadrel Guanadrel may increase the hypotensive activities of Bupranolol.
Bosentan Bosentan may increase the hypotensive activities of Bupranolol.
Candoxatril Candoxatril may increase the hypotensive activities of Bupranolol.
Metyrosine Metyrosine may increase the hypotensive activities of Bupranolol.
Cryptenamine Cryptenamine may increase the hypotensive activities of Bupranolol.
Dorzolamide Dorzolamide may increase the hypotensive activities of Bupranolol.
Bimatoprost Bimatoprost may increase the hypotensive activities of Bupranolol.
Pentolinium Pentolinium may increase the hypotensive activities of Bupranolol.
Trimethaphan Trimethaphan may increase the hypotensive activities of Bupranolol.
Tienilic acid Tienilic acid may increase the hypotensive activities of Bupranolol.
Debrisoquine Debrisoquine may increase the hypotensive activities of Bupranolol.
Sitaxentan Sitaxentan may increase the hypotensive activities of Bupranolol.
Ambrisentan Ambrisentan may increase the hypotensive activities of Bupranolol.
Diethylnorspermine Diethylnorspermine may increase the hypotensive activities of Bupranolol.

Target Protein

Beta-1 adrenergic receptor ADRB1
Beta-2 adrenergic receptor ADRB2
Beta-3 adrenergic receptor ADRB3

Referensi & Sumber

Synthesis reference: Kunz, W., Jacobi, H., Koch, C. and Geus, R.J.; U.S. Patent 3,309,406; March 14, 1967.

Contoh Produk & Brand

Produk: 0 • International brands: 2
International Brands
  • Betadrenol — Desma
  • Ophtorenin — Winzer (Germany)

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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