Peringatan Keamanan

Data regarding acute overdose of nandrolone decanoate are not readily available.L9464 However, patients experiencing a chronic overdose of anabolic steroids may experience adverse effects including suppression of testosterone and spermatogenesis, shrinking of testicles, decreased libido, and erectile dysfunction in men; and suppressed estrogen, progesterone, and ovulation, amenorrhea, and clitoromegaly in women.A233789 Patients may also experience neuropsychiatric, cardiovascular, and hepatic adverse effects.A233789 Alkylated anabolic steroids such as nandrolone decanoate are more likely to cause hepatic adverse effects.A233789 Treat patients with symptomatic and supportive measures.

The intraperitoneal LD50 in mice is >566 mg/kg.L33229

Nandrolone decanoate

DB08804

small molecule approved illicit

Deskripsi

Nandrolone decanoate, also known as nandrolone caprinate, is an alkylated anabolic steroid indicated in the management of anemia of renal insufficiency and as an adjunct therapy in the treatment of senile and postmenopausal osteoporosis.A233789,A233849,L32564,L9464 The process for creating esters of nandrolone was patented in Spain in 1959L33244 and in 1960, it was described as having a long duration of action and strong anabolic effect compared to nandrolone and other esters.A233849

Nandrolone decanoate was granted FDA approval on 5 October 1962.L32564

Struktur Molekul 2D

Berat 428.6472
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Nandrolone decanoate has an absorption half life of 6 days and an elimination half life of 4.3 hours.[L9464] Alternate studies have shown that nandrolone decanoate has a terminal half life of 7.1, 11.7, and 11.8 hours for doses of 50, 100, and 150 mg respectively.[A231754]
Volume Distribusi -
Klirens (Clearance) 50 mg, 100 mg, and 150 mg doses of nadrolone decanoate had mean apparent clearances of 80.0 L/h, 74.3 L/h, and 76.2 L/h respectively.[A231754]

Absorpsi

A 50 mg intramuscular dose of nandrolone decanoate reaches a mean Cmax 2.14 ng/mL, with a mean Tmax of 30 hours, and a mean AUC of 400 h\*ng/mL.A231754 A 100 mg intramuscular dose of nandrolone decanoate reaches a mean Cmax 4.26 ng/mL, with a mean Tmax of 30 hours, and a mean AUC of 862 h\*ng/mL.A231754 A 150 mg intramuscular dose of nandrolone decanoate reaches a mean Cmax 5.16 ng/mL, with a mean Tmax of 72 hours, and a mean AUC of 1261 h\*ng/mL.A231754

Metabolisme

Nandrolone decanoate is hydrolyzed to nandrolone, possibly by PDE7B.A233754,A233774 Nandrolone is further metabolized to the urinary metabolites 19-norandrosterone, 19-noretiocholanolone, and 19-norepiandrosterone.A233759,L9464 19-norandrosterone is 3-O-glucuronidated by UGT2B7, UGT 1A4, UGT2B4, UGT1A3, and UGT1A1.A233764 19-noretiocholanolone is 3-O-glucuronidated by UGT2B7, UGT2B4, UGT1A4, UGT1A10, UGT1A3, and UGT1A1.A233764

Rute Eliminasi

Nandrolone decanoate is eliminated as urinary metabolites, however data regarding elimination in the feces are not readily available.A233784 Data in cattle shows that nandrolone is 30% eliminated in the feces.A233784

Interaksi Obat

207 Data
Cyclosporine The risk or severity of liver damage can be increased when Nandrolone decanoate is combined with Cyclosporine.
Dicoumarol Nandrolone decanoate may increase the anticoagulant activities of Dicoumarol.
Phenindione Nandrolone decanoate may increase the anticoagulant activities of Phenindione.
Warfarin Nandrolone decanoate may increase the anticoagulant activities of Warfarin.
Phenprocoumon Nandrolone decanoate may increase the anticoagulant activities of Phenprocoumon.
Acenocoumarol Nandrolone decanoate may increase the anticoagulant activities of Acenocoumarol.
4-hydroxycoumarin Nandrolone decanoate may increase the anticoagulant activities of 4-hydroxycoumarin.
Coumarin Nandrolone decanoate may increase the anticoagulant activities of Coumarin.
(R)-warfarin Nandrolone decanoate may increase the anticoagulant activities of (R)-warfarin.
Ethyl biscoumacetate Nandrolone decanoate may increase the anticoagulant activities of Ethyl biscoumacetate.
Fluindione Nandrolone decanoate may increase the anticoagulant activities of Fluindione.
Clorindione Nandrolone decanoate may increase the anticoagulant activities of Clorindione.
Diphenadione Nandrolone decanoate may increase the anticoagulant activities of Diphenadione.
Tioclomarol Nandrolone decanoate may increase the anticoagulant activities of Tioclomarol.
(S)-Warfarin Nandrolone decanoate may increase the anticoagulant activities of (S)-Warfarin.
Insulin human Nandrolone decanoate may increase the hypoglycemic activities of Insulin human.
Insulin lispro Nandrolone decanoate may increase the hypoglycemic activities of Insulin lispro.
Insulin glargine Nandrolone decanoate may increase the hypoglycemic activities of Insulin glargine.
Insulin pork Nandrolone decanoate may increase the hypoglycemic activities of Insulin pork.
Troglitazone Nandrolone decanoate may increase the hypoglycemic activities of Troglitazone.
Glimepiride Nandrolone decanoate may increase the hypoglycemic activities of Glimepiride.
Sulfisoxazole Nandrolone decanoate may increase the hypoglycemic activities of Sulfisoxazole.
Disopyramide Nandrolone decanoate may increase the hypoglycemic activities of Disopyramide.
Acarbose Nandrolone decanoate may increase the hypoglycemic activities of Acarbose.
Metformin Nandrolone decanoate may increase the hypoglycemic activities of Metformin.
Sulfadiazine Nandrolone decanoate may increase the hypoglycemic activities of Sulfadiazine.
Rosiglitazone Nandrolone decanoate may increase the hypoglycemic activities of Rosiglitazone.
Acetohexamide Nandrolone decanoate may increase the hypoglycemic activities of Acetohexamide.
Quinine Nandrolone decanoate may increase the hypoglycemic activities of Quinine.
Miglitol Nandrolone decanoate may increase the hypoglycemic activities of Miglitol.
Chlorpropamide Nandrolone decanoate may increase the hypoglycemic activities of Chlorpropamide.
Nateglinide Nandrolone decanoate may increase the hypoglycemic activities of Nateglinide.
Pentamidine Nandrolone decanoate may increase the hypoglycemic activities of Pentamidine.
Mifepristone Nandrolone decanoate may increase the hypoglycemic activities of Mifepristone.
Tolazamide Nandrolone decanoate may increase the hypoglycemic activities of Tolazamide.
Repaglinide Nandrolone decanoate may increase the hypoglycemic activities of Repaglinide.
Phenformin Nandrolone decanoate may increase the hypoglycemic activities of Phenformin.
Sulfamethoxazole Nandrolone decanoate may increase the hypoglycemic activities of Sulfamethoxazole.
Glyburide Nandrolone decanoate may increase the hypoglycemic activities of Glyburide.
Glipizide Nandrolone decanoate may increase the hypoglycemic activities of Glipizide.
Gliclazide Nandrolone decanoate may increase the hypoglycemic activities of Gliclazide.
Tolbutamide Nandrolone decanoate may increase the hypoglycemic activities of Tolbutamide.
Pioglitazone Nandrolone decanoate may increase the hypoglycemic activities of Pioglitazone.
Bromocriptine Nandrolone decanoate may increase the hypoglycemic activities of Bromocriptine.
Gliquidone Nandrolone decanoate may increase the hypoglycemic activities of Gliquidone.
Mitiglinide Nandrolone decanoate may increase the hypoglycemic activities of Mitiglinide.
Sitagliptin Nandrolone decanoate may increase the hypoglycemic activities of Sitagliptin.
Sunitinib Nandrolone decanoate may increase the hypoglycemic activities of Sunitinib.
Exenatide Nandrolone decanoate may increase the hypoglycemic activities of Exenatide.
Mecasermin Nandrolone decanoate may increase the hypoglycemic activities of Mecasermin.
Pramlintide Nandrolone decanoate may increase the hypoglycemic activities of Pramlintide.
Glisoxepide Nandrolone decanoate may increase the hypoglycemic activities of Glisoxepide.
Insulin aspart Nandrolone decanoate may increase the hypoglycemic activities of Insulin aspart.
Insulin detemir Nandrolone decanoate may increase the hypoglycemic activities of Insulin detemir.
Insulin glulisine Nandrolone decanoate may increase the hypoglycemic activities of Insulin glulisine.
Glymidine Nandrolone decanoate may increase the hypoglycemic activities of Glymidine.
AICA ribonucleotide Nandrolone decanoate may increase the hypoglycemic activities of AICA ribonucleotide.
Buformin Nandrolone decanoate may increase the hypoglycemic activities of Buformin.
Vildagliptin Nandrolone decanoate may increase the hypoglycemic activities of Vildagliptin.
Voglibose Nandrolone decanoate may increase the hypoglycemic activities of Voglibose.
NN344 Nandrolone decanoate may increase the hypoglycemic activities of NN344.
AMG-222 Nandrolone decanoate may increase the hypoglycemic activities of AMG-222.
Bisegliptin Nandrolone decanoate may increase the hypoglycemic activities of Bisegliptin.
Alogliptin Nandrolone decanoate may increase the hypoglycemic activities of Alogliptin.
Dapagliflozin Nandrolone decanoate may increase the hypoglycemic activities of Dapagliflozin.
Saxagliptin Nandrolone decanoate may increase the hypoglycemic activities of Saxagliptin.
Liraglutide Nandrolone decanoate may increase the hypoglycemic activities of Liraglutide.
Gosogliptin Nandrolone decanoate may increase the hypoglycemic activities of Gosogliptin.
Linagliptin Nandrolone decanoate may increase the hypoglycemic activities of Linagliptin.
Canagliflozin Nandrolone decanoate may increase the hypoglycemic activities of Canagliflozin.
Glibornuride Nandrolone decanoate may increase the hypoglycemic activities of Glibornuride.
Benfluorex Nandrolone decanoate may increase the hypoglycemic activities of Benfluorex.
Empagliflozin Nandrolone decanoate may increase the hypoglycemic activities of Empagliflozin.
Albiglutide Nandrolone decanoate may increase the hypoglycemic activities of Albiglutide.
Dulaglutide Nandrolone decanoate may increase the hypoglycemic activities of Dulaglutide.
Lobeglitazone Nandrolone decanoate may increase the hypoglycemic activities of Lobeglitazone.
Netoglitazone Nandrolone decanoate may increase the hypoglycemic activities of Netoglitazone.
Rivoglitazone Nandrolone decanoate may increase the hypoglycemic activities of Rivoglitazone.
Ciglitazone Nandrolone decanoate may increase the hypoglycemic activities of Ciglitazone.
Lixisenatide Nandrolone decanoate may increase the hypoglycemic activities of Lixisenatide.
Insulin beef Nandrolone decanoate may increase the hypoglycemic activities of Insulin beef.
Insulin degludec Nandrolone decanoate may increase the hypoglycemic activities of Insulin degludec.
Insulin peglispro Nandrolone decanoate may increase the hypoglycemic activities of Insulin peglispro.
Insulin tregopil Nandrolone decanoate may increase the hypoglycemic activities of Insulin tregopil.
Ipragliflozin Nandrolone decanoate may increase the hypoglycemic activities of Ipragliflozin.
Dutogliptin Nandrolone decanoate may increase the hypoglycemic activities of Dutogliptin.
Allicin Nandrolone decanoate may increase the hypoglycemic activities of Allicin.
Tofogliflozin Nandrolone decanoate may increase the hypoglycemic activities of Tofogliflozin.
Ertugliflozin Nandrolone decanoate may increase the hypoglycemic activities of Ertugliflozin.
2,4-thiazolidinedione Nandrolone decanoate may increase the hypoglycemic activities of 2,4-thiazolidinedione.
Teneligliptin Nandrolone decanoate may increase the hypoglycemic activities of Teneligliptin.
Omarigliptin Nandrolone decanoate may increase the hypoglycemic activities of Omarigliptin.
Carmegliptin Nandrolone decanoate may increase the hypoglycemic activities of Carmegliptin.
Gemigliptin Nandrolone decanoate may increase the hypoglycemic activities of Gemigliptin.
Anagliptin Nandrolone decanoate may increase the hypoglycemic activities of Anagliptin.
Evogliptin Nandrolone decanoate may increase the hypoglycemic activities of Evogliptin.
Sotagliflozin Nandrolone decanoate may increase the hypoglycemic activities of Sotagliflozin.
Balaglitazone Nandrolone decanoate may increase the hypoglycemic activities of Balaglitazone.
Remogliflozin etabonate Nandrolone decanoate may increase the hypoglycemic activities of Remogliflozin etabonate.
Carbutamide Nandrolone decanoate may increase the hypoglycemic activities of Carbutamide.

Target Protein

Androgen receptor AR
Protein c-Fos FOS
5-hydroxytryptamine 2 receptor HTR2A
5-hydroxytryptamine receptor 1B HTR1B
Insulin-like growth factor 1 receptor IGF1R
Dopamine receptor DRD1

Referensi & Sumber

Artikel (PubMed)
  • PMID: -
    Bagchus WM, Smeets JMW, Verheul HAM, De Jager-Van Der Veen SM, Port A, Guerts TBP: Pharmacokinetic Evaluation of Three Different Intramuscular Doses of Nandrolone Decanoate: Analysis of Serum and Urine Samples in Healthy Men The Journal of Clinical Endocrinology & Metabolism. 2005 May 1;90(5):2624-2630.
  • PMID: 14633920
    Baume N, Avois L, Schweizer C, Cardis C, Dvorak J, Cauderay M, Mangin P, Saugy M: 13CNandrolone excretion in trained athletes: interindividual variability in metabolism. Clin Chem. 2004 Feb;50(2):355-64. doi: 10.1373/clinchem.2003.022848. Epub 2003 Nov 21.
  • PMID: 3865478
    Wijnand HP, Bosch AM, Donker CW: Pharmacokinetic parameters of nandrolone (19-nortestosterone) after intramuscular administration of nandrolone decanoate (Deca-Durabolin) to healthy volunteers. Acta Endocrinol Suppl (Copenh). 1985;271:19-30. doi: 10.1530/acta.0.109s00019.
  • PMID: 12920167
    Kuuranne T, Kurkela M, Thevis M, Schanzer W, Finel M, Kostiainen R: Glucuronidation of anabolic androgenic steroids by recombinant human UDP-glucuronosyltransferases. Drug Metab Dispos. 2003 Sep;31(9):1117-24. doi: 10.1124/dmd.31.9.1117.
  • PMID: 24910615
    Strahm E, Rane A, Ekstrom L: PDE7B is involved in nandrolone decanoate hydrolysis in liver cytosol and its transcription is up-regulated by androgens in HepG2. Front Pharmacol. 2014 May 30;5:132. doi: 10.3389/fphar.2014.00132. eCollection 2014.
  • PMID: 133117
    Victor A, Weiner E, Johansson ED: Sex hormone binding globulin: the carrier protein for d-norgestrel. J Clin Endocrinol Metab. 1976 Jul;43(1):244-7. doi: 10.1210/jcem-43-1-244.
  • PMID: 7879862
    Calvarese S, Rubini P, Urbani G, Ferri N, Ramazza V, Zucchi M: Experimental administration of 19-nortestosterone and dexamethasone in cattle: elimination of the two drugs in different biological matrices. Analyst. 1994 Dec;119(12):2611-5. doi: 10.1039/an9941902611.
  • PMID: 30753550
    Anawalt BD: Diagnosis and Management of Anabolic Androgenic Steroid Use. J Clin Endocrinol Metab. 2019 Jul 1;104(7):2490-2500. doi: 10.1210/jc.2018-01882.
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Contoh Produk & Brand

Produk: 5 • International brands: 3
Produk
  • Deca Durabolin Inj 100mg/ml
    Solution • 100 mg / mL • Intramuscular • Canada • Approved
  • Deca Durabolin Inj 50mg/ml
    Liquid • 50 mg / mL • Intramuscular • Canada • Approved
  • Nandrolone Decanoate
    Injection • 100 mg/1mL • Intramuscular • US • Approved
  • Nandrolone Decanoate
    Injection • 200 mg/1mL • Intramuscular • US • Approved
  • Nandrolone Decanoate
    Injection, solution • 200 mg/1mL • Intramuscular • US • Generic • Approved
International Brands
  • Deca-Durabol
  • Deca-Durabolin
  • Retabolil

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