Isothipendyl

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) -

Volume Distribusi -

Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

36 Data

Benzylpenicilloyl polylysine	Isothipendyl may decrease effectiveness of Benzylpenicilloyl polylysine as a diagnostic agent.
Betahistine	The therapeutic efficacy of Betahistine can be decreased when used in combination with Isothipendyl.
Amphetamine	Amphetamine may decrease the sedative activities of Isothipendyl.
Phentermine	Phentermine may decrease the sedative activities of Isothipendyl.
Pseudoephedrine	Pseudoephedrine may decrease the sedative activities of Isothipendyl.
Benzphetamine	Benzphetamine may decrease the sedative activities of Isothipendyl.
Diethylpropion	Diethylpropion may decrease the sedative activities of Isothipendyl.
Lisdexamfetamine	Lisdexamfetamine may decrease the sedative activities of Isothipendyl.
Mephentermine	Mephentermine may decrease the sedative activities of Isothipendyl.
MMDA	MMDA may decrease the sedative activities of Isothipendyl.
Midomafetamine	Midomafetamine may decrease the sedative activities of Isothipendyl.
2,5-Dimethoxy-4-ethylamphetamine	2,5-Dimethoxy-4-ethylamphetamine may decrease the sedative activities of Isothipendyl.
4-Bromo-2,5-dimethoxyamphetamine	4-Bromo-2,5-dimethoxyamphetamine may decrease the sedative activities of Isothipendyl.
Tenamfetamine	Tenamfetamine may decrease the sedative activities of Isothipendyl.
Chlorphentermine	Chlorphentermine may decrease the sedative activities of Isothipendyl.
Methylenedioxyethamphetamine	Methylenedioxyethamphetamine may decrease the sedative activities of Isothipendyl.
Dextroamphetamine	Dextroamphetamine may decrease the sedative activities of Isothipendyl.
Metamfetamine	Metamfetamine may decrease the sedative activities of Isothipendyl.
Iofetamine I-123	Iofetamine I-123 may decrease the sedative activities of Isothipendyl.
Ritobegron	Ritobegron may decrease the sedative activities of Isothipendyl.
Mephedrone	Mephedrone may decrease the sedative activities of Isothipendyl.
Methoxyphenamine	Methoxyphenamine may decrease the sedative activities of Isothipendyl.
Gepefrine	Gepefrine may decrease the sedative activities of Isothipendyl.
2,5-Dimethoxy-4-ethylthioamphetamine	2,5-Dimethoxy-4-ethylthioamphetamine may decrease the sedative activities of Isothipendyl.
Phendimetrazine	Phendimetrazine may decrease the sedative activities of Isothipendyl.
Pitolisant	The therapeutic efficacy of Pitolisant can be decreased when used in combination with Isothipendyl.
Norepinephrine	The therapeutic efficacy of Norepinephrine can be increased when used in combination with Isothipendyl.
Epinephrine	The therapeutic efficacy of Epinephrine can be increased when used in combination with Isothipendyl.
Droxidopa	The therapeutic efficacy of Droxidopa can be increased when used in combination with Isothipendyl.
Levonordefrin	The therapeutic efficacy of Levonordefrin can be increased when used in combination with Isothipendyl.
Protokylol	The therapeutic efficacy of Protokylol can be increased when used in combination with Isothipendyl.
Racepinephrine	The therapeutic efficacy of Racepinephrine can be increased when used in combination with Isothipendyl.
Theodrenaline	The therapeutic efficacy of Theodrenaline can be increased when used in combination with Isothipendyl.
Deoxyepinephrine	The therapeutic efficacy of Deoxyepinephrine can be increased when used in combination with Isothipendyl.
Ephedrine	The therapeutic efficacy of Ephedrine can be increased when used in combination with Isothipendyl.
Hyoscyamine	Isothipendyl may increase the anticholinergic activities of Hyoscyamine.

Target Protein

Histamine H1 receptor HRH1

Referensi & Sumber

Synthesis reference: U.S. Patent 2,974,139.

Artikel (PubMed)

PMID: 8546983
Moreau A, Dompmartin A, Dubreuil A, Leroy D: Phototoxic and photoprotective effects of topical isothipendyl. Photodermatol Photoimmunol Photomed. 1995 Apr;11(2):50-4.

Contoh Produk & Brand

Produk: 0 • International brands: 6

International Brands

Actapront — Purissimus
Alergis Jalea — Deutsche Pharma
Andantol — Deutsche Pharma
Apaisyl — Merck
Calmogel — Sanofi
Nilergex — I.C.I.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.

Deskripsi

Struktur Molekul 2D

Deskripsi metode visualisasi