Antazoline

DB08799

small molecule approved

Deskripsi

Antazoline is a 1st generation antihistamine with anticholinergic activity. It is used to relieve nasal congestion. It is also formulated as eye drops with naphazoline to relieve allergic conjunctivitis.

Struktur Molekul 2D

Berat 265.3529
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

405 Data
Ivabradine Ivabradine may increase the QTc-prolonging activities of Antazoline.
Benzylpenicilloyl polylysine Antazoline may decrease effectiveness of Benzylpenicilloyl polylysine as a diagnostic agent.
Betahistine The therapeutic efficacy of Betahistine can be decreased when used in combination with Antazoline.
Hyaluronidase (ovine) The therapeutic efficacy of Hyaluronidase (ovine) can be decreased when used in combination with Antazoline.
Hyaluronidase (human recombinant) The therapeutic efficacy of Hyaluronidase (human recombinant) can be decreased when used in combination with Antazoline.
Hyaluronidase The therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Antazoline.
Amphetamine Amphetamine may decrease the sedative activities of Antazoline.
Phentermine Phentermine may decrease the sedative activities of Antazoline.
Pseudoephedrine Pseudoephedrine may decrease the sedative activities of Antazoline.
Benzphetamine Benzphetamine may decrease the sedative activities of Antazoline.
Diethylpropion Diethylpropion may decrease the sedative activities of Antazoline.
Lisdexamfetamine Lisdexamfetamine may decrease the sedative activities of Antazoline.
Mephentermine Mephentermine may decrease the sedative activities of Antazoline.
MMDA MMDA may decrease the sedative activities of Antazoline.
Midomafetamine Midomafetamine may decrease the sedative activities of Antazoline.
2,5-Dimethoxy-4-ethylamphetamine 2,5-Dimethoxy-4-ethylamphetamine may decrease the sedative activities of Antazoline.
4-Bromo-2,5-dimethoxyamphetamine 4-Bromo-2,5-dimethoxyamphetamine may decrease the sedative activities of Antazoline.
Tenamfetamine Tenamfetamine may decrease the sedative activities of Antazoline.
Chlorphentermine Chlorphentermine may decrease the sedative activities of Antazoline.
Methylenedioxyethamphetamine Methylenedioxyethamphetamine may decrease the sedative activities of Antazoline.
Dextroamphetamine Dextroamphetamine may decrease the sedative activities of Antazoline.
Metamfetamine Metamfetamine may decrease the sedative activities of Antazoline.
Iofetamine I-123 Iofetamine I-123 may decrease the sedative activities of Antazoline.
Ritobegron Ritobegron may decrease the sedative activities of Antazoline.
Mephedrone Mephedrone may decrease the sedative activities of Antazoline.
Methoxyphenamine Methoxyphenamine may decrease the sedative activities of Antazoline.
Gepefrine Gepefrine may decrease the sedative activities of Antazoline.
2,5-Dimethoxy-4-ethylthioamphetamine 2,5-Dimethoxy-4-ethylthioamphetamine may decrease the sedative activities of Antazoline.
Phendimetrazine Phendimetrazine may decrease the sedative activities of Antazoline.
Dofetilide The risk or severity of QTc prolongation can be increased when Antazoline is combined with Dofetilide.
Citalopram The risk or severity of QTc prolongation can be increased when Antazoline is combined with Citalopram.
Anagrelide The risk or severity of QTc prolongation can be increased when Antazoline is combined with Anagrelide.
Disopyramide The risk or severity of QTc prolongation can be increased when Antazoline is combined with Disopyramide.
Clemastine The risk or severity of QTc prolongation can be increased when Antazoline is combined with Clemastine.
Ibutilide The risk or severity of QTc prolongation can be increased when Antazoline is combined with Ibutilide.
Valproic acid The risk or severity of QTc prolongation can be increased when Antazoline is combined with Valproic acid.
Terfenadine The risk or severity of QTc prolongation can be increased when Antazoline is combined with Terfenadine.
Grepafloxacin The risk or severity of QTc prolongation can be increased when Antazoline is combined with Grepafloxacin.
Quinine The risk or severity of QTc prolongation can be increased when Antazoline is combined with Quinine.
Sotalol The risk or severity of QTc prolongation can be increased when Antazoline is combined with Sotalol.
Erlotinib The risk or severity of QTc prolongation can be increased when Antazoline is combined with Erlotinib.
Toremifene The risk or severity of QTc prolongation can be increased when Antazoline is combined with Toremifene.
Cisapride The risk or severity of QTc prolongation can be increased when Antazoline is combined with Cisapride.
Imatinib The risk or severity of QTc prolongation can be increased when Antazoline is combined with Imatinib.
Astemizole The risk or severity of QTc prolongation can be increased when Antazoline is combined with Astemizole.
Thioridazine The risk or severity of QTc prolongation can be increased when Antazoline is combined with Thioridazine.
Trovafloxacin The risk or severity of QTc prolongation can be increased when Antazoline is combined with Trovafloxacin.
Mifepristone The risk or severity of QTc prolongation can be increased when Antazoline is combined with Mifepristone.
Flupentixol The risk or severity of QTc prolongation can be increased when Antazoline is combined with Flupentixol.
Cocaine The risk or severity of QTc prolongation can be increased when Antazoline is combined with Cocaine.
Quinidine The risk or severity of QTc prolongation can be increased when Antazoline is combined with Quinidine.
Procainamide The risk or severity of QTc prolongation can be increased when Antazoline is combined with Procainamide.
Pimozide The risk or severity of QTc prolongation can be increased when Antazoline is combined with Pimozide.
Amiodarone The risk or severity of QTc prolongation can be increased when Antazoline is combined with Amiodarone.
Arsenic trioxide The risk or severity of QTc prolongation can be increased when Antazoline is combined with Arsenic trioxide.
Escitalopram The risk or severity of QTc prolongation can be increased when Antazoline is combined with Escitalopram.
Domperidone The risk or severity of QTc prolongation can be increased when Antazoline is combined with Domperidone.
Sparfloxacin The risk or severity of QTc prolongation can be increased when Antazoline is combined with Sparfloxacin.
Halofantrine The risk or severity of QTc prolongation can be increased when Antazoline is combined with Halofantrine.
Bepridil The risk or severity of QTc prolongation can be increased when Antazoline is combined with Bepridil.
Paliperidone The risk or severity of QTc prolongation can be increased when Antazoline is combined with Paliperidone.
Lithium cation The risk or severity of QTc prolongation can be increased when Antazoline is combined with Lithium cation.
Temafloxacin The risk or severity of QTc prolongation can be increased when Antazoline is combined with Temafloxacin.
Zuclopenthixol The risk or severity of QTc prolongation can be increased when Antazoline is combined with Zuclopenthixol.
Tetrabenazine The risk or severity of QTc prolongation can be increased when Antazoline is combined with Tetrabenazine.
Dronedarone The risk or severity of QTc prolongation can be increased when Antazoline is combined with Dronedarone.
Nilotinib The risk or severity of QTc prolongation can be increased when Antazoline is combined with Nilotinib.
Iloperidone The risk or severity of QTc prolongation can be increased when Antazoline is combined with Iloperidone.
Vandetanib The risk or severity of QTc prolongation can be increased when Antazoline is combined with Vandetanib.
Romidepsin The risk or severity of QTc prolongation can be increased when Antazoline is combined with Romidepsin.
Asenapine The risk or severity of QTc prolongation can be increased when Antazoline is combined with Asenapine.
Artemether The risk or severity of QTc prolongation can be increased when Antazoline is combined with Artemether.
Lumefantrine The risk or severity of QTc prolongation can be increased when Antazoline is combined with Lumefantrine.
Vemurafenib The risk or severity of QTc prolongation can be increased when Antazoline is combined with Vemurafenib.
Eliglustat The risk or severity of QTc prolongation can be increased when Antazoline is combined with Eliglustat.
Ribociclib The risk or severity of QTc prolongation can be increased when Ribociclib is combined with Antazoline.
Glasdegib The risk or severity of QTc prolongation can be increased when Antazoline is combined with Glasdegib.
Deutetrabenazine The risk or severity of QTc prolongation can be increased when Antazoline is combined with Deutetrabenazine.
Macimorelin The risk or severity of QTc prolongation can be increased when Antazoline is combined with Macimorelin.
Terodiline The risk or severity of QTc prolongation can be increased when Antazoline is combined with Terodiline.
Leuprolide The risk or severity of QTc prolongation can be increased when Leuprolide is combined with Antazoline.
Goserelin The risk or severity of QTc prolongation can be increased when Goserelin is combined with Antazoline.
Erythromycin The risk or severity of QTc prolongation can be increased when Erythromycin is combined with Antazoline.
Azithromycin The risk or severity of QTc prolongation can be increased when Azithromycin is combined with Antazoline.
Moxifloxacin The risk or severity of QTc prolongation can be increased when Moxifloxacin is combined with Antazoline.
Ranolazine The risk or severity of QTc prolongation can be increased when Ranolazine is combined with Antazoline.
Sulfisoxazole The risk or severity of QTc prolongation can be increased when Sulfisoxazole is combined with Antazoline.
Amitriptyline The risk or severity of QTc prolongation can be increased when Amitriptyline is combined with Antazoline.
Methadone The risk or severity of QTc prolongation can be increased when Methadone is combined with Antazoline.
Diltiazem The risk or severity of QTc prolongation can be increased when Diltiazem is combined with Antazoline.
Clozapine The risk or severity of QTc prolongation can be increased when Antazoline is combined with Clozapine.
Sulpiride The risk or severity of QTc prolongation can be increased when Sulpiride is combined with Antazoline.
Nimodipine The risk or severity of QTc prolongation can be increased when Nimodipine is combined with Antazoline.
Promazine The risk or severity of QTc prolongation can be increased when Promazine is combined with Antazoline.
Prochlorperazine The risk or severity of QTc prolongation can be increased when Prochlorperazine is combined with Antazoline.
Droperidol The risk or severity of QTc prolongation can be increased when Droperidol is combined with Antazoline.
Imipramine The risk or severity of QTc prolongation can be increased when Imipramine is combined with Antazoline.
Chlorpromazine The risk or severity of QTc prolongation can be increased when Chlorpromazine is combined with Antazoline.
Oxaliplatin The risk or severity of QTc prolongation can be increased when Oxaliplatin is combined with Antazoline.
Ciprofloxacin The risk or severity of QTc prolongation can be increased when Ciprofloxacin is combined with Antazoline.

Target Protein

Histamine H1 receptor HRH1

Referensi & Sumber

Synthesis reference: Miescher, K. and Klarer, W.; US. Patent 2,449,241; September 14,1948: assigned to Ciba Pharmaceutical Products, Inc.
Artikel (PubMed)
  • PMID: 20383847
    Figus M, Fogagnolo P, Lazzeri S, Capizzi F, Romagnoli M, Canovetti A, Iester M, Ferreras A, Rossetti L, Nardi M: Treatment of allergic conjunctivitis: results of a 1-month, single-masked randomized study. Eur J Ophthalmol. 2010 Sep-Oct;20(5):811-8.

Contoh Produk & Brand

Produk: 8 • International brands: 1
Produk
  • Albalon A
    Liquid • - • Ophthalmic • Canada • OTC • Approved
  • Cooper A.R.
    Solution / drops • - • Ophthalmic • Canada • OTC • Approved
  • Ophtrivin A Ophthalmic Dps
    Solution / drops • - • Ophthalmic • Canada • OTC • Approved
  • Refresh Eye Allergy Relief
    Solution • - • Ophthalmic • Canada • OTC • Approved
  • Steritears Ar
    Solution / drops • - • Ophthalmic • Canada • OTC • Approved
  • Vasocon A Eye Drops
    Solution / drops • - • Ophthalmic • Canada • OTC • Approved
  • Vasocon A Oph Soln
    Solution / drops • - • Ophthalmic • Canada • OTC • Approved
  • Zincfrin A
    Solution / drops • - • Ophthalmic • Canada • OTC • Approved
International Brands
  • Vasocon-a

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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