Peringatan Keamanan

Oral LD50, Rat: 3700 mg/kg; Dermal LD50, Rabbit: 9300 mg/kg

Triclosan

DB08604

small molecule approved investigational

Deskripsi

An aromatic ether that is phenol which is substituted at C-5 by a chloro group and at C-2 by a 2,4-dichlorophenoxy group. It is widely used as a preservative and antimicrobial agent in personal care products such as soaps, skin creams, toothpaste and deodorants as well as in household items such as plastic chopping boards, sports equipment and shoes.

Struktur Molekul 2D

Berat 289.542
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) The terminal plasma half life of triclosan is 21 h.[A263242]
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

A study conducted in 2000 demonstrated that low amounts of triclosan can be absorbed through skin and can enter the bloodstream.A7171 Triclosan is rapidly absorbed and distributed in the human body.A263242 Maximum concentrations are reached within three hours after oral intake. However, the metabolism and excretion of the compound is fast.

Metabolisme

Triclosan is prone to phase II metabolism via sulfotransferase and glucuronosyltransferase enzymes (Wang et al., 2004). In humans the resulting conjugates are excreted primarily in urine.A263242

Rute Eliminasi

In one study, after in vivo topical application of a 64.5mM alcoholic solution of (3)Htriclosan to rat skin, 12% radioactivity was recovered in the faeces, 8% in the carcass 1% in the urine, 30% in the stratum corneum and 26% was rinsed from the skin surface at 24 hours after application.A7171

Interaksi Obat

0 Data
Tidak ada data.

Target Protein

Enoyl-[acyl-carrier-protein] reductase [NADH] FabI fabI
Enoyl-[acyl-carrier-protein] reductase [NADH] inhA
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI fabI
Enoyl-[acyl-carrier-protein] reductase [NADH] fabI
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI fabI
Nuclear receptor subfamily 1 group I member 2 NR1I2
Androgen receptor AR
Nuclear receptor subfamily 1 group I member 3 NR1I3
Peroxisome proliferator-activated receptor gamma PPARG
Thyroid peroxidase TPO

Referensi & Sumber

Synthesis reference: Michael A. Mitchell, "Process For Producing Triclosan-Coated Superabsorbents." U.S. Patent US20120157302, issued June 21, 2012.
Artikel (PubMed)
  • PMID: 15073159
    Russell AD: Whither triclosan? J Antimicrob Chemother. 2004 May;53(5):693-5. Epub 2004 Apr 8.
  • PMID: 10196195
    Heath RJ, Rubin JR, Holland DR, Zhang E, Snow ME, Rock CO: Mechanism of triclosan inhibition of bacterial fatty acid synthesis. J Biol Chem. 1999 Apr 16;274(16):11110-4.
  • PMID: 12384334
    Fan F, Yan K, Wallis NG, Reed S, Moore TD, Rittenhouse SF, DeWolf WE Jr, Huang J, McDevitt D, Miller WH, Seefeld MA, Newlander KA, Jakas DR, Head MS, Payne DJ: Defining and combating the mechanisms of triclosan resistance in clinical isolates of Staphylococcus aureus. Antimicrob Agents Chemother. 2002 Nov;46(11):3343-7.
  • PMID: 10722890
    Moss T, Howes D, Williams FM: Percutaneous penetration and dermal metabolism of triclosan (2,4, 4'-trichloro-2'-hydroxydiphenyl ether). Food Chem Toxicol. 2000 Apr;38(4):361-70.
  • PMID: 16952905
    Sandborgh-Englund G, Adolfsson-Erici M, Odham G, Ekstrand J: Pharmacokinetics of triclosan following oral ingestion in humans. J Toxicol Environ Health A. 2006 Oct;69(20):1861-73. doi: 10.1080/15287390600631706.

Contoh Produk & Brand

Produk: 2130 • International brands: 2
Produk
  • 1% Triclosan Anti-microbial Foaming Skin Cleanser
    Liquid • 1.0 % • Topical • Canada • OTC • Approved
  • 1% Triclosan Anti-microbial Skin Cleanser
    Gel • 1.0 % • Topical • Canada • OTC • Approved
  • 1014 Foaming Antimicrobial
    Soap • 0.003 mg/1mL • Topical • US • OTC
  • 3 in 1 Antibacterial Hair and Body Wash
    Solution • 11.7 g/100mL • Topical • US • OTC
  • Ab Handsoap
    Liquid • 0.375 % • Topical • Canada • OTC • Approved
  • Accent Plus Antibacterial Skin Cleanser
    Liquid • .3 % • Topical • Canada • OTC • Approved
  • Acclaim
    Liquid • 0.10 % • Topical • Canada • OTC • Approved
  • Acnopur Mousse Assainissante
    Cream • 0.3 % • Topical • Canada • OTC • Approved
Menampilkan 8 dari 2130 produk.
International Brands
  • DERMAPROT
  • Stri-Dex cleansing bar

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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