Parecoxib

DB08439

small molecule approved

Deskripsi

Parecoxib is a water-soluble and injectable prodrug of valdecoxib. It is marketed as Dynastat in the European Union. Parecoxib is a COX2 selective inhibitor in the same category as celecoxib (Celebrex) and rofecoxib (Vioxx). As it is injectable, it can be used perioperatively when patients are unable to take oral medications. It is approved through much of Europe for short term perioperative pain control much in the same way ketorolac (Toradol) is used in the United States. A letter of non-approval for parecoxib was issued by the FDA in 2005.

Struktur Molekul 2D

Berat 370.422
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 22 minutes (parecoxib); 8 hours (valdecoxib)
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Hepatic. Metabolized primarily via CYP3A4 and 2C9 to valdecoxib and propionic acid.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

1606 Data
Amlodipine The metabolism of Parecoxib can be decreased when combined with Amlodipine.
Midodrine The risk or severity of hypertension can be increased when Midodrine is combined with Parecoxib.
Isoetharine The risk or severity of hypertension can be increased when Isoetharine is combined with Parecoxib.
Zolmitriptan The risk or severity of hypertension can be increased when Zolmitriptan is combined with Parecoxib.
Norepinephrine The risk or severity of hypertension can be increased when Norepinephrine is combined with Parecoxib.
Phenylephrine The risk or severity of hypertension can be increased when Phenylephrine is combined with Parecoxib.
Phenylpropanolamine The risk or severity of hypertension can be increased when Phenylpropanolamine is combined with Parecoxib.
Droperidol The risk or severity of hypertension can be increased when Droperidol is combined with Parecoxib.
Doxapram The risk or severity of hypertension can be increased when Doxapram is combined with Parecoxib.
Atropine The risk or severity of hypertension can be increased when Atropine is combined with Parecoxib.
Linezolid The risk or severity of hypertension can be increased when Linezolid is combined with Parecoxib.
Metaraminol The risk or severity of hypertension can be increased when Metaraminol is combined with Parecoxib.
Furazolidone The risk or severity of hypertension can be increased when Furazolidone is combined with Parecoxib.
Thioridazine The risk or severity of hypertension can be increased when Thioridazine is combined with Parecoxib.
Nicergoline The risk or severity of hypertension can be increased when Nicergoline is combined with Parecoxib.
Methoxamine The risk or severity of hypertension can be increased when Methoxamine is combined with Parecoxib.
Isoflurane The risk or severity of hypertension can be increased when Isoflurane is combined with Parecoxib.
Propiomazine The risk or severity of hypertension can be increased when Propiomazine is combined with Parecoxib.
Minaprine The risk or severity of hypertension can be increased when Minaprine is combined with Parecoxib.
Orciprenaline The risk or severity of hypertension can be increased when Orciprenaline is combined with Parecoxib.
Phenmetrazine The risk or severity of hypertension can be increased when Phenmetrazine is combined with Parecoxib.
Trifluoperazine The risk or severity of hypertension can be increased when Trifluoperazine is combined with Parecoxib.
Pseudoephedrine The risk or severity of hypertension can be increased when Pseudoephedrine is combined with Parecoxib.
Ritodrine The risk or severity of hypertension can be increased when Ritodrine is combined with Parecoxib.
Flupentixol The risk or severity of hypertension can be increased when Flupentixol is combined with Parecoxib.
Remifentanil The risk or severity of hypertension can be increased when Remifentanil is combined with Parecoxib.
Bitolterol The risk or severity of hypertension can be increased when Bitolterol is combined with Parecoxib.
Oxymetazoline The risk or severity of hypertension can be increased when Oxymetazoline is combined with Parecoxib.
Diethylpropion The risk or severity of hypertension can be increased when Diethylpropion is combined with Parecoxib.
Naratriptan The risk or severity of hypertension can be increased when Naratriptan is combined with Parecoxib.
Frovatriptan The risk or severity of hypertension can be increased when Frovatriptan is combined with Parecoxib.
Isoprenaline The risk or severity of hypertension can be increased when Isoprenaline is combined with Parecoxib.
Arbutamine The risk or severity of hypertension can be increased when Arbutamine is combined with Parecoxib.
Desflurane The risk or severity of hypertension can be increased when Desflurane is combined with Parecoxib.
Isocarboxazid The risk or severity of hypertension can be increased when Isocarboxazid is combined with Parecoxib.
Lisdexamfetamine The risk or severity of hypertension can be increased when Lisdexamfetamine is combined with Parecoxib.
Fenoterol The risk or severity of hypertension can be increased when Fenoterol is combined with Parecoxib.
Pirbuterol The risk or severity of hypertension can be increased when Pirbuterol is combined with Parecoxib.
Ephedra sinica root The risk or severity of hypertension can be increased when Ephedra sinica root is combined with Parecoxib.
Ephedrine The risk or severity of hypertension can be increased when Ephedrine is combined with Parecoxib.
Mephentermine The risk or severity of hypertension can be increased when Mephentermine is combined with Parecoxib.
Procaterol The risk or severity of hypertension can be increased when Procaterol is combined with Parecoxib.
Methotrimeprazine The risk or severity of hypertension can be increased when Methotrimeprazine is combined with Parecoxib.
Clenbuterol The risk or severity of hypertension can be increased when Clenbuterol is combined with Parecoxib.
Bambuterol The risk or severity of hypertension can be increased when Bambuterol is combined with Parecoxib.
MMDA The risk or severity of hypertension can be increased when MMDA is combined with Parecoxib.
Midomafetamine The risk or severity of hypertension can be increased when Midomafetamine is combined with Parecoxib.
2,5-Dimethoxy-4-ethylamphetamine The risk or severity of hypertension can be increased when 2,5-Dimethoxy-4-ethylamphetamine is combined with Parecoxib.
4-Methoxyamphetamine The risk or severity of hypertension can be increased when 4-Methoxyamphetamine is combined with Parecoxib.
4-Bromo-2,5-dimethoxyamphetamine The risk or severity of hypertension can be increased when 4-Bromo-2,5-dimethoxyamphetamine is combined with Parecoxib.
Tenamfetamine The risk or severity of hypertension can be increased when Tenamfetamine is combined with Parecoxib.
Chlorphentermine The risk or severity of hypertension can be increased when Chlorphentermine is combined with Parecoxib.
Dextroamphetamine The risk or severity of hypertension can be increased when Dextroamphetamine is combined with Parecoxib.
Phendimetrazine The risk or severity of hypertension can be increased when Phendimetrazine is combined with Parecoxib.
Periciazine The risk or severity of hypertension can be increased when Periciazine is combined with Parecoxib.
Acepromazine The risk or severity of hypertension can be increased when Acepromazine is combined with Parecoxib.
Thioproperazine The risk or severity of hypertension can be increased when Thioproperazine is combined with Parecoxib.
Epicaptopril The risk or severity of hypertension can be increased when Epicaptopril is combined with Parecoxib.
Clorgiline The risk or severity of hypertension can be increased when Clorgiline is combined with Parecoxib.
1-benzylimidazole The risk or severity of hypertension can be increased when 1-benzylimidazole is combined with Parecoxib.
Nialamide The risk or severity of hypertension can be increased when Nialamide is combined with Parecoxib.
Amibegron The risk or severity of hypertension can be increased when Amibegron is combined with Parecoxib.
Naluzotan The risk or severity of hypertension can be increased when Naluzotan is combined with Parecoxib.
Pizotifen The risk or severity of hypertension can be increased when Pizotifen is combined with Parecoxib.
Solabegron The risk or severity of hypertension can be increased when Solabegron is combined with Parecoxib.
Esmirtazapine The risk or severity of hypertension can be increased when Esmirtazapine is combined with Parecoxib.
Nitrous oxide The risk or severity of hypertension can be increased when Nitrous oxide is combined with Parecoxib.
Xylometazoline The risk or severity of hypertension can be increased when Xylometazoline is combined with Parecoxib.
Dexmethylphenidate The risk or severity of hypertension can be increased when Dexmethylphenidate is combined with Parecoxib.
Isometheptene The risk or severity of hypertension can be increased when Isometheptene is combined with Parecoxib.
Levonordefrin The risk or severity of hypertension can be increased when Levonordefrin is combined with Parecoxib.
Naphazoline The risk or severity of hypertension can be increased when Naphazoline is combined with Parecoxib.
Tetryzoline The risk or severity of hypertension can be increased when Tetryzoline is combined with Parecoxib.
Cinitapride The risk or severity of hypertension can be increased when Parecoxib is combined with Cinitapride.
Tyramine The risk or severity of hypertension can be increased when Parecoxib is combined with Tyramine.
Adrafinil The risk or severity of hypertension can be increased when Parecoxib is combined with Adrafinil.
Isoxsuprine The risk or severity of hypertension can be increased when Parecoxib is combined with Isoxsuprine.
Ifenprodil The risk or severity of hypertension can be increased when Parecoxib is combined with Ifenprodil.
Hexoprenaline The risk or severity of hypertension can be increased when Parecoxib is combined with Hexoprenaline.
Etilefrine The risk or severity of hypertension can be increased when Parecoxib is combined with Etilefrine.
Cirazoline The risk or severity of hypertension can be increased when Parecoxib is combined with Cirazoline.
Synephrine The risk or severity of hypertension can be increased when Parecoxib is combined with Synephrine.
Hydracarbazine The risk or severity of hypertension can be increased when Parecoxib is combined with Hydracarbazine.
Benmoxin The risk or severity of hypertension can be increased when Parecoxib is combined with Benmoxin.
Mebanazine The risk or severity of hypertension can be increased when Parecoxib is combined with Mebanazine.
Octamoxin The risk or severity of hypertension can be increased when Parecoxib is combined with Octamoxin.
Pheniprazine The risk or severity of hypertension can be increased when Parecoxib is combined with Pheniprazine.
Phenoxypropazine The risk or severity of hypertension can be increased when Parecoxib is combined with Phenoxypropazine.
Pivhydrazine The risk or severity of hypertension can be increased when Parecoxib is combined with Pivhydrazine.
Safrazine The risk or severity of hypertension can be increased when Parecoxib is combined with Safrazine.
Caroxazone The risk or severity of hypertension can be increased when Parecoxib is combined with Caroxazone.
Doxofylline The risk or severity of hypertension can be increased when Parecoxib is combined with Doxofylline.
Iofetamine I-123 The risk or severity of hypertension can be increased when Parecoxib is combined with Iofetamine I-123.
Racepinephrine The risk or severity of hypertension can be increased when Parecoxib is combined with Racepinephrine.
Amitraz The risk or severity of hypertension can be increased when Parecoxib is combined with Amitraz.
Medetomidine The risk or severity of hypertension can be increased when Parecoxib is combined with Medetomidine.
Xylazine The risk or severity of hypertension can be increased when Parecoxib is combined with Xylazine.
Atipamezole The risk or severity of hypertension can be increased when Parecoxib is combined with Atipamezole.
Ractopamine The risk or severity of hypertension can be increased when Parecoxib is combined with Ractopamine.
Romifidine The risk or severity of hypertension can be increased when Parecoxib is combined with Romifidine.

Target Protein

Prostaglandin G/H synthase 2 PTGS2
Lactotransferrin LTF

Referensi & Sumber

Belum ada data referensi/link/attachment untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field referensi.

Contoh Produk & Brand

Produk: 5 • International brands: 0
Produk
  • Dynastat
    Injection, powder, for solution • 40 mg • Intramuscular; Intravenous • EU • Approved
  • Dynastat
    Injection, powder, for solution • 40 mg • Intramuscular; Intravenous • EU • Approved
  • Dynastat
    Injection, powder, for solution • 40 mg • Intramuscular; Intravenous • EU • Approved
  • Dynastat
    Injection, powder, for solution • 40 mg • Intramuscular; Intravenous • EU • Approved
  • Parecoxib Sodium
    Injection, powder, for solution • 40 mg/1 • Intramuscular; Intravenous • US

Sekuens Gen/Protein (FASTA)

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