Hexestrol

DB07931

small molecule withdrawn

Deskripsi

A synthetic estrogen that has been used as a hormonal antineoplastic agent.

Struktur Molekul 2D

Berat 270.3661
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

600 Data
Prasterone The risk or severity of adverse effects can be increased when Prasterone is combined with Hexestrol.
Exemestane The therapeutic efficacy of Exemestane can be decreased when used in combination with Hexestrol.
Hyaluronidase (ovine) The therapeutic efficacy of Hyaluronidase (ovine) can be decreased when used in combination with Hexestrol.
Hyaluronidase (human recombinant) The therapeutic efficacy of Hyaluronidase (human recombinant) can be decreased when used in combination with Hexestrol.
Hyaluronidase The therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Hexestrol.
Lenalidomide Hexestrol may increase the thrombogenic activities of Lenalidomide.
Ospemifene The risk or severity of adverse effects can be increased when Hexestrol is combined with Ospemifene.
Ropinirole Hexestrol may increase the excretion rate of Ropinirole which could result in a lower serum level and potentially a reduction in efficacy.
Thalidomide Hexestrol may increase the thrombogenic activities of Thalidomide.
Cetuximab Hexestrol may increase the thrombogenic activities of Cetuximab.
Human immunoglobulin G Hexestrol may increase the thrombogenic activities of Human immunoglobulin G.
Omalizumab Hexestrol may increase the thrombogenic activities of Omalizumab.
Adalimumab Hexestrol may increase the thrombogenic activities of Adalimumab.
Gemtuzumab ozogamicin Hexestrol may increase the thrombogenic activities of Gemtuzumab ozogamicin.
Indium In-111 satumomab pendetide Hexestrol may increase the thrombogenic activities of Indium In-111 satumomab pendetide.
Infliximab Hexestrol may increase the thrombogenic activities of Infliximab.
Trastuzumab Hexestrol may increase the thrombogenic activities of Trastuzumab.
Rituximab Hexestrol may increase the thrombogenic activities of Rituximab.
Basiliximab Hexestrol may increase the thrombogenic activities of Basiliximab.
Muromonab Hexestrol may increase the thrombogenic activities of Muromonab.
Digoxin Immune Fab (Ovine) Hexestrol may increase the thrombogenic activities of Digoxin Immune Fab (Ovine).
Ibritumomab tiuxetan Hexestrol may increase the thrombogenic activities of Ibritumomab tiuxetan.
Tositumomab Hexestrol may increase the thrombogenic activities of Tositumomab.
Alemtuzumab Hexestrol may increase the thrombogenic activities of Alemtuzumab.
Capromab pendetide Hexestrol may increase the thrombogenic activities of Capromab pendetide.
Efalizumab Hexestrol may increase the thrombogenic activities of Efalizumab.
Antithymocyte immunoglobulin (rabbit) Hexestrol may increase the thrombogenic activities of Antithymocyte immunoglobulin (rabbit).
Natalizumab Hexestrol may increase the thrombogenic activities of Natalizumab.
Palivizumab Hexestrol may increase the thrombogenic activities of Palivizumab.
Daclizumab Hexestrol may increase the thrombogenic activities of Daclizumab.
Bevacizumab Hexestrol may increase the thrombogenic activities of Bevacizumab.
Technetium Tc-99m arcitumomab Hexestrol may increase the thrombogenic activities of Technetium Tc-99m arcitumomab.
Eculizumab Hexestrol may increase the thrombogenic activities of Eculizumab.
Panitumumab Hexestrol may increase the thrombogenic activities of Panitumumab.
Ranibizumab Hexestrol may increase the thrombogenic activities of Ranibizumab.
Galiximab Hexestrol may increase the thrombogenic activities of Galiximab.
Pexelizumab Hexestrol may increase the thrombogenic activities of Pexelizumab.
Afelimomab Hexestrol may increase the thrombogenic activities of Afelimomab.
Epratuzumab Hexestrol may increase the thrombogenic activities of Epratuzumab.
Bectumomab Hexestrol may increase the thrombogenic activities of Bectumomab.
Oregovomab Hexestrol may increase the thrombogenic activities of Oregovomab.
IGN311 Hexestrol may increase the thrombogenic activities of IGN311.
Adecatumumab Hexestrol may increase the thrombogenic activities of Adecatumumab.
Labetuzumab Hexestrol may increase the thrombogenic activities of Labetuzumab.
Matuzumab Hexestrol may increase the thrombogenic activities of Matuzumab.
Fontolizumab Hexestrol may increase the thrombogenic activities of Fontolizumab.
Bavituximab Hexestrol may increase the thrombogenic activities of Bavituximab.
CR002 Hexestrol may increase the thrombogenic activities of CR002.
Rozrolimupab Hexestrol may increase the thrombogenic activities of Rozrolimupab.
Girentuximab Hexestrol may increase the thrombogenic activities of Girentuximab.
Obiltoxaximab Hexestrol may increase the thrombogenic activities of Obiltoxaximab.
XTL-001 Hexestrol may increase the thrombogenic activities of XTL-001.
NAV 1800 Hexestrol may increase the thrombogenic activities of NAV 1800.
Briakinumab Hexestrol may increase the thrombogenic activities of Briakinumab.
Otelixizumab Hexestrol may increase the thrombogenic activities of Otelixizumab.
AMG 108 Hexestrol may increase the thrombogenic activities of AMG 108.
Iratumumab Hexestrol may increase the thrombogenic activities of Iratumumab.
Enokizumab Hexestrol may increase the thrombogenic activities of Enokizumab.
Ramucirumab Hexestrol may increase the thrombogenic activities of Ramucirumab.
Farletuzumab Hexestrol may increase the thrombogenic activities of Farletuzumab.
Veltuzumab Hexestrol may increase the thrombogenic activities of Veltuzumab.
Ustekinumab Hexestrol may increase the thrombogenic activities of Ustekinumab.
Trastuzumab emtansine Hexestrol may increase the thrombogenic activities of Trastuzumab emtansine.
PRO-542 Hexestrol may increase the thrombogenic activities of PRO-542.
TNX-901 Hexestrol may increase the thrombogenic activities of TNX-901.
Inotuzumab ozogamicin Hexestrol may increase the thrombogenic activities of Inotuzumab ozogamicin.
RI 624 Hexestrol may increase the thrombogenic activities of RI 624.
Stamulumab Hexestrol may increase the thrombogenic activities of MYO-029.
CT-011 Hexestrol may increase the thrombogenic activities of CT-011.
Leronlimab Hexestrol may increase the thrombogenic activities of Leronlimab.
Glembatumumab vedotin Hexestrol may increase the thrombogenic activities of Glembatumumab vedotin.
Olaratumab Hexestrol may increase the thrombogenic activities of Olaratumab.
IPH 2101 Hexestrol may increase the thrombogenic activities of IPH 2101.
TB-402 Hexestrol may increase the thrombogenic activities of TB-402.
Caplacizumab Hexestrol may increase the thrombogenic activities of Caplacizumab.
IMC-1C11 Hexestrol may increase the thrombogenic activities of IMC-1C11.
Eldelumab Hexestrol may increase the thrombogenic activities of Eldelumab.
Lumiliximab Hexestrol may increase the thrombogenic activities of Lumiliximab.
Canakinumab Hexestrol may increase the thrombogenic activities of Canakinumab.
Ipilimumab Hexestrol may increase the thrombogenic activities of Ipilimumab.
Nimotuzumab Hexestrol may increase the thrombogenic activities of Nimotuzumab.
Clenoliximab Hexestrol may increase the thrombogenic activities of Clenoliximab.
Tocilizumab Hexestrol may increase the thrombogenic activities of Tocilizumab.
BIIB015 Hexestrol may increase the thrombogenic activities of BIIB015.
Sonepcizumab Hexestrol may increase the thrombogenic activities of Sonepcizumab.
Motavizumab Hexestrol may increase the thrombogenic activities of Motavizumab.
Elotuzumab Hexestrol may increase the thrombogenic activities of Elotuzumab.
AVE9633 Hexestrol may increase the thrombogenic activities of AVE9633.
Carotuximab Hexestrol may increase the thrombogenic activities of Carotuximab.
XmAb 2513 Hexestrol may increase the thrombogenic activities of XmAb 2513.
Coltuximab ravtansine Hexestrol may increase the thrombogenic activities of Coltuximab ravtansine.
Lucatumumab Hexestrol may increase the thrombogenic activities of Lucatumumab.
Pertuzumab Hexestrol may increase the thrombogenic activities of Pertuzumab.
Siplizumab Hexestrol may increase the thrombogenic activities of Siplizumab.
Apolizumab Hexestrol may increase the thrombogenic activities of Apolizumab.
Sibrotuzumab Hexestrol may increase the thrombogenic activities of Sibrotuzumab.
Bivatuzumab Hexestrol may increase the thrombogenic activities of Bivatuzumab.
Lerdelimumab Hexestrol may increase the thrombogenic activities of Lerdelimumab.
Lexatumumab Hexestrol may increase the thrombogenic activities of Lexatumumab.
Reslizumab Hexestrol may increase the thrombogenic activities of Reslizumab.

Target Protein

Aldo-keto reductase family 1 member C1 AKR1C1
Estrogen receptor ESR1
Nuclear receptor subfamily 1 group I member 2 NR1I2
Nuclear receptor subfamily 1 group I member 3 NR1I3

Referensi & Sumber

Synthesis reference: U.S. Patent 2,357,985; U.S. Patent 2,421,401.
Artikel (PubMed)
  • PMID: 2998630
    Liehr JG, Ballatore AM, Dague BB, Ulubelen AA: Carcinogenicity and metabolic activation of hexestrol. Chem Biol Interact. 1985 Oct;55(1-2):157-76.

Contoh Produk & Brand

Produk: 0 • International brands: 5
International Brands
  • Estrifar
  • Estronal
  • Hexoestrol — Tai Yu
  • Synestrol — Biopharm
  • Synoestrol

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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