Tranilast is an antiallergic drug developed by Kissei Pharmaceuticals. In 1982, it was approved in Japan and South Korea for the management of bronchial asthma. Indications for keloid and hypertrophic scar were added in 1993. It has been used for the treatment of allergic disorders such as asthma, allergic rhinitis and atopic dermatitis.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Apixaban | The risk or severity of adverse effects can be increased when Tranilast is combined with Apixaban. |
| Dasatinib | Dasatinib may increase the anticoagulant activities of Tranilast. |
| Ursodeoxycholic acid | The risk or severity of adverse effects can be increased when Tranilast is combined with Ursodeoxycholic acid. |
| Glycochenodeoxycholic Acid | The risk or severity of adverse effects can be increased when Tranilast is combined with Glycochenodeoxycholic Acid. |
| Cholic Acid | The risk or severity of adverse effects can be increased when Tranilast is combined with Cholic Acid. |
| Glycocholic acid | The risk or severity of adverse effects can be increased when Tranilast is combined with Glycocholic acid. |
| Deoxycholic acid | The risk or severity of adverse effects can be increased when Tranilast is combined with Deoxycholic acid. |
| Taurocholic acid | The risk or severity of adverse effects can be increased when Tranilast is combined with Taurocholic acid. |
| Obeticholic acid | The risk or severity of adverse effects can be increased when Tranilast is combined with Obeticholic acid. |
| Chenodeoxycholic acid | The risk or severity of adverse effects can be increased when Tranilast is combined with Chenodeoxycholic acid. |
| Taurochenodeoxycholic acid | The risk or severity of adverse effects can be increased when Tranilast is combined with Taurochenodeoxycholic acid. |
| Tauroursodeoxycholic acid | The risk or severity of adverse effects can be increased when Tranilast is combined with Tauroursodeoxycholic acid. |
| Bamet-UD2 | The risk or severity of adverse effects can be increased when Tranilast is combined with Bamet-UD2. |
| Dehydrocholic acid | The risk or severity of adverse effects can be increased when Tranilast is combined with Dehydrocholic acid. |
| Hyodeoxycholic Acid | The risk or severity of adverse effects can be increased when Tranilast is combined with Hyodeoxycholic Acid. |
| Glucosamine | Glucosamine may increase the antiplatelet activities of Tranilast. |
| Ibritumomab tiuxetan | The risk or severity of adverse effects can be increased when Tranilast is combined with Ibritumomab tiuxetan. |
| Ibrutinib | The risk or severity of adverse effects can be increased when Ibrutinib is combined with Tranilast. |
| Obinutuzumab | The risk or severity of adverse effects can be increased when Tranilast is combined with Obinutuzumab. |
| Pentoxifylline | Pentoxifylline may increase the antiplatelet activities of Tranilast. |
| Rivaroxaban | Tranilast may increase the anticoagulant activities of Rivaroxaban. |
| Tipranavir | Tipranavir may increase the antiplatelet activities of Tranilast. |
| Urokinase | Tranilast may increase the anticoagulant activities of Urokinase. |
| Vitamin E | Vitamin E may increase the antiplatelet activities of Tranilast. |
| Ceritinib | Tranilast may increase the bradycardic activities of Ceritinib. |
| Ivabradine | Tranilast may increase the bradycardic activities of Ivabradine. |
| Ruxolitinib | Ruxolitinib may increase the bradycardic activities of Tranilast. |
| Cimetidine | The serum concentration of Tranilast can be increased when it is combined with Cimetidine. |
| Clopidogrel | The therapeutic efficacy of Clopidogrel can be decreased when used in combination with Tranilast. |
| Efavirenz | The serum concentration of Tranilast can be decreased when it is combined with Efavirenz. |
| Melatonin | The therapeutic efficacy of Tranilast can be decreased when used in combination with Melatonin. |
| Nafcillin | The therapeutic efficacy of Tranilast can be decreased when used in combination with Nafcillin. |
| Nitroprusside | Tranilast may increase the hypotensive activities of Nitroprusside. |
| Dantrolene | The risk or severity of hyperkalemia can be increased when Dantrolene is combined with Tranilast. |
| Lithium citrate | The risk or severity of adverse effects can be increased when Tranilast is combined with Lithium citrate. |
| Lithium carbonate | The risk or severity of adverse effects can be increased when Tranilast is combined with Lithium carbonate. |
| Lithium hydroxide | The risk or severity of adverse effects can be increased when Tranilast is combined with Lithium hydroxide. |
| Boceprevir | The serum concentration of Tranilast can be increased when it is combined with Boceprevir. |
| Pentosan polysulfate | The risk or severity of adverse effects can be increased when Pentosan polysulfate is combined with Tranilast. |
| Limaprost | Limaprost may increase the antiplatelet activities of Tranilast. |
| Omega-3 fatty acids | Omega-3 fatty acids may increase the antiplatelet activities of Tranilast. |
| Tositumomab | The risk or severity of adverse effects can be increased when Tranilast is combined with Tositumomab. |
| Ibutilide | Ibutilide may increase the arrhythmogenic activities of Tranilast. |
| Hyoscyamine | Hyoscyamine may increase the arrhythmogenic activities of Tranilast. |
| Atropine | Atropine may increase the arrhythmogenic activities of Tranilast. |
| Adenosine | Adenosine may increase the arrhythmogenic activities of Tranilast. |
| Moricizine | Moricizine may increase the arrhythmogenic activities of Tranilast. |
| Levosimendan | Levosimendan may increase the arrhythmogenic activities of Tranilast. |
| Procainamide | Procainamide may increase the arrhythmogenic activities of Tranilast. |
| Tocainide | Tocainide may increase the arrhythmogenic activities of Tranilast. |
| Encainide | Encainide may increase the arrhythmogenic activities of Tranilast. |
| Ajmaline | Ajmaline may increase the arrhythmogenic activities of Tranilast. |
| Aprindine | Aprindine may increase the arrhythmogenic activities of Tranilast. |
| Azimilide | Azimilide may increase the arrhythmogenic activities of Tranilast. |
| Tedisamil | Tedisamil may increase the arrhythmogenic activities of Tranilast. |
| Vernakalant | Vernakalant may increase the arrhythmogenic activities of Tranilast. |
| Cariporide | Cariporide may increase the arrhythmogenic activities of Tranilast. |
| Xylometazoline | Xylometazoline may increase the arrhythmogenic activities of Tranilast. |
| Sparteine | Sparteine may increase the arrhythmogenic activities of Tranilast. |
| Carteolol | Tranilast may increase the arrhythmogenic activities of Carteolol. |
| Metipranolol | Tranilast may increase the arrhythmogenic activities of Metipranolol. |
| Fasudil | Tranilast may increase the arrhythmogenic activities of Fasudil. |
| Melperone | Tranilast may increase the arrhythmogenic activities of Melperone. |
| Tropisetron | Tranilast may increase the arrhythmogenic activities of Tropisetron. |
| Simendan | Tranilast may increase the arrhythmogenic activities of Simendan. |
| Spiradoline | Tranilast may increase the arrhythmogenic activities of Spiradoline. |
| Pilsicainide | Tranilast may increase the arrhythmogenic activities of Pilsicainide. |
| Cicletanine | Tranilast may increase the arrhythmogenic activities of Cicletanine. |
| Cibenzoline | Tranilast may increase the arrhythmogenic activities of Cibenzoline. |
| Nizofenone | Tranilast may increase the arrhythmogenic activities of Nizofenone. |
| Prajmaline | Tranilast may increase the arrhythmogenic activities of Prajmaline. |
| Tiracizine | Tranilast may increase the arrhythmogenic activities of Tiracizine. |
| Ethacizine | Tranilast may increase the arrhythmogenic activities of Ethacizine. |
| Lorajmine | Tranilast may increase the arrhythmogenic activities of Lorajmine. |
| Bunaftine | Tranilast may increase the arrhythmogenic activities of Bunaftine. |
| Lorcainide | Tranilast may increase the arrhythmogenic activities of Lorcainide. |
| Hydroquinine | Tranilast may increase the arrhythmogenic activities of Hydroquinine. |
| Bioallethrin | Tranilast may increase the arrhythmogenic activities of Bioallethrin. |
| Fosfructose | Tranilast may increase the arrhythmogenic activities of Fosfructose. |
| Hydroquinidine | Tranilast may increase the arrhythmogenic activities of Hydroquinidine. |
| SOR-C13 | Tranilast may increase the arrhythmogenic activities of SOR-C13. |
| Digoxin | Digoxin may increase the arrhythmogenic activities of Tranilast. |
| Acetyldigitoxin | Acetyldigitoxin may increase the arrhythmogenic activities of Tranilast. |
| Deslanoside | Deslanoside may increase the arrhythmogenic activities of Tranilast. |
| Cymarin | Tranilast may increase the arrhythmogenic activities of Cymarin. |
| Metildigoxin | Tranilast may increase the arrhythmogenic activities of Metildigoxin. |
| Acetyldigoxin | Tranilast may increase the arrhythmogenic activities of Acetyldigoxin. |
| Niguldipine | Tranilast may increase the arrhythmogenic activities of Niguldipine. |
| Bretylium | Bretylium may increase the arrhythmogenic activities of Tranilast. |
| Isradipine | Isradipine may increase the arrhythmogenic activities of Tranilast. |
| Diltiazem | Diltiazem may increase the arrhythmogenic activities of Tranilast. |
| Trimethadione | Trimethadione may increase the arrhythmogenic activities of Tranilast. |
| Amlodipine | Amlodipine may increase the arrhythmogenic activities of Tranilast. |
| Nimodipine | Nimodipine may increase the arrhythmogenic activities of Tranilast. |
| Lercanidipine | Lercanidipine may increase the arrhythmogenic activities of Tranilast. |
| Lamotrigine | Lamotrigine may increase the arrhythmogenic activities of Tranilast. |
| Cinnarizine | Cinnarizine may increase the arrhythmogenic activities of Tranilast. |
| Verapamil | Verapamil may increase the arrhythmogenic activities of Tranilast. |
| Losartan | Losartan may increase the arrhythmogenic activities of Tranilast. |
| Levomenthol | Levomenthol may increase the arrhythmogenic activities of Tranilast. |