Unoprostone

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) Half-life of Unoprostone is 14 minutes.

Volume Distribusi Intended for local use only, very low systemic absorption.

Klirens (Clearance) Intended for local use only, very low systemic absorption.

Absorpsi

After application to the eye, unoprostone isopropyl is absorbed through the cornea and conjunctival epithelium where it is hydrolyzed by esterases to unoprostone free acid. mean peak unoprostone free acid plasma concentration was <1.5 ng/mL and dro pped below the lower limit of quantitation (<0.250 ng/mL) 1 hour following instillation, indicating low systemic absorption and rapid plasma excretion.

Metabolisme

After ocular application, unoprostone isopropyl is hydrolyzed by esterases in the cornea to its biological active metabolite, unoprostone free acid. Unoprostone free acid is then metabolized to several inactive metabolites with lower molecular weight and increased polarity via ?- or ?-oxidation. No secondary conjugation is found and no significant effect on hepatic microsomal enzyme activity has been observed.

Rute Eliminasi

Elimination of unoprostone free acid from human plasma is rapid. Plasma levels of unoprostone free acid dropped below the lower limit of quantitation ( < 0.25 ng/mL) 1 hour following ocular instillation. Urinary elimination is the predominant elimination route.

Interaksi Obat

289 Data

Valsartan	Valsartan may increase the hypotensive activities of Unoprostone.
Ramipril	Ramipril may increase the hypotensive activities of Unoprostone.
Esmolol	Esmolol may increase the hypotensive activities of Unoprostone.
Betaxolol	Betaxolol may increase the hypotensive activities of Unoprostone.
Reserpine	Reserpine may increase the hypotensive activities of Unoprostone.
Remikiren	Remikiren may increase the hypotensive activities of Unoprostone.
Torasemide	Torasemide may increase the hypotensive activities of Unoprostone.
Bethanidine	Bethanidine may increase the hypotensive activities of Unoprostone.
Guanadrel	Guanadrel may increase the hypotensive activities of Unoprostone.
Metoprolol	Metoprolol may increase the hypotensive activities of Unoprostone.
Isradipine	Isradipine may increase the hypotensive activities of Unoprostone.
Olmesartan	Olmesartan may increase the hypotensive activities of Unoprostone.
Chlorthalidone	Chlorthalidone may increase the hypotensive activities of Unoprostone.
Nitroprusside	Nitroprusside may increase the hypotensive activities of Unoprostone.
Atenolol	Atenolol may increase the hypotensive activities of Unoprostone.
Diltiazem	Diltiazem may increase the hypotensive activities of Unoprostone.
Minoxidil	Minoxidil may increase the hypotensive activities of Unoprostone.
Timolol	Timolol may increase the hypotensive activities of Unoprostone.
Treprostinil	Treprostinil may increase the hypotensive activities of Unoprostone.
Amlodipine	Amlodipine may increase the hypotensive activities of Unoprostone.
Nimodipine	Nimodipine may increase the hypotensive activities of Unoprostone.
Nisoldipine	Nisoldipine may increase the hypotensive activities of Unoprostone.
Prazosin	Prazosin may increase the hypotensive activities of Unoprostone.
Fosinopril	Fosinopril may increase the hypotensive activities of Unoprostone.
Trandolapril	Trandolapril may increase the hypotensive activities of Unoprostone.
Carteolol	Carteolol may increase the hypotensive activities of Unoprostone.
Metolazone	Metolazone may increase the hypotensive activities of Unoprostone.
Lercanidipine	Lercanidipine may increase the hypotensive activities of Unoprostone.
Benazepril	Benazepril may increase the hypotensive activities of Unoprostone.
Bosentan	Bosentan may increase the hypotensive activities of Unoprostone.
Propranolol	Propranolol may increase the hypotensive activities of Unoprostone.
Clonidine	Clonidine may increase the hypotensive activities of Unoprostone.
Enalapril	Enalapril may increase the hypotensive activities of Unoprostone.
Doxazosin	Doxazosin may increase the hypotensive activities of Unoprostone.
Labetalol	Labetalol may increase the hypotensive activities of Unoprostone.
Bisoprolol	Bisoprolol may increase the hypotensive activities of Unoprostone.
Candoxatril	Candoxatril may increase the hypotensive activities of Unoprostone.
Nicardipine	Nicardipine may increase the hypotensive activities of Unoprostone.
Guanabenz	Guanabenz may increase the hypotensive activities of Unoprostone.
Mecamylamine	Mecamylamine may increase the hypotensive activities of Unoprostone.
Losartan	Losartan may increase the hypotensive activities of Unoprostone.
Moexipril	Moexipril may increase the hypotensive activities of Unoprostone.
Phentolamine	Phentolamine may increase the hypotensive activities of Unoprostone.
Eplerenone	Eplerenone may increase the hypotensive activities of Unoprostone.
Lisinopril	Lisinopril may increase the hypotensive activities of Unoprostone.
Nitroglycerin	Nitroglycerin may increase the hypotensive activities of Unoprostone.
Metyrosine	Metyrosine may increase the hypotensive activities of Unoprostone.
Cryptenamine	Cryptenamine may increase the hypotensive activities of Unoprostone.
Perindopril	Perindopril may increase the hypotensive activities of Unoprostone.
Candesartan cilexetil	Candesartan cilexetil may increase the hypotensive activities of Unoprostone.
Tolazoline	Tolazoline may increase the hypotensive activities of Unoprostone.
Fenoldopam	Fenoldopam may increase the hypotensive activities of Unoprostone.
Tadalafil	Tadalafil may increase the hypotensive activities of Unoprostone.
Alprenolol	Alprenolol may increase the hypotensive activities of Unoprostone.
Dorzolamide	Dorzolamide may increase the hypotensive activities of Unoprostone.
Eprosartan	Eprosartan may increase the hypotensive activities of Unoprostone.
Quinapril	Quinapril may increase the hypotensive activities of Unoprostone.
Omapatrilat	Omapatrilat may increase the hypotensive activities of Unoprostone.
Bimatoprost	Bimatoprost may increase the hypotensive activities of Unoprostone.
Phenoxybenzamine	Phenoxybenzamine may increase the hypotensive activities of Unoprostone.
Pindolol	Pindolol may increase the hypotensive activities of Unoprostone.
Telmisartan	Telmisartan may increase the hypotensive activities of Unoprostone.
Methyldopa	Methyldopa may increase the hypotensive activities of Unoprostone.
Guanfacine	Guanfacine may increase the hypotensive activities of Unoprostone.
Felodipine	Felodipine may increase the hypotensive activities of Unoprostone.
Irbesartan	Irbesartan may increase the hypotensive activities of Unoprostone.
Nitrendipine	Nitrendipine may increase the hypotensive activities of Unoprostone.
Deserpidine	Deserpidine may increase the hypotensive activities of Unoprostone.
Pentolinium	Pentolinium may increase the hypotensive activities of Unoprostone.
Trimethaphan	Trimethaphan may increase the hypotensive activities of Unoprostone.
Diazoxide	Diazoxide may increase the hypotensive activities of Unoprostone.
Carvedilol	Carvedilol may increase the hypotensive activities of Unoprostone.
Bretylium	Bretylium may increase the hypotensive activities of Unoprostone.
Terazosin	Terazosin may increase the hypotensive activities of Unoprostone.
Guanethidine	Guanethidine may increase the hypotensive activities of Unoprostone.
Rescinnamine	Rescinnamine may increase the hypotensive activities of Unoprostone.
Acebutolol	Acebutolol may increase the hypotensive activities of Unoprostone.
Captopril	Captopril may increase the hypotensive activities of Unoprostone.
Nadolol	Nadolol may increase the hypotensive activities of Unoprostone.
Metipranolol	Metipranolol may increase the hypotensive activities of Unoprostone.
Epoprostenol	Epoprostenol may increase the hypotensive activities of Unoprostone.
Bepridil	Bepridil may increase the hypotensive activities of Unoprostone.
Hydralazine	Hydralazine may increase the hypotensive activities of Unoprostone.
Bevantolol	Bevantolol may increase the hypotensive activities of Unoprostone.
Practolol	Practolol may increase the hypotensive activities of Unoprostone.
Cilazapril	Cilazapril may increase the hypotensive activities of Unoprostone.
Saprisartan	Saprisartan may increase the hypotensive activities of Unoprostone.
Spirapril	Spirapril may increase the hypotensive activities of Unoprostone.
Penbutolol	Penbutolol may increase the hypotensive activities of Unoprostone.
Mibefradil	Mibefradil may increase the hypotensive activities of Unoprostone.
Oxprenolol	Oxprenolol may increase the hypotensive activities of Unoprostone.
Pargyline	Pargyline may increase the hypotensive activities of Unoprostone.
Dexpropranolol	Dexpropranolol may increase the hypotensive activities of Unoprostone.
Tienilic acid	Tienilic acid may increase the hypotensive activities of Unoprostone.
Debrisoquine	Debrisoquine may increase the hypotensive activities of Unoprostone.
Celiprolol	Celiprolol may increase the hypotensive activities of Unoprostone.
Nebivolol	Nebivolol may increase the hypotensive activities of Unoprostone.
Lofexidine	Lofexidine may increase the hypotensive activities of Unoprostone.
Sitaxentan	Sitaxentan may increase the hypotensive activities of Unoprostone.
Ambrisentan	Ambrisentan may increase the hypotensive activities of Unoprostone.

Referensi & Sumber

Link

Contoh Produk & Brand

Produk: 2 • International brands: 0

Produk

Rescula

Solution / drops • 1.5 mg/1mL • Ophthalmic • US • Approved
Rescula

Solution • 0.15 % • Ophthalmic • Canada • Approved

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.

Peringatan Keamanan

Deskripsi

Struktur Molekul 2D

Deskripsi metode visualisasi