Peringatan Keamanan

Sulconazole has been shown to be embryotoxic in a study of rats given 125 times the human dose (in mg/kg) and also resulted in prolonged gestation and dystocia. There are no adequate or controlled studies in pregnant women, therefore sulconazole should only be used during pregnancy if potential benefit justifies potential risk to the fetus.L44592,L44597

Sulconazole

DB06820

small molecule approved

Deskripsi

Sulconazole, brand name Exelderm, is a broad-spectrum anti-fungal agent available as a topical cream and solution. Sulconazole nitrate, the active ingredient, is an imidazole derivative that inhibits the growth of common pathogenic dermatophytes, making it an effective treatment for tinea cruris and tinea corporis infections.L44592,L44597 Sulconazole appears to be effective and well-tolerated in the treatment of superficial fungal infections.^A255612

Struktur Molekul 2D

Berat 397.74

Wujud solid

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) -

Volume Distribusi -

Klirens (Clearance) -

Absorpsi

A study done on healthy subjects given sulconazole 1% cream over a seven-day period, showed that the total percutaneous absorption of sulconazole after topical administration was 8.71-11.3% of the dose.^A7140 Another study also done on healthy volunteers given 1 g of sulconazole 1% cream, estimated that about 12% of the dose was absorbed through the skin.^A255612 In general, topical imidazoles are poorly absorbed (<15%); however, sulconazole may have higher levels of absorption compared to others.A7140,A255617

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

About 6.70% of the dose was recovered in urine, and 2.01% in feces over a 7 day collection period. Radioactivity could be detected in both urine and feces at 7 days potentially due to a reservoir effect.^A7140

Interaksi Obat

8 Data

Haloperidol	The serum concentration of Haloperidol can be increased when it is combined with Sulconazole.
Oliceridine	The serum concentration of Oliceridine can be increased when it is combined with Sulconazole.
Stiripentol	The metabolism of Sulconazole can be decreased when combined with Stiripentol.
Roflumilast	The serum concentration of Roflumilast can be increased when it is combined with Sulconazole.
Clozapine	The serum concentration of Clozapine can be increased when it is combined with Sulconazole.
Doxorubicin	The serum concentration of Doxorubicin can be increased when it is combined with Sulconazole.
Fezolinetant	The serum concentration of Fezolinetant can be increased when it is combined with Sulconazole.
Lisdexamfetamine	The serum concentration of dextroamphetamine, an active metabolite of Lisdexamfetamine, can be increased when used in combination with Sulconazole.

Target Protein

Lanosterol 14-alpha demethylase ERG11

Referensi & Sumber

Artikel (PubMed)

PMID: 3171926
Franz TJ, Lehman P: Percutaneous absorption of sulconazole nitrate in humans. J Pharm Sci. 1988 Jun;77(6):489-91.
PMID: 945306
Holt RJ: Topical pharmacology of imidazole antifungals. J Cutan Pathol. 1976;3(1):45-59.
PMID: 26776224
Mazu TK, Bricker BA, Flores-Rozas H, Ablordeppey SY: The Mechanistic Targets of Antifungal Agents: An Overview. Mini Rev Med Chem. 2016;16(7):555-78.
PMID: 3281821
Benfield P, Clissold SP: Sulconazole. A review of its antimicrobial activity and therapeutic use in superficial dermatomycoses. Drugs. 1988 Feb;35(2):143-53. doi: 10.2165/00003495-198835020-00004.
PMID: 2408257
Cleary JD, Taylor JW, Chapman SW: Imidazoles and triazoles in antifungal therapy. DICP. 1990 Feb;24(2):148-52. doi: 10.1177/106002809002400207.

Link

Contoh Produk & Brand

Produk: 9 • International brands: 0

Produk

Exelderm

Solution • 10 mg/1mL • Topical • US • Approved
Exelderm

Cream • 10 mg/1g • Topical • US • Approved
Exelderm

Cream • 10 mg/1g • Topical • US • Approved
Exelderm

Cream • 10 mg/1g • Topical • US • Approved
Exelderm

Solution • 10 mg/1mL • Topical • US • Approved
Exelderm

Cream • 10 mg/1g • Topical • US • Approved
Exelderm

Solution • 10 mg/1mL • Topical • US • Approved
Sulconazole Nitrate

Cream • 10 mg/1g • Topical • US • Approved

Menampilkan 8 dari 9 produk.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.